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Patent # Description
2016/0317658 UPCONVERSION OF LIGHT FOR USE IN OPTOGENETIC METHODS
Provided herein are compositions comprising lanthanide-doped nanoparticles which upconvert electromagnetic radiation from infrared or near infrared wavelengths...
2016/0317657 COMBINATION OF EPIGENETIC FACTORS AND BISPECIFIC COMPOUNDS TARGETING CD33 AND CD3 IN THE TREATMENT OF MYELOID...
The present invention provides a combination epigenetic factors and bispecific compounds targeting CD33 and CD3 in the treatment of myeloid leukemia, wherein...
2016/0317656 COMBINATION OF ANTI-FGFR2 ANTIBODY AND OTHER AGENT
The present invention provides a combination of an antibody binding to a fibroblast growth factor receptor, and another agent.
2016/0317655 TRADITIONAL CHINESE MEDICINE MULBERRY LEAVES POLYSACCHARIDE AND EUCOMMIA POLYSACCHARIDE IMMUNOSTIMULANT AND...
A traditional Chinese medicine immunopotentiator prepared from mulberry leaves polysaccharide and eucommia polysaccharide. The immunopotentiator can stimulate...
2016/0317654 COMBINATION THERAPY WITH RAR ALPHA AGONISTS FOR ENHANCING TH1 RESPONSE
Encompassed are methods of potentiating anti-tumor immunity comprising administering an RAR.alpha. agonist to a patient having a tumor in combination with at...
2016/0317653 Bacterial Compositions and Methods of Use Thereof for Treatment of Immune System Disorders
Provided are compositions containing combinations of bacteria useful for the maintenance or restoration of a healthy microbiota in the gastrointestinal tract,...
2016/0317652 Nucleic Acid Molecule Encoding Hepatitis B Virus Core Protein And Vaccine Comprising The Same
Provided herein are nucleic acid sequences that encode novel consensus amino acid sequences of HBV core protein, as well as genetic constructs/vectors and...
2016/0317651 Method of Attenuating Porcine Pseudorabies Virus, Attenuated Strains of Porcine Pseudorabies Virus, Vaccine...
This invention provides a method of attenuating porcine pseudorabies virus, which can effectively and reproducibly attenuate porcine pseudorabies virus. The...
2016/0317650 Gene-Deleted Variant Strain Of Porcine Pseudorabies Virus, Vaccine Composition, Method Of Making The Same And...
The present invention provides an attenuated strain of porcine pseudorabies virus (PRV), in which said attenuated strain of PRV is a variant strain of PRV with...
2016/0317649 EPITOPES OF HERPES SIMPLEX VIRUS
The present invention relates to diagnosis, prevention and treatment of Herpes simplex viruses and infection. In particular embodiments the present invention...
2016/0317648 CAP260, CAP174 AND K0224 HIV-1 ENVELOPES, PEPTIDE AND COMPOSITIONS
The invention is directed to HIV-1 envelope proteins and peptides, and compositions comprising the same to increase the breadth of vaccine coverage of the V1...
2016/0317647 NUCLEIC ACID VACCINES
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use ribonucleic acid vaccines (NAVs) comprising...
2016/0317646 FORMULATIONS FOR VIROSOMES
This disclosure provides virosome formulations, in particular, liquid pharmaceutical formulations comprising virosomes.
2016/0317645 VIRUS LIKE PARTICLE PURIFICATION
Methods for purifying human Calciviruses are disclosed, including Noroviruses and Sapoviruses.
2016/0317644 VACCINE COMPOSITIONS AND USES THEREOF
The present disclosure relates to nonstructural protein 1 (NS1) from flaviviruses and uses thereof. In particular, the present invention relates to diagnostic...
2016/0317643 IMMUNOGENIC JC POLYOMAVIRUS COMPOSITIONS AND METHODS OF USE
Disclosed herein are methods of eliciting an immune response to a JC polyomavirus (JCV) by administering an effective amount of an immunogenic composition...
2016/0317642 PRRS VIRUS VARIANT, EUROPEAN PRRS VIRUS CDNA CLONE, AND USES THEREOF
The present invention belongs to the field of animal health and provides means to study Porcine Reproductive and Respiratory Syndrome (PRRS), a viral disease...
2016/0317641 Methods of Treatment of HPV Related Diseases
The present invention provides methods of mucosal tissue administration of therapeutic HPV vaccines, in a prime-boost regimen, which generated antigen-specific...
2016/0317640 PHARMACEUTICAL COMPOSITIONS CONTAINING CLOSTRIDIUM DIFFICILE TOXOIDS A AND B
This invention relates to compositions including Clostridium difficile toxins and/or toxoids and corresponding methods. The compositions of the invention...
2016/0317639 USE OF BACTERIAL ENDOTOXINS AND LIPOTEICHOIC ACIDS TO IMPROVE POSTPARTAL HEALTH AND PRODUCTIVITY OF DAIRY COWS...
A combination of a bacterial endotoxin, in particular a lipopolysaccharide, and a lipoteichoic acid for treating or preventing a metabolic disorder or...
2016/0317638 MULTIEPITOPE FUSION ANTIGENS AND VACCINES AND THEIR USE IN TREATMENT OF ENTEROTOXIGENIC DIARRHEA
Provided herein are polypeptides comprising up to 9 antigenic elements of ETEC virulence determinants: 7 CFA adhesins [CFA/I, CFA/II (CS1, CS2, CS3), CFA/IV...
2016/0317637 IMMUNOMODULATORY COMPOSITIONS AND METHODS OF USE THEREOF
The present disclosure provides immunomodulatory compositions comprising heat-killed Caulobacter crescentus (HKCC). Immunomodulatory compositions of the...
2016/0317636 COMPOSITION FOR TREATING LUNG CANCER, PARTICULARLY OF NON-SMALL LUNG CANCERS (NSCLC)
The present invention relates to an active (immunostimulatory) composition comprising at least one RNA, preferably a mRNA, encoding at least two (preferably...
2016/0317635 Multivalent Breast Cancer Vaccine
Compositions and methods for immunization against human breast cancer are disclosed. In one embodiment the multivalent antigenic composition is provided...
2016/0317634 NOVEL MSLN TARGETING DNA VACCINE FOR CANCER IMMUNOTHERAPY
The present invention relates to an attenuated mutant strain of Salmonella comprising a recombinant DNA molecule encoding Mesothelin. In particular, the...
2016/0317633 Conditional Superagonist CTL Ligands for the Promotion of Tumor-Specific CTL Responses
What is described is a novel genetic screen, involving recombinant technology and class I antigen cross-presentation, to search for supraoptimal superagonists...
2016/0317632 USE OF CBP/EP300 BROMODOMAIN INHIBITORS FOR CANCER IMMUNOTHERAPY
The present invention relates to use of CBP/EP300 bromodomain inhibitors for the treatment of cancer.
2016/0317631 INCREASED T-CELL TUMOR INFILTRATION AND ERADICATION OF METASTASES BY MUTANT LIGHT
Mutant LIGHT expressed in a tumor environment elicited high levels of chemokines and adhesion molecules, accompanied by massive infiltration of naive T...
2016/0317630 Programming of Cells for Tolerogenic Therapies
Biomaterial systems, e.g., gel scaffolds, are used in vivo to recruit immune cells and promote their activation towards a non-inflammatory phenotype, thereby...
2016/0317629 AQUAPORIN TOLERIZING VACCINES AND METHODS OF USE THEREOF
The instant disclosure provides aquaporin DNA tolerizing vaccines and methods of using such vaccines for treating individuals having neuromyelitis optica (NMO)...
2016/0317628 SERPIN DRUGS FOR TREATMENT OF VIRAL INFECTION AND METHOD OF USE THEREOF
The invention includes a heparin activated Antithrombin III encapsulated into a sterically stabilized anti-HLA-DR immunoliposome for the treatment of a HIV...
2016/0317627 PHARMACEUTICAL COMPOSITIONS CONTAINING PROTEASES AND METHODS FOR THE TREATMENT OF LYSOSOMAL STORAGE DISEASES
The invention provides a method and compositions for treating a subject with a lysosomal storage disease such as gaucher disease, by administering to a subject...
2016/0317626 Lysosomal Phospholipase A2 (LPLA2) Activity as a Diagnostic and Therapeutic Target for Identifying and Treating...
The present invention is directed to methods for diagnosis and treatment of systemic lupus erythematosus and drug-induced systemic lupus erythematosus. More...
2016/0317625 BIOACTIVE COLLAGEN BIOMATERIALS AND METHODS FOR MAKING
A bioactive collagen biomaterial according to the invention that is biocompatible with cells and tissues and distinguished by containing certain cryptic and...
2016/0317624 METHODS FOR TREATING AN ANIMAL
Provided herein are methods for treating an animal using a composition that includes active IGF. The methods include treating an animal at risk of having an...
2016/0317623 MODIFIED THERAPEUTIC AGENTS, STAPLED PEPTIDE LIPID CONJUGATES, AND COMPOSITIONS THEREOF
Methods and compositions are provided for extending the half-life of a therapeutic agent. A modified therapeutic agent (mTA) comprises a therapeutic agent, a...
2016/0317622 Methods of Treatment of Heart Failure With Natriuretic Peptides
Methods of treating heart failure, or decreasing blood pressure, comprising administering an NP at an appropriate does, or in an amount sufficient to provide...
2016/0317621 SYSTEMS AND METHODS FOR SYMPATHETIC CARDIOPULMONARY NEUROMODULATION
Methods, devices and systems are described for decreasing the activity of the sympathetic nervous innervation to and from the lungs and the vessels supplying...
2016/0317620 Novel Compositions and Uses Thereof
The present invention provides a composition for stimulating hair growth in a mammal comprising a modified osteopontin polypeptide in which an RGD domain is...
2016/0317619 USE OF NEUREGULIN-4 FOR TREATMENT OF INFLAMMATORY BOWEL DISEASE AND NECROTIZING ENTEROCOLITIS
The invention provides methods, pharmaceutical compositions and kits for treating, inhibiting and/or reducing the severity of inflammatory bowel disease and...
2016/0317618 ANTI-INFECTIVE PROPERTIES OF ANTIFREEZE PROTEIN
As microbial drug-resistance increases, there is a critical need for new classes of compounds to combat infectious diseases. The Ixodes scapularis tick...
2016/0317617 Peptide Compounds and Methods of Production and Use Thereof
Peptide compounds based on the CAP37 protein are disclosed, along with methods for treating various infections, wounds, and conditions, and methods of...
2016/0317616 PHARMACEUTICAL COMPOSITIONS TARGETING WNT PATHWAY PROTEINS
Provided is a composition comprising a peptide comprising amino acids and/or amino acid analogs comprising a continuous sequence of a sclerostin fragment...
2016/0317615 T CELL MODULATOR
Compositions, methods of use, and pharmaceutical preparations useful for modulation of immune responses are disclosed herein. In one embodiment a composition...
2016/0317614 Compositions and Formulations for Treatment of Gastrointestinal Tract Malabsorption Diseases and Inflammatory...
Nutritive polypeptides are provided herein. Also provided are various other embodiments including nucleic acids encoding the polypeptides, recombinant...
2016/0317613 ULTRASOUND-ASSISTED GENE TRANSFER FOR TREATMENT OF XEROSTOMIA
Methods and compositions useful for gene transfer into a salivary gland are provided. In certain aspects, methods and compositions useful in the treatment of...
2016/0317612 ENGINEERED POLYPEPTIDE AGENTS FOR TARGETED BROAD SPECTRUM INFLUENZA NEUTRALIZATION
The present invention provides novel agents for broad spectrum influenza neutralization. The present invention provides agents for inhibiting influenza...
2016/0317611 Antimicrobial Peptide and Uses Thereof
The invention relates to antimicrobial peptides, pharmaceutical compositions comprising the peptides and to uses thereof for in the treatment or prevention of...
2016/0317610 COMPOSITIONS AND METHODS FOR TREATING OVARIAN CANCER INCLUDING PREVENTING THE RECURRENCE THEREOF
A method of treating ovarian cancer (OC) includes administering to a subject in need thereof an effective amount of a pharmaceutical composition comprising...
2016/0317609 FORMULATIONS COMPRISING CYCLOSPORIN A
A modified release composition comprising cyclosporin A for oral administration. The composition may comprise a core and a modified release coating, wherein...
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