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Patent # Description
2016/0333054 SMALL MOLECULE COMPOSITE SURFACES AS INHIBITORS OF PROTEIN-PROTEIN INTERACTIONS
A method of inhibiting a binding event between a target protein and a binding protein, comprising administering to a cell in vitro an effective amount of a...
2016/0333053 BETA-HAIRPIN PEPTIDOMIMETICS AS SELECTIVE ELASTASE INHIBITORS
.beta.-Hairpin peptidomimetics of the general formula cyclo(-Xaa.sup.1-Xaa.sup.2-Thr.sup.3-Xaa.sup.4-Ser.sup.5-Xaa.sup.6-Xaa.su- ...
2016/0333052 NOVEL CROSS-LINKED PEPTIDES CONTAINING NON-PEPTIDE CROSS-LINKED STRUCTURE, METHOD FOR SYNTHESIZING CROSS-LINKED...
The purpose of the present invention is to provide a cross-linked peptide containing a novel non-peptide cross-linked structure, and a method for synthesizing...
2016/0333051 TEMPLATE-FIXED BETA-HAIRPIN PEPTIDOMIMETICS WITH PROTEASE INHIBITORY ACTIVITY
Template-fixed .beta.-hairpin peptidomimetics of the general formulae ##STR00001## wherein Z is a chain of 11 .alpha.-amino acid residues which, depending on...
2016/0333050 NOVEL CROSS-LINKED PEPTIDES CONTAINING NON-PEPTIDE CROSS-LINKED STRUCTURE, METHOD FOR SYNTHESIZING CROSS-LINKED...
The purpose of the present invention is to provide a cross-linked peptide containing a novel non-peptide cross-linked structure, and a method for synthesizing...
2016/0333049 PEPTIDOMIMETIC MACROCYCLES AND USES THEREOF
Methods for treating liquid cancer, determined to lack a p53 deactivation mutation, in a subject are provided. Also provided are peptidomimetic macrocycles for...
2016/0333048 Antimicrobial Peptidomimetics
The present invention relates to peptidomimetics of the formula (I) or (I)c wherein L.sub.1, L.sub.2, L.sub.3, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5,...
2016/0333047 Novel Peptidomimetics With Antiangiogenic Activity
We disclose novel peptidomimetics with antiangiogenic activity and their uses, particularly in the treatment of neoplasms and chronic inflammation (in...
2016/0333046 METHODS FOR VIRAL INACTIVATION USING ECO-FRIENDLY DETERGENTS
The invention provides for methods of inactivating virus in product feedstream in a manufacturing process of a therapeutic polypeptide using an environmentally...
2016/0333045 Preparation of Oligo Conjugates
Conjugated molecules are prepared that comprise a predetermined number of oligo conjugation components. The conjugated molecules also may comprise one or more...
2016/0333044 SYNTHETIC MEMBRANE ANCHORS
Cells incorporating a synthetic molecule construct of the structure F--S.sub.1--S.sub.2-L where: F--S.sub.1 is an aminoalkylglycoside where F is a mono-, di-,...
2016/0333043 E-Selectin Antagonists Modified By Macrocycle Formation to the Galactose
Provided herein are glycomimetic E-selectin antagonist compounds of formula (I)) and pharmaceutical compositions comprising at least one of the same. The...
2016/0333042 PROCESS FOR EFFICIENT PURIFICATION OF NEUTRAL HUMAN MILK OLIGOSACCHARIDES (HMOs) FROM MICROBIAL FERMENTATION
The present application discloses a simple process for the purification of neutral human milk oligosaccharides (HMOs) produced by microbial fermentation. The...
2016/0333041 METHOD FOR PURIFYING BETA-NICOTINAMIDE MONONUCLEOTIDE
The present invention discloses a method for purifying .beta.-nicotinamide mononucleotide, comprising the steps of: a. sequentially microfiltrating and...
2016/0333040 Novel Process for the Recovery of Beta Acetylfuranoside
There is provided an improved method for the recovery of residual, unseparated .beta.-ACF from reaction mixtures remaining from an initial synthesis of ACF,...
2016/0333039 PROCESS FOR THE PREPARATION OF DOPO-DERIVED COMPOUNDS AND COMPOSITIONS THEREOF
This invention relates to a process for producing compounds derived from 9,10-Dihydro-9-Oxa-10-Phosphaphenantrene-10-oxide (DOPO). In particular, the invention...
2016/0333038 NOVEL DERIVATIVES OF OXAZAPHOSPHORINES THAT ARE PRE-ACTIVATED, USE AND METHOD OF PREPARATION
The present invention relates to novel derivatives of oxazaphosphorines that are pre-activated, to the methods for preparing same, to the pharmaceutical...
2016/0333037 PHOSPHOLE COMPOUND AND FLUORESCENT DYE CONTAINING THE SAME
The following formula is an example of a phosphole compound of the present invention. The phosphole compound of the present invention has the characteristic of...
2016/0333036 POLYKETONE POLYMERIZATION CATALYST
Provided are a novel polyketone polymerization catalyst and a method of preparing a ligand, which can reduce production costs and can enable commercial mass...
2016/0333035 PYRABACTIN ANALOGUES TO MODULATE PLANT DEVELOPMENT
The present invention relates to compounds which can be used to control plant development. Indeed, the present invention discloses a new class of pyrabactin...
2016/0333034 PREPARATION OF PURIFIED PHOSPHORODIAMIDITE
The instant invention relates to a method of phosphorodiamidite production that comprises: (E1) preparing a purified solution of a dialkylamine in a polar...
2016/0333033 O-Phenyl Chalcone Compounds And Preparation Method And Use Thereof
Disclosed are an o-phenyl chalcone compounds and preparation methods and uses thereof. The o-phenyl chalcone compounds are capable of inhibiting the...
2016/0333032 Complexing Agent and Preparation Method and Use Thereof
The present invention relates to a complexing agent and preparation method and use thereof, the complexing agent has a general formula ...
2016/0333031 PROTEASOME ACTIVITY ENHANCING COMPOUNDS
The present invention is directed to compounds having the Formula (I), (II), (III), (IV), and (V), compositions thereof, and methods for the treatment of a...
2016/0333030 NOVEL TRISILYL AMINE DERIVATIVE, METHOD FOR PREPARING THE SAME AND SILICON-CONTAINING THIN FILM USING THE SAME
Provided are a novel trisilyl amine derivative, a method for preparing the same, and a silicon-containing thin film using the same, wherein the trisilyl amine...
2016/0333029 TRIFLUOROBORATE MASS SPECTROMETRIC TAGS
The invention provides compositions and methods for mass spectrometric (MS), organic synthesis, and applications of organo-trifluoroborate, for example, as...
2016/0333028 LANTHANIDE ION COMPLEXES AND IMAGING METHOD
A lanthanide complex, method of forming and method of using the lanthanide complex as a near-infrared luminescent material are described. The complex includes...
2016/0333027 6,7-TRANS CEPHALOSPORIN-BASED PROBES FOR DETECTING BACTERIA EXPRESSING A METALLO-BETA-LACTAMASE
The present invention discloses a probe useful for the selective detection of metallo-beta-lactamases, in particular carbapenemases, thereby distinguishing...
2016/0333026 NOVEL PROCESS FOR THE PREPARATION OF DOLUTEGRAVIR AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF
The present invention relates to a novel process for the preparation of dolutegravir and pharmaceutically acceptable salts thereof using novel intermediates.
2016/0333025 Method for Preparing Curable Bicyclic Compound Derived from Biomass
The present invention relates to a curable bicyclic compound derived from biomass, solvent-free curable composition and a method for preparing thereof. The...
2016/0333024 OXABICYCLOHEPTANE PRODRUGS
The present invention provides a compound having the structure: ##STR00001##
2016/0333023 HARRINGTONINES SALTS IN THE CRYSTALLINE STATE AND THEIR USE FOR THE PURIFICATION OF THE CORRESPONDING DRUG...
The present disclosure concerns harringtonines salts at the crystalline state exhibiting a protonated nitrogen seen in solid state analysis and having general...
2016/0333022 WATER SOLUBLE 4-AZAPODOPHYLLOTOXIN ANALOGS
The present invention relates to 4-azapodophyllotoxin analogs of formula (I) in which X, R.sub.1, R.sub.2, R.sub.3, R.sub.4 and Ar are as defined in claim 1,...
2016/0333021 METALLO-BETA-LACTAMASE INHIBITORS
The present invention relates to compounds of formula (I) that are metallo-.beta.-lactamase inhibitors, the synthesis of such compounds, and the use of such...
2016/0333020 7-BETA ANALOGS OF ORVINOLS
The application is directed to compounds of Formula I (I) and pharmaceutically acceptable salts and solvates thereof, wherein R.sup.1, R.sup.1a, R.sup.1b, X,...
2016/0333019 SYNTHESIS AND FORMULATIONS OF PORPHYRIN COMPOUNDS
Provided herein, inter alia, are methods of synthesizing and formulating porphyrins, including manganese containing porphyrins. Also provided herein are...
2016/0333018 (HETERO)ARYL IMIDAZOLES/PYRAZOLES FOR TREATMENT OF NEUROLOGICAL DISORDERS
The present invention relates to compounds of formula I, wherein A, B, R.sup.1, R.sup.2, and Z are as defined hereinbefore. ##STR00001##
2016/0333017 HETEROCYCLIC COMPOUNDS AND THEIR USES
Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis,...
2016/0333016 MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF
Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.
2016/0333015 4-Substituted Pyrrolo[2,3-d]pyrimidine Compound and Use Thereof
The invention relates to a 4-substituted pyrrolo[2,3-d]pyrimidine compound and the use thereof in preparing medications for treating JAK-targeted diseases such...
2016/0333014 SMALL-MOLECULE HSP90 INHIBITORS
Purine scaffold Hsp90 inhibitors are useful in therapeutic applications and as radioimaging ligands.
2016/0333013 TRICYCLIC COMPOUNDS AS ANTICANCER AGENTS
The present invention is directed to tricyclic compounds of the formula ##STR00001## wherein all substituents are defined herein, as well as pharmaceutically ...
2016/0333012 COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES
The present invention provides compounds of formula I: ##STR00001## or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the...
2016/0333011 TRIAZOLOPYRIDINE JAK INHIBITOR COMPOUNDS AND METHODS
A compound of Formula I, enantiomers, diastereomers, tautomers or pharmaceutically acceptable salts thereof, wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and...
2016/0333010 COMPOUNDS AND METHOD FOR TREATMENT OF HIV
The invention relates to a compound of Formulae I and/or II: ##STR00001## and/or a pharmaceutically-acceptable salt, hydrate, solvate, tautomer, optical isomer,...
2016/0333009 BENZIMIDAZOLE AND IMADAZOPYRIDINE CARBOXIMIDAMIDE COMPOUNDS
The present disclosure provides indoleamine 2,3-dioxygenase 1 (IDOL) inhibitors of Formula I: ##STR00001## or pharmaceutically acceptable salts thereof, in which...
2016/0333008 HETEROCYCLIC COMPOUNDS AND USES THEREOF
The present disclosure relates to heterocyclic compounds, and pharmaceutical compositions of the same, that are inhibitors of the TAM protein kinases and are...
2016/0333007 HETEROARYLS AND USES THEREOF
The present invention provides a compound of formula I: ##STR00001## wherein R.sup.1, X.sup.1, X.sup.2, R.sup.2, R.sup.3, R.sup.4, R.sup.5, n, and m are as...
2016/0333006 ARYL LACTA KINASE INHIBITORS
The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and...
2016/0333005 ISOPROPYL TRIAZOLO PYRIDINE COMPOUNDS
The present invention provides a compound of the Formula (I) below: Wherein R.sup.1 is selected from the group consisting of H, CH.sub.3, CN, CH.sub.2CN,...
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