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Patent # Description
2016/0340383 (3A,9B,10A,13A,14B,17A,20S,22E)-ERGOSTA-5,7,22-TRIEN-3-OL AND METHODS OF PREPARING AND USING THE SAME
(3.alpha.,9.beta.,10.alpha.,13.alpha.,14.beta.,17.alpha.,20S,22E)-Ergosta- -5,7,22-trien-3-ol. A method for preparing the same by drying a fruiting body of...
2016/0340382 RNA MONOMERS CONTAINING O-ACETAL LEVULINYL ESTER GROUPS AND THEIR USE IN RNA MICROARRAYS
The present invention is directed to RNA monomers comprising O-acetal levulinyl protecting groups at the 2' and/or the 5'-hydroxy functionalities of the ribose...
2016/0340381 METHOD FOR PURIFYING REDUCED FORM OF BETA-NICOTINAMIDE ADENINE DINUCLEOTIDE
The present invention discloses a method for purifying reduced form of .beta.-nicotinamide adenine dinucleotide, comprising the steps of: sequentially...
2016/0340380 HCV POLYMERASE INHIBITORS
The invention provides compounds of the formula: ##STR00001## wherein B is a nucleobase selected from the groups (a) to (d): ##STR00002## and the other variables...
2016/0340379 PROCESSES AND INTERMEDIATES FOR PREPARING ANTI-HIV AGENTS
The invention provides synthetic processes and synthetic intermediates that can be used to prepare compounds having useful anti-HIV properties.
2016/0340378 METHOD FOR PURIFYING OXIDIZED FORM OF BETA-NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE
The present invention discloses an oxidized form of .beta.-nicotinamide adenine dinucleotide phosphate and a method for purifying the same. The method...
2016/0340377 METHOD FOR PURIFYING OXIDIZED FORM OF BETA-NICOTINAMIDE ADENINE DINUCLEOTIDE
The present invention discloses a method for purifying oxidized form of .beta.-nicotinamide adenine dinucleotide, comprising the steps of: sequentially...
2016/0340376 ALVOCIDIB PRODRUGS HAVING INCREASED BIOAVAILABILITY
Compounds having the following structure (I): ##STR00001## or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, wherein one of R.sup.1,...
2016/0340375 KINASE INHIBITORS
There are provided compounds of formula I. ##STR00001## wherein R.sup.1 to R.sup.5, X.sup.1, X.sup.2, Ar, L, A, A.sup.1, E and G have meanings given in the...
2016/0340374 BORATE-BASED BASE GENERATOR, AND BASE-REACTIVE COMPOSITION COMPRISING SUCH BASE GENERATOR
An object of the present invention is to provide a compound which is capable of attaining a composition having high storage stability without reacting with a...
2016/0340373 PROCESS FOR THE PREPARATION OF CYCLOHEPTAPYRIDINE CGRP RECEPTOR ANTAGONISTS
The disclosure generally relates to a process for the preparation of compounds of formula I, including synthetic intermediates which are useful in the...
2016/0340372 SILANE-MODIFIED FORMAMIDES
The invention relates to novel silane-modified formamide-polymers and/or pre-polymers for bonding and/or sealing diverse substrate materials, such as, for...
2016/0340371 SILANE MODIFIED FORMAMIDES
The invention relates to novel silane-modified formamides and/or pre-polymers for bonding and/or sealing diverse substrate materials, such as, for example...
2016/0340370 METHOD FOR PRODUCING 1-INDANOLES AND 1-INDANAMINES
A description is given of a process for preparing 1-indanols and 1-indanamines by palladium-catalyzed arylation and of the use thereof as intermediates for the...
2016/0340369 BORON-CONTAINING SMALL MOLECULES AS ANTIPROTOZOAL AGENTS
This invention provides, among other things, novel compounds useful for treating protozoal infections, pharmaceutical compositions containing such compounds,...
2016/0340368 ENERGY STORAGE MOLECULAR MATERIAL, CRYSTAL DIELECTRIC LAYER AND CAPACITOR
The present disclosure provides an energy storage molecular material, crystal dielectric layer and capacitor which may solve a problem of the further increase...
2016/0340367 COLORING COMPOSITION, ANISOTROPIC LIGHT ABSORPTION FILM, LAMINATE, POLARIZING PLATE, IMAGE DISPLAY DEVICE AND...
A coloring composition containing one or more species of compounds represented by Formula (I) or Formula (II) below, wherein each of R.sub.1 and R.sub.2...
2016/0340366 BICYCLIC HETEROCYCLYL DERIVATES AS IRAK4 INHIBITORS
The present invention provides bicyclic heterocyclyl kinase enzyme inhibitor compounds of formula (I), which are therapeutically useful as kinase inhibitors,...
2016/0340365 TAXANE COMPOUND, AND PREPARATION METHOD AND USE THEREOF
Provided are taxanes compounds having the structure of formula I, preparation method thereof, and uses of compositions having the compound, pharmaceutical...
2016/0340364 SYNTHESIS METHOD OF 9-ALLYLCAMPTOTHECIN DERIVATIVES
A method for preparing 9-allylcamptothecin derivatives using compound 14 as an essential intermediate. The total yield of the method is high.
2016/0340363 SPIRO-CYCLIC AMINE DERIVATIVES AS S1P MODULATORS
The present invention relates spiro-cyclic amine derivatives of the formula (1) wherein R1; R2; R3; Q; --W-T-; R5; Z; and A have the definitions provided in...
2016/0340362 Process For The Preparation Of Oxymorphone Freebase
The present invention is directed to a process for the preparation oxymorphone freebase, comprising hydrogenation of 14-hydroxymorphinone in DMF, to yield...
2016/0340361 PIPERIDINE INHIBITORS OF JANUS KINASE 3
The present invention relates to new piperidine inhibitors of Janus kinase 3 activity, pharmaceutical compositions thereof, and methods of use thereof. ...
2016/0340360 DIHYDROPYRIDONE P1 AS FACTOR XIA INHIBITORS
The present invention provides compounds of Formula (V): ##STR00001## or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the...
2016/0340359 A PROCESS FOR PREPARATION OF (2S,5R)-6-SULPHOOXY-7-OXO-2-[((3R)-PIPERIDINE-3-CARBONYL)-HYDRAZINOCARBON- ...
A process for preparation of a compound of Formula (I) is disclosed. ##STR00001##
2016/0340358 SYNTHESIS OF HETEROCYCLIC COMPOUNDS
Provided herein are intermediates and processes useful for facile synthesis of compounds of formula (I): ##STR00001## or a pharmaceutically acceptable salt, a...
2016/0340357 SOLID FORMS OF A COMPOUND FOR MODULATING KINASES
Solid forms of Compound I (and its S-enantiomer, Compound II), active on protein kinases, were prepared and characterized: ##STR00001## Also provided are methods...
2016/0340356 CCR2 MODULATORS
Compounds are provided that are modulators of the CCR2 receptor. The compounds have the general formula (I): ##STR00001## and are useful in pharmaceutical...
2016/0340355 COMPOUNDS FOR TREATMENT OF METABOLIC SYNDROME
Present invention refers to new compounds of formula I or II, its synthesis and its use in the treatment of metabolic syndrome, particularly for the treatment...
2016/0340354 METHODS FOR TREATING CANCER AND NON-NEOPLASTIC CONDITIONS
Compounds that selectively inhibit pathological production of human vascular endothelial growth factor (VEGF) and compositions comprising such Compounds are...
2016/0340353 AZAINDOLE DERIVATIVE
Provided is a novel compound having a selective JAK3-inhibitory effect and also having excellent oral absorbability. Also provided is a pharmaceutical agent,...
2016/0340352 Opioid Analgesic
Provided are a compound represented by formula (I) or (II), a salt thereof, or solvates of the compound and salt, having an analgesic effect and high metabolic...
2016/0340351 THIAZOLE-SUBSTITUTED AMINOHETEROARYLS AS SPLEEN TYROSINE KINASE INHIBITORS
The invention provides certain thiazole-substituted aminoheteroaryl compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein ring...
2016/0340350 Separation Method for Active Pharmaceutical Ingredients from Excipients
The present invention provides a method for physically separating the active pharmaceutical ingredient (API) from the excipients in a pharmaceutical...
2016/0340349 PYRIDONE DERIVATIVE AND PHARMACEUTICAL CONTAINING SAME
General formula (I): The present invention pertains to: a pyridone derivate or a salt thereof represented by general formula (I); or a medicine containing the...
2016/0340348 Cognition Enhancing Compounds and Compositions, Methods of Making, and Methods of Treating
The invention relates generally to muscarinic agonists, which are useful for stimulating muscarine receptors, and treating cognitive disorders. Included among...
2016/0340347 THERAPEUTIC AGENTS FOR OCULAR HYPERTENSION
This invention provides well defined 6-alkyl or hydroxyalkyl-1-naphthamide or quinoline compounds for treating glaucoma or ocular hypertension.
2016/0340346 ITRACONAZOLE ANALOGUES AND METHODS OF USE THEREOF
Disclosed herein are analogues of itraconazole that are both angiogenesis and hedgehog signaling pathway inhibitors. The compounds are expected to be useful in...
2016/0340345 SYNTHESIS OF ANTIVIRAL COMPOUND
The present disclosure provides processes for the preparation of a compound of formula I: ##STR00001## which is useful as an antiviral agent. The disclosure also...
2016/0340344 BENZIMIDAZOLE-IMIDAZOLE DERIVATIVES
Inhibitors of HCV replication of formula I ##STR00001## including stereochemically isomeric forms, and salts, solvates thereof, wherein R and R' are, each...
2016/0340343 KINASE INHIBITORS
There are provided compounds of formula I, ##STR00001## wherein R.sup.1 to R.sup.5, X.sup.1, X.sup.2, Ar, L, E, A, A.sup.1, G and G.sup.1 have meanings given in...
2016/0340342 QUINAZOLINE INHIBITORS OF ACTIVATING MUTANT FORMS OF EPIDERMAL GROWTH FACTOR RECEPTOR
The invention relates to compounds of formula (I), or a pharmaceutically acceptable salt thereof: ##STR00001## which possess inhibitory activity against...
2016/0340341 DNA-PK INHIBITORS
The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said...
2016/0340340 HERBICIDAL SUBSTITUTED PYRIMIDINYLOXY BENZENE COMPOUNDS
Disclosed are compounds of Formula 1, including all stereoisomers, N-oxides, and salts thereof, ##STR00001## wherein each Y.sup.1, Y.sup.2, Y.sup.3, Y.sup.4, Z,...
2016/0340339 PYRAZOLE COMPOUNDS AS BTK INHIBITORS
The present invention encompasses compounds of the formula (I) wherein the groups R.sub.1, Cy, and Y are defined herein, which are suitable for the treatment...
2016/0340338 MEGLUMINE SALT FORMULATIONS OF 1-(5,6-DICHLORO-1H-BENZO[D]IMIDAZOL-2-YL)-1H-PYRAZOLE-4-CARBOXYLIC ACID
The meglumine salt of 1-(5,6-dichloro-1H-benzo[d]imidazol-2-yl)-1H-pyrazole-4-carboxylic acid (compound (1)) and pharmaceutically acceptable formulations...
2016/0340337 BENZOIMIDAZOL-2-YL PYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR
Benzoimidazol-2-yl pyrimidines, purification methods for the same, and pharmaceutical compositions and methods for the treatment of disease states, disorders,...
2016/0340336 TRIAZOLE AGONISTS OF THE APJ RECEPTOR
Compounds of Formula I and Formula II, pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the...
2016/0340335 METHOD OF TREATING NEUROPATHIC PAIN
Provided are methods for using bis-quaternary ammonium compounds to treat inflammatory pain, neuropathic pain and nociceptive pain.
2016/0340334 METHOD FOR ISOLATION OF ALKALOIDS AND AMINO ACIDS, AND COMPOSITIONS CONTAINING ISOLATED ALKALOIDS AND AMINO ACIDS
Described herein are methods to purify alkaloids and amino acids. Also described are compositions and methods to treat or prevent a disease using the purified...
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