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Patent # Description
2016/0311856 PEPTIDE COMPOUNDS TO REGULATE THE COMPLEMENT SYSTEM
The present invention provides peptide compounds that regulate the complement system and methods of using these compounds. The invention is an isolated,...
2016/0311855 Growth Hormone Releasing Peptides
Disclosed are peptide and peptidomimetic compounds generally according to formula (I) that are useful as GHRP analogs: ...
2016/0311854 IMMUNE SYSTEM MODULATORS
The present invention described herein relates to compositions that interact with molecules that suppress the immune system. More specifically, embodiments...
2016/0311853 CYTOTOXIC PEPTIDES AND CONJUGATES THEREOF
Disclosed herein are novel cytotoxic peptides of formula (I) as described herein: ##STR00001## and the use of such peptides in making immunoconjugates (i.e...
2016/0311852 METHODS FOR THE SYNTHESIS OF CERAGENINS
Disclosed herein are methods of making ceragnenin compounds for treating, preventing, or diagnosing diseases, disorders, or conditions associated with...
2016/0311851 METHODS FOR THE SYNTHESIS OF CERAGENINS
Disclosed herein are methods of making ceragnenin compounds for treating, preventing, or diagnosing diseases, disorders, or conditions associated with...
2016/0311850 CATIONIC STEROIDAL ANTIMICROBIAL SALTS
Disclosed herein are acid addition salts of cationic steroidal antimicrobials ("CSAs" or "ceragenins") and methods of making the same. Particularly...
2016/0311849 Industrial Process for the Synthesis of Ulipristal Acetate and its 4'-Acetyl Analogue
The present invention relates to a new process for the synthesis of compounds of formula (I) (wherein the meaning of R is dimethylamino or acetyl group) using...
2016/0311848 11-SUBSTITUTED BILE ACID DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND USE OF THESE COMPOUNDS AS MEDICAMENTS
The present invention discloses a novel bile acid derivatives having substituted nitrogen functionality at C-11 and process for synthesis thereof. These C-11...
2016/0311847 LINKER AND SUPPORT FOR SOLID PHASE SYNTHESIS OF NUCLEIC ACID, AND PRODUCTION METHOD OF NUCLEIC ACID USING SAID...
The present invention provides a linker for solid phase synthesis of nucleic acid, which consists of a compound represented by the formula (I) or the formula...
2016/0311846 FLUORESCENT DYES AND METHODS OF USE THEREOF
Provided are methods for labeling target molecules, such as nucleic acids, with fluorescent dye compounds having the formula ##STR00001## One method embodiment...
2016/0311845 NUCLEOTIDE DERIVATIVE OR SALT THEREOF, NUCLEOTIDE-DERIVED 5'-PHOSPHATE ESTER OR SALT THEREOF,...
A nucleoside derivative represented by any of the following formulae (I-1) to (I-6) or a salt thereof: ##STR00001## ##STR00002## in the formulae (I-1) to (I-6),...
2016/0311844 RIBOFURANOSYL PURINE COMPOUNDS, METHODS FOR PREPARING THE SAME AND USE THEREOF
The present invention relates to the compounds of the formulae (I) and (I-1) and the process for preparing the same, uses of the compounds for the treatment of...
2016/0311843 SUBSTITUTED NUCLEOSIDE DERIVATIVES WITH ANTIVIRAL AND ANTIMICROBIAL PROPERTIES
The present invention relates to fatty acid and fatty alcohol substituted nucleoside derivatives and nucleoside and nucleoside derivatives substituted on...
2016/0311842 ALLOSTERIC MODULATORS OF FACTOR XIa AS ANTICOAGULANT AGENTS
Compounds which allosterically modulate and/or inhibit factor XIa activity are provided, as are methods of their use. These compounds include i) sulfated...
2016/0311841 METAL CATALYZED HYDROLYSIS OF CELLULOSE AND HEMICELLULOSE TO PRODUCE MONOMERIC CARBOHYDRATES FOR TRANSPORTATION...
Methods and compositions for processing biomass using [Co(CN)5]3'' are disclosed. The resulting products include monomeric carbohydrate units that can also be...
2016/0311840 METHODS FOR PREPARING ANTI-VIRAL NUCLEOTIDE ANALOGS
Methods for isolating 9-{(R)-2-[((S)-{[(S)-1-(isopropoxycarbonyl)ethyl]amino}phenoxyphosphinyl)- methoxy]propyl}adenine (compound 16): ##STR00001## a method...
2016/0311839 PYRAZOLE COMPOUNDS AND METHOD FOR MAKING AND USING THE COMPOUNDS
Disclosed embodiments concern novel interleukin receptor associated kinases (IRAK) inhibitors and compositions comprising such inhibitors. Also disclosed are...
2016/0311838 PHOSPHOHISTIDINE MIMETICS AND ANTIBODIES TO SAME
Provided are phosphonopyrazole-based phosphohistidine analogs that are useful as haptens for the preparation of immunogens, immunogens that include these...
2016/0311837 METAL-LIGAND COMPLEX, OLEFIN POLYMERIZATION CATALYST DERIVED THEREFROM, AND OLEFIN POLYMERIZATION METHOD...
A metal-ligand complex has formula (I): wherein J, L, M, R.sup.1, R.sup.2, R.sup.3, R.sup.4, X, p, q, and r are defined herein. The metal-ligand complex is...
2016/0311836 PRODUCTION METHOD FOR 2-FLUORO-4-BORONO-L-PHENYLALANINE, AND PRECURSOR OF 2-FLUORO-4-BORONO-L-PHENYLALANINE
The present invention involves preparing compounds represented by the formula. (In the formula: R.sup.1 represents a Br group, an iodine group, a Cl group, an...
2016/0311835 NOVEL ANTIBIOTICS
The invention relates generally to novel antibiotics and their analogs, to processes for the preparation of these novel antibiotics, to pharmaceutical...
2016/0311834 PSEUDOPOLYMORPHS OF AN HCV NS5A INHIBITOR AND USES THEREOF
The present invention relates to novel Pseudopolymorphs of Compound A, compositions comprising at least one Pseudopolymorph of Compound A, and methods of using...
2016/0311833 NOVEL INDAZOLECARBOXAMIDES, PROCESSES FOR THEIR PREPARATION, PHARMACEUTICAL PREPARATIONS COMPRISING THEM AND...
The present application relates to novel 6-substituted indazoles having a carboxamide side chain, to processes for their preparation, to their use alone or in...
2016/0311832 COMPOUNDS FOR TREATING PRURITIC CONDITIONS
The present invention includes compounds having structural formula (I), or pharmaceutically acceptable salts, solvates, and/or esters thereof. These compounds...
2016/0311831 Imidazotriazinones as PDE1 Inhibitors
The present invention provides imidazotriazinones as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative...
2016/0311830 TETRAHYDRO-TETRAZOLO[1,5-A]PYRAZINES AS ROR-GAMMA INHIBITORS
The present invention relates to tetrahydro-tetrazolo[1,5-a]pyrazine compounds of formula (I), wherein R.sup.1 denotes --R.sup.3, --CH.sub.2--R.sup.3 or...
2016/0311829 WNT PATHWAY MODULATORS
The present invention relates to dihydropyrazolo[1,5-a]pyrimidine compounds of formula I, defined herein, as WNT pathways modulators, processes for making...
2016/0311828 FUSED IMIDAZOLYL DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS
The present invention relates to new fused imidazolyl derivatives having a high affinity for sigma receptors, especially sigma-1 receptors, as well as to the...
2016/0311827 THE METHOD FOR MANUFACTURING OF VARDENAFIL AND ITS SALTS
The method of synthesizing vardenafil base, in anhydrous conditions, by chlorosulfonation of ...
2016/0311826 SGC STIMULATORS
The present patent application discloses at least the compounds according to Formula I shown below, or pharmaceutically acceptable salts thereof, ##STR00001## ...
2016/0311825 IMIDAZOPYRIDAZINES USEFUL AS INHIBITORS OF THE PAR-2 SIGNALING PATHWAY
The present invention relates to compounds useful as inhibitors of the PAR-2 signaling pathway. The invention also relates to pharmaceutically acceptable...
2016/0311824 SUBSTITUTED 4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRAZINE DERIVATIVES AS CASEIN KINASE 1 D/E INHIBITORS
The invention provides compounds of Formula (I): ##STR00001## and pharmaceutically acceptable salts thereof. The compounds of Formula (I) inhibit protein kinase...
2016/0311823 SYNTHETIC VOACANGINE
Synthetic voacangine, including in substantially enantiomerically enriched forms, and derivatives thereof are provided.
2016/0311822 1,6- DIAZABICYCLO [3,2,1] OCTAN-7-ONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF BACTERIAL INFECTIONS
Compounds of Formula (I), their preparation and use in preventing or treating bacterial infections are disclosed. ##STR00001##
2016/0311821 Compound (S) and (R)-N-(2-fluoropyridin-4-yl)-3-methyl-2-(5-methyl-2,4-dioxo-1,2-dihydropy- ...
The present invention relates to a compound of Formula (I) having pharmacological activity, processes for its preparation, pharmaceutical compositions and...
2016/0311820 BTK INHIBITORS
The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula I or pharmaceutically acceptable salts thereof. Formula...
2016/0311819 ERK INHIBITORS
Disclosed are the ERK inhibitors of formula (1.0) and the pharmaceutically acceptable salts thereof. Also disclosed are methods of treating cancer using the...
2016/0311818 QUINOLINONE FIVE-MEMBERED HETEROCYCLIC COMPOUNDS AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS
The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation...
2016/0311817 HETEROARYL SULTAM DERIVATIVES AS RORc MODULATORS
Compounds of the formula I ##STR00001## or a pharmaceutical salt thereof, wherein m, n, q, r, A, W, X.sup.1, X.sup.2, X.sup.3, X.sup.4, Y, Z, R.sup.1, R.sup.2,...
2016/0311816 COMPOSITIONS AND METHODS FOR INHIBITING KINASES
The present invention provides compounds for the prevention or treatment of cancer or a bacterial or viral infection. Additionally, the present invention...
2016/0311815 Quinazolinone Derivatives for Use in the Treatment of Chlamydiales Infections
The present invention relates to a method for treating a Chlamydiae infection comprising the administration of a therapeutically effective amount of a compound...
2016/0311814 CYCLOPROPANAMINE COMPOUND AND USE THEREOF
The present invention provides a compound having a lysine-specific demethylase-1 inhibitory action, and useful as a medicament such as a prophylactic or...
2016/0311813 THIAZOLE-SUBSTITUTED AMINOHETEROARYLS AS SPLEEN TYROSINE KINASE INHIBITORS
The invention provides certain thiazole-substituted aminoheteroaryl compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein R.sup.1,...
2016/0311812 ADENOSINE A1 AGONISTS AS MEDICAMENTS FOR KIDNEY DISORDERS
The present application relates to selective partial adenosine A1 receptor agonists of the formula (I) and their use for treating and/or preventing diseases...
2016/0311811 HETEROCYCLIC COMPOUND
The present invention provides a heterocyclic compound having an IRAK-4 inhibitory action, which is useful for the prophylaxis or treatment of inflammatory...
2016/0311810 SYNTHESIS OF RALTEGRAVIR
The present invention relates to a novel synthetic route for the preparation of raltegravir and pharmaceutically acceptable salts, starting from...
2016/0311809 COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE
The present invention relates to pyrazine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable...
2016/0311808 CYCLOPROPANAMINE COMPOUND AND USE THEREOF
The present invention provides a compound having a lysine-specific demethylase-1 inhibitory action, and useful as a medicament such as a prophylactic or...
2016/0311807 METHODS TO TREAT LYMPHOPLASMACYTIC LYMPHOMA
The present invention provides compounds of any one of Formulae (I) to (V) (e.g., compounds of any one of Formulae (I-1) to (I-9)), and methods for treating...
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