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UPCONVERSION OF LIGHT FOR USE IN OPTOGENETIC METHODS
Provided herein are compositions comprising lanthanide-doped nanoparticles which upconvert electromagnetic radiation from infrared or near infrared wavelengths...
COMBINATION OF EPIGENETIC FACTORS AND BISPECIFIC COMPOUNDS TARGETING CD33
AND CD3 IN THE TREATMENT OF MYELOID...
The present invention provides a combination epigenetic factors and bispecific compounds targeting CD33 and CD3 in the treatment of myeloid leukemia, wherein...
COMBINATION OF ANTI-FGFR2 ANTIBODY AND OTHER AGENT
The present invention provides a combination of an antibody binding to a fibroblast growth factor receptor, and another agent.
TRADITIONAL CHINESE MEDICINE MULBERRY LEAVES POLYSACCHARIDE AND EUCOMMIA
POLYSACCHARIDE IMMUNOSTIMULANT AND...
A traditional Chinese medicine immunopotentiator prepared from mulberry leaves polysaccharide and eucommia polysaccharide. The immunopotentiator can stimulate...
COMBINATION THERAPY WITH RAR ALPHA AGONISTS FOR ENHANCING TH1 RESPONSE
Encompassed are methods of potentiating anti-tumor immunity comprising administering an RAR.alpha. agonist to a patient having a tumor in combination with at...
Bacterial Compositions and Methods of Use Thereof for Treatment of Immune
Provided are compositions containing combinations of bacteria useful for the maintenance or restoration of a healthy microbiota in the gastrointestinal tract,...
Nucleic Acid Molecule Encoding Hepatitis B Virus Core Protein And Vaccine
Comprising The Same
Provided herein are nucleic acid sequences that encode novel consensus amino acid sequences of HBV core protein, as well as genetic constructs/vectors and...
Method of Attenuating Porcine Pseudorabies Virus, Attenuated Strains of
Porcine Pseudorabies Virus, Vaccine...
This invention provides a method of attenuating porcine pseudorabies virus, which can effectively and reproducibly attenuate porcine pseudorabies virus. The...
Gene-Deleted Variant Strain Of Porcine Pseudorabies Virus, Vaccine
Composition, Method Of Making The Same And...
The present invention provides an attenuated strain of porcine pseudorabies virus (PRV), in which said attenuated strain of PRV is a variant strain of PRV with...
EPITOPES OF HERPES SIMPLEX VIRUS
The present invention relates to diagnosis, prevention and treatment of Herpes simplex viruses and infection. In particular embodiments the present invention...
CAP260, CAP174 AND K0224 HIV-1 ENVELOPES, PEPTIDE AND COMPOSITIONS
The invention is directed to HIV-1 envelope proteins and peptides, and compositions comprising the same to increase the breadth of vaccine coverage of the V1...
NUCLEIC ACID VACCINES
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use ribonucleic acid vaccines (NAVs) comprising...
FORMULATIONS FOR VIROSOMES
This disclosure provides virosome formulations, in particular, liquid pharmaceutical formulations comprising virosomes.
VIRUS LIKE PARTICLE PURIFICATION
Methods for purifying human Calciviruses are disclosed, including Noroviruses and Sapoviruses.
VACCINE COMPOSITIONS AND USES THEREOF
The present disclosure relates to nonstructural protein 1 (NS1) from flaviviruses and uses thereof. In particular, the present invention relates to diagnostic...
IMMUNOGENIC JC POLYOMAVIRUS COMPOSITIONS AND METHODS OF USE
Disclosed herein are methods of eliciting an immune response to a JC polyomavirus (JCV) by administering an effective amount of an immunogenic composition...
PRRS VIRUS VARIANT, EUROPEAN PRRS VIRUS CDNA CLONE, AND USES THEREOF
The present invention belongs to the field of animal health and provides means to study Porcine Reproductive and Respiratory Syndrome (PRRS), a viral disease...
Methods of Treatment of HPV Related Diseases
The present invention provides methods of mucosal tissue administration of therapeutic HPV vaccines, in a prime-boost regimen, which generated antigen-specific...
PHARMACEUTICAL COMPOSITIONS CONTAINING CLOSTRIDIUM DIFFICILE TOXOIDS A AND
This invention relates to compositions including Clostridium difficile toxins and/or toxoids and corresponding methods. The compositions of the invention...
USE OF BACTERIAL ENDOTOXINS AND LIPOTEICHOIC ACIDS TO IMPROVE POSTPARTAL
HEALTH AND PRODUCTIVITY OF DAIRY COWS...
A combination of a bacterial endotoxin, in particular a lipopolysaccharide, and a lipoteichoic acid for treating or preventing a metabolic disorder or...
MULTIEPITOPE FUSION ANTIGENS AND VACCINES AND THEIR USE IN TREATMENT OF
Provided herein are polypeptides comprising up to 9 antigenic elements of ETEC virulence determinants: 7 CFA adhesins [CFA/I, CFA/II (CS1, CS2, CS3), CFA/IV...
IMMUNOMODULATORY COMPOSITIONS AND METHODS OF USE THEREOF
The present disclosure provides immunomodulatory compositions comprising heat-killed Caulobacter crescentus (HKCC). Immunomodulatory compositions of the...
COMPOSITION FOR TREATING LUNG CANCER, PARTICULARLY OF NON-SMALL LUNG
The present invention relates to an active (immunostimulatory) composition comprising at least one RNA, preferably a mRNA, encoding at least two (preferably...
Multivalent Breast Cancer Vaccine
Compositions and methods for immunization against human breast cancer are disclosed. In one embodiment the multivalent antigenic composition is provided...
NOVEL MSLN TARGETING DNA VACCINE FOR CANCER IMMUNOTHERAPY
The present invention relates to an attenuated mutant strain of Salmonella comprising a recombinant DNA molecule encoding Mesothelin. In particular, the...
Conditional Superagonist CTL Ligands for the Promotion of Tumor-Specific
What is described is a novel genetic screen, involving recombinant technology and class I antigen cross-presentation, to search for supraoptimal superagonists...
USE OF CBP/EP300 BROMODOMAIN INHIBITORS FOR CANCER IMMUNOTHERAPY
The present invention relates to use of CBP/EP300 bromodomain inhibitors for the treatment of cancer.
INCREASED T-CELL TUMOR INFILTRATION AND ERADICATION OF METASTASES BY
Mutant LIGHT expressed in a tumor environment elicited high levels of chemokines and adhesion molecules, accompanied by massive infiltration of naive T...
Programming of Cells for Tolerogenic Therapies
Biomaterial systems, e.g., gel scaffolds, are used in vivo to recruit immune cells and promote their activation towards a non-inflammatory phenotype, thereby...
AQUAPORIN TOLERIZING VACCINES AND METHODS OF USE THEREOF
The instant disclosure provides aquaporin DNA tolerizing vaccines and methods of using such vaccines for treating individuals having neuromyelitis optica (NMO)...
SERPIN DRUGS FOR TREATMENT OF VIRAL INFECTION AND METHOD OF USE THEREOF
The invention includes a heparin activated Antithrombin III encapsulated into a sterically stabilized anti-HLA-DR immunoliposome for the treatment of a HIV...
PHARMACEUTICAL COMPOSITIONS CONTAINING PROTEASES AND METHODS FOR THE
TREATMENT OF LYSOSOMAL STORAGE DISEASES
The invention provides a method and compositions for treating a subject with a lysosomal storage disease such as gaucher disease, by administering to a subject...
Lysosomal Phospholipase A2 (LPLA2) Activity as a Diagnostic and
Therapeutic Target for Identifying and Treating...
The present invention is directed to methods for diagnosis and treatment of systemic lupus erythematosus and drug-induced systemic lupus erythematosus. More...
BIOACTIVE COLLAGEN BIOMATERIALS AND METHODS FOR MAKING
A bioactive collagen biomaterial according to the invention that is biocompatible with cells and tissues and distinguished by containing certain cryptic and...
METHODS FOR TREATING AN ANIMAL
Provided herein are methods for treating an animal using a composition that includes active IGF. The methods include treating an animal at risk of having an...
MODIFIED THERAPEUTIC AGENTS, STAPLED PEPTIDE LIPID CONJUGATES, AND
Methods and compositions are provided for extending the half-life of a therapeutic agent. A modified therapeutic agent (mTA) comprises a therapeutic agent, a...
Methods of Treatment of Heart Failure With Natriuretic Peptides
Methods of treating heart failure, or decreasing blood pressure, comprising administering an NP at an appropriate does, or in an amount sufficient to provide...
SYSTEMS AND METHODS FOR SYMPATHETIC CARDIOPULMONARY NEUROMODULATION
Methods, devices and systems are described for decreasing the activity of the sympathetic nervous innervation to and from the lungs and the vessels supplying...
Novel Compositions and Uses Thereof
The present invention provides a composition for stimulating hair growth in a mammal comprising a modified osteopontin polypeptide in which an RGD domain is...
USE OF NEUREGULIN-4 FOR TREATMENT OF INFLAMMATORY BOWEL DISEASE AND
The invention provides methods, pharmaceutical compositions and kits for treating, inhibiting and/or reducing the severity of inflammatory bowel disease and...
ANTI-INFECTIVE PROPERTIES OF ANTIFREEZE PROTEIN
As microbial drug-resistance increases, there is a critical need for new classes of compounds to combat infectious diseases. The Ixodes scapularis tick...
Peptide Compounds and Methods of Production and Use Thereof
Peptide compounds based on the CAP37 protein are disclosed, along with methods for treating various infections, wounds, and conditions, and methods of...
PHARMACEUTICAL COMPOSITIONS TARGETING WNT PATHWAY PROTEINS
Provided is a composition comprising a peptide comprising amino acids and/or amino acid analogs comprising a continuous sequence of a sclerostin fragment...
T CELL MODULATOR
Compositions, methods of use, and pharmaceutical preparations useful for modulation of immune responses are disclosed herein. In one embodiment a composition...
Compositions and Formulations for Treatment of Gastrointestinal Tract
Malabsorption Diseases and Inflammatory...
Nutritive polypeptides are provided herein. Also provided are various other embodiments including nucleic acids encoding the polypeptides, recombinant...
ULTRASOUND-ASSISTED GENE TRANSFER FOR TREATMENT OF XEROSTOMIA
Methods and compositions useful for gene transfer into a salivary gland are provided. In certain aspects, methods and compositions useful in the treatment of...
ENGINEERED POLYPEPTIDE AGENTS FOR TARGETED BROAD SPECTRUM INFLUENZA
The present invention provides novel agents for broad spectrum influenza neutralization. The present invention provides agents for inhibiting influenza...
Antimicrobial Peptide and Uses Thereof
The invention relates to antimicrobial peptides, pharmaceutical compositions comprising the peptides and to uses thereof for in the treatment or prevention of...
COMPOSITIONS AND METHODS FOR TREATING OVARIAN CANCER INCLUDING PREVENTING
THE RECURRENCE THEREOF
A method of treating ovarian cancer (OC) includes administering to a subject in need thereof an effective amount of a pharmaceutical composition comprising...
FORMULATIONS COMPRISING CYCLOSPORIN A
A modified release composition comprising cyclosporin A for oral administration. The composition may comprise a core and a modified release coating, wherein...