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Patent # Description
2016/0326547 TRANSGENIC PRODUCTION OF HEPARIN
The disclosure provides methods, cells and transgenic non human mammals for the production of heparin. Specifically, the method comprising providing a...
2016/0326546 GENERATION OF LAYERED TRANSCRIPTIONAL CIRCUITRY USING CRISPR SYSTEMS
Provided herein, in some embodiments, are modular transcriptional architectures and methods for regulated expression of guide RNAs in cells, such as human...
2016/0326545 IDENTIFICATION OF P. PACHYRHIZI PROTEIN EFFECTORS AND THEIR USE IN PRODUCING ASIAN SOYBEAN RUST (ASR) RESISTANT...
The invention relates to novel nucleic acids and their encoded polypeptides from ASR and methods of use that enhance the plant's defensive elicitation response.
2016/0326544 Disease Resistant Grape Plants
The present invention relates to a plant, which is resistant to a pathogen of viral, bacterial, fungal or oomycete origin, wherein the plant has a reduced...
2016/0326543 Disease Resistant Tobacco Plants
The present invention relates to a plant, which is resistant to a pathogen of viral, bacterial, fungal or oomycete origin, wherein the plant has a reduced...
2016/0326542 DROUGHT AND SALT TOLERANT PLANTS
The invention provides methods and compositions for enhancing drought and/or salt tolerance in plants. Nucleic acid constructs therefore are also described....
2016/0326541 PLANTS WITH ENHANCED PHOTOSYNTHESIS AND METHODS OF MANUFACTURE THEREOF
A transgenic plant having enhanced photosynthesis is disclosed. The transgenic plant is transformed with a transgenic polynucleotide encoding a heterologous...
2016/0326540 Methods and Compositions Employing a Sulfonylurea-Dependent Stabilization Domain
Methods and compositions are provided which employ polypeptides having a SU-dependent stabilization domain, and nucleotide sequences encoding the same. Such...
2016/0326539 AP2 DOMAIN TRANSCRIPTION FACTOR ODP2 (OVULE DEVELOPMENT PROTEIN 2) AND METHODS OF USE
Methods and compositions for modulating plant development are provided. Nucleotide sequences and amino acid sequences encoding Ovule Development Protein 2...
2016/0326538 SMALL INTERFERING RNAS WITH TARGET-SPECIFIC SEED SEQUENCES
Disclosed are methods for design and synthesis of siRNA libraries, siRNA libraries produced thereby, siRNA molecules, and uses thereof.
2016/0326537 ZINC FINGER NUCLEASE-MEDIATED HOMOLOGOUS RECOMBINATION
Disclosed herein are methods and compositions for targeted integration of an exogenous sequence into a predetermined target site in a plant genome.
2016/0326536 REPRODUCTION OF FEMALE STERILITY LINES AND ITS APPLICATION IN HYBRID SEED PRODUCTION
Provided in the present invention is a method for preparing hybrid rice, comprising the reproduction and maintenance of the female sterility line and the use...
2016/0326535 METABOLIC FLUX BIOSENSOR
Metabolic flux biosensors are provided herein, as are related compositions and methods useful for, inter alia, identifying factors which increase the...
2016/0326534 MODULATION OF SYNAPTIC MAINTENANCE
C1q is shown to be expressed in neurons, where it acts as a signal for synapse elimination. Methods are provided for protecting or treating an individual...
2016/0326533 RNAi-Related Inhibition of TNF-alpha Signaling Pathway for Treatment of Ocular Angiogenesis
RNA interference is provided for inhibition of tumor necrosis factor .alpha. (TNF.alpha.) by silencing TNF.alpha. cell surface receptor TNF receptor-1 (TNFR1)...
2016/0326532 TARGETING WSB1 AND pVHL TO TREAT CANCER
Materials and methods for treating cancer (e.g., by reducing metastasis) are provided herein. For example, materials and methods for treating cancer by...
2016/0326531 SDF-1 Binding Nucleic Acids and the Use Thereof
The present invention is related to a nucleic acid molecule binding to SDF-1, whereby the nucleic acid molecule influences migration of cells.
2016/0326530 APTAMERS INHIBITING THE ENZYMATIC ACTIVITY OF THE MMP-9 PROTEIN
The invention relates to an aptamer that has a G-quadruplex structure and is able to inhibit the enzymatic activity of the MMP-9 protein, as well as to the...
2016/0326529 ANTI-VIRAL THERAPY
The disclosure relates to anti-viral agents that mimic or inhibit packaging singles of RNA viruses that function in viral capsid formation and their use in the...
2016/0326528 METHODS AND COMPOSITIONS FOR PANIC DISORDERS
Methods and compositions that down regulate the activity of orexins to treat panic disorder and panic-like responses associated with hypercapnic conditions are...
2016/0326527 Compositions and Methods for Treatment of Prostate and Other Cancers
Therapeutic agents which target heat shock protein (hsp) 27 in vivo are used to provide treatment to individuals, particularly human individuals, suffering...
2016/0326526 OLIGONUCLEOTIDE-BASED INHIBITORS COMPRISING LOCKED NUCLEIC ACID MOTIF
The present invention relates to chemical modification motifs for oligonucleotides. The oligonucleotides of the present invention, such as chemically modified...
2016/0326525 USE OF MIRNA-214 INHIBITOR IN INHIBITING REGULATORY CELLS
Provided is a use of miRNA-214 inhibitor in inhibiting regulatory T cells (Treg cells). The microRNA-214 (miRNA-214) can promote Treg cells, and can assist...
2016/0326524 RAAV-BASED COMPOSITIONS AND METHODS FOR TREATING ALPHA-1 ANTI-TRYPSIN DEFICIENCIES
The invention relates to isolated nucleic acids and rAAV-based compositions, methods and kits useful for treating genetic diseases (e.g., alpha-1 antitrypsin...
2016/0326523 APPARATUS AND METHOD FOR ESTIMATING HEAT TREATMENT CONDITION, SYSTEM AND METHOD FOR FRAGMENTING NUCLEIC ACID,...
Disclosed is an apparatus configured to estimate a heat treatment condition, the apparatus including: an input unit configured to receive an input of...
2016/0326522 METHOD FOR PERFORMING MULTIPLEXED GENOTYPING
The invention relates to a method for genotyping individuals, through multiplexing genotyping, when samples carrying different loci of various individuals are...
2016/0326521 METHODS AND COMPOSITIONS FOR CREATING ALTERED AND IMPROVED CELLS AND ORGANISMS
The present invention relates to compositions involving randomized in-frame fusion polynucleotides and their introduction into a host organism to identify...
2016/0326520 Methods and Apparatuses for Chip-Based DNA Error Reduction
Methods and apparatus relate to reduction of sequence errors generated during synthesis of nucleic acids on a microarray chip. The error reduction can include...
2016/0326519 METHODS FOR DETECTING MODIFICATION RESISTANT NUCLEIC ACIDS
Methods are provided for, inter alia, detecting nucleic acid molecules resistant to degradation, such as a plurality of RNA molecules bound to a ribosome,...
2016/0326518 QUANTITATIVE LIGANDOMICS FOR SYSTEMATIC IDENTIFICATION OF THERAPEUTIC LIGANDS
The present invention is directed to methods for systematic identification of cellular ligands, disease-associated ligands, age-related ligands and...
2016/0326517 COMPOSITIONS AND METHODS FOR THE CONSTRUCTION OF A RANDOM ALLELIC SERIES
The present disclosure provides a method of making a systematic single point mutation in a target nucleic acid and a method of generating a mutational library...
2016/0326516 METHOD AND KIT FOR PURIFYING NUCLEIC ACIDS
Methods for automated extraction of nucleic acids are disclosed. Also disclosed are method and kits for isolating fetal nucleic acids from a plasma sample of a...
2016/0326515 METHODS AND KITS FOR EXTRACTION OF DNA
Methods and materials are disclosed for use in recovering a biopolymer from a solution. In particular, the invention provides methods for extraction and...
2016/0326514 METHOD AND SYSTEM FOR SAMPLE PREPARATION
A method for preparing a sample by utilizing a shearing force in the presence of a size stabilizer to break apart the sample to obtain nucleic acid molecules...
2016/0326513 SYSTEMS AND METHODS FOR ISOLATING NUCLEIC ACIDS FROM CELLULAR SAMPLES
The present disclosure relates to systems and methods for nucleic acid isolation from cellular samples. In particular, the present disclosure provides systems...
2016/0326512 METHODS AND COLUMNS FOR NUCLEIC ACID PURIFICATION
Provided are methods and columns employing a solid support comprising silica and silicon carbide for the isolation and purification of nucleic acids, and in...
2016/0326511 PLASMA TREATMENT FOR DNA BINDING
The invention provides a composition including DNA bonded to a plasma-treated surface, the plasma can be any suitable plasma, such as an argon plasma, a...
2016/0326510 MUTANT GLUTAMATE-CYSTEINE LIGASE AND METHOD FOR MANUFACTURING GAMMA-GLUTAMYL-VALYL-GLYCINE
A mutant glutamate-cysteine ligase (GSHA) suitable for generating .gamma.-Glu-Val, and a method for producing .gamma.-Glu-Val-Gly using the same are provided....
2016/0326509 METHYL BUTENOL SYNTHASE
The present invention provides novels genes encoding methyl butenol (MBO) synthase, methy butenol synthases and their use in methyl butenol production.
2016/0326508 PENICILLIN-G ACYLASES
The present disclosure relates to engineered penicillin G acylase (PGA) enzymes having improved properties, polynucleotides encoding such enzymes, compositions...
2016/0326507 VARIANTS OF GH FAMILY 5 ENDOGLUCANASE AND POLYNUCLEOTIDES ENCODING SAME
The present invention relates to GH Family 5 endoglucanase variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid...
2016/0326506 ALPHA-AMYLASE VARIANTS
The present invention relates to variants of a parent alpha-amylase. The present invention also relates to polynucleotides encoding the variants; nucleic acid...
2016/0326505 METHODS AND COMPOSITIONS FOR GENE INACTIVATION
Disclosed herein are methods and compositions for inactivating CCR-5 genes, using zinc finger nucleases (ZFNs) comprising a zinc finger protein and a cleavage...
2016/0326504 COMPOSITION AND FORMULATION COMPRISING RECOMBINANT HUMAN IDURONATE-2-SULFATASE AND PREPARATION METHOD THEREOF
A composition comprising recombinant iduronate-2-sulfatase (IDS) and a method for producing a purified recombinant IDS are provided. The glycosylation pattern...
2016/0326503 PHOSPHOLIPASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM
In alternative embodiments, the invention provides phosphatidylinositol-specific phospholipase C (PI-PLC) enzymes, nucleic acids encoding them, antibodies that...
2016/0326502 Recombinase Polymerase Amplification
The present invention features novel, diverse, hybrid and engineered recombinase enzymes, and the utility of such proteins with associated recombination...
2016/0326501 VEGF ANTAGONIST COMPOSITIONS AND USES THEREOF
The invention provides compositions and methods for treating a disease or disorder associate with vascular endothelial growth factor (VEGF). Specifically, the...
2016/0326500 3-HYDROXYISOVALERATE (HIV) SYNTHASE VARIANTS
Described are 3-hydroxyisovalerate (HIV) synthase variants having improved activity in converting acetone and a compound which provides an activated acetyl...
2016/0326499 NOVEL CAR ENZYMES AND IMPROVED PRODUCTION OF FATTY ALCOHOLS
The disclosure relates to variant carboxylic acid reductase (CAR) enzymes for the improved production of fatty alcohols in recombinant host cells.
2016/0326498 CELL STRAIN HAVING INCREASED VIRUS PRODUCTION ABILITY AND PRODUCTION METHOD THEREFOR
The present invention relates to a cell line having an increased ability to produce virus and a method for preparing thereof, and more particularly, to a cell...
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