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Patent # Description
2016/0339033 ANTIVIRAL THERAPY
The present invention relates to combinations of compounds comprising HIV integrase inhibitors and other therapeutic agents. Such combinations are useful in...
2016/0339032 TETRAHYDROPYRAZOLOPYRIMIDINE COMPOUNDS
Embodiments of the disclosure relate to tetrahydropyrazolopyrimidine compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and...
2016/0339031 SALTS OF THE JANUS KINASE INHIBITOR (R)-3-(4-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)-1H-PYRAZOL-1-YL)-3-CYCLOPENTYL- ...
The present invention provides salt forms of (R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentyl- propanenitrile that are useful in the...
2016/0339030 TREATMENT AGENTS FOR INHIBITING HIV AND CANCER IN HIV INFECTED PATIENTS
Methods are provided for treating HIV and cancer in a subject in need thereof by administering to the subject therapeutically effective amounts of an mTOR...
2016/0339029 FUSED HETEROTRICYCLIC ORGANIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND MEDICAL USES THEREOF
The invention provides fused heterocyclic organic compounds such as dihydropyrazolopyridotriazinones, compositions containing such compounds, medical kits, and...
2016/0339028 NOVEL HETEROCYCLIC CARBOXAMIDES AS MODULATORS OF KINASE ACTIVITY
The invention provides novel heterocyclic carboxamide compounds compounds according to Formula (I) their manufacture and use for the treatment of ...
2016/0339027 BICYCLIC HETEROAROMATIC COMPOUNDS AS PROTEIN TYROSINE KINASE INHIBITORS
A pharmaceutical formulation comprising the compound of formula ##STR00001##
2016/0339026 TOPICAL COMPOSITIONS COMPRISING MODULATORS OF TRPM8
The present disclosure relates to topical compositions comprising one or more compounds which are cooling agents.
2016/0339025 KINASE MODULATION, AND INDICATIONS THEREFOR
The present disclosure provides methods of treating a subject suffering from or at risk of a BRAF V600 mutation or BRAF fusion mutation related disease or...
2016/0339024 CO-CRYSTALS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME
The present invention relates to compositions and co-crystals each comprising a compound of formula I having the structure: ##STR00001## wherein each of R.sup.1...
2016/0339023 Pharmaceutical Combinations
A pharmaceutical combination comprising (a) an ALK inhibitor, or a pharmaceutically acceptable salt thereof, and (b) at least one HDMA-2/p53 receptor inhibitor...
2016/0339022 TREATMENT OF NEUROBLASTOMA WITH HISTONE DEACETYLASE INHIBITORS
Provided herein are combinations comprising an HDAC inhibitor and retinoic acid for the treatment of neuroblastoma in a subject in need thereof. Also provided...
2016/0339021 USE OF KINASE INHIBTORS
The invention provides a compound for use for treating, preventing or managing a condition associated with the activation, mutation and/or over-expression of...
2016/0339020 PHARMACEUTICAL COMPOSITION COMPRISING DIAMINO HETEROCYCLIC CARBOXAMIDE COMPOUND AS ACTIVE INGREDIENT
A pharmaceutical composition is suitable for treating AXL-related cancer. The cancer can be cancer with high expression of AXL. The cancer can also be cancer...
2016/0339019 METHODS AND COMPOSITIONS FOR KILLING SENESCENT CELLS AND FOR TREATING SENESCENCE-ASSOCIATED DISEASES AND DISORDERS
Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic...
2016/0339018 THERAPEUTIC AGENT FOR OCULAR FUNDUS DISEASE
Disclosed herein is a prophylactic or therapeutic agent for ocular fundus disease, especially diabetic retinopathy or age-related macular degeneration. The...
2016/0339017 BUPROPION AS A MODULATOR OF DRUG ACTIVITY
Dosage forms, drug delivery systems, and methods related to sustained release of dextromethorphan or improved therapeutic effects are disclosed. Typically,...
2016/0339016 ABUSE-RESISTANT MUCOADHESIVE DEVICES FOR DELIVERY OF BUPRENORPHINE
The present invention provides abuse deterrent mucoadhesive devices for delivery of buprenorphine. Each device comprises a mucoadhesive layer and a backing...
2016/0339015 ORAL PHARMACEUTICAL COMPOSITION OF METHYLERGONOVINE
An oral modified release pharmaceutical composition of methylergonovine suitable for oral once daily administration is provided. The composition includes at...
2016/0339014 Liposomes Useful for Drug Delivery
The present invention provides liposome compositions containing substituted ammonium and/or polyanion, and optionally with a desired therapeutic or imaging...
2016/0339013 COMBINATION-BASED TREATMENT METHOD
The invention relates to (among other things) a method comprising the steps of (a) administering to a patient a PARP-inhibiting amount of a PARP inhibitor; and...
2016/0339012 Modulation of Tissue Transglutaminase Activation in Disease
Compositions and methods are provided for modulating the physiological activation of tissue transglutaminase (TG2); which methods can include inhibiting the...
2016/0339011 PHARMACEUTICAL COMPOSITIONS COMPRISING AN ANTIPSYCHOTIC DRUG AND A VMAT2 INHIBITOR AND USES THEREOF
New methods of treating schizophrenia and schizoaffective disorder by administration of pharmaceutical compositions comprising an antipsychotic compound and a...
2016/0339010 Treatment of Partly Controlled or Uncontrolled Severe Asthma
Method for the treatment of partly controlled or uncontrolled severe asthma comprising administering either a) a phosphodiesterase 4 (PDE4) inhibitor or b) a...
2016/0339009 OPSIN-BINDING LIGANDS, COMPOSITIONS AND METHODS OF USE
Compounds are disclosed that are useful for treating ophthalmic conditions caused by or related to production of toxic visual cycle products that accumulate in...
2016/0339008 METHODS OF TREATING OR PREVENTING VASCULAR DISEASES OF THE RETINA
The present invention features, in part, methods of treating or preventing vascular diseases of the retina in a subject, methods of treating or preventing...
2016/0339007 OPHTHALMIC COMPOSITION
Provided herein is an ophthalmic composition. In some embodiments, the ophthalmic composition includes a low concentration of an ophthalmic agent for treatment...
2016/0339006 METHODS FOR TREATING POST TRAUMATIC STRESS DISORDER
Compounds and compositions are described herein for treating post traumatic stress disorder.
2016/0339005 COMPOSITIONS AND METHODS FOR TREATING OCULAR DISEASES
Disclosed are methods for treating diseases or conditions of the eye, especially retinopathies, ocular edema and ocular neovascularization. Non-limiting...
2016/0339004 PHARMACEUTICAL COMPOSITIONS AND METHODS FOR TREATING CANCER AND BIOMARKERS FOR DRUG SCREENING
A pharmaceutical composition comprising sorafenib and GW5074. Said combination therapy inhibits cancer cell growth via c-Raf-PP2A-DAPK signaling transduction...
2016/0339003 TIOTROPIUM INHALATION SOLUTION FOR NEBULIZATION
The present invention relates to a sterile pharmaceutical composition comprising tiotropium or a pharmaceutically acceptable salt thereof, for inhalation via...
2016/0339002 PEDIATRIC ORAL SUSPENSION FORMULATIONS OF AMOXICILLIN AND CLAVULANATE POTASSIUM AND METHOD FOR USING SAME
The invention is directed to a pediatric oral suspension composition containing amoxicillin and clavulanate potassium where the clavulanate potassium is...
2016/0339001 Novel Methods for Treating Cancer
The invention provides thiazole-substituted indolin-2-ones as inhibitors of cancer stem cell pathway kinases (CSCPK) and related kinases, and methods of using...
2016/0339000 TRIAZOLONE COMPOUNDS AS mPGES-1 INHIBITORS
The present disclosure is directed to compounds of formula (I), and pharmaceutically acceptable salts thereof, as mPGES-1 inhibitors. These compounds are...
2016/0338999 HEPATITIS C VIRUS INHIBITORS
The present disclosure relates to compounds, compositions and methods for the treatment of Hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical...
2016/0338998 HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS AND COMBINATIONS THEREOF
Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such...
2016/0338997 KELOID REDUCTION USING TOPICAL ALLANTOIN
This invention is directed to a topical cream containing allantoin in an oil-in-water emulsion formulation. A method is provided for treating or reducing...
2016/0338996 2-Acylaminopropoanol-Type Glucosylceramide Synthase Inhibitors
A compound for use in treating polycystic kidney disease is represented by Structural Formula (I): ##STR00001## or a pharmaceutically acceptable salt thereof. A...
2016/0338995 METHODS AND COMPOSITIONS FOR MODULATING HORMONE LEVELS
Provided herein are compositions and methods for the treatment of androgen and estrogen receptors mediated conditions. Specifically, a composition that...
2016/0338994 Trans-2-nonadecyl-4-hydroxymethyl-1,3-dioxolane and producing methodthereof
The present invention discloses a method for producing trans-2-nonadecyl-4-hydroxymethyl-1,3-dioxolane comprising mixing alkanes and pyridinium chlorochromat...
2016/0338993 WOUND HEALING
A method of treating a chronic wound in a subject in need of such treatment is provided. The method includes administering to the subject at least one...
2016/0338992 COMPOSITE COMPRISING 3'-HYDROXYGENISTEIN AND USE FOR INHIBITION OF MELANOGENESIS
A composite comprising 3'-hydroxygenistein and a use for inhibition of melanogenesis are revealed herein. An effective dose of 3'-hydroxygenistein is applied...
2016/0338991 NOVEL COMPOUND OBTAINED FROM GAMBOGE RESIN, AND MEDICAL USES OF THE SAME
Disclosed herein are seventeen new compounds obtained from an acetone-extracted product of gamboge resin. The seventeen new compounds have activities in...
2016/0338990 MONOTERPENES FOR TREATING RESPIRATORY DISORDERS, IN PARTICULAR BRONCHOPULMONARY DISORDERS
The invention relates to the combined use of at least one monoterpene which can be applied systemically, in particular perorally, and at least one respiratory...
2016/0338989 SOLID PHARMACEUTICAL COMPOSITIONS CONTAINING BENZOFURAN DERIVATIVES
The present invention relates to a solid pharmaceutical composition for oral administration characterized in that it comprises a benzofuran derivative with...
2016/0338988 TOFA ANALOGS USEFUL IN TREATING DERMATOLOGICAL DISORDERS OR CONDITIONS
This invention is directed to analogs of 5-(tetradecyloxy)-2-furancarboxylic acid (TOFA) and their use in the treatment of dermatological disorders or...
2016/0338987 COMPOSITION COMPRISING EPA AND DHA TRIGLYCERIDES FOR PARENTERAL ADMINISTRATION
Described herein are compositions that include an aqueous phase and 5 to 30%, by weight, of an oil phase, based on the total weight of the composition. The oil...
2016/0338986 METHODS AND COMPOSITIONS FOR PREVENTING AND TREATING AUDITORY DYSFUNCTIONS
The invention provides methods for treating auditory impairments in a subject in need of treatment comprising administering to said subject an effective amount...
2016/0338985 TOPICAL SOLUTION OF ISOTRETINOIN
The present invention relates to a topical solution comprising a retinoid or its pharmaceutically acceptable salts thereof and process of preparing it.
2016/0338984 PARTICLE FORMULATIONS OF ALL-TRANS RETINOIC ACID AND TRANSFORMING GROWTH FACTOR BETA FOR THE TREATMENT OF TYPE...
Particle formulations are disclosed that include polymeric particles containing a small molecule drug and a high molecular weight therapeutic protein. Methods...
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