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Patent # Description
2016/0340433 SELECTION AND TREATMENT OF SUBJECTS
The invention relates to methods of selecting a subject, and methods of treating the subject with an anti-VLA-1 antibody. In one embodiment the first...
2016/0340432 FORMULATION FOR ANTI-ALPHA4BETA7 ANTIBODY
Methods for achieving clinical response of Crohn's disease in a human patient are described comprising administration of an antibody that has binding...
2016/0340431 FORMULATION FOR ANTI-ALPHA4BETA7 ANTIBODY
Methods for maintaining clinical remission of ulcerative colitis in a human patient are described comprising administration of an antibody that has binding...
2016/0340430 COMPOSITIONS AND METHODS FOR TARGETED IMMUNOMODULATORY ANTIBODIES AND FUSION PROTEINS
The present invention is based on the seminal discovery that targeted immunomodulatory antibodies and fusion proteins can counter act or reverse immune...
2016/0340429 IMMUNOMODULATORY AGENTS
The invention provides antibodies that specifically bind to PD-L1 and fusion molecules comprising PD-L1 binding proteins constructed with an IL15...
2016/0340428 Treatment of PD-L1-Negative Melanoma Using an Anti-PD-1 Antibody and an Anti-CTLA-4 Antibody
The invention provides a method of treating a melanoma comprising (i) identifying a patient having a PD-L1-negative melanoma and (ii) administering to the...
2016/0340427 Molecular constructs for treating infectious diseases
The present disclosure provides various molecular constructs having a targeting element and an effector element. Methods for treating various diseases using...
2016/0340426 MODULATORS OF THE NAV 1.9 SODIUM CHANNEL FOR TREATING AN INFLAMMATORY SKIN DISEASE AND DIAGNOSTIC METHODS
The use of a modulator of the Nav 1.9 sodium channel is described for treating an inflammatory skin disease. Also described, is a pharmaceutical composition...
2016/0340425 CANCER TARGETS AND USES THEREOF
Methods and compositions are provided for assessing, treating, and preventing diseases, especially cancer, using cancer-associated targets ("CAT"). Methods and...
2016/0340424 AGENTS FOR USE IN THE TREATMENT OF RETINAL INFLAMMATION
The present invention relates to preventive and/or therapeutic agents for use in the treatment of retinal inflammation, and more specifically of Age-related...
2016/0340423 ANTI-IL-6 ANTIBODIES FOR THE TREATMENT OF ANEMIA
The present invention is directed to therapeutic methods using IL-6 antagonists such as anti-IL-6 antibodies and fragments thereof having binding specificity...
2016/0340422 BIFUNCTIONAL FUSION PROTEIN, PREPARATION METHOD THEREFOR, AND USE THEREOF
The present invention provides a bifunctional fusion protein comprising the extracellular region of CTLA4 and an anti-IL-17 antibody, a gene encoding the...
2016/0340421 ANTIBODIES TO HUMAN GDF8
The present invention provides isolated human or humanized antibodies or antigen-binding fragments thereof which specifically bind to Growth and ...
2016/0340420 STABLE PROTEIN SOLUTION FORMULATION CONTAINING HIGH CONCENTRATION OF AN ANTI-VEGF ANTIBODY
The present invention provides anti-VEGF antibodies formulated as high concentration, aqueous pharmaceutical compositions, suitable for an injection,...
2016/0340419 ANTI-TRANSTHYRETIN HUMAN ANTIBODY
A human antibody which comprises a complementarity determining region of an H chain consisting of the amino acid sequence as shown in SEQ ID NOs: 1 to 3 and a...
2016/0340418 CARTILAGE TARGETING AGENTS AND THEIR USE
Monoclonal antibodies and antibody fragments that specifically bind to matrilin-3, conjugates including these molecules, and nucleic acid molecules encoding...
2016/0340417 MEANS AND METHODS FOR MANUFACTURING HIGHLY PURE NEUROTOXIN
The present invention relates to an antibody which specifically binds to unprocessed and/or partially processed neurotoxin polypeptide or an antibody which...
2016/0340416 ANTIBODY AND ANTIBODY-CONTAINING COMPOSITION
For many diseases due to microbes or the like, proliferation of microbes themselves is a cause of a symptom. However, there were cases where a substance...
2016/0340415 ANTIBODIES DIRECTED AGAINST THE LukGH (LukAB) TOXIN OF STAPHYLOCOCCUS AUREUS AND ANTIBODY SEQUENCES
The invention provides for an antibody comprising at least one binding site that specifically binds to a LukGH complex, which antibody comprises at least an...
2016/0340414 RSV-SPECIFIC ANTIBODIES AND FUNCTIONAL PARTS THEREOF
This application provides antibodies and functional equivalents thereof which are capable of specifically binding RSV, as well as means and methods for...
2016/0340413 INTERLEUKIN-10 FUSION PROTEINS AND USES THEREOF
The present invention generally relates to fusion proteins of antibodies and interleukin-10 (IL-10). In addition, the present invention relates to ...
2016/0340412 NOVEL METHODS FOR THE STABILISATION OF IMMUNOGLOBULIN CONSTANT DOMAINS
The present invention relates to a method of producing a modified protein having an increased stability and/or improved folding efficiency as compared to the...
2016/0340411 SECRETION OF HEME-CONTAINING POLYPEPTIDES
This disclosure provides for methods and compositions for the expression and secretion of heme-containing polypeptides.
2016/0340410 A PROCESS FOR MANUFACTURING FACTOR VIII HAVING AN IMPROVED RATIO OF FVIII:C/FVIII:AG
A process for manufacturing of a Factor VIII product having a ratio of FVIII:C/FVIII:Ag of at least 0.7 in the Factor VIII product by using chromatography...
2016/0340409 COMPOSITIONS AND METHODS FOR TREATMENT OF HEMATOLOGICAL MALIGNANCIES
Use of a chimeric protein selected from the group consisting of CTLA4-FasL and CD40-FasL proteins for treatment of lymphoma and/or a multiple myeloma and/or a...
2016/0340408 B7-RELATED NUCLEIC ACIDS AND POLYPEPTIDES USEFUL FOR IMMUNOMODULATION
The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as...
2016/0340407 COMPOSITIONS AND METHODS FOR IDENTIFICATION, ASSESSMENT, PREVENTION, AND TREATMENT OF MELANOMA USING PD-L1 ISOFORMS
The present invention relates to compositions and methods for identifying, assessing, preventing, and treating melanoma, A variety of PD-L1 isoform biomarkers...
2016/0340406 ENHANCED ANTIGEN PRESENTING ABILITY OF RNA CAR T CELLS BY CO-INTRODUCTION OF COSTIMULATORY MOLECULES
The invention provides T cells comprising nucleic acid sequence encoding a chimeric antigen receptor and a nucleic acid sequence encoding an enhancer of T cell...
2016/0340405 METHODS AND COMPOSITIONS FOR PROTECTION AGAINST LENTIVIRAL INFECTIONS
The present invention provides methods and compositions for optimally co-expressing in a primate subject a tyrosylprotein sulfotransferase (TPST) and a...
2016/0340404 THERAPEUTICALLY USEFUL MOLECULES
A T cell receptor molecule (TCR) containing an alpha chain portion and a beta chain portion wherein the alpha chain portion contains three complementarity...
2016/0340403 METHODS AND COMPOSITIONS FOR PRODUCING A CELL EXPRESSING A T CELL RECEPTOR
Provided is a method for determining a TCR polypeptide chain that can form a TCR specific for a peptide of interest. Also provided are methods and compositions...
2016/0340402 FKBP-L AND USES THEREOF
Disclosed are methods and compositions that employ FKBP-L polypeptides for modulating angiogenesis and/or tumor metastasis. The FKBP-L polypeptides may be used...
2016/0340401 FKBP-L AND USES THEREOF
Disclosed are methods and compositions that employ FKBP-L polypeptides for modulating angiogenesis and/or tumor metastasis. The FKBP-L polypeptides may be used...
2016/0340400 SINGLE CHAIN INSULIN AGONISTS EXHIBITING HIGH ACTIVITY AT THE INSULIN RECEPTOR
Single chain insulin analogs are provided having high potency and specificity for the insulin receptor. As disclosed herein optimally sized linking moieties...
2016/0340399 ANTIGEN BINDING MOLECULES COMPRISING A TRIMERIC TNF FAMILY LIGAND
The invention relates to novel TNF family ligand trimer-containing antigen binding molecules comprising (a) at least one moiety capable of specific binding to...
2016/0340398 NEIL3 PEPTIDES AND VACCINES INCLUDING THE SAME
The present invention provides isolated peptides or the fragments derived from SEQ ID NO: 45, which bind to an HLA antigen and induce cytotoxic T lymphocytes...
2016/0340397 SIRP POLYPEPTIDE COMPOSITIONS AND METHODS OF USE
Provided herein are SIRP-gamma, SIRP-beta or SIRP-beta2 decoy polypeptides for immunotherapy and/or treatment of cancer, anemia, transplant, asthma, allergy,...
2016/0340396 TREATMENT OF DAMAGED NERVE WITH PTEN INHIBITOR
The present application discloses a method of growing or proliferating nerve cells by contacting the cells with phosphatase and tensin homolog (PTEN) lipid...
2016/0340395 POLYPEPTIDE TAGGING FUSIONS AND METHODS
This disclosure describes fusion polypeptides and complexes, compositions, and methods involving the fusion polypeptides. Generally, the fusion polypeptides...
2016/0340394 DE-IMMUNIZED SHIGA TOXIN A SUBUNIT EFFECTOR POLYPEPTIDES FOR APPLICATIONS IN MAMMALS
The present invention relates to Shiga toxin effector polypeptides with reduced antigenic and/or immunogenic potential. Immunogenicity can be a limitation for...
2016/0340393 MUTANT ADENO-ASSOCIATED VIRUS VIRIONS AND METHODS OF USE THEREOF
The present invention provides mutant adeno-associated virus (AAV) that exhibit altered capsid properties, e.g., reduced binding to neutralizing antibodies in...
2016/0340392 BETA SHEET TAPES RIBBONS IN TISSUE ENGINEERING
There is described a material comprising tapes, ribbons, fibrils or fibres characterized in that each of the ribbons, fibrils or fibres have an antiparallel...
2016/0340391 Macrocyclic Inhibitors of the PD-1/PD-L1 and CD80(B7-1)/PD-L1 Protein/Protein Interactions
The present disclosure provides novel macrocyclic peptides which inhibit the PD-1/PD-L1 and PD-L1/CD80 protein/protein interaction, and thus are useful for the...
2016/0340390 AGONISTS OF GUANYLATE CYCLASE USEFUL FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS, INFLAMMATION, CANCER AND...
The invention provides novel guanylate cyclase-C agonist peptides and their use in the treatment of human diseases including gastrointestinal disorders,...
2016/0340389 PHARMACEUTICALLY RELEVANT AROMATIC-CATIONIC PEPTIDES
The present technology provides peptides, methods of generating the peptides, and pharmaceutically acceptable salts of the peptides. In some embodiments, the...
2016/0340388 METHODS OF MAKING CARFILZOMIB AND INTERMEDIATES THEREOF
Racemization-free methods are disclosed for the synthesis of carfilzomib. Novel intermediates and methods of making carfilzomib employing fragment condensation...
2016/0340387 NOVEL LIGANDS FOR PREVENTION OF NEUROTOXICITY OF THE ALZHEIMER'S DISEASE RELATED AMYLOID-BETA PEPTIDE
The present invention relates to the field of molecular biochemistry and medicine, and in particular to ligands comprising modified amino acid residues,...
2016/0340386 CYTOTOXIC TUBULYSIN COMPOUNDS FOR CONJUGATION
The present invention provides one or more compounds of formula (I) for conjugation to small molecules, polymers, peptides, proteins, antibodies, antibody...
2016/0340385 NOVEL SEPARATION PROCESSES FOR PEA PROTEIN
The invention provides a process for the separation of pea protein. The process begins with an aqueous extract or solution of pea protein, which is passed...
2016/0340384 METHOD FOR REFOLDING RECOMBINANTLY PRODUCED POLYPEPTIDES
Disclosed is a method for refolding recombinantly produced polypeptides comprising the steps of (a)providing inclusion bodies comprising recombinantly produced...
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