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Patent # Description
2016/0331854 RADIOACTIVE MICROSPHERES MADE OF NANOPOROUS GLASS FOR RADIATION THERAPY
A radiation therapy product of spherical nanoporous glass beads that are loaded with a radionuclide. Each microsphere has a diameter in the range of about 25...
2016/0331853 COMPOSITIONS FOR RADIOTHERAPY AND USES THEREOF
Provided herein are compositions and methods for treatment of a disease, disorder, or condition, such as a proliferative disease, disorder, or condition. One...
2016/0331852 RADIOLIGANDS FOR PRETARGETED PET IMAGING AND METHODS OF THEIR THERAPEUTIC USE
Described herein are Tz/TCO-based pretargeting strategies using an Al[.sup.18F]-NOTA-labeled tetrazine radioligand. This imaging strategy enables delineation...
2016/0331851 LIPID-ENCAPSULATED GAS MICROSPHERE COMPOSITIONS AND RELATED METHODS
The invention provides, inter alia, improved lipid formulations used to generate lipid-encapsulated gas microspheres, and methods of their use.
2016/0331850 MAGNETIC NANOPARTICLES FUNCTIONALIZED WITH CATHECOL, PRODUCTION AND USE THEREOF
There are described magnetic nanoparticles the surface of which is functionalized with catechol and constructs comprising a plurality of said nanoparticles...
2016/0331849 GADOLINIUM COMPLEX COMPRISING DO3A-TRANEXAMIC ACID CONJUGATE
The present disclosure relates to a magnetic resonance imaging (MRI) contrast agent containing a gadolinium complex, and more specifically, to a...
2016/0331848 LIQUID COMPOSITION IN THE FORM OF EMULSION OR MICROEMULSION FOR RECTAL ADMINISTRATION CONTAINING AT LEAST ONE...
The present invention provides a novel liquid composition in the form of an emulsion or microemulsion for rectal administration comprising at least one dye, at...
2016/0331847 SHK-BASED PHARMACEUTICAL COMPOSITIONS AND METHODS OF MANUFACTURING AND USING THE SAME
Disclosed herein are pharmaceutical compositions having the sequence Arg-Ser-Cys-Ile-Asp-Thr-Ile-Pro-Lys-Ser-Arg-Cys-Thr-Ala-Phe-Gln-Cys-Lys-H- ...
2016/0331846 POLYNUCLEOTIDES, VECTORS AND METHODS FOR INSERTION AND EXPRESSION OF TRANSGENES
Embodiments herein include polynucleotides, vectors and methods for the insertion and expression of transgenes. In an embodiment, a polynucleotide is included....
2016/0331845 COMPOSITIONS OF NUCLEIC ACID-CONTAINING NANOPARTICLES FOR IN VIVO DELIVERY
Compositions comprising a polymeric micellar nanoparticle composition comprising a block or graft copolymer comprising at least one polycationic polymer and at...
2016/0331844 RNA CONTAINING COMPOSITION FOR TREATMENT OF TUMOR DISEASES
The present invention relates to RNA containing compositions for use in the treatment or prophylaxis of tumor and/or cancer diseases, to a pharmaceutical...
2016/0331843 TARGETED DELIVERY OF IMMUNOREGULATORY DRUGS
The present disclosure provides, inter alia, compositions comprising drug containing polymeric particles that mimic lymphocyte migration in vivo and can...
2016/0331842 ENZYMATIC CONJUGATION OF POLYPEPTIDES
The present application relates to methods for the enzymatic functionalization of immunoglobulins, in particular with drugs. Also disclosed herein are linking...
2016/0331841 BIOCONJUGATES AND USES THEREOF
Provided herein are bioconjugates comprising a glycan and from 1 to about 50 peptide(s) bound thereto, wherein the peptide(s) comprise a collagen-binding unit,...
2016/0331840 RECEPTOR TARGETING CONSTRUCTS AND USES THEREOF
Disclosed herein are drug delivery molecules that comprise a ligand that targets a cell surface molecule; a membrane penetration domain; and a payload binding...
2016/0331839 METHOD FOR INCREASING THE BIOAVAILABILITY OF INHALED COMPOUNDS
The present invention relates to a compound comprising one or more PEG moieties, wherein said compound is a therapeutic agent active for treating a respiratory...
2016/0331838 CARRIER COMPOSITION
A carrier composition of the present invention comprises a phosphate compound of an electron transfer agent and a relatively high concentration of a polar...
2016/0331837 TARGETING OF INTERLEUKIN-1 AND -18 SIGNALING IN TREATMENT OF SEPTIC SHOCK
The present invention relates to the inactivation of interleukin-1 and interleukin-18 signaling in treatment of inflammation and septic shock. More...
2016/0331836 CHIRAL NUCLEIC ACID ADJUVANT HAVING ANTITUMOR EFFECT AND ANTITUMOR AGENT
Summary Problem The purpose of the present invention is to provide: a chiral nucleic acid adjuvant having anti-tumor activity; and an anti-tumor agent. Solution ...
2016/0331835 CHIRAL NUCLEIC ACID ADJUVANT HAVING ANTI-ALLERGIC ACTIVITY, AND ANTI-ALLERGIC AGENT
An adjuvant which comprises oligonucleotides which comprise two to four CpG motifs each represented by 5'-X.sub.1CpGX.sub.2-3' and has a length of 14 to 32...
2016/0331834 EPICUTANEOUS IMMUNOREBALANCING
The present invention relates to compositions and methods for improving a subject condition by epicutaneous immunobalancing. The invention shows that...
2016/0331833 Method of Enhancing KSHV LANA1 Immunogenicity
An immunogenically-enhanced Kaposi sarcoma-associated herpesvirus latency-associated nuclear antigen 1 ("KSHV LANA1") polypeptide and related methods of...
2016/0331832 PURIFICATION OF HERPES VIRUS
The present disclosure provides a method to prepare purified enveloped viral particle preparations employing ion exchange chromatography and tangential flow...
2016/0331831 LENTIVIRAL VECTORS FOR GENERATING IMMUNE RESPONSES AGAINST HUMAN T LYMPHOTROPHIC VIRUS TYPE 1
The present invention relates to compositions, methods, and uses employing lentiviral vector particles for induction of an immune response by administration to...
2016/0331830 RAS PATHWAYS AS MARKERS OF PROTECTION AGAINST HIV AND METHODS TO IMPROVE VACCINE EFFICACY
Compositions including a therapeutically effective amount of an HIV immunogen in combination with an agent that stimulates the Ras pathway, wherein the agent...
2016/0331829 HENDRA AND NIPAH VIRUS G GLYCOPROTEIN IMMUNOGENIC COMPOSITIONS
This invention relates to Hendra and Nipah immunogenic compositions and methods of use. The invention also relates to methods of distinguishing subjects...
2016/0331828 NUCLEIC ACID VACCINES
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use ribonucleic acid vaccines (NAVs) comprising...
2016/0331827 RECOMBINANT RIFT VALLEY FEVER (RVF) VIRUSES AND METHODS OF USE
Described herein are recombinant RVF viruses comprising deletions in one or more viral virulence genes, such as NSs and NSm. The recombinant RVF viruses,...
2016/0331826 NOVEL BACULOVIRUS DISPLAY VECTORS AND USES THEREOF
A recombinant baculovirus displaying on its envelop a fusion protein is disclosed. The fusion protein comprises a heterologous antigen, and a C-terminal region...
2016/0331825 NOVEL VACCINES AGAINST HPV AND HPV-RELATED DISEASES
Embodiments relate to novel vaccines against human papillomavirus (HPV) and HPV-related diseases, including multiple types of cancers. The HPV vaccines are...
2016/0331824 MULTIVALENT MENINGOCOCCAL CONJUGATES AND METHODS FOR PREPARING CONJUGATES
Disclosed herein are meningococcal immunogenic conjugates which can elicit immune responses against meningococcal polysaccharides (PS) from groups A, C, W-135,...
2016/0331823 Fusion of Heterooligomeric Mycobacterial Antigens
The present invention relates generally to novel immunogenic combinations comprising or encoding at least two heterooligomeric mycobacterial antigens and...
2016/0331822 COMPOSITIONS AND METHODS OF IDENTIFYING TUMOR SPECIFIC NEOANTIGENS
The present invention related to immunotherapeutic peptides and their use in immunotherapy, in particular the immunotherapy of cancer. Specifically, the...
2016/0331821 VACCINES FOR TREATMENT AND PREVENTION OF CANCER
Provided are compositions useful as therapeutic vaccines (e.g., cancer vaccines), and methods of producing such compositions. The compositions disclosed herein...
2016/0331820 PEPTIDE MIXTURE
There is disclosed a peptide mixture suitable for eliciting an immune response. It comprises a first and a second peptide, each corresponding to a fragment of...
2016/0331819 TUMOR VASCULAR MARKER-TARGETED VACCINES
The present invention provides methods of immunizing a subject against a tumor, inhibiting tumor growth, inhibiting tumor recurrence, treating, suppressing the...
2016/0331818 NOVEL ANTIGEN PEPTIDE AND USES THEREOF
The invention relates to antigen peptide derived from the Nectin4 and its use for preventing and treating cancer.
2016/0331817 COMPOSITIONS AND METHODS FOR TREATING FIBROTIC MYOPATHY CONDITIONS USING COLLAGENASE
Compositions and methods for treating fibrotic myopathy in a subject.
2016/0331816 ORAL DELIVERY OF ANGIOTENSIN CONVERTING ENZYME 2 (ACE2) OR ANGIOTENSIN-(1-7) BIOENCAPSULATED IN PLANT CELLS...
Emerging evidence indicates that diminished activity of the vasoprotective axis of the renin-angiotensin system, constituting angiotensin converting enzyme2...
2016/0331815 FIBROIN-DERIVED PROTEIN COMPOSITION
The invention provides a protein composition derived from silk fibroin, which composition possesses enhanced solubility and stability in aqueous solutions. The...
2016/0331814 Col 11A1 AND NOVEL FRAGMENT THEREOF FOR REGULATION OF BONE MINERALIZATION
The present invention relates to the discovery that the collagen 11a1 (Col 11A1) protein, and/or fragments thereof, may be used to modulate bone...
2016/0331813 MEDICAMENT FOR THERAPEUTIC TREATMENT AND/OR IMPROVEMENT OF SEPSIS
A medicament for therapeutic treatment and/or improvement of sepsis in a patient with severe sepsis accompanied with one or more organ dysfunctions, wherein a...
2016/0331812 LIPIDATED PEPTIDES AS ANTI-OBESITY AGENTS
Lipidated peptides, analogs of both forms of the prolactin-releasing peptide. PrRP31 and PrRP20, represent anorexigenic compounds that lower food intake and...
2016/0331811 NON-AGGLOMERATING BIOCONJUGATES OF AMYLIN-MIMETIC COMPOUNDS AND POLYETHYLENEGLYCOL
The present invention generally concerns new non-agglomerating bioconjugates of amylin-mimetic compounds with polyethylene glycol, and their use mainly in the...
2016/0331810 COMPOSITIONS AND METHODS FOR TREATING MELANOMA
Toll-like receptor (TLR) agonists can induce chemokine production. We find that TLR2 and TLR6 are widely expressed on human melanoma cells, and that TLR2/6...
2016/0331809 THE USE OF SDF-1 TO MITIGATE SCAR FORMATION
The subject matter provided herein relates to method for inhibiting or mitigating scar formation in a wound of the skin, by increasing the concentration of...
2016/0331808 CARDIAC MYOFIBRIL INDUCTION
Methods and products for altering or promoting the development of heart tissue are disclosed. The methods include the use of nucleic acids of cardiogenic...
2016/0331807 THERAPEUTIC USE OF VEGFR-3 LIGANDS
The present invention relates to therapeutic methods, uses and compositions for treating glaucoma or ocular hypertension. More specifically, the present...
2016/0331806 APPLICATION OF YB-1 PROTEIN AND FRAGMENTS THEREOF FOR PREPARING MEDICINAL AGENTS IN TREATING ALZHEIMER'S DISEASE
The present invention relates to the field of genetic engineering and medicine. Proposed is a method for treating neurodegenerative diseases and Alzheimer's...
2016/0331805 ANTI-CONNEXIN COMPOUNDS AND USES THEREOF
Methods and compositions for modulating the activities of connexins are provided, including, for example, for use for treatment of cardiovascular, vascular,...
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