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Patent # Description
2016/0311806 4,4'-BIPHENYLDIYL-BIS-(1 H-IMIDAZOLYL) DERIVATIVES AS HEPATITIS HCV INHIBITORS
The present disclosure relates to compounds of formula (I), pharmaceutical compositions and use thereof in treatment of hepatitis C virus (HCV) infection. ...
2016/0311805 ANTI-ESTROGENIC COMPOUNDS
The present disclosure provides a compound of Formula I: ##STR00001## or a pharmaceutically acceptable salt wherein X, R.sup.1-R.sup.8, Y.sup.1-Y.sup.5, m, n, p,...
2016/0311804 Process
The present invention relates to a process for preparing (R)-5-(2-(benzylamino)ethyl)-1-(6,8-difluorochroman-3-yl)-1H-imidazole-2(- 3H)-thione, and...
2016/0311803 HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS
Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such...
2016/0311802 BIARYL INHIBITORS OF BRUTON'S TYROSINE KINASE
The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable...
2016/0311801 INHIBITORS OF BRUTON'S TYROSINE KINASE
This application discloses compounds according to generic Formula (I) wherein all variables are defined as described herein, which inhibit Btk. The compounds...
2016/0311800 PYRAZOLYL QUINOXALINE KINASE INHIBITORS
The invention relates to new quinoxaline derivative compounds, to pharmaceutical compositions comprising said compounds, to processes for the preparation of...
2016/0311799 METHOD FOR SYNTHESIZING 2,6-BIS[3'-(N-CARBAZOLYL)PHENYL]PYRIDINE COMPOUND
The present invention relates to "a method for synthesizing 2,6-bis[3'-(N-carbazolyl)phenyl]pyridine compound", and belongs to the field of chemical synthesis....
2016/0311798 N1-(3,3,3-TRIFLUORO-2-HYDROXO-2-METHYLPROPIONYL)-PIPERIDINE DERIVATIVES AS INHIBITORS OF PYRUVATE DEHYDROGENASE...
Compounds of the formula (I) in which R, R.sup.1 and R.sup.3 have the meanings indicated in claim 1, are inhibitors of pyruvate dehydrogenase kinase (PDHK),...
2016/0311797 INDAZOLE COMPOUNDS AS 5-HT4 RECEPTOR AGONISTS
The present invention relates to novel indazole compounds of the Formula (I), wherein, R.sub.1 is alkyl or cycloalkyl; (Formula II) including their...
2016/0311796 QUINAZOLINE DERIVATIVE
Disclosed are N-[4-(3-chloro-4-fluorophenylamino)-7-(2-methoxyethoxy) quinazolin-6-yl]-2 -[1-(2-methoxyethyl)piperidin-4-ylidene]acetamide and a...
2016/0311795 PYRIMIDINE DIAMINE DERIVATIVES AS INHIBITORS OF CYTOSOLIC HSP90
The present application describes organic compounds that inhibit the activity of cytosolic heat shock protein Hsp90. Also described are methods useful for...
2016/0311794 COMPOUND HAVING SOMATOSTATIN RECEPTOR AGONISTIC ACTIVITY AND PHARMACEUTICAL USE THEREOF
The present invention provides a somatostatin receptor subtype 2 agonist. A disclosed compound represented by the general formula (I): ##STR00001## wherein all...
2016/0311793 Production of Meso-Lactide, D-Lactide, and L-Lactide by Back Biting of Polylactide
Process for increasingly producing D-Lactide and meso lactide by depolymerizing by back biting polylactide (PLA) said process which comprises: (i)...
2016/0311792 Sulfamate Derivative Compounds for Use in Treating or Alleviating Pain
The present invention relates to sulfamate derivative compounds and a composition for treating and/or alleviating pain containing the sulfamate derivative...
2016/0311791 NOVEL TRICYCLIC CALCIUM SENSING RECEPTOR ANTOGONISTS FOR THE TREATMENT OF OSTEOPOSOSIS
Novel tricyclic compounds of Formula (I) and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing osteoporosis and...
2016/0311790 PURIFYING CRUDE FURAN 2,5-DICARBOXYLIC ACID BY HYDROGENATION AND A PURGE ZONE
A process for purifying a crude furan 2,5-dicarboxylic acid composition (cFDCA) by hydrogenation of a FDCA composition dissolved in a hydrogenation solvent...
2016/0311789 METHOD FOR PREPARING HIGH-QUALITY EPOXIDIZED FATTY ACID ESTER WITH MICRO-REACTION DEVICE
A method for preparing a high-quality epoxidized fatty acid ester with a micro-reaction device, including: respectively pumping an aqueous hydrogen peroxide...
2016/0311788 Antifouling Compounds And Use Thereof
The present invention relates to the use of compounds which have the following general formula (I): ##STR00001## wherein R.sup.1 and R.sup.2 are independently...
2016/0311787 CARBAMATE BENZOXAZINE PROPIONIC ACIDS AND ACID DERIVATIVES FOR MODULATION OF RORgamma ACTIVITY AND THE...
The invention provides certain benzoxazine compounds of the Formula (I) or pharmaceutically acceptable salts thereof wherein R.sup.1, R.sup.2, R.sup.a1,...
2016/0311786 HIV PROTEASE INHIBITORS
The present invention is directed to 2,5,6-substituted morpholine derivatives and their use in the inhibition of HIV protease, the inhibition of HIV...
2016/0311785 TRIAZINE MEDIATED LIVING RADICAL CONTROLLED POLYMERIZATION
The disclosure provides modular triazine-based unimolecular initiator compounds useful in controlled radical polymerizations of vinyl-containing monomers.
2016/0311784 CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS
A method of treating a disorder. The method includes administering to a subject in need thereof a compound of general formula (I): ##STR00001## Each of A, N*, X,...
2016/0311783 Benzodiazepine Derivatives for Use in the Treatment of Chlamydiales Infections
The invention relates to a method for treating a Chlamidyales infection comprising the administration of a therapeutically effective amount of a compound of...
2016/0311782 N-ARYLMETHYL SULFONAMIDE NEGATIVE MODULATORS OF NR2A
Compounds that selectively negatively modulate NMDA receptors containing an NR2A subunit, pharmaceutical compositions comprising the compounds, and methods of...
2016/0311781 PROCESS FOR MAKING SUBSTITUTED QUINAZOLINE COMPOUNDS
The present invention is directed to a process for making Substituted Quinazoline Compounds of formula (I): which are useful for the treatment and prophylaxis...
2016/0311780 HETEROARYL COMPOUNDS AND USES THEREOF
The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
2016/0311779 2-BENZYL-BENZIMIDAZOLE COMPLEMENT FACTOR B INHIBITORS AND USES THEREOF
The present invention provides a compound of formula (I) a method for manufacturing the compounds of the invention, and its therapeutic uses. The present...
2016/0311778 Hepatitis C Virus Inhibitors
The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical...
2016/0311777 Method for preparing nilotinib intermediate
Disclosed in the present invention is a method for preparing nilotinib intermediate 3-(4-methyl-1H-imidazol-1-yl)-5trifluoromethyl phenylamine (I). The method...
2016/0311776 SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITIORS
The present invention relates to substituted indazole compounds which modulate the activity of protein kinases and are therefore useful in treating diseases...
2016/0311775 AROMATIC COMPOUND AND USE THEREOF
An aromatic compound represented by formula (1): wherein R.sup.1 and R.sup.2 each independently represents a halogen atom, a C1-C4 alkyl group, or a C1-C4...
2016/0311774 FUSED-BICYCLIC ARYL QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS
The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation...
2016/0311773 GLUCOSE METABOLISM MODULATING COMPOUNDS
The present invention provides, inter alia, dihydropyridone compounds and compositions, including analogs of a vesicular monoamine transporter type 2 (VMAT2)...
2016/0311772 COMPOUNDS AS TNIK, IKKEPSILON AND TBK1 INHIBITORS AND PHARMACEUTICAL COMPOSITION COMPRISING SAME
Provided is a compound of formula (I) as a TNIK (Traf2- and NCK-interacting kinase), IKK.epsilon. (I-kappa-B kinase epsilon) and TBK1 (TANK-binding kinase 1)...
2016/0311771 Oxygen Scavengers, Compositions Comprising the Scavengers, and Articles Made from the Compositions
The disclosure relates to oxygen scavenging molecules, compositions, methods of making the compositions, articles prepared from the compositions, and methods...
2016/0311770 OXINDOLE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE IN THE TREATMENT OF AMPK-RELATED DISEASES
The present invention relates to compounds corresponding to formula (I). Process for the preparation thereof and therapeutic use thereof. The compounds are...
2016/0311769 NOVEL FUNCTIONALIZED 1,3-BENZENE DIOLS AND THEIR METHOD OF USE FOR THE TREATMENT OF HEPATIC ENCEPHALOPTHY
Pharmaceutical compositions of the invention include novel functionalized 1,3-benzenediols having a disease-modifying action in the treatment of hepatic...
2016/0311768 METHOD OF PREPARING CORE-SHELL COPPER NANOPARTICLES IMMOBILIZED ON ACTIVATED CARBON AND METHOD OF PREPARING...
Disclosed herein is a method of preparing a Cu/Cu.sub.2O core-shell copper nanoparticle catalyst having high catalytic activity from [Cu.sub.3(BTC).sub.2] and...
2016/0311767 Novel Urea Compounds, Preparation Methods and Uses Thereof
The invention provides a compound of Formula I, an isomer, a pharmaceutically acceptable salt, or a solvate thereof, and use thereof in manufacture of a...
2016/0311766 BICYCLIC ALKYL COMPOUNDS AND SYNTHESIS
Disclosed herein are compounds of the general Formula (I), and methods of synthesizing a substituted bicyclo[1.1.1]pentane using a Group VII or Group IX...
2016/0311765 Method For Preparing Biuret Polyisocyanate
A method for continuously preparing biuret polyisocyanate, comprising: a mixed solution of a diisocyanate and a catalyst with water vapour, in an aerosol form,...
2016/0311764 ACTIVATORS OF MYOSIN II FOR MODULATING CELL MECHANICS
The present invention discloses small molecule compounds as activators of myosin II by promoting its assembly and recruitment to contractile structures in the...
2016/0311763 HETEROGENEOUS HYDROCYANATION
The present invention relates to an improved process for addition of hydrogen cyanide across olefins and, in particular, to the use of a specific aluminum...
2016/0311762 HYDRAZINYL LIPIDOIDS AND USES THEREOF
The present disclosure is directed to hydrazinyl lipidoids, formulations thereof further comprising at least one active agent, as well as methods of delivering...
2016/0311761 DOCOSAHEXAENOYL ETHANOLAMIDES
The invention describes novel mono or dihydroxy docosahexaenoic acid (DHA) analogues, their preparation, isolation, identification, purification and uses thereof.
2016/0311760 COMPOUNDS FOR TREATMENT OF CARDIAC ARRHYTHMIAS
Compounds and methods thereof for reducing cardiac arrhythmia are described. In particular, compounds generated by adding chemical groups that enhance the...
2016/0311759 Lipids and Lipid Compositions for the Delivery of Active Agents
This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R.sup.1-R.sup.4, n and p are defined herein. The...
2016/0311758 Method of Producing An Aminocarboxylic Acid
An aminocarboxylic acid is produced from a solution that includes an aminocarboxylate and a solvent. A method of producing the aminocarboxylic acid comprises...
2016/0311757 METHODS OF TREATING NEUROLOGICAL AND OTHER DISORDERS USING ENANTIOPURE DEUTERIUM-ENRICHED BUPROPION
The invention provides enantiopure deuterium-enriched bupropion, pharmaceutical compositions, and methods of treating neurological disorders, movement...
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