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Patent # Description
2016/0319008 METHOD OF TREATING WOUNDS
The present disclosure provides a method of treating wound healing in a subject, the method comprising administering to the subject a compound that inhibits...
2016/0319007 ADRENOMEDULLIN BINDER FOR USE IN THERAPY OF CANCER
Subject matter of the present invention is an anti-ADM antibody or anti-ADM antibody fragment or anti-ADM non-Ig scaffold binding to the C-terminal portion of...
2016/0319006 ANTIBODIES SPECIFIC FOR THE PROTOFIBRIL FORM OF BETA-AMYLOID PROTEIN
Isolated antibodies have been characterized which show specific affinity to a repeating conformational epitope of a protofibril form of the human ...
2016/0319005 METHODS FOR THE TREATMENT OF CANCER AND INFLAMMATORY DISEASES USING CEREBLON AS A PREDICTOR
Uses of the protein cereblon as a predictor of clinical sensitivity to cancer, inflammatory diseases, and patient response to drug treatment.
2016/0319004 METHODS AND COMPOSITIONS FOR TREATING COMPLEMENT-ASSOCIATED DISORDERS
The present disclosure relates to, inter alia, compositions containing an inhibitor of human complement and use of the compositions in methods for treating or...
2016/0319003 Anti-aP2 Antibodies and Antigen Binding Agents to Treat Metabolic Disorders
This invention is in the area of improved anti-aP2 antibodies and antigen binding agents, and compositions thereof, which target the lipid chaperone aP2/FABP4...
2016/0319002 COMPOSITIONS AND METHODS OF TREATING OCULAR DISEASES
A method of treating a complement mediated ocular inflammation, hemorrhaging and fibrosis, and the pathological consequences thereof, in a subject in need...
2016/0319001 Motif-Specific and Context-Independent Antibodies That Specifically Bind to a Cleaved Caspase Motif
There is provided a motif-specific, context-independent antibody that specifically binds a recurring, modified motif consisting of (i) at least one sumoylated...
2016/0319000 DRG11-RESPONSIVE (DRAGON) GENE AND USES THEREOF
This invention features methods and compositions useful for treating and diseases caused by a dysregulation of the BMP/GDF branch of the TGF-.beta. signaling...
2016/0318999 VISTA-Ig for Treatment of Autoimmune, Allergic and Inflammatory Disorders
The present invention relates to a fusion proteins comprising regulatory T cell protein, VISTA (V-domain Immunoglobulin Suppressor of T cell Activation (PD-L3)...
2016/0318998 AFLATOXIN NANOBODY IMMUNOABSORBENT AND IMMUNOAFFINITY COLUMN AND PREPARATION METHOD AND USE THEREOF
An aflatoxin nanobody immunoabsorbent and immunoaffinity column and preparation method and use thereof. The immunoabsorbent comprises a solid phase carrier and...
2016/0318997 Opsonic and Protective Monoclonal Antibodies Against Gram-Positive Pathogens
The present invention in the fields of immunology and infectious diseases relates to opsonic and protective antibodies that are specific for Gram-positive...
2016/0318996 TYPE III SECRETION SYSTEM TARGETING MOLECULES
This invention relates generally to molecules that specifically bind bacterial V-tip proteins of the type III secretion system of Gram negative bacteria such...
2016/0318995 Randomized Humanized Antibody Libraries Engineered with Sequence and Insert Diversity
A phage display library is formed by a plurality of recombinant phages; each of the plurality of recombinant phages comprising an M13-derived expression...
2016/0318994 METHODS OF USE OF SECRETORY IgA
Described herein are methods of preventing and/or treating inflammation in a barrier surface structure in an individual in need thereof by orally administering...
2016/0318993 OPTIMIZED Fc VARIANTS AND METHODS FOR THEIR GENERATION
The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
2016/0318992 METHODS FOR DEPYROGENATION OF PROTEINS
Methods relating to depyrogenaton of proteins including vapor hydrogen peroxide treatment, gaseous chloride dioxide treatment or dehydrothermal treatment are...
2016/0318991 Compounds Suitable for Treatment of Haemophilia
The present invention relates to VWF compounds as well as compositions suitable for treatment of blood clotting diseases.
2016/0318990 RECOMBINANT FIBRINOGEN HIGH-PRODUCTION LINE AND METHOD FOR PRODUCING SAME
The present invention provides a recombinant strain highly producing fibrinogen which is an animal cell strain coexpressing a fibrinogen and an .alpha.2PI...
2016/0318989 ISOFORM OF THE TGF-BETA RECEPTOR II
An isoform of the TGF beta receptor II comprising a sequence of about of 80 amino acids and lacking a transmembrane domain; wherein the isoform is a...
2016/0318988 T CELL RECEPTOR BINDING TO ALWGPDPAAA, DERIVED FROM HUMAN PRE-PRO INSULIN (PPI) PROTEIN
The present invention provides a T cell receptor (TCR) having the property of binding to ALWGPDPAAA (derived from human pre-pro insulin (PPI) protein) HLA-A*02...
2016/0318987 PROTEASE RESISTANT PEPTIDES
The present invention provides protease-resistant peptides, methods of making such peptides, as well as compositions comprising protease-resistant peptides and...
2016/0318986 IL-15 AND IL-15R\alpha SUSHI DOMAIN BASED IMMUNOCYTOKINES
The present invention relates to an immunocytokine comprising (a) a conjugate, and (b) an antibody or a fragment thereof directly or indirectly linked by...
2016/0318985 Chimeric Virus-Like Particles Incorporating Fusion GPI Anchored GM-CSF and IL-4 Conjugates
This disclosure relates to a GM-CSF and IL-4 conjugate fused to a glycolipid (GPI)-anchoring sequence that is incorporated into chimeric virus-like particles...
2016/0318984 PEPTIDE FOR PROMOTING OSTEOGENIC DIFFERENTIATION OR VASCULARIZATION AND USE THEREOF
A peptide has the amino acid sequence of SEQ ID NO: 1. The peptide exhibits the activity of a differentiation factor by promoting differentiation by acting on...
2016/0318983 METHODS FOR TREATING FATTY LIVER DISEASE
In certain aspects, the present invention provides compositions and methods for treating fatty liver disease by administering an antagonist of an ActRIIB...
2016/0318982 METHOD FOR PREPARING SINGLE-VALENT, MODIFIED AVIDIN-LIKE MOLECULES AND MODIFIED FUNCTIONAL CONJUGATES
Disclosed herein are methods for preparing modified, functional conjugates that includes the steps as follows. First, biotinylated peptides, each having a...
2016/0318981 POLYPEPTIDES TARGETING GLYCOSYLATED MUC2 PROTEINS, METHODS OF SYNTHESIS, THEIR NUCLEIC ACIDS AND USES THEREOF
The invention relates to polypeptides, defined through a consensus sequence, having a length from 10 to 80 amino-acid residues, and whose polypeptidic sequence...
2016/0318980 Chemically Modified Graphene
This disclosure relates to graphene derivatives, as well as related devices including graphene derivatives and methods of using graphene derivatives.
2016/0318979 INTERACTION OF MORAXELLA CATARRHALIS WITH EPITHELIAL CELLS, EXTRACELLULAR MATRIX PROTEINS AND THE COMPLEMENT SYSTEM
The present disclosure relates to surface proteins of Moraxella catarrhalis and their ability to interact with epithelial cells via cell-associated fibronectin...
2016/0318978 Methods of Transcription Activator Like Effector Assembly
The disclosure describes methods that include providing a first nucleic acid having a sequence encoding a first set comprising one or more transcription...
2016/0318977 Melanocortin Receptor-Specific Peptides
Melanocortin receptor-specific cyclic peptides of the formula ##STR00001## where R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9,...
2016/0318976 BETA-HAIRPIN PEPTIDOMIMETICS AS SELECTIVE ELASTASE INHIBITORS
.beta.-Hairpin peptidomimetics of the general formula cyclo(-Xaa.sup.1-Xaa.sup.2-Thr.sup.3-Xaa.sup.4-Ser.sup.5-Xaa.sup.6-Xaa.su- ...
2016/0318975 METHOD FOR PROMOTING EXPRESSION OF CALRETICULIN, AND SYNTHETIC PEPTIDE FOR USE IN METHOD FOR PROMOTING...
A method for promoting expression of calreticulin in at least one kind of eukaryotic cell, and a synthetic peptide useful in this method are provided. In the...
2016/0318974 METHOD OF LOADING A CRYSTALLIZATION DEVICE
The present invention pertains to a method for loading a crystallization device and for manufacturing a crystallization device comprising multiple receptacles...
2016/0318973 COMPOSITIONS AND METHODS FOR INCREASING TELOMERASE ACTIVITY
The present invention relates to methods and compositions for increasing telomerase activity in cells. Such compositions include pharmaceutical formulations....
2016/0318972 PREPARATION METHOD AND ANALYTIC METHOD FOR THE EXTRACT OF ANTRODIA CINNAMOMEA
An optimal preparation and analytic method for the extraction of Antrodia cinnamomea is disclosed. The important parameters for the extraction efficiency of...
2016/0318971 NUCLEIC ACID COATED COLLOIDS
DNA-coated colloids are introduced that can rearrange and anneal using single-stranded DNA coatings with thicknesses that are smaller than the colloidal...
2016/0318970 NOVEL 7-DEAZAPURINE NUCLEOSIDES FOR THERAPEUTIC USES
The invention provides compounds of formula I: ##STR00001## wherein R.sub.1, R.sub.2 and R.sub.3 have values defined in the specification and a pharmaceutically...
2016/0318969 SOLID FORMS OF A THIOPHOSPHORAMIDATE NUCLEOTIDE PRODRUG
The present application relates to solid state forms, for example, crystalline forms of ...
2016/0318968 URIDINE DIPHOSPHATE DERIVATIVES, COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISORDERS
This disclosure relates to uridine di phosphate (UDP) derivatives, compositions comprising therapeutically effective amounts of those UDP derivatives and...
2016/0318967 SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF
Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs...
2016/0318966 Process for the Preparation of Sofosbuvir
The present disclosure relates to processes for the preparation of sofosbuvir or of its pharmaceutically acceptable salts. The present disclosure also provides...
2016/0318965 Process for the Preparation of Empagliflozin
An improved process for the preparation of empagliflozin is disclosed. Novel intermediates of formulas (13) and (14) for the preparation of empagliflozin are...
2016/0318964 NOVEL FERROCENYL COMPOUNDS
A ferrocenyl compound having the general formula (I): (I) Het is a substituted or unsubstituted heterocyclic moiety. L1, L2 and L3 are each a linker...
2016/0318963 BASE METAL CATALYZED BORYLATION OF ARENES AND AROMATIC HETEROCYCLES
In one aspect, cobalt complexes are described herein. In some embodiments, such cobalt complexes employ bis(phosphine) or bis(imine) ligand and are operable as...
2016/0318962 COMPOUNDS, COMPOSITIONS, AND METHODS FOR THE TREATMENT OF CANCERS
The present teachings relate to compounds and compositions for treatment of cancers. In some embodiments, the composition comprises a platinum (IV) complex...
2016/0318961 COMPLEXES AND CATALYTIC PROCESSES
The present application is directed towards complexes of formula (I), to methods for preparing such complexes, and to use of such complexes in catalysis. The...
2016/0318960 NOVEL MONOPHOSPHITE COMPOUNDS HAVING AN ETHER GROUP
Novel monophosphite compounds having an ether group, and a process for preparing these compounds, which are especially suitable for use as ligands in...
2016/0318959 NOVEL MONOPHOSPHITE COMPOUNDS HAVING A METHYL GROUP
Novel monophosphite compounds having a methyl group, and a process for preparing these compounds, which are especially suitable for use as ligands in...
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