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Patent # Description
2016/0333104 Antibodies Against TL1a and Uses Thereof
The disclosure provides TNF-like ligand 1a (TL1a)-binding proteins comprising an antigen binding domain of an antibody which binds specifically to TL1a and...
2016/0333103 BAFF SELECTIVE BINDING COMPOUNDS AND RELATED METHODS
The present invention relates to peptide antagonists that bind with high specificity and affinity to B-Lymphocyte stimulator ("BAFF"), thereby antagonizing...
2016/0333102 ANTI-CD154 ANTIBODIES HAVING IMPAIRED FcR BINDING AND/OR COMPLEMENT BINDING PROPERTIES AND RELATED THERAPIES
Improved anti-CD154 antibodies are provided herein which have ablated FcR binding and/or complement binding/activation. The use of these antibodies for...
2016/0333101 ANTI-HUMAN RANKL ANTIBODY, HUMANIZED ANTIBODY OF THE SAME, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF
An anti-human RANKL antibody, a humanized antibody for the anti-human RANKL antibody, a pharmaceutical composition and a use thereof are provided. The...
2016/0333100 CONJUGATES FOR TREATING INFLAMMATORY DISEASE AND IDENTIFICATION OF PATIENTS LIKELY TO BENEFIT FROM SUCH TREATMENT
The present invention relates to a conjugate that specifically targets a calcineurin inhibitor to T cells, such as Th17 cells, for use in a method for the...
2016/0333099 AMINO ACID SEQUENCES DIRECTED AGAINST IL-6R AND POLYPEPTIDES COMPRISING THE SAME FOR THE TREATMENT OF IL-6R...
The present invention relates to amino acid sequences that are directed against/and or that can specifically bind Interleukin-6 Receptor (IL-6R) with improved...
2016/0333098 METHODS OF TREATING CANCER WITH ANTIBODIES THAT TARGET THE INSULIN-LIKE GROWTH FACTOR TYPE I RECEPTOR (IGF-1R)
The present invention provides compositions and methods of use of anti-IGF-1R antibodies or antibody fragments. Preferably the antibodies bind to IGF-1R but...
2016/0333097 USE OF ANTAGONISTS OF THE INTERACTION BETWEEN HIV GP120 AND A4B7 INTEGRIN
Methods are provided for the treatment of a HIV infection. The methods can include administering to a subject with an HIV infection a therapeutically effective...
2016/0333096 ANTIBODIES AGAINST CANINE PD-1
The present invention discloses antibodies to canine PD-1 that have specific sequences and a high binding affinity for canine PD-1. The invention also...
2016/0333095 HUMANIZED OR CHIMERIC CD3 ANTIBODIES
The present invention relates to humanized or chimeric antibodies binding CD3. It furthermore relates to bispecific antibodies, compositions, pharmaceutical...
2016/0333094 CHIMERIC ANTIGEN RECEPTOR USING ANTIGEN RECOGNITION DOMAINS DERIVED FROM CARTILAGINOUS FISH
The present invention relates to a new generation of chimeric antigen receptors (CAR), under single-chain or multi-chain forms, the specificity of which, to a...
2016/0333093 Targeted Therapy for Small Cell Lung Cancer
Methods are provided for treatment of lung cancers, particularly small cell lung cancer with targeted therapy, which optionally includes an agent that...
2016/0333092 THERAPEUTIC PHARMACEUTICAL COMPOSITION EMPLOYING ANTI-SLC6A6 ANTIBODY
The present invention aims to provide a pharmaceutical composition for cancer treatment, which comprises a novel monoclonal antibody binding to SLC6A6 or its...
2016/0333091 Anti-IL-23 Antibodies
The present invention relates to anti-IL-23p19 binding compounds, in particular new humanized anti-IL-23p19 antibodies and therapeutic and diagnostic methods...
2016/0333090 ANTIBODIES DIRECTED AGAINST INTERLEUKIN-33 (IL-33)
The invention relates to an isolated immunoglobulin heavy chain polypeptide and an isolated immunoglobulin light chain polypeptide that bind to interleukin-33...
2016/0333089 Antigenic GM-CSF Peptides and Antibodies to GM-CSF
Hybridoma lines that secrete human monoclonal antibodies with high binding specificity and biological activity, particularly neutralizing activity against...
2016/0333088 METHODS
The present invention provides method, uses and agents for preventing or reducing cognitive decline in a patient following a planned inflammatory trigger. Such...
2016/0333087 METHODS AND COMPOSITIONS FOR INHIBITION OF EGF/EGFR PATHWAY IN COMBINATION WITH TYROSINE KINASE INHIBITORS
A method of treating patients suffering from cancers driven by deregulated Human Epidermal Growth Factor Receptor (HER1/Human EGFR) comprising administering to...
2016/0333086 ANTIGEN BINDING PROTEINS
The present invention relates to antigen binding proteins, such as antibodies, which bind to serum amyloid P component (SAP), polynucleotides encoding such...
2016/0333085 Anti-p40 Antibodies Systems and Methods
The present invention is related to the anti-p40 antibodies, kits, cocktails, and use of anti-p40 antibodies for detection of cancer.
2016/0333084 METHODS AND COMPOSITIONS FOR MODULATION OF OLFML3 MEDIATED ANGIOGENESIS
The present invention relates to antibodies against specific domains of Olfml3 and the use of such in angiogenesis. In particular aspects, angiogenesis-related...
2016/0333083 TARGETING CLPTM1L FOR TREATMENT AND PREVENTION OF CANCER
Provided herein are therapeutic agents having specificity for human CLPTM1 L polypeptide, including therapeutic agents comprising one or more CLPTM1...
2016/0333082 ANTIBODY TARGETING CELL SURFACE DEPOSITED COMPLEMENT PROTEIN C3d AND USE THEREOF
An anti-C3d antibody or antibody fragment; method for use thereof to kill cancer cells; and related methods and compositions.
2016/0333081 TREATMENT OF SEPSIS AND SEPTIC SHOCK
The technology described herein is directed to the treatment of sepsis and/or septic shock by, e.g. administering an agent that can reduce the level of...
2016/0333080 AGLYCOSYLATED ANTI-Bb ANTIBODIES AND USES THEREOF
An aglycosylated humanized anti-Bb (AAfBb) antibody or antigen binding fragment thereof includes a modification at a conserved N-linked site in the CH2 domains...
2016/0333079 AGLYCOSYLATED ANTI-C3b ANTIBODIES AND USES THEREOF
An aglycosylated humanized anti-C3b (AAC3b) antibody or antigen binding fragment thereof includes a modification at a conserved N-linked site in the CH2...
2016/0333078 HUMAN IgM ANTIBODIES, AND DIAGNOSTIC AND THERAPEUTIC USES THEREOF PARTICULARLY IN THE CENTRAL NERVOUS SYSTEM
Antibodies, and particularly human antibodies, are disclosed that demonstrate activity in the treatment of demyelinating diseases as well as other diseases of...
2016/0333077 TARGETING IMMUNOLOGICAL FUNCTIONS TO THE SITE OF BACTERIAL INFECTIONS USING CELL WALL TARGETING DOMAINS OF...
This disclosure provides a comprehensive approach to specifically target various immune functions to the site of infection by a variety of fusion proteins that...
2016/0333076 NEUTRALIZING GP41 ANTIBODIES AND THEIR USE
Monoclonal neutralizing antibodies are disclosed that specifically bind to the HIV-1 gp41 membrane-proximal external region (MPER). Also disclosed are...
2016/0333075 ANTIBODIES SPECIFIC FOR ENTEROVIRUSES THAT INFECT HUMANS
This invention provides antibodies or fragments thereof that are capable of specifically binding to at least one conformational epitope of enterovirus 71...
2016/0333074 NOVEL POLYPEPTIDE AND USES THEREOF
The present invention relates to a novel polypeptide having specific modifications compared to the natural polypeptide. The said novel polypeptide has improved...
2016/0333073 DRUG DELIVERY SYSTEM
The present invention concerns peptides comprising at least one motif having the amino acid sequence B.sup.1-X.sub.3-10-B.sup.2, wherein B.sup.1 and B.sup.2...
2016/0333072 IMPROVED CELL COMPOSITIONS AND METHODS FOR CANCER THERAPY
Provided is directed to the field of immunotherapy. Specifically, provided are compositions and methods for improved T cell modulation ex vivo and in vivo and...
2016/0333071 Biological Pacemakers Incorporating HCN2 and SkM1 Genes
It is demonstrated that hyperpolarization-activated cyclic nucleotide-gated (HCN)-based biological pacing, especially that achieved by transduction of the HCN2...
2016/0333070 PRO-ANGIOGENIC PEPTIDES AND PEPTIDE CONJUGATES
Short bioactive sequences derived from the 2.sup.nd loop of the 7-transmembranal receptor of endothelial differentiation gene 3 (EDG3) useful in stimulation of...
2016/0333069 SYSTEM AND METHOD FOR CONTROLLING G-PROTEIN COUPLED RECEPTOR PATHWAYS
A light-sensitive G-protein coupled receptor includes a light sensitive extracellular cone opsin or melanopsin domain and a hetorologous intracellular domain...
2016/0333068 COMPOSITIONS AND METHODS FOR IMAGING CANCER
Somatostatin derivative compounds of general formula (I) that may be readily labelled with the isotope fluorine-18 and that have affinity and selectivity for...
2016/0333067 Compositions and Methods for Immunomodulation in an Organism
The present invention relates to a therapeutic polypeptide and methods for its creation and use for modulating an immune response in a host organism in need...
2016/0333066 PURIFICATION OF ERYTHROPOIETIN
In the present invention a method for purifying erythropoietin comprising at least one chromatography step using a stationary phase containing hydroxyapatite...
2016/0333065 PRAME DERIVED PEPTIDES AND IMMUNOGENIC COMPOSITIONS COMPRISING THESE
The invention relates to a peptide having a length of no more than 100 amino acids and comprising at least 19 contiguous amino acids from the amino acid...
2016/0333064 MULTIMODAL TRAIL MOLECULES AND USES IN CELLULAR THERAPIES
Described herein are novel compositions comprising multimodal TRAIL agents and cells engineered to express such multimodal TRAIL agents, including cells...
2016/0333063 SOLUBLE HIGH MOLECULAR WEIGHT (HMW) TAU SPECIES AND APPLICATIONS THEREOF
The disclosure provides novel forms of tau species and applications thereof, as well as methods of diagnosing and/or treating tau-associated neurodegeneration....
2016/0333062 DERMASEPTIN-TYPE AND PISCIDIN-TYPE ANTIMICROBIAL PEPTIDES
Antimicrobial agents, including antimicrobial peptides (AMPs) and uses thereof. Compositions and methods of using dermaseptin-type and piscidin-type...
2016/0333061 FUSION TAGS FOR PROTEIN EXPRESSION
Fluorescent and non-fluorescent fusion tags derived from green fluorescent protein (GFP). The fusion tags harbor substitutions with respect to GFP that...
2016/0333060 ANTI-VIRAL CNIDARINS
An isolated and purified nucleic acid molecule that encodes a polypeptide comprising at least eight contiguous amino acids of SEQ ID NO: 1, 2, or 3, wherein...
2016/0333059 Improvements in the Synthesis of Phycocyanins
The invention discloses microorganism cell culture conditions that result in increased cellular and media concentrations of a biological pigment. The invention...
2016/0333058 PROMOTERS SUITABLE FOR HETEROLOGOUS GENE EXPRESSION IN YEAST
The present invention relates to the use of novel promoters for heterologous gene expression, preferably for expression of genes in organisms of the genus...
2016/0333057 Expression and Purification of CRM197 and Related Proteins
The present invention is directed to the cells, compositions and methods for the production of recombinant protein. In particular, the invention is directed to...
2016/0333056 MUTANT FRAGMENTS OF OSPA AND METHODS AND USES RELATING THERETO
The present invention relates to compositions and methods for the prevention and treatment of Borrelia infection. Particularly, the present invention relates...
2016/0333055 HIV-1 V3 Mimotopes Capable of Inducing Cross-Clade Neutralizing Antibodies
The invention provides methods, compositions and kits for treating and or preventing an HIV infection. For example, HIV envelope-like polypeptides (wild-type...
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