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Patent # Description
2016/0333004 SUBSTITUTED BICYCLIC HETEROARYL COMPOUNDS AS RXR AGONISTS
The present invention relates to certain substituted bicyclic compounds that are agonists of RXR and which are therefore useful in the treatment of certain...
2016/0333003 READ-THROUGH COMPOUND PRODRUGS SUPPRESSING PREMATURE NONSENSE MUTATIONS
Premature termination codon readthrough prodrug compounds, compositions thereof, and methods of making and using the same are provided. In certain embodiments,...
2016/0333002 N, N' SUBSTITUTED PIPERIDINAMINE COMPOUNDS, AND PREPARATION METHOD AND USAGE THEREOF
The present invention relates to a compound of formula (I), a stereomeride, pharmaceutically acceptable salt, a solvate or an N-oxide thereof, a medicine...
2016/0333001 HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF
Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use. ##STR00001##
2016/0333000 PYRIMIDINYLOXY BENZENE DERIVATIVES AS HERBICIDES
Disclosed are compounds of Formula 1, including all stereoisomers, N-oxides, and salts thereof, ##STR00001## wherein Q, Z, R.sup.2, R.sup.3 and m are as...
2016/0332999 HETEROCYCLIC SULFONAMIDE DERIVATIVE AND MEDICINE COMPRISING SAME
The present invention provides a compound represented by the formula (I): ##STR00001## wherein each symbol is as defined in the DESCRIPTION, or a ...
2016/0332998 SELECTIVE IMMUNOPROTEASOME INHIBITORS WITH NON-PEPTIDE SCAFFOLDS
Compounds useful for inhibiting the immunoproteasome have the formula of ##STR00001## Methods and compounds for inhibiting the immunoproteasome, particularly, ...
2016/0332997 MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS
Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters...
2016/0332996 Hepatitis B Antiviral Agents
The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: X-A-Y--Z-L-R.sub.1 (I) which...
2016/0332995 Photochromic Comounds
A photochromic compound is provided, which may be a pyran, an oxazine, or a fulgide. The photochromic compound has at least one substituent Q attached thereto,...
2016/0332994 MUTANT-SELECTIVE EGFR INHIBITORS AND USES THEREOF
The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
2016/0332993 DIAMINOPYRIMIDINE BENZENESULFONE DERIVATIVES AND USES THEREOF
The present invention provides compounds of Formula (II) (e.g., compounds of Formula (I)), and pharmaceutically compositions thereof. Compounds of Formula (II)...
2016/0332992 PYRIMIDINES AND USE THEREOF
The present disclosure provides pyrimidines of Formula I: and pharmaceutically acceptable salts and solvates thereof, wherein A.sup.1, X, A.sup.2, G, Y, n,...
2016/0332991 PYRAZOLYL PYRIMIDINAMINE COMPOUND AND APPLICATION THEREOF
Disclosed are pyrazolyl pyrimidinamine compounds with structures as shown in Formula I: ##STR00001## The definitions of each of the substituents can be seen in...
2016/0332990 FUSED PYRIMIDINES AS INHIBITORS OF P97 COMPLEX
The present invention is directed to certain fused pyrimidines having a homo or hetero cyclopentyl, cyclohexyl or cycloheptyl ring as the pyrimidine fusion...
2016/0332989 Kinase Inhibitor And Use Thereof
The invention relates to a CDK4/6 kinase inhibitor, or a pharmaceutically acceptable salt, ester, or solvate thereof, or their isomers; a pharmaceutical...
2016/0332988 2-PENTAFLUOROSULFANYL (SF5) MEFLOQUINE DERIVATIVES, FORMULATIONS, METHODS OF MAKING, AND USES THEREOF
Provided herein herein are pentafluorosulfanyl (SF.sub.5) mefloquine derivatives, formulations, methods of making the SF.sub.5 derivatives, and uses thereof.
2016/0332987 PROCESSES FOR THE PREPARATION OF PESTICIDAL COMPOUNDS
The present application provides processes for making pesticidal compounds and compounds useful both as pesticides and in the making of pesticidal compounds.
2016/0332986 PROCESS FOR THE PREPARATION OF 3-(3-CHLORO-1H-PYRAZOL-1-YL)PYRIDINE
This disclosure relates to the field of preparation of 3-(3-chloro-1H-pyrazol-1-yl)pyridine and intermediates therefrom. These intermediates are useful in the...
2016/0332985 Quinoline-Based Kinase Inhibitors
The present disclosure is generally directed to compounds of formula (I) which can inhibit AAKI (adaptor associated kinase 1), compositions comprising such...
2016/0332984 COMPOUNDS AND USES THEREOF FOR THE MODULATION OF HEMOGLOBIN
Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods...
2016/0332983 STABILIZED LEVULINIC ESTER KETALS
The invention describes methods of preparation and compositions of plasticizers. The plasticizers include at least 2 alkyl ketal ester moieties and have a...
2016/0332982 Prodrugs Of Urolithins And Uses Thereof
The invention provides compounds of formula (I) or salts thereof: ##STR00001## wherein: A, B, C, D, W, X, Y and Z are as defined in the specification, and at...
2016/0332981 3-ARYL-4H-CHROMENE-4-ONES AS ANTINEOPLASTIC AGENTS FOR THE TREATMENT OF CANCER
Isoflavonoids or pharmaceutically acceptable salts thereof or pharmaceutically acceptable compositions thereof for the treatment of prostate cancer or for the...
2016/0332980 NOVEL 2-PHENYLBENZOFURAN DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PRODUCTION METHOD FOR SAME AND...
The present invention relates to a novel 2-phenylbenzofuran derivative or a pharmaceutically acceptable salt thereof, a production method for the same, and a...
2016/0332979 FURAN-2,5-DICARBOXYLIC ACID PURGE PROCESS
Disclosed is an oxidation process to produce a crude carboxylic acid product carboxylic acid product. The process comprises oxidizing a feed stream comprising...
2016/0332978 PROCESS FOR MAKING HMF FROM SUGARS WITH REDUCED BYPRODUCT FORMATION, AND IMPROVED STABILITY HMF COMPOSITIONS
Disclosed is a process for making HMF or a derivative of HMF by dehydrating one or more hexose sugars in a reduced oxygen environment. In another, related...
2016/0332977 PROCESSES FOR PREPARING FUSED HETEROCYCLIC ION CHANNEL MODULATORS
The present disclosure provides processes for the preparation of a compound of formula: ##STR00001## which is a selective late sodium current inhibitor. The...
2016/0332976 PROCESSES FOR PREPARING FUSED HETEROCYCLIC ION CHANNEL MODULATORS
The present disclosure provides processes for the preparation of a compound of formula: ##STR00001## which is a selective late sodium current inhibitor. The...
2016/0332975 ISOXAZOLINE COMPOSITIONS AND THEIR USE AS ANTIPARASITICS
This invention relates to methods for controlling parasitic infestations of animals and their environments, and, more particularly, to methods using...
2016/0332974 CARBONYL ERASTIN ANALOGS AND THEIR USE
The present invention provides, inter alia, compounds having the structure of formula (I): Compositions containing such compounds are also provided. Methods...
2016/0332973 PROCESS FOR PREPARING ANTIVIRAL COMPOUNDS
This disclosure is directed to: (a) processes for preparing compounds and salts thereof that, inter alia, are useful for inhibiting hepatitis C virus (HCV);...
2016/0332972 UREA HYDANTOIN DERIVATIVES AS FORMYL PEPTIDE MODULATORS
The present invention relates to urea hydantoin compounds, processes for preparing them, pharmaceutical compositions containing them, and their use as...
2016/0332971 ARYLQUINOLINE, ARYLQUINOLONE AND ARYLTHIOQUINOLONE DERIVATIVES AND USE THEREOF TO TREAT CANCER
Arylquinoline derivatives and their use for treating cancer or cancer metastasis is disclosed. The compounds of the subject technology promote cells to secrete...
2016/0332970 HISTONE DEMETHYLASE INHIBITORS
The present disclosure relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted pyridine...
2016/0332969 SUBSTITUTED BENZENE COMPOUNDS
The present invention relates to substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds...
2016/0332968 ANTIDIABETIC COMPOUNDS
Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may...
2016/0332967 CRYSTALLINE FORMS
This invention relates to crystalline forms of (R)-1-(1-(methylsulfonyl)propan-2-yl)-4-(trifluoromethyl)indoline-5-carbo- nitrile, a modulator of the androgen...
2016/0332966 INDOLE COMPOUND
[Problem] To provide a compound useful as a MT.sub.1 and/or MT.sub.2 receptor agonist. [Solution] The present inventors have studied on MT.sub.1 and/or MT.sub.2...
2016/0332965 Process For Annealing Amorphous Atorvastatin
Processes for annealing amorphous atorvastatin is described. Pharmaceutical compositions and formulations containing annealed amorphous atorvastatin are also...
2016/0332964 PROCESS FOR PRODUCING 7-DEHYDROCHOLESTEROL AND VITAMIN D3
According to the present invention, there can be provided A process for producing 7-dehydrocholesterol (hereinafter, "7DHC"), comprising culturing, in a...
2016/0332963 12-EPI PLEUROMUTILINS
A compound selected from 14-O-[((Alkyl-, cycloalkyl-, heterocycloalkyl-, heteoroaryl-, or aryl)-sulfanyl)-acetyl]-12-epi-mutilins, or 14-O-[((Alkyl-,...
2016/0332962 (S)-CSA SALT OF S-KETAMINE, (R)-CSA SALT OF S-KETAMINE AND PROCESSES FOR THE PREPARATION OF S-KETAMINE
The present invention is directed to processes for the preparation of esketamine. The present invention is further directed to processes for the resolution of...
2016/0332961 METHOD FOR PRODUCING INTERNAL OLEFIN SULFONATE
The present invention provides a method for producing a high-quality internal olefin sulfonate in which the content of any internal olefin and inorganic...
2016/0332960 NOVEL FLUORENYL B-OXIME ESTER COMPOUNDS, PHOTOPOLYMERIZATION INITIATOR AND PHOTORESIST COMPOSITION CONTAINING...
The present invention relates to a novel .beta.-oximester fluorene derivative compound, a photopolymerization initiator comprising the same, and a photoresist...
2016/0332959 FLUORINATED ARYLALKYLAMINOCARBOXAMIDE DERIVATIVES
Fluorinated arylalkylaminocarboxamide derivatives of formula (I) are described wherein W, J, n, R.sup.1, R.sup.2, R.sup.2', R.sup.3, R.sup.4, R.sup.5 and...
2016/0332958 METHOD FOR PREPARING LACOSAMIDE
The present invention provides a novel method for preparing lacosamide with high chiral purity from D-serine. The method of the present invention can obtain...
2016/0332957 PROCESS AND APPARATUS FOR PURIFYING A HYDROCARBON STREAM COMPRISING LINEAR ALPHA-OLEFINS (LAO) FROM AMINES
A process for purifying linear a-olefins, comprises: providing an organic phase comprising a linear a-olefin; providing an alkaline aqueous phase I; providing...
2016/0332956 METHOD FOR PRODUCING 2-(HALOGENOMETHYL)-3-METHYLNITROBENZENE
Position-1 halogen can be selectively reduced by reacting a compound represented by formula (3): ##STR00001## [wherein X represents a chlorine atom, a bromine...
2016/0332955 Compositions And Methods Of Use Of Phorbol Esters In The Treatment Of Neoplasms
Methods and compositions containing a phorbol ester or a derivative of a phorbol ester are provided for the treatment of chronic and acute conditions. Such...
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