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NOVEL IMIDAZOLIDINE-2,4-DIONE DERIVATIVES
Imidazolidine-2,4-dione derivatives of formula (I): ##STR00001## These compounds have anti-proliferative activity and are useful for treating pathological states...
INHIBITORS OF BRUTON'S TYROSINE KINASE
This application discloses compounds according to generic Formula (I): wherein all variables are defined as described herein, which inhibit Btk. The compounds...
DIHYDRO-HYDANTOIN DERIVATIVES WITH HERBICIDAL ACTIVITY
The invention relates to substituted dihydro-hydantoin derivatives of the formula (I) wherein X, R.sup.a, R.sup.b, R.sup.c, R.sup.1, R.sup.2 and R.sup.3 are as...
Novel benzimidazole derivatives as EP4 ligands
The present invention relates to novel benzimidazole derivatives of the general formula (I), to processes for their preparation and to their use for preparing...
SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUNDS AS FACTOR XIA INHIBITORS
The present invention provides compounds of Formula (I): ##STR00001## or stereoisomers, pharmaceutically acceptable salts thereof, wherein all of the variables...
THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHODS OF USE
Provided are compounds useful for treating cancer and methods of treating cancer comprising administering to a subject in need thereof a compound described...
NOVEL IMIDAZOLIDINE-2,4-DIONE DERIVATIVES
Imidazolidine-2,4-dione derivatives of formula (I): ##STR00001## The compounds have anti-proliferative activity and are useful for treating pathological states...
The present application relates to novel substituted piperidinyltetrahydroquinolines, to processes for their preparation, to their use for the treatment and/or...
2-AMINO-3-ESTER-PYRIDYL OREXIN RECEPTOR ANTAGONISTS
The present invention is directed to 2-amino-3-ester pyridyl compounds which are antagonists of orexin receptors. The present invention is also directed to...
THIOETHER-PIPERIDINYL OREXIN RECEPTOR ANTAGONISTS
The present invention is directed to thioether-piperidinyl compounds which are antagonists of orexin receptors. The present invention is also directed to uses...
Processes for the Preparation of Axitinib
Processes for the preparation of Axitinib in good yield (generally greater than 80%) are provided that avoid the use of a palladium-catalyzed coupling reaction.
AZOLE COMPOUNDS CARRYING AN IMINE-DERIVED SUBSTITUENT
The present invention relates to azole compounds of formula I ##STR00001## wherein the variables are as defined in the claims or the description. The invention also...
NOVEL PIPERIDINE CARBOXAMIDE COMPOUND, PREPARATION METHOD, AND USAGE
The present invention provides a compound of a general formula I, a stereomeride, pharmaceutically acceptable salt or a solvate thereof, a preparation method...
Inhibitors of 17Beta-Hydroxysteroid Dehydrogenases Type 1 and Type 2
Provided herein are non-steroidal 17beta-hydroxysteroid dehydrogenase type 1 and type 2 (17.beta.-HSD1 and 17.beta.-HSD2) inhibitors, their production and use,...
Sulfamate Derivative Compounds for Use in Treating or Alleviating Pain
The present invention relates to sulfamate derivative compounds and a composition for treating and/or alleviating pain containing the sulfamate derivative...
STEREO-SPECIFIC SYNTHESIS OF (13R)-MANOYL OXIDE
The present invention relates to a method for manufacturing enantiomerically pure (13R)-manoyl oxide, said method comprising the steps of contacting...
A compound of formula (Ia) or (Ib), or a pharmaceutically acceptable salt thereof, Wherein Q, R.sup.2, Ar, A and R.sup.1 are as defined in claim 1. The claimed...
The invention relates to pharmaceutically active compounds having improved pharmacokinetic properties and being useful for the treatment or prevention of a...
NOVEL KINASE MODULATORS
The present invention provides PI3K protein kinase modulators, methods of preparing them, pharmaceutical compositions containing them and methods of treatment,...
SECOND-ORDER NONLINEAR OPTICAL COMPOUND AND NONLINEAR OPTICAL ELEMENT
COMPRISING THE SAME
Problem to Be Solved: to provide a chromophore having a far superior nonlinear optical activity to conventional chromophores and to provide a nonlinear optical...
CRYSTALLINE FORM OF CABAZITAXEL AND PROCESS FOR PREPARING THE SAME
The present invention relates to a novel crystalline ethyl acetate solvate form of cabazitaxel or ...
The use of compounds of formula ##STR00001## wherein R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6 and R.sup.7 have several meanings, for the treatment of...
Novel Compound, Organic Cation Transporter 3 Detection Agent, And Organic
Cation Transporter 3 Activity Inhibitor
[Problem] The present invention addresses the problem of providing a novel compound. The present invention also addresses the problem of providing an OCT3...
GAMMA-AMINOBUTYRIC ACID (GABA) ANALOGUES FOR THE TREATMENT OF PAIN AND
A compound of Formula (1) wherein R.sub.1 represents hydrogen, halo, a C1-C4 alkyl group, a C1-C4 alkylhalide group, a C1-C4 alkoxy-C2-C4 alkyl group, a C2-C4...
3-(5-CHLORO-2-OXOBENZO[D]OXAZOL-3(2H)-YL) PROPANOIC ACID DERIVATIVES AS
A compound of formula (I) or a salt thereof are provided: ##STR00001## wherein R.sup.1, X and R.sup.3 are defined in the specification, useful in the treatment...
INTEGRATED PRODUCTION OF UREA AND MELAMINE
Disclosed is a process for the integrated production of urea and melamine. A urea production zone produces a urea synthesis stream comprising urea, water and...
TRIAZOLES AS KV3 INHIBITORS
Compounds of formula (I) are of use in the modulation of Kv3.1, Kv.3.2 and Kv3.3 channels and have utility in the treatment or prevention of related...
PROCESS FOR THE PREPARATION OF SUBSTITUTED PHENOXYPHENYL KETONES
The present invention relates to a process for the preparation of the ketone compounds (IA) ##STR00001## and their use as intermediates for the preparation of...
SUBSTITUTED [1,2,4]TRIAZOLE AND IMIDAZOLE COMPOUNDS
The present invention relates to compounds of the formula I ##STR00001## and the N-oxides and the salts thereof for combating phytopathogenic fungi, and to the...
PREPARATION OF PYRIMIDINE INTERMEDIATES USEFUL FOR THE MANUFACTURE OF
The present invention relates to a new synthetic intermediate, namely the compound of formula I-2 ##STR00001## or a salt thereof. Said compound of formula I-2 or...
METHODS TO TREAT LYMPHOPLASMACYTIC LYMPHOMA
The present invention provides compounds of any one of Formulae (A), (I-11), (II), and (V) (e.g., compounds of Formula (A-1)-(A-18)), and methods for treating...
PROCESS FOR MAKING HYDROXYLATED CYCLOPENTYLPYRIMIDINE COMPOUNDS
The invention provides processes for preparing a compound of formula I ##STR00001## and salts thereof, wherein R.sup.1 is defined herein, and compounds and ...
Compounds of the formula I ##STR00001## in which R.sup.1, X and n have the meanings indicated in Claim 1, are inhibitors of Tankyrase, and can be employed, inter...
PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF ENZALUTAMIDE
The present invention provides processes for the preparation of enzalutamide.
PROCESS FOR THE REGIOSELECTIVE SYNTHESIS OF PYRAZOLES
A process is described for the synthesis of pyrazoles having general formula (I) ##STR00001## which comprises the steps of mixing a compound having general...
POLYMORPHIC FORMS OF IVABRADINE HYDROCHLORIDE
Stable crystalline Form II and stable crystalline Form III of ivabradine hydrochloride and processes for their preparation are disclosed.
6-SUBSTITUTED AND 7-SUBSTITUTED MORPHINAN ANALOGS AND THE USE THEREOF
The application is directed to compounds of Formula I or II: and pharmaceutically acceptable salts and solvates thereof, wherein R', R'', R''' R.sup.1,...
NOVEL INHIBITOR COMPOUNDS OF PHOSPHODIESTERASE TYPE 10A
The present invention relates to compounds which are inhibitors of phosphodiesterase type 10A and to their use for the manufacture of a medicament and which...
Described are ROR.gamma. modulators of the formula (I), or pharmaceutically acceptable salts thereof, wherein all substituents are defined herein. The...
Heterocyclic Compounds for the Treatment of Neurological and Psychological
Lactam compounds of Formula I and their use for the treatment of neurological and psychiatric disorders including schizophrenia, bipolar disorder, anxiety...
METHOD OF PRODUCING 2-AMINONICOTINIC ACID BENZYL ESTER DERIVATIVES
The present invention provides a method of producing a 2-aminonicotinic acid benzyl ester derivative at a high yield and with a high purity. By reacting a...
METHOD FOR PRODUCING 5-HYDROXYPIPERIDINE-2-CARBOXYLIC ACID
A method for producing (2S,5S)/(2R,5R)-5-hydroxypiperidine-2-carboxylic acid represented by formula (10) below: ##STR00001## the method including removing the...
SUBSTITUTED BIPIPERIDINYL DERIVATIVES
The invention relates to novel substituted bipiperidinyl derivatives, to processes for their preparation, to their use for the treatment and/or prevention of...
TRICYCLIC LACTAM DERIVATIVES AS 11-BETA HYDROXYSTEROID DEHYDROGENASE
Compounds of the formula (I) useful as 11-Beta Hydroxysteroid Dehydrogenase Inhibitors ##STR00001##
4-(PIPERRAZIN-1-YL)-PYRROLIDIN-2-ONE COMPOUNDS AS MONOACYLGLYCEROL LIPASE
The present invention aims to provide a compound having an MAGL inhibitory action, and useful as a prophylactic or therapeutic agent for neurodegenerative...
CATALYST FOR SYNTHESIZING ETHYLENIMINE AS WELL AS PREPARATION METHOD AND
The present invention relates to a catalyst for synthesizing ethylenimine as well as a preparation method and application thereof. The related catalyst...
SYNTHESIS OF DELTA 12-PGJ3 AND RELATED COMPOUNDS
In one aspect, the present invention provides novel derivatives of .DELTA..sup.12-PGJ.sub.3 and modular synthetic pathways to obtaining ...
NOVEL PRODRUGS OF DITHIOL MUCOLYTIC AGENTS
Provided are mucolytic compounds that are more effective, and/or absorbed less rapidly from mucosal surfaces, and/or are better tolerated as compared to...
OXIDATION OF 2-MERCAPTOETHANOL
The present invention relates to a process for the preparation of bis-(2-hydroxyethyl)-disulfide by oxidizing 2-mercaptoethanol with oxygen in a reaction...
FLORFENICOL SYNTHESIZING METHOD
The present invention discloses a new florfenicol synthesizing method. The method synthesizes florfenicol products meeting requirements of the Drug...