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Patent # Description
2016/0326147 AMINOESTER DERIVATIVES
Compounds of formula (I) are both phosphodiesterase 4 (PDE4) enzyme inhibitors and muscarinic M3 receptor antagonists and are useful for the prevention and/or...
2016/0326146 THIENOMETHYLPIPERAZINE DERIVATIVES AS INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE
The present invention relates to compounds of the formula (I), wherein R1, R2, R3, R4 and X have the meanings indicated in the claims. The compounds of formula...
2016/0326145 METHOD FOR PRODUCING SILYMARIN
The present invention relates to a method for producing silymarin. The method comprises: pressing silybum marianum seeds to obtain silymarin powder, and...
2016/0326144 FLOURO-NAPHTHYL DERIVATIVES
The present invention relates to compounds of formula ##STR00001## wherein R.sup.1 is C.sub.4-6-cycloalkyl or C.sub.4-6-heterocycloalkyl, which are optionally...
2016/0326143 COMPOUNDS AND USES
There is provided compounds of formula I, ##STR00001## wherein E.sup.1, E.sup.2, E.sup.3, E.sup.4, L.sup.1, Y.sup.1, Y.sup.2, Y.sup.3, R.sup.a and z have...
2016/0326142 PYRAZOLE CARBOXAMIDE COMPOUNDS, COMPOSITIONS AND METHODS OF USE
Provided herein are compounds of formula (AA): ##STR00001## stereoisomers or a pharmaceutically acceptable salt thereof, wherein A, R.sup.a, p, R.sup.5 and...
2016/0326141 HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS FOR USE AGAINST CANCER AND VIRAL INFECTIONS
Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such...
2016/0326140 NOVEL PYRAZOLYL-HETEROARYLAMIDES AS PESTICIDES
The invention comprises, inter alia, pyrazolylheteroarylamides of the general formula (I) ##STR00001## in which the A.sub.1-A.sub.4, T, W, Q, R.sup.1 and...
2016/0326139 PYRIDAZINE COMPOUNDS, COMPOSITIONS AND METHODS
The invention relates to novel chemical compounds, compositions and methods of making and using the same. In particular, the invention provides pyridazine...
2016/0326138 Process for preparing an anti-cancer agent, ...
The present invention relates a new process to synthesize 1-((4-(4-Fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxyquinolin-7-yloxy)meth- yl)cyclopropanamine...
2016/0326137 Compounds and Methods of Use
This disclosure provides compounds and compositions and methods of using those compounds and compositions to treat diseases and disorders associated with...
2016/0326136 1-ARYLCARBONYL-4-OXY-PIPERIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES
The present invention provides a compound useful as an agent for the prophylaxis or treatment of neurodegenerative disease and the like, or a salt thereof. ...
2016/0326135 2-HETARYL-PYRIDAZINONE DERIVATIVES AND THEIR USE AS HERBICIDES
2-Hetaryl-pyridazinone derivatives of the general formula (I) are described as herbicides. ##STR00001## In this formula (I), R.sup.1, R.sup.2 and R.sup.3 are...
2016/0326134 SYNTHESIS AND RESOLUTION OF NICOTINE
The present disclosure generally relates to methods of preparing nicotine and resolving R,S nicotine to enrich the (S)(-) enantiomer. The method may comprise...
2016/0326133 CYCLIC COMPOUNDS
The present invention provides compounds having a Toll-like receptor 4 (TLR4) signaling inhibitory action useful as preventive and therapeutic drugs of...
2016/0326132 FIVE-MEMBERED CYCLIC BISCARBONATES BEARING AMIDE LINKAGES, THEIR PREPARATION AND THEIR USES FOR THE PREPARATION...
A compound is of formula (I): ##STR00001## in which A.sub.1 and A.sub.1' are independently from each other a linear or branched alkylene radical including from 1...
2016/0326131 PROCESS-SCALE SYNTHESIS OF UROLITHINS
Disclosed is a method of preparing a urolithin, or an intermediate or analog thereof, having a dibenzo[b,d]pyran-6-one core. The method is especially...
2016/0326130 PROCESS TO EXTRACT AND PURIFY DELTA-9-TETRAHYDROCANNABINOL
.DELTA..sup.9-THC acid is extracted from cannabis flowers using a first organic solvent, then separated using a second aqueous solvent. .DELTA..sup.9-THC acid...
2016/0326129 COCKROACH ATTRACTION-AGGREGATION SUBSTANCE, COCKROACH AGGREGATION ATTRACTANT AND COCKROACH CONTROLLING AGENT
Provided is a solution for the problems associated with cockroach aggregation pheromones and cockroach aggregation attractants or cockroach controlling agents...
2016/0326128 NOVEL EICOSANOID DERIVATIVES
The present invention provides compounds (n-3 PUFA derivatives) of formula (I): ##STR00001## that modulate conditions associated with cardiac damage, especially ...
2016/0326127 NEUROACTIVE SUBSTITUTED CYCLOPENTA[b]PHENANTHRENES AS MODULATORS FOR GABA TYPE-A RECEPTORS
The present disclosure is generally directed to neuroactive substituted cyclopenta[b]phenanthrenes as referenced herein, and pharmaceutically acceptable salts...
2016/0326126 AMYLOID TARGETING AGENTS AND METHODS OF USING THE SAME
Provided herein is the design and synthesis of novel molecular rotor fluorophores useful for detection of amyloid or amyloid like proteins. The fluorophores...
2016/0326125 SULFONE AMIDE LINKED BENZOTHIAZOLE INHIBITORS OF ENDOTHELIAL LIPASE
The present invention provides compounds of Formula (I) as defined in the specification and compositions comprising any of such novel compounds. These...
2016/0326124 HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF
Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use. ##STR00001##
2016/0326123 SUBSTITUTED BENZOXAZINE AND RELATED COMPOUNDS
The present invention relates to compounds including but not limited to of any one of formulas Ia, Ib, IIa, IIb, IIIa, IIIb, and IV to VI, VIIa, VIIb, VIIIa,...
2016/0326122 Anti-Angiogenic Compounds
Compounds and compositions are described which are useful especially for treatment of angiogenesis-related diseases or disorders such as neovascularisation of...
2016/0326121 2-THIOPYRIMIDINONES
Myeloperoxidase inhibitor, pharmaceutical compositions containing the inhibitor and the use of the inhibitor to treat, for example, cardiovascular conditions.
2016/0326120 N-CYCLOALKYL-N--(THIO)CARBOXAMIDE DERIVATIVES
The present invention relates to fungicidal N-cycloalkyl-N-{[2-(1-substitutedcycloalkyl)phenyl]methylene} carboxamide derivatives and their thiocarbonyl...
2016/0326119 MORPHAN AND MORPHINAN ANALOGUES, AND METHODS OF USE
The present application relates to analogues of morphan and morphinan, compositions thereof, and methods for treating a disease or condition comprising...
2016/0326118 Novel Process for Preparation of Indacaterol or Its Pharmaceutically Acceptable Salts
A novel process the for preparation of Indacaterol or its pharmaceutically acceptable salts and novel intermediates employed in the preparation thereof that is...
2016/0326117 PROCESS FOR THE PREPARATION OF A PDE4 INHIBITOR
The present invention relates to a process for the preparation of compounds endowed with phosphodiesterase (PDE4) inhibitory activity having formula (I). The...
2016/0326116 CATIONIC LIPID
The present invention provides a cationic lipid which can be used for nucleic acid delivery to a cytoplasm and which is possible to solve the problem of...
2016/0326115 HETEROCYCLIC SULFONE ROR GAMMA MODULATORS
Described are ROR.gamma. modulators of the formula (I), [INSERT CHEMICAL STRUCTURE HERE] or stereoisomers, tautomers, pharmaceutically acceptable salts,...
2016/0326114 NOVEL COMPOSITIONS FOR PREVENTING AND/OR TREATING DEGENERATIVE DISORDERS OF THE CENTRAL NERVOUS SYSTEM
The present invention provides novel compounds as well as compositions and methods using the same for preventing and/or treating degenerative disorders of the...
2016/0326113 Synthetic Processes of Carprofen
Methods and intermediates for the synthesis of carprofen and its derivatives starting from cyclohexanone are disclosed.
2016/0326112 Method For Purifying Aromatic Amino Acids
A method for purifying an amino acid from an initial mixture is disclosed, in which the amino acid includes an aromatic ring and has an acidity constant Ka,...
2016/0326111 ARYL SUBSTITUTED INDOLES AND THE USE THEREOF
The invention relates to aryl and heteroaryl substituted compounds of Formula (I), and pharmaceutically acceptable salts, prodrugs, or solvates thereof,...
2016/0326110 NOVEL SUBSTITUTED 5 MEMBERED HETEROCYCLIC COMPOUNDS AND PREPARATION THEREOF
Novel substituted 5 membered heterocyclic compounds of Formula I are disclosed. The invention further discloses a process for the preparation of compounds of...
2016/0326109 RADIOIODINATED COMPOUNDS
This disclosure relates to reagents and methods useful in the synthesis of aryl iodines, for example, in the preparation of iodine labeled radiotracers. The...
2016/0326108 PYRROLIDINYL SULFONE DERIVATIVES AND THEIR USE AS ROR GAMMA MODULATORS
Described are ROR.gamma. modulators of the formula (I), or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein...
2016/0326107 HEPATOPROTECTANT ACETAMINOPHEN MUTUAL PRODRUGS
The present invention provides hepatoprotectant acetaminophen mutual prodrugs, which have an acetaminophen moiety covalently linked to a second moiety that may...
2016/0326106 USE OF MAGNETIC IRON OXIDE RED IN CATALYZING AND OXIDIZING METHANTHIOL AND METHODS FOR PREPARING AND APPLING SAME
The present invention relates to a novel use of magnetic iron oxide red Fe.sub.21.333O.sub.32 as a catalyst in oxidizing methanthiol to prepare dimethyl...
2016/0326105 CATALYST FOR THE SYNTHESIS OF METHYL MERCAPTAN AND PROCESS FOR PRODUCING METHYL MERCAPTAN FROM SYNTHESIS GAS...
The invention relates to a catalyst comprising an active component based on molybdenum and on potassium and a support based on hydroxyapatite, and also to a...
2016/0326104 CYCLOHEXYL SULFONE ROR GAMMA MODULATORS
Described are ROR.gamma. modulators of the formula (I), or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein...
2016/0326103 CARBOCYCLIC SULFONE ROR GAMMA MODULATORS
Described are ROR.gamma. modulators of the formula (I), or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein...
2016/0326102 CYCLIC COMPOUNDS
The present invention provides compounds having a Toll-like receptor 4 (TLR4) signaling inhibitory action useful as preventive and therapeutic drugs of...
2016/0326101 Process for the Synthesis of Chiral Propargylic Alcohols
A process for the synthesis of chiral propargylic alcohols.
2016/0326100 MODULARIZED SYSTEM AND METHOD FOR UREA PRODUCTION USING A BIO-MASS FEEDSTOCK
A modular system and method for producing urea from bio-mass includes means and steps for "homogenizing" a biomass feedstock stream having components with...
2016/0326099 COMPOUNDS WITH NEURAL PROTECTIVE EFFECT, AND PREPARATION AND USE THEREOF
The invention generally relates to compounds of formula (I) with neural protective effect, and preparation and uses thereof. ##STR00001## The compounds have...
2016/0326098 Pharmaceutically Active Compound for Use as Anti-inflammatory Agent
The present application refers to a medicinally active compound of formula (I) and its possible use as anti-inflammatory agent. Further, the present...
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