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METHOD OF TREATING WOUNDS
The present disclosure provides a method of treating wound healing in a subject, the method comprising administering to the subject a compound that inhibits...
ADRENOMEDULLIN BINDER FOR USE IN THERAPY OF CANCER
Subject matter of the present invention is an anti-ADM antibody or anti-ADM antibody fragment or anti-ADM non-Ig scaffold binding to the C-terminal portion of...
ANTIBODIES SPECIFIC FOR THE PROTOFIBRIL FORM OF BETA-AMYLOID PROTEIN
Isolated antibodies have been characterized which show specific affinity to a repeating conformational epitope of a protofibril form of the human ...
METHODS FOR THE TREATMENT OF CANCER AND INFLAMMATORY DISEASES USING
CEREBLON AS A PREDICTOR
Uses of the protein cereblon as a predictor of clinical sensitivity to cancer, inflammatory diseases, and patient response to drug treatment.
METHODS AND COMPOSITIONS FOR TREATING COMPLEMENT-ASSOCIATED DISORDERS
The present disclosure relates to, inter alia, compositions containing an inhibitor of human complement and use of the compositions in methods for treating or...
Anti-aP2 Antibodies and Antigen Binding Agents to Treat Metabolic
This invention is in the area of improved anti-aP2 antibodies and antigen binding agents, and compositions thereof, which target the lipid chaperone aP2/FABP4...
COMPOSITIONS AND METHODS OF TREATING OCULAR DISEASES
A method of treating a complement mediated ocular inflammation, hemorrhaging and fibrosis, and the pathological consequences thereof, in a subject in need...
Motif-Specific and Context-Independent Antibodies That Specifically Bind
to a Cleaved Caspase Motif
There is provided a motif-specific, context-independent antibody that specifically binds a recurring, modified motif consisting of (i) at least one sumoylated...
DRG11-RESPONSIVE (DRAGON) GENE AND USES THEREOF
This invention features methods and compositions useful for treating and diseases caused by a dysregulation of the BMP/GDF branch of the TGF-.beta. signaling...
VISTA-Ig for Treatment of Autoimmune, Allergic and Inflammatory Disorders
The present invention relates to a fusion proteins comprising regulatory T cell protein, VISTA (V-domain Immunoglobulin Suppressor of T cell Activation (PD-L3)...
AFLATOXIN NANOBODY IMMUNOABSORBENT AND IMMUNOAFFINITY COLUMN AND
PREPARATION METHOD AND USE THEREOF
An aflatoxin nanobody immunoabsorbent and immunoaffinity column and preparation method and use thereof. The immunoabsorbent comprises a solid phase carrier and...
Opsonic and Protective Monoclonal Antibodies Against Gram-Positive
The present invention in the fields of immunology and infectious diseases relates to opsonic and protective antibodies that are specific for Gram-positive...
TYPE III SECRETION SYSTEM TARGETING MOLECULES
This invention relates generally to molecules that specifically bind bacterial V-tip proteins of the type III secretion system of Gram negative bacteria such...
Randomized Humanized Antibody Libraries Engineered with Sequence and
A phage display library is formed by a plurality of recombinant phages; each of the plurality of recombinant phages comprising an M13-derived expression...
METHODS OF USE OF SECRETORY IgA
Described herein are methods of preventing and/or treating inflammation in a barrier surface structure in an individual in need thereof by orally administering...
OPTIMIZED Fc VARIANTS AND METHODS FOR THEIR GENERATION
The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
METHODS FOR DEPYROGENATION OF PROTEINS
Methods relating to depyrogenaton of proteins including vapor hydrogen peroxide treatment, gaseous chloride dioxide treatment or dehydrothermal treatment are...
Compounds Suitable for Treatment of Haemophilia
The present invention relates to VWF compounds as well as compositions suitable for treatment of blood clotting diseases.
RECOMBINANT FIBRINOGEN HIGH-PRODUCTION LINE AND METHOD FOR PRODUCING SAME
The present invention provides a recombinant strain highly producing fibrinogen which is an animal cell strain coexpressing a fibrinogen and an .alpha.2PI...
ISOFORM OF THE TGF-BETA RECEPTOR II
An isoform of the TGF beta receptor II comprising a sequence of about of 80 amino acids and lacking a transmembrane domain; wherein the isoform is a...
T CELL RECEPTOR BINDING TO ALWGPDPAAA, DERIVED FROM HUMAN PRE-PRO INSULIN
The present invention provides a T cell receptor (TCR) having the property of binding to ALWGPDPAAA (derived from human pre-pro insulin (PPI) protein) HLA-A*02...
PROTEASE RESISTANT PEPTIDES
The present invention provides protease-resistant peptides, methods of making such peptides, as well as compositions comprising protease-resistant peptides and...
IL-15 AND IL-15R\alpha SUSHI DOMAIN BASED IMMUNOCYTOKINES
The present invention relates to an immunocytokine comprising (a) a conjugate, and (b) an antibody or a fragment thereof directly or indirectly linked by...
Chimeric Virus-Like Particles Incorporating Fusion GPI Anchored GM-CSF and
This disclosure relates to a GM-CSF and IL-4 conjugate fused to a glycolipid (GPI)-anchoring sequence that is incorporated into chimeric virus-like particles...
PEPTIDE FOR PROMOTING OSTEOGENIC DIFFERENTIATION OR VASCULARIZATION AND
A peptide has the amino acid sequence of SEQ ID NO: 1. The peptide exhibits the activity of a differentiation factor by promoting differentiation by acting on...
METHODS FOR TREATING FATTY LIVER DISEASE
In certain aspects, the present invention provides compositions and methods for treating fatty liver disease by administering an antagonist of an ActRIIB...
METHOD FOR PREPARING SINGLE-VALENT, MODIFIED AVIDIN-LIKE MOLECULES AND
MODIFIED FUNCTIONAL CONJUGATES
Disclosed herein are methods for preparing modified, functional conjugates that includes the steps as follows. First, biotinylated peptides, each having a...
POLYPEPTIDES TARGETING GLYCOSYLATED MUC2 PROTEINS, METHODS OF SYNTHESIS,
THEIR NUCLEIC ACIDS AND USES THEREOF
The invention relates to polypeptides, defined through a consensus sequence, having a length from 10 to 80 amino-acid residues, and whose polypeptidic sequence...
Chemically Modified Graphene
This disclosure relates to graphene derivatives, as well as related devices including graphene derivatives and methods of using graphene derivatives.
INTERACTION OF MORAXELLA CATARRHALIS WITH EPITHELIAL CELLS, EXTRACELLULAR
MATRIX PROTEINS AND THE COMPLEMENT SYSTEM
The present disclosure relates to surface proteins of Moraxella catarrhalis and their ability to interact with epithelial cells via cell-associated fibronectin...
Methods of Transcription Activator Like Effector Assembly
The disclosure describes methods that include providing a first nucleic acid having a sequence encoding a first set comprising one or more transcription...
Melanocortin Receptor-Specific Peptides
Melanocortin receptor-specific cyclic peptides of the formula ##STR00001## where R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9,...
BETA-HAIRPIN PEPTIDOMIMETICS AS SELECTIVE ELASTASE INHIBITORS
.beta.-Hairpin peptidomimetics of the general formula cyclo(-Xaa.sup.1-Xaa.sup.2-Thr.sup.3-Xaa.sup.4-Ser.sup.5-Xaa.sup.6-Xaa.su- ...
METHOD FOR PROMOTING EXPRESSION OF CALRETICULIN, AND SYNTHETIC PEPTIDE FOR
USE IN METHOD FOR PROMOTING...
A method for promoting expression of calreticulin in at least one kind of eukaryotic cell, and a synthetic peptide useful in this method are provided. In the...
METHOD OF LOADING A CRYSTALLIZATION DEVICE
The present invention pertains to a method for loading a crystallization device and for manufacturing a crystallization device comprising multiple receptacles...
COMPOSITIONS AND METHODS FOR INCREASING TELOMERASE ACTIVITY
The present invention relates to methods and compositions for increasing telomerase activity in cells. Such compositions include pharmaceutical formulations....
PREPARATION METHOD AND ANALYTIC METHOD FOR THE EXTRACT OF ANTRODIA
An optimal preparation and analytic method for the extraction of Antrodia cinnamomea is disclosed. The important parameters for the extraction efficiency of...
NUCLEIC ACID COATED COLLOIDS
DNA-coated colloids are introduced that can rearrange and anneal using single-stranded DNA coatings with thicknesses that are smaller than the colloidal...
NOVEL 7-DEAZAPURINE NUCLEOSIDES FOR THERAPEUTIC USES
The invention provides compounds of formula I: ##STR00001## wherein R.sub.1, R.sub.2 and R.sub.3 have values defined in the specification and a pharmaceutically...
SOLID FORMS OF A THIOPHOSPHORAMIDATE NUCLEOTIDE PRODRUG
The present application relates to solid state forms, for example, crystalline forms of ...
URIDINE DIPHOSPHATE DERIVATIVES, COMPOSITIONS AND METHODS FOR TREATING
This disclosure relates to uridine di phosphate (UDP) derivatives, compositions comprising therapeutically effective amounts of those UDP derivatives and...
SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF
Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs...
Process for the Preparation of Sofosbuvir
The present disclosure relates to processes for the preparation of sofosbuvir or of its pharmaceutically acceptable salts. The present disclosure also provides...
Process for the Preparation of Empagliflozin
An improved process for the preparation of empagliflozin is disclosed. Novel intermediates of formulas (13) and (14) for the preparation of empagliflozin are...
NOVEL FERROCENYL COMPOUNDS
A ferrocenyl compound having the general formula (I): (I) Het is a substituted or unsubstituted heterocyclic moiety. L1, L2 and L3 are each a linker...
BASE METAL CATALYZED BORYLATION OF ARENES AND AROMATIC HETEROCYCLES
In one aspect, cobalt complexes are described herein. In some embodiments, such cobalt complexes employ bis(phosphine) or bis(imine) ligand and are operable as...
COMPOUNDS, COMPOSITIONS, AND METHODS FOR THE TREATMENT OF CANCERS
The present teachings relate to compounds and compositions for treatment of cancers. In some embodiments, the composition comprises a platinum (IV) complex...
COMPLEXES AND CATALYTIC PROCESSES
The present application is directed towards complexes of formula (I), to methods for preparing such complexes, and to use of such complexes in catalysis. The...
NOVEL MONOPHOSPHITE COMPOUNDS HAVING AN ETHER GROUP
Novel monophosphite compounds having an ether group, and a process for preparing these compounds, which are especially suitable for use as ligands in...
NOVEL MONOPHOSPHITE COMPOUNDS HAVING A METHYL GROUP
Novel monophosphite compounds having a methyl group, and a process for preparing these compounds, which are especially suitable for use as ligands in...