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Patent # Description
2016/0333354 DOUBLE STRANDED RNA COMPOUNDS TO RHOA AND USE THEREOF
The present invention relates to compounds, pharmaceutical compositions comprising same, methods of use thereof and kits for the down-regulation of RhoA gene....
2016/0333353 MIRNA FOR TREATING DISEASES AND CONDITIONS ASSOCIATED WITH NEO-ANGIOGENESIS
The invention relates to the diagnostic and therapeutic uses of a miRNA molecule, an equivalent or a source thereof in a disease and condition associated with...
2016/0333352 5' TRIPHOSPHATE OLIGONUCLEOTIDE WITH BLUNT END AND USES THEREOF
The present invention provides an oligonucleotide which is capable of activating RIG-I and inducing an anti-viral, in particular, an IFN, response in cells...
2016/0333351 Bi-Functional Short-Hairpin RNA (Bi-shRNA) Specific for Single-Nucleotide KRAS Mutations
The present invention includes compositions and methods for making and using a bifunctional shRNAs capable of reducing an expression of a K-ras gene, e.g., a...
2016/0333350 STAT3 INHIBITORS AND USES THEREOF
Described herein, inter alia, are STAT-binding nucleic acids-including compositions and methods of using the same.
2016/0333349 CHIRAL NUCLEIC ACID ADJUVANT HAVING IMMUNITY INDUCTION ACTIVITY, AND IMMUNITY INDUCTION ACTIVATOR
Problem The purpose of the present invention is to provide: a chiral nucleic acid adjuvant having immunity-inducing activity and an immunity-inducing ...
2016/0333348 ALTERING MICROBIAL POPULATIONS & MODIFYING MICROBIOTA
The invention relates to methods, uses, systems, arrays, engineered nucleotide sequences and vectors for inhibiting bacterial population growth or for altering...
2016/0333347 5' TRIPHOSPHATE OLIGONUCLEOTIDE WITH BLUNT END AND USES THEREOF
The present invention provides an oligonucleotide which is capable of activating RIG-I and inducing an anti-viral, in particular, an IFN, response in cells...
2016/0333346 NUCLEIC ACID CAPABLE OF INHIBITING EXPRESSION OF BETA-2GPI
The present invention provides a nucleic acid having activity to suppress expression of .beta.2GPI, a pharmaceutical composition comprising the nucleic acid,...
2016/0333345 Materials and Methods for Modulation of Tendon Healing
The invention relates to the use of microRNA 29 and precursors and mimics thereof for the modulation of tendon injury and the biomechanical properties of...
2016/0333344 MIR-122* AS AN ACTIVE MICRO-RNA, COMPOSITIONS COMPRISING THE SAME AND USES THEREOF
Provided is a miR-122* as a functional microRNA molecule, compositions including the same and uses thereof for treatment of various conditions, such as, cancer.
2016/0333343 Method of Treatment of Vascular Complications
The present invention provides methods for the prevention or treatment of one or more vascular complication(s) in a subject at risk of developing diabetes...
2016/0333342 Compositions and Methods for Inhibition of Expression of Apolipoprotein C-III (APOC3) Genes
The invention relates to double-stranded ribonucleic acid (dsRNA) targeting an APOC3 gene, and methods of using the dsRNA to inhibit expression of APOC3.
2016/0333341 MICRORNA COMPOUNDS AND METHODS FOR MODULATING MIR-21 ACTIVITY
Described herein are compositions and methods for the inhibition of miR-21 activity. The compositions have certain nucleoside modifications that yield potent...
2016/0333340 COMPOSITIONS AND METHODS FOR NUCLEIC ACID AMPLIFICATION
The present disclosure provides compositions, methods and systems for the efficient removal of a non-target nucleic acid sequence from a double stranded...
2016/0333339 Rapid Methods for the Extraction of Nucleic Acids from Biological Samples
The invention is directed to compositions and methods for rapidly and efficiently extracting nucleic acids and/or targeted nucleic acids sequences from...
2016/0333338 METHODS FOR EXTRACELLULAR VESICLE ISOLATION AND SELECTIVE REMOVAL
Disclosed is a method for the isolation of extracellular vesicles, including exosomes, from a liquid sample, the method comprising the steps of: adjusting the...
2016/0333337 RACK FOR SAMPLE TUBES AND REAGENT HOLDERS
A rack for holding samples and various reagents, wherein the rack may be used for loading the samples and reagents prior to using the reagents. The rack...
2016/0333336 TETHERING CYSTEINE RESIDUES USING CYCLIC DISULFIDES
Described herein are compounds and methods for tethering proteins. For example, dimers of proteins, including SOD1 and DJ-1, are described, where the dimers...
2016/0333335 L-arabinose Isomerase Variants with Improved Conversion Activity and Method for Production of D-tagatose Using them
The present invention relates to the development of an L-arabinose isomerase variant from Thermotoga neapolitana DSM 5068, which is a kind of thermophile, on...
2016/0333334 CRYSTAL
The present invention relates to a crystal. In particular the present invention relates to a crystal of the N-domain of ACE protein. The present invention also...
2016/0333333 Process for Degrading Mannan-Containing Cellulosic Materials
The present invention relates to processes comprising enzymatic degradation of mannan-containing cellulosic materials for producing a hydrolyzate. The...
2016/0333332 Methods for Improving By-Products from Fermentation Processes Using Xylanase
Provided are GH10 xylanases or a fragment thereof including modified xlyanase enzymes, all having xylanase activity, wherein the enzyme or fragment thereof...
2016/0333331 IMPROVED ENZYME VARIANTS
The invention relates to a variant polypeptide having lactase activity. The invention also relates to a nucleic acid sequence encoding such a variant...
2016/0333330 Variants of a Family 44 Xyloglucanase
The present invention relates to variants of a parent xyloglucanase. The present invention also relates to polynucleotides encoding the variant xyloglucanases...
2016/0333329 FUNGAL PROTEASES
The present invention provides fungal proteases and improved fungal strains that are deficient in protease production.
2016/0333328 ENHANCED NUCLEIC ACID CONSTRUCTS FOR EUKARYOTIC GENE EXPRESSION
The present invention provides polynucleotide vectors for high expression of heterologous genes, and methods for constructing such vectors. Some vectors...
2016/0333327 Polymerase Variants and Uses Thereof
Described herein is a variant pol6 polymerase having at least one mutation selected from H223, N224, Y225, H227, 1295, Y342, T343, I357, S360, L361, I363,...
2016/0333326 Bacteria Engineered to Treat Diseases Associated with Hyperammonemia
Genetically engineered bacteria, pharmaceutical compositions thereof, and methods of modulating and treating disorders associated with hyperammonemia are...
2016/0333325 PRODUCTION OF FATTY ACID DERIVATIVES
Methods and compositions for producing fatty acid derivatives, for example, fatty esters, and commercial fuel compositions comprising fatty acid derivatives...
2016/0333324 DESATURASE NUCLEIC ACIDS AND POLYPEPTIDES
The disclosure relates to delta (12) and delta (15) desaturases and their use in the modification of oil content in hemp.
2016/0333323 CONDITIONALLY REPLICATING ADENOVIRUS
The object of the present invention is to provide a novel conditionally replicating adenovirus and a reagent comprising the same for cancer cell detection or...
2016/0333322 METHOD FOR PORCINE CIRCOVIRUS PRODUCTION AND PCV2 VACCINES
This invention relates to a method for rapid production of PCV2 such that an optimum yield of the virus can be obtained. This invention also relates to the...
2016/0333321 ASSAY AND MEDICAMENT
The invention relates to defective interfering viruses and defective interfering virus RNAs that are effective as antiviral agents. The invention also relates...
2016/0333320 SKIN EQUIVALENT CULTURE
Disclosed is a method of preparing a collagenous construct comprising (i) casting viable collagen-producing human dermal fibroblasts in a support matrix...
2016/0333319 Avian Induced Pluripotent Stem Cells and Their Use
The present invention relates to the production of avian induced pluripotent stem cells from non-pluripotent somatic cells, including embryonic fibroblasts and...
2016/0333318 METHOD FOR THE ISOLATION, PURIFICATION AND AMPLIFICATION OF RENAL PROGENITORS CD133+CD24+ FROM THE URINE OF...
The present invention describes a non-invasive method to isolate with high efficiency, purity and reproducibility the population of renal progenitors...
2016/0333317 METHOD FOR PROMOTING GENERATION OF STEM CELL-DERIVED EXOSOME BY USING THROMBIN
The present invention relates to a method of promoting generation of exosomes from stem cell by using thrombin. The method according to the present invention...
2016/0333316 METHOD OF PRODUCING MICROGLIAL CELLS
The present invention provides a method of inducing microglia cells from blood cells, comprising culturing the blood cells in the presence of interleukin-34...
2016/0333315 AUTOMATED METHODS AND SYSTEMS FOR WASHING PLATELET CONCENTRATES
Automated systems and methods for providing platelet concentrates and synthetic storage media with reduced residual plasma volumes are disclosed. The disclosed...
2016/0333314 Cell Expansion
Embodiments are described that relate to methods and systems for growing cells in a hollow fiber bioreactor. In embodiments, the cells may be exposed to an...
2016/0333313 Synthetic Surfaces For Culturing Stem Cell Derived Oligodendrocyte Progenitor Cells
Synthetic surfaces suitable for culturing stem cell derived oligodendrocyte progenitor cells contain acrylate polymers formed from one or more acrylate...
2016/0333312 METHODS FOR FORMING THREE-DIMENSIONAL HUMAN RETINAL TISSUE IN VITRO
The present invention relates to the field of stem cells. More specifically, the invention provides methods and compositions useful for forming...
2016/0333311 METHODS AND COMPOSITIONS RELATED TO INDUCED SENSORY NEURONS
This invention provides methods of generating induced sensory neurons (iSNs) from non-neuronal cells such as fibroblasts. The invention also provides methods...
2016/0333310 CAPSULES CONTAINING CELLS WITH HEMATOPOIETIC POTENTIAL
The present invention relates to a capsule comprising at least one cell with hematopoietic potential, said capsule being formed with a liquid core and at least...
2016/0333309 METHOD FOR EVALUATING CELL POPULATIONS
The invention describes specific sialylated structures present on human stem cells and cell populations derived thereof. The invention is especially directed...
2016/0333308 SYNTHETIC METHYLOTROPHY TO LIQUID FUELS AND CHEMICALS
A non-naturally occurring microbe capable of growing in a medium comprising methanol is provided. The methanol contributes to a significant percentage (e.g.,...
2016/0333307 COMPOSITIONS AND METHODS FOR RECOVERY OF STRANDED GAS AND OIL
The present disclosure provides compositions and methods for using recombinant C1 metabolizing microorganisms capable of metabolizing sulfur containing...
2016/0333306 New Bacteria and Consortia for the Reduction of Ammonia and/or Methane Emission in Manure or Soil
The invention is related to a new bacterium comprising a partial 16S rDNA nucleic acid sequence having more than 85% sequence identity to the sequence...
2016/0333305 Device and Method for Breaking Down and Sizing Harvested Fat
A fat sizing device includes a first filter element and a second filter element. The first filter element has an exterior formed from a ceramic such as...
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