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Patent # Description
2016/0347799 INSECTICIDAL PROTEINS FROM PLANTS AND METHODS FOR THEIR USE
Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal...
2016/0347798 MHC CLASS I EPITOPE DELIVERING POLYPEPTIDES AND CELL-TARGETED MOLECULES FOR DIRECT CELL KILLING AND IMMUNE...
The present invention is directed to T-cell epitope delivering polypeptides which deliver one or more CD8+ T-cell epitopes to the MHC class I presentation...
2016/0347797 NEISSERIA MENINGITIDIS COMPOSITION AND METHODS THEREOF
In one aspect, the invention relates to an isolated polypeptide comprising an amino acid sequence that is at least 95% identical to SEQ ID NO: 68. In another...
2016/0347796 METHOD FOR PRODUCING PLASTIC RAW MATERIAL FROM BLUE-GREEN ALGAE
An object of the present invention is to construct a production system that enables efficient production of organic acids using blue-green algae, which are...
2016/0347795 TEICOPLANIN ANALOGS AND USES THEREOF
Described herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present...
2016/0347794 ANG-(1-7) Derivative Oligopeptides and Methods for Using and Producing the Same
The present invention provides oligopeptides, in particular, Ang-(1-7) derivatives, and methods for using and producing the same. In one particular embodiment,...
2016/0347793 Biologically Cleavable Tetrapeptide Linking Agents
Tetrapeptide linkers for reversibly linking a first compound to a amine-containing second compound are described. Compounds containing the tetrapeptide linkers...
2016/0347792 FLUORINATED EPOXYKETONE-BASED COMPOUNDS AND USES THEREOF AS PROTEASOME INHIBITORS
The present application relates to novel fluorinated epoxyketone-based compounds, compositions comprising these compounds and their use, in particular for the...
2016/0347791 BORONIC ACID ESTERS AND PHARMACEUTICAL FORMULATIONS THEREOF
Provided herein are boronic acid esters of boronic acid therapeutic agents, such as bortezomib. The boronic acid esters can be used to prepare liposomal...
2016/0347790 SYNTHESIS OF SYRBACTIN PROTEASOME INHIBITORS
The disclosure relates generally to methods for the preparation of a family of natural compounds, the syrbactins and their analogs.
2016/0347789 Method for purification of antibodies, antibody fragments or engineered variants thereof using specific...
The present invention relates to novel adsorbents applicable a process for the separation or purification of antibodies, antibody fragments or engineered...
2016/0347788 On-Column Viral Inactivation Methods
The present invention is directed to a method of inactivating virus that is present during production of a polypeptide of interest. In particular, the present...
2016/0347787 USE OF CATION-EXCHANGE CHROMATOGRAPHY IN THE FLOW-THROUGH MODE TO ENRICH POST-TRANSLATIONAL MODIFICATIONS
The present invention relates to improved methods in the separation recombinant polypeptides with post-translational modifications from complex mixtures...
2016/0347786 PROCEDURE FOR THE PREPARATION OF ABIRATERONE ACETATE AND INTERMEDIATES THEREOF
Disclosed is a process for the preparation of abiraterone and abiraterone acetate with high yields and purity. A key element of the method is the isolation of...
2016/0347785 METHODS, COMPOSITIONS, AND KITS USING HETEROGENEOUS CATALYSTS
Described herein are methods, compositions and kits utilizing heterogeneous metal catalysts for the preparation of cycloaddition compounds, such as triazoles...
2016/0347784 NOVEL NUCLEIC ACID PRODRUGS AND METHODS OF USE THEREOF
Described herein are nucleic acid prodrugs and nucleic acid prodrugs comprising chiral phosphorous moieties. Also described herein are methods of making and...
2016/0347783 DERIVATIVES OF URIDINE 5'-CYCLOPHOSPHATE USEFUL TO TREAT HEPATITIS C VIRAL INFECTIONS
Some embodiments of the present invention include nucleoside 5'-monophosphate derivative compounds, their preparation and their uses. In some embodiments, such...
2016/0347782 4-methylcatechol Derivatives and Uses Thereof
The invention relates to phenoxy derivatives with glycosidically bound sugar moieties, pharmaceutical compositions containing such compounds, uses of such...
2016/0347781 NOVEL PROCESS FOR CONVERSION OF HEMICELLULOSE INTO C5 SUGARS USING IONIC LIQUIDS
The present invention discloses one pot process for the conversion of hemicellulose into C5 sugars using ionic liquids in water media.
2016/0347780 METHOD FOR THE SYNTHESIS OF PHOSPHORUS ATOM MODIFIED NUCLEIC ACIDS
Described herein are methods of syntheses of phosphorous atom-modified nucleic acids comprising chiral X-phosphonate moieties. The methods described herein...
2016/0347779 METHOD FOR ANTAGONIZING STAT3 DIMERIZATION AND COMPOUNDS FOR USE THEREIN
A compound of the formula: ##STR00001## Also, a method for antagonizing STAT3 dimerization in a patient in need thereof which by administering to such patient a...
2016/0347778 ALKENES AS ALKYNE EQUIVALENTS IN RADICAL CASCADES TERMINATED BY FRAGMENTATIONS
Disclosed are methods for rerouting radical cascade cyclizations by using alkenes as alkyne equivalents. The reaction sequence is initiated by a novel 1,2...
2016/0347777 COMPOUNDING SILICA-REINFORCED RUBBER WITH LOW VOLATILE ORGANIC COMPOUND (VOC) EMISSION
Alkoxy-modified silsesquioxane compounds are described. The alkoxy-modified silsesquioxane compounds contain an alkoxysilane group that participates in an...
2016/0347776 BASE-CATALYZED SILYLATION OF TERMINAL OLEFINIC C-H BONDS
The present invention is directed to a mild, efficient, and general direct C(sp.sup.2)-H bond silylation of terminal olefins. Various embodiments includes...
2016/0347775 CARBOXYLIC ACID FUNCTIONAL SILOXANES OF DEFINED STRUCTURE
Organopolysiloxanes bearing regularly spaced pendent carboxylic acid groups or salts thereof have a block polymer structure and are derived by the double...
2016/0347774 PRODUCTION OF METAL-ORGANIC FRAMEWORKS
An apparatus for producing metal organic frameworks, comprising: a tubular flow reactor comprising a tubular body into which, in use, precursor compounds which...
2016/0347773 MICROBIOCIDALLY ACTIVE BENZOXABOROLES
Compounds of formula (I) are as defined in the claims, and their use in compositions and methods for the control and/or prevention of microbial infection,...
2016/0347772 NAPHTHYRIDINE COMPOUNDS AS JAK KINASE INHIBITORS
The invention provides compounds of formula (I): ##STR00001## wherein the variables are defined in the specification, or a pharmaceutically-acceptable salt...
2016/0347771 TRICYCLIC HETEROCYCLIC COMPOUNDS AS PHOSPHOINOSITIDE 3-KINASE INHIBITORS
A compound of formula I: ##STR00001## or a pharmaceutically acceptable salt thereof, wherein: W is O, N--H, N--(C.sub.1-C.sub.10 alkyl) or S; each X is...
2016/0347770 3-(PYRIMIDINE-2-YL)IMIDAZO[1,2-A]PYRIDINES
The present application relates to novel 3-(pyrimidin-2-yl)imidazo[1,2-a]pyridines, to processes for preparation thereof, to the use thereof, alone or in...
2016/0347769 METHOD FOR THE PREPARATION OF [1,2,4]-TRIAZOLO[4,3-A]PYRIDINES
Disclosed herein are methods for preparing [1,2,4]triazolo[4,3-a]pyridines, particularly ...
2016/0347768 COMPOUNDS FOR USE AS GPR120 AGONISTS
The present invention relates to a compound of formula (I), or a tautomer, stereoisomer, geometrical isomer, prodrug, carboxylic acid isostere, solvate,...
2016/0347767 HETEROCYCLE AMINES AND USES THEREOF
Compounds and methods in the fields of chemistry and medicine are disclosed. Some of the disclosed embodiments include compounds, compositions and methods of...
2016/0347766 Crystalline Forms of Dolutegravir Sodium
The present disclosure relates to novel crystalline dolutegravir sodium Form-M2, Form-M3, Form-M4 and process for the preparation thereof.
2016/0347765 TRYPTOPHANOL-DERIVED OXAZOLOISOINDOLINONES: SMALL-MOLECULE P53 ACTIVATORS
The present application discloses novel family of Tryptophanol-Derived Oxazoloisoindolinones for use in the treatment of p53 associated conditions, such as...
2016/0347764 AZA-EPOXY-GUAIANE DERIVATIVES AND TREATMENT OF CANCER
Disclosed is a compound of formula (I) or formula (II): (Formulas should be inserted here) wherein R.sup.1-R.sup.6 are as defined herein. Also disclosed are a...
2016/0347763 PRODUCTION METHOD FOR EPOXY COMPOUND USING SOLID CATALYST
A method for producing an epoxy compound by reacting a compound having a carbon-carbon double bond with hydrogen peroxide in the coexistence of the compound...
2016/0347762 ARYL SUBSTITUTED AMINOMETHYL SPECTINOMYCIN ANALOGS AS ANTIBACTERIAL AGENTS
The invention relates to aryl substituted aminomethyl spectinomycin analogs, derivatives thereof, and related compounds, which are useful as anti-bacterial...
2016/0347761 INHIBITORS OF HISTONE DEACETYLASE
The present invention relates to compounds of formula (I): ##STR00001## or a pharmaceutically acceptable salt, hydrate, solvate, or prodrug thereof, wherein U,...
2016/0347760 Bicyclic-Fused Heteroaryl or Aryl Compounds
Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula Ia, ...
2016/0347759 Hexahydrofuropyrroles as PDE1 Inhibitors
The present invention provides hexahydrofuropyrroles as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative...
2016/0347758 NOVEL MACROCYCLE WITH REPEATING TRAZOLE-CARBAZOLE UNITS
Disclosed herein are compositions of tricarbazole triazolophane (tricarb) of Formulas (I), (II) and (III): ##STR00001## wherein R of Formula (I) is selected from...
2016/0347757 FACTOR XIa INHIBITORS
The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said...
2016/0347756 PYRROLOTRIAZINES AS ALK INHIBITORS
This application provides compounds of the general formula (I) ##STR00001## and/or a salt thereof, where X, R.sup.1 and R.sup.2 are as defined herein....
2016/0347755 PYRIMIDO-DIAZEPINONE KINASE SCAFFOLD COMPOUNDS AND METHODS OF TREATING DISORDERS
The present invention relates to novel pyrimido-diazepinone compounds, methods of modulating protein kinases, including MPS1 (TTK), ERK5 (BMK1, MAPK7), polo...
2016/0347754 COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE
The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions...
2016/0347753 Synthesis of Duocarmycin Analogues
A novel Fmoc protected duocarmycin subunit and utilisation as a reagent in solid phase protein synthesis methodology. Also provided is a novel method of solid...
2016/0347752 N1-PYRAZOLOSPIROKETONE ACETYL-CoA CARBOXYLASE INHIBITORS
The invention provides a compound of Formula (I) ##STR00001## or a pharmaceutically acceptable salt of the compound, wherein R.sup.1, R.sup.2, R.sup.3, Z,...
2016/0347751 NOVEL PYRAZOLE DERIVATIVE
It has been desired to develop a pharmaceutical composition, which is used in agents for preventing and/or treating various diseases related to PDE10 (e.g....
2016/0347750 DIHYDROPTERIDINONE DERIVATIVES AND USES THEREOF
The present invention provides compounds of Formula (I), and pharmaceutically compositions thereof. Compounds of Formula (I) are binders of bromodomains and/or...
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