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Patent # Description
2016/0318958 UREA DERIVATIVES USEFUL AS KINASE INHIBITORS
There are provided compounds of formula I, wherein R.sup.1, R.sup.1A, R.sup.1C to R.sup.1E, R.sup.a, R.sup.b, X.sup.1, E and G have meanings given in the...
2016/0318957 CRYSTAL (1) OF PYRAZINO[2,1-c][1,2,4]TRIAZINE COMPOUND
Provided is a crystal of hydrate of 4-(((6S,9S)-1-(benzylcarbamoyl)-2,9-dimethyl-4,7-dioxo-8-(quinolin-8-ylme- ...
2016/0318956 HYDROGENATION OF ESTERS WITH FE/TRIDENTATE LIGANDS COMPLEXES
The present invention relates to the field of catalytic hydrogenation and, more particularly, to the use of Fe complexes with tridentate ligands, having one...
2016/0318955 Boron-Containing Small Molecules as Anti-Inflammatory Agents
Compounds and methods of treating anti-inflammatory conditions are disclosed.
2016/0318954 1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF
Provided herein are compounds according to Formulas (I) or (II) and pharmaceutically acceptable salts thereof, and compositions comprising the same, for use in...
2016/0318953 Selective BACE1 Inhibitors
The present invention provides a compound of Formula I: ##STR00001## or a pharmaceutically acceptable salt thereof.
2016/0318952 5-ARYL-1-IMINO-1-OXO-[1,2,4]THIADIAZINES
The present invention provides a compound of formula I' having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and...
2016/0318951 Tetrahydro[1,8]naphthyridine Sulfonamide And Related Compounds for Use as Agonists of RORy and the Treatment of...
The invention provides tetrahydro[1,8]naphthyridine and related compounds, pharmaceutical compositions, methods of promoting ROR.gamma. activity, increasing...
2016/0318950 FUSED BICYCLIC ISOXAZOLINES AS INHIBITORS OF CHOLESTEROL ESTER TRANSFER PROTEIN
Compounds having the structure of Formula I, including pharmaceutically acceptable salts of the compounds, wherein X is (CH.sub.2) or O, are CETP inhibitors...
2016/0318949 METHODS AND COMPOUNDS FOR SYNTHESIZING FUSED THIOPHENES
Disclosed herein are thiophene compounds of formulae (I), (I'), (II), (II'), (II''), and (II'''), methods for making such compounds, and methods for making...
2016/0318948 Compounds Inhibiting Eukaryotic Elongation Factor 2 Kinase Activity
Eukaryotic elongation factor 2 kinase inhibitors of the formula ##STR00001## where R.sub.1, R.sub.2, R.sub.3a, R.sub.3b, R.sub.4a, R.sub.4b, R.sub.5a, R.sub.5b,...
2016/0318947 PHARMACOLOGICALLY ACTIVE COMPOUNDS
The present invention relates to compounds of formula I shown below: ##STR00001## wherein Q is as defined herein. The compounds of formula I act as selective...
2016/0318946 ALCOHOL-, DIOL-, AND CARBOHYDRATE-SUBSTITUTED INDENOISOQUINOLINES AS TOPOISOMERASE I INHIBITORS
The invention described herein pertains to substituted indenoisoquinoline compounds as described herein, wherein R.sup.A, R.sup.D, W, X and Y are defined...
2016/0318945 TRITOQUALINE HYDROCHLORIDE IN CRYSTALLINE FORM AND A PROCESS FOR OBTAINING SAME
A crystalline form of tritoqualine hydrochloride and also a process for obtaining same. The process for obtaining tritoqualine hydrochloride is made of...
2016/0318944 PIPERIDINYLOXY LACTONE OREXIN RECEPTOR ANTAGONISTS
The present invention is directed to piperidinyloxy lactone compounds which are antagonists of orexin receptors. The present invention is also directed to uses...
2016/0318943 IMIDAZOLE DERIVATIVE USED AS ANTIVIRAL AGENT AND USE THEROF IN PREPARATION OF MEDICAMENT
Disclosed are an antiviral compound and a use thereof in the preparation of a medicament for the treatment of virus infections. Specifically, the present...
2016/0318942 TETRAHYDRO-PYRIMIDOAZEPINES AS MODULATORS OF TRPV1
Certain tetrahydro-pyrimidoazepine compounds are described, which are useful as TRPV1 modulators. Such compounds may be used in pharmaceutical compositions and...
2016/0318941 SUBSTITUTED [1,2,4]TRIAZOLO[4,3-a]PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS
Novel compounds of Formula I ##STR00001## and their use in therapeutic treatments.
2016/0318940 SOLID FORMS OF 1-ETHYL-7-(2-METHYL-6-(1H-1,2,4-TRIAZOL-3-YL)PYRIDIN-3-YL)-3,4-DIHYDROPYR- ...
Provided herein are formulations, processes, solid forms and methods of use relating to ...
2016/0318939 Imidazopyrazinones as PDE1 Inhibitors
The present invention provides imidazopyrazinones as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative...
2016/0318938 CRYSTALS (2) OF PYRAZINO[2,1-c][1,2,4]TRIAZINE COMPOUND
Provided are a crystal of a hydrate of compound 1, showing diffraction peaks at diffraction angles (2.theta..+-.0.2.degree.) of 10.7.degree., 10.9.degree.,...
2016/0318937 PYRAZOLO[1,5-A]PYRIMIDINES AS ANTIVIRAL COMPOUNDS
A compound of formula (I) or a pharmaceutically acceptable salt thereof, useful in therapy, in particular in the treatment of a viral infection. ##STR00001##
2016/0318936 PYRIMIDOPYRIMIDINONES USEFUL AS WEE-1 KINASE INHIBITORS
The present invention relates to compounds that are useful as inhibitors of the activity of Wee-1 kinase. The present invention also relates to pharmaceutical...
2016/0318935 BIARYL BRUTON'S TYROSINE KINASE INHIBITORS
The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable...
2016/0318934 2-METHYLSULPHANYL-6-NITRO-7-OXO-1, 2, 4-TRIAZOLO [5, 1-C] [1, 2, 4] TRIAZINIDE L-ARGININE DIHYDRATE ACTIVE...
The claimed invention relates to the field of biologically active compounds and concerns ...
2016/0318933 FUSED PYRAZOLE DERIVATIVE
The present invention provides a cyclic aminomethyl pyrimidine derivative including a pharmaceutically acceptable salt thereof with high selectivity for...
2016/0318932 PYRIDONE-SULFONE MORPHINAN ANALOGS AS OPIOID RECEPTOR LIGANDS
The application is directed to Pyridone-sulfone morphinan analogs compounds of Formula I: or pharmaceutically acceptable salts and solvates thereof, wherein...
2016/0318931 MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS
The present invention relates to modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane...
2016/0318930 METHOD FOR TREATING PAIN SYNDROME AND OTHER DISORDERS
The present invention provides the use of certain compounds to treat peripheral or central pain syndrome and other disorders associated with the T-type calcium...
2016/0318929 PYRAZOLO[1,5-A]PYRIDINE DERIVATIVES AND METHODS OF THEIR USE
The invention is directed to pyrazolo[1,5-a]pyridine derivatives and their use as AXL and c-MET kinase inhibitors.
2016/0318928 TRICYCLIC COMPOUNDS AS ANTICANCER AGENTS
The present invention is directed to tricyclic compounds (I), pharmaceutically acceptable compositions comprising compounds of the invention and methods of...
2016/0318927 P2X3 AND/OR P2X2/3 COMPOUNDS AND METHODS
The present application provides novel compounds and methods for preparing and using these compounds. In one embodiment, the compounds are of the structure of...
2016/0318926 MALEIMIDE DERIVATIVES AS MODULATORS OF WNT PATHWAY
The present invention relates to compounds of formula (I), combinations and uses thereof for disease therapy, or a pharmaceutically acceptable salt, solvate or...
2016/0318925 IMIDAZO [1,2-a]PYRIDINE COMPOUNDS, SYNTHESIS THEREOF, AND METHODS OF USING SAME
Embodiments relate to the field of chemistry and biochemistry, and, more specifically, to imidazopyridine compounds, synthesis thereof, and methods of using...
2016/0318924 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO
This document discloses molecules having the following formula ("Formula One"): ##STR00001## and processes related thereto.
2016/0318923 DIAZEPANE OREXIN RECEPTOR ANTAGONISTS
The present invention is directed to diazepane compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the...
2016/0318922 APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS
The present application relates to compounds having the inhibitory activity to apoptosis signal-regulating kinase (ASK1), thus are thus useful in treating...
2016/0318921 NOVEL GLUTAMINASE INHIBITORS
The present disclosure provides compounds of formula (I) to (III) as glutaminase inhibitors, methods of preparing them, pharmaceutical compositions containing...
2016/0318920 TRPV1 ANTAGONISTS INCLUDING DIHYDROXY SUBSTITUENT AND USES THEREOF
The disclosure relates to Compounds of Formula (I): ##STR00001## and pharmaceutically acceptable derivatives thereof wherein Ar.sub.1, Ar.sub.2, L.sub.1,...
2016/0318919 OXIME-SUBSTITUTED AMIDE COMPOUND AND PEST CONTROL AGENT
To provide a novel pesticide, especially a fungicide and a nematocide. An oxime-substituted amide compound represented by the formula (I) or its salt, and a...
2016/0318918 SMALL MOLECULE MODIFIERS OF THE HEC1-NEK2 INTERACTION IN G2/M
Certain embodiments of the present invention provide selected compounds having a molecular structure according to Formula 1: ##STR00001## In Formula 1, Z is...
2016/0318917 NRF2 REGULATORS
The present invention relates to bis aryl analogs, pharmaceutical compositions containing them and their use as Nrf2 regulators.
2016/0318916 NITROGEN-CONTAINING SIX-MEMBERED CYCLIC DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
A compound represented by formula (I): ##STR00001## wherein Z.sub.1 is C(R.sup.2) or N; Z.sub.3 is CH or N; Z.sub.2 is C(R.sup.3) or N; provided that Z.sub.1...
2016/0318915 3-PYRIMIDIN-4-YL-OXAZOLIDIN-2-ONES AS INHIBITORS OF MUTANT IDH
The invention is directed to a formula (I): ##STR00001## or a pharmaceutically acceptable salt thereof, wherein R.sup.1, R.sup.2a, R.sup.2b and R.sup.3-R.sup.7...
2016/0318914 SUBSTITUTED AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE
The invention relates to the preparation and use of new aminopyrimidine derivatives as drug candidates in free form or in pharmaceutically acceptable salt form...
2016/0318913 SUBSTITUTED AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE
The invention relates to the preparation and use of new aminopyrimidine derivatives as drug candidates in free form or in pharmaceutically acceptable salt form...
2016/0318912 A Novel Compound for the Treatment of Hepatitis C
The present invention provides (R)-5-(3-((2-(1,2,4-oxadiazol-3-yl)propan-2-yl)carbamoyl)phenyl)-6-(sec-b- ...
2016/0318911 1-HETEROARYL-INDOLINE-4-CARBOXAMIDES AS MODULATORS OF GPR52 USEFUL FOR THE TREATMENT OR PREVENTION OF DISORDERS...
The present invention relates to compounds of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of GPR52. Compounds of the...
2016/0318910 Quinazolin-THF-Amines as PDE1 Inhibitors
The present invention provides Quinazolin-THF-amines as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative...
2016/0318909 KINASE INHIBITORS
There are provided compounds of formula I, ##STR00001## wherein: Y represents NR.sup.2R.sup.3; one of R.sup.2 and R.sup.3 represents --[C.sub.2-4...
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