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CONJUGATES OF A PHOSPHOLIPID AND A DRUG FOR THE TREATMENT OF INFLAMMATORY
Conjugates of drugs suitable for use in the treatment of inflammatory bowel disease and phospholipids, and their use in the treatment of inflammatory bowel...
A PHARMACEUTICAL COMPOSITION CONTAINING COMBINATIONS OF NICOTINAMIDE AND
5-AMINOSALICYLIC ACID FOR BENEFICIALLY...
The present invention relates to a new pharmaceutical composition containing a combination of 5-aminosalicylic acid and nicotinamide or related compounds. The...
ATP SYNTHASE INHIBITORS AND STEROID ALKALOIDS AND USES THEREOF AS
ANTIMICROBIAL AGENTS AND AS POTENTIATORS FOR...
The present invention provides bacterial ATP synthase inhibitors such as a compound of formula (I): (Formula (I)) (A) in combination with an aminoglycoside...
METHOD FOR ON-DEMAND CONTRACEPTION
The invention relates to a method for on-demand contraception, which method comprises administering a progestogen agent or progesterone receptor modulator,...
Antihistamines In Combination With A Range Of Substances For Improved
The present invention provides for novel combinations comprising an antihistamine with selected pharmaceutical and nutraceutical agents which alleviate some of...
ORAL PHARMACEUTICAL PRODUCTS AND METHODS OF USE COMBINING TESTOSTERONE
ESTERS WITH HYPOLIPIDEMIC AGENTS
Pharmaceutical products comprising a hypolipidemic agent and a testosterone ester such as testosterone undecanoate are provided. Methods of safely treating a...
PHARMACEUTICAL FORMULATIONS FOR TREATING MALE SEXUAL DYSFUNCTIONS
Pharmaceutical compositions and methods for treating various male sexual dysfunction disorders, such as erectile dysfunction or Peyronie's disease, are...
Treating Basal-Like Genotype Cancers
Provided herein are methods of treating a subject with cancer comprising administering to the subject a death receptor agonist. Also provided herein are...
METHODS FOR FAT REDUCTION
Disclosed herein are methods, compounds, and compositions for fat reduction, and in particular fat reduction without significant hair growth and/or additional...
PLATINUM COMPOUNDS, COMPOSITIONS, AND USES THEREOF
The present teachings relate to compounds and compositions for treatment of cancers. In some embodiments, the composition comprises a platinum (IV) complex...
Methods for Treating Epithelian Mesenchymal Transition Related Diseases
Certain embodiments are directed to methods of treating chronic lung diseases in a subject comprising administering to a subject diagnosed with, exhibiting...
Male Contraceptive Compositions And Methods Of Use
The invention relates to compositions and methods for effecting male contraception.
METHOD FOR TREATING OTIC INFECTIONS AFTER TYMPANOSTOMY TUBE PLACEMENT
The present invention relates to methods for treating a microbial infection comprising administering a composition comprising one or more antibiotic compounds...
SUBSTITUTED ANILINES AS CCR(4) ANTAGONISTS
Aniline compounds are provided which bind to CCR(4) and are useful for the treatment of diseases such as allergic diseases, autoimmune diseases, graft...
USE OF NON-PEPTIDE NK1 ANTAGONISTS IN A PREDETERMINED DOSE FOR THE
TREATMENT OF CANCER
Use of the non-peptide NK1 receptor antagonist, preferably Aprepitant, for the treatment of cancer in predetermined doses. The present invention also describes...
SPIROCYCLIC HETERCYCLE COMPOUNDS USEFUL AS HIV INTEGRASE INHIBITORS
The present invention relates to Spirocyclic Heterocycle Compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, B, X, Y, R.sup.1,...
PDE5 INHIBITOR POWDER FORMULATIONS AND METHODS RELATING THERETO
Novel dry powder compositions comprising and methods relating thereto are provided. The dry powder compositions comprise PDE5 inhibitors, such as vardenafil,...
PROPHYLACTIC AGENT AND/OR THERAPEUTIC AGENT FOR DIFFUSE LARGE B-CELL
To provide a medicament which shows more remarkable effect in treatment of activated B-cell like diffuse large B-cell lymphoma (ABC-CLBCL) than the existing...
The present invention relates to a combination comprising (S)-4-amino-N-(1-(4-chlorophenyl)-3-hydroxypropyl)-1-(7H-pyrrolo[2,3-d]py- ...
PHARMACEUTICAL COMPOSITION NOT CONTAINING ANTIOXIDANT AND PREPARATION
Provided are a composition containing an unstable drug against oxidation like pemetrexed with improved stability and a preparation method thereof, by removing...
CANCER TREATMENTS USING COMBINATIONS OF CDK AND ERK INHIBITORS
The present invention provides, inter alia, methods, kits, and pharmaceutical compositions for treating or ameliorating the effects of a cancer in a subject in...
Compounds of formula (I): ##STR00001## are described herein. Compounds of the disclosure are modulators of Kv3 channels and may be used in the prophylaxis or...
MNK INHIBITORS AND METHODS RELATED THERETO
The present invention relates to compounds according to Formula (I): ##STR00001## or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, ...
METHOD OF PREVENTING OR TREATING SKIN NECROPTOSIS DISEASE COMPRISING
RIP3-MLKL PATHWAY BLOCKER
The present invention relates to methods of preventing or treating skin necroptosis diseases, including administering to subjects receptor-interacting protein...
FREEZE DRIED DRUG NANOSUSPENSIONS
The present invention relates to a freeze-dried (also called lyophilized) drug nanosuspension. The present freeze-dried drug nanosuspension composition has an...
SUBSTITUTED QUINOXALINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC
MODULATORS OF MGLUR4
The present invention relates to the use of novel quinoxaline derivatives of formula (I) ##STR00001## as positive allosteric modulators for modulating...
COMPOUNDS USEFUL AS MODULATORS OF TRPM8
The present invention includes compounds useful as modulators of TRPM8, such as compounds of Formula (I) and the subgenus and species thereof; personal...
RIBONUCLEOTIDE REDUCTASE INHIBITORS SENSITIZE TUMOR CELLS TO DNA DAMAGING
The present invention relates to methods for treatment of tumors comprising administering to a subject in need thereof a DNA damaging agent and a...
ABUSE-RESISTANT DRUG FORMULATIONS
Disclosed are abuse resistant oral pharmaceutical compositions that reduce the likelihood of improper administration of drugs that are susceptible to abuse....
Novel quinoline compounds pharmaceutical compositions containing such compounds and their use in therapy.
COMBINED AGENT FOR CELL THERAPY OF CORNEAL ENDOTHELIAL CELL
The present invention provides an agent for treating or preventing a disease, a disorder or a condition of a corneal endothelium, said agent comprising a...
TETRAHYDRONAPHTHYRIDINYL PROPIONIC ACID DERIVATIVES AND USES THEREOF
The present application relates to use of compounds of formula I for treating or preventing a fibrosis.
PROLYLHYDROXYLASE/ATF4 INHIBITORS AND METHODS OF USE FOR TREATING NEURAL
CELL INJURY OR DEATH AND CONDITIONS...
Methods for treating a patient suffering from neural cell injury, the method comprising administering to the patient an effective amount of a HIF...
TREATMENT OF MULTIPLE SCLEROSIS WITH COMBINATION OF LAQUINIMOD AND
This invention provides a method of treating a subject afflicted with multiple sclerosis (MS) or presenting a clinically isolated syndrome (CIS) comprising...
PHARMACEUTICAL COMPOSITION CONTAINING PALONOSETRON
Provided are a pharmaceutical composition with improved stability including palonosetron, a preparation method thereof, and a pharmaceutical package including...
Treatment of Retinopathy of Prematurity (ROP)
Disclosed herein are methods of treating retinopathy of prematurity (ROP) in a premature and/or low birth weight infant in need thereof, comprising ...
INHALABLE SUSTAINED THERAPEUTIC FORMULATIONS
The present invention is based, in part, on the unexpected discovery that particles for pulmonary delivery of a therapeutic, prophylactic or diagnostic agent...
REDUCING MEMORY LOSS IN MAMMALS SUFFERING FROM ALZHEIMER'S DISEASE
The disclosure relates to methods and compositions for reducing memory loss. Specifically, methods of using inhibitors of GAT-3 polypeptide activity to reduce...
ANIMAL PEST CONTROL METHOD
Disclosed is a method for protecting an animal from a parasitic invertebrate pest comprising treating an animal orally or by injection with a pesticidally...
METHODS AND COMPOSITIONS FOR TREATING NON-ERK MAPK PATHWAY
The present invention provides, inter alia, methods, pharmaceutical compositions, and kits for treating or ameliorating the effects of a cancer in a subject,...
COMPOSITION FOR REDUCING SENESCENCE OF CELL OR SUBJECT INCLUDING BRAF
INHIBITOR AND USE THEREOF
Provided is a method of reducing senescence in a cell or subject, or treating or preventing a symptom or disease associated therewith, by administering a BRAF...
CANCER TREATMENTS USING COMBINATIONS OF PI3K/AKT PATHWAY AND ERK
The present invention provides, inter alia, methods, kits, and compositions for treating or ameliorating the effects of a cancer in a subject in need thereof....
RAC1 INHIBITORS OF NEUROFIBROMA FORMATION
Small molecule inhibitor compounds for inhibiting Rac1 activity and their use for treating, preventing, or reducing the incidences of malignant and ...
Cyclooxygenase Inhibitor and Calcium Channel Antagonist Compositions and
Methods for Use in Urological Procedures
Compositions of a cyclooxygenase inhibitor and a calcium channel antagonist in a liquid carrier. The composition may be administered the urinary tract during...
USE OF EP4 RECEPTOR ANTAGONISTS IN THE TREATMENT OF CARTILAGE DISEASE
This invention relates to a compound with EP4 antagonistic activity, or a pharmaceutically acceptable salt with EP4 receptor antagonistic activities, which is...
Compositions comprising isolated ido-BR1 are described for use in therapy or prophylaxis, including the treatment of inflammatory diseases (for example as...
PYRIDYLAMINOACETIC ACID COMPOUND AND POLYOXYETHYLENE CASTOR OIL-CONTAINING
The purpose of the present invention is to provide: a pharmaceutical composition that comprises the pyridylaminoacetic acid compound of the present invention,...
BENZAMIDES AND RELATED INHIBITORS OF FACTOR XA
Novel benzamide compounds including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives having activity against...
METHODS OF USING
Methods of treating, preventing or managing cancers are disclosed. The methods encompass the administration of SNS-595 in combination with a second active...
MLK INHIBITORS AND METHODS OF USE
Provided are compounds having an inhibitory effect on Mixed Lineage Kinases. Also provided are pharmaceutical compositions, methods of preparing the compounds,...