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Patent # Description
2016/0347749 DIAZEPANE DERIVATIVES AND USES THEREOF
The present invention provides compounds of any one of Formulae (I), (II-C) (e.g., Formula (II)), and (III), and pharmaceutically compositions thereof....
2016/0347748 BENZAMIDE AND NICOTINAMIDE COMPOUNDS AND METHODS OF USING SAME
The present disclosure provides benzamide and nicotinamide compounds and pharmaceutical uses of the compounds. The compounds can be used to treat, for example,...
2016/0347747 SUBSTITUTED BERBINES AND PROCESSES FOR THEIR SYNTHESIS
The present invention provides processes for the synthesis of substituted berbine compounds. Also provided are intermediates used in the synthesis of...
2016/0347746 DIHYDROPYRIMIDINE COMPOUNDS AND THEIR APPLICATION IN PHARMACEUTICALS
Provided herein are dihydropyrimidine compounds and their pharmaceutical applications, especially for use in treating and preventing HBV diseases. ...
2016/0347745 IMMUNE ADJUSTMENT COMPOUND, USE THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING SAME
The present invention provides a compound represented by formula I, wherein R is a halogen element or a C1-C6 alkyl group. The compound has S1P1 receptor...
2016/0347744 FUSED HETEROCYCLIC COMPOUNDS AS ION CHANNEL MODULATORS
The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including...
2016/0347743 PREPARATION OF SUFENTANIL CITRATE AND SUFENTANIL BASE
Provided herein are processes for forming sufentanil citrate from sufentanil base. One process comprises forming sufentanil citrate in the presence of a polar...
2016/0347742 HETEROCYCLIC ESTROGEN RECEPTOR MODULATORS AND USES THEREOF
Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds...
2016/0347741 SULPHAMOYLPYRROLAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B
Inhibitors of HBV replication of Formula (A) ##STR00001## including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein R.sup.a to...
2016/0347740 PYRROLE-SUBSTITUTED INDOLONE DERIVATIVE, PREPARATION METHOD THEREFOR, COMPOSITION COMPRISING SAME AND USE THEREOF
The present invention relates to a pyrrole-substituted indolone derivative, a preparation method therefor, a composition comprising the derivative, and use...
2016/0347739 5-OXOPYRROLIDINE DERIVATIVES AS HIV INTEGRASE INHIBITORS
A method for treating against HIV, such as by inhibiting HIV integrase, in target cells or in a patient involves administering to target cells or to a patient...
2016/0347738 sGC STIMULATORS
Compounds of Formulae I' and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds...
2016/0347737 PROTEIN KINASE C INHIBITORS AND METHODS OF THEIR USE
PKC inhibitors are disclosed. The PKC inhibitors are useful for treating PKC associated diseases, including certain cancers. The PKC inhibitors have improved...
2016/0347736 STERICALLY HINDERED AMINE STABILIZER
The present invention relates to oxygen-substituted sterically hindered amines of the formulae I or II: (II), wherein, for example, F.sub.2, R.sub.3, R.sub.5,...
2016/0347735 PYRIDINEAMINE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS
The present disclosure describes pyridineamine compounds, as well as their compositions and methods of use. The compounds inhibit the activity of the Pim...
2016/0347734 PROCESSES AND INTERMEDIATES FOR MAKING A JAK INHIBITOR
This invention relates to processes and intermediates for making {1-{1-[3-fluoro-2-(trifluoromethyl)isonicotinoyl]piperidin-4-yl}-3-[4-(7H- ...
2016/0347733 HISTONE DEMETHYLASE INHIBITORS
Provided herein are substituted pyrazolylpyridine, pyrazolylpyridazine, and pyrazolylpyrimidine derivative compounds and pharmaceutical compositions comprising...
2016/0347732 SELECTIVE HDAC6 INHIBITORS
The present invention provides a compound having the structure: ##STR00001## wherein R.sub.1 is halogen, --NR.sub.5R.sub.6, --NR.sub.5--C(.dbd.O)--R.sub.6,...
2016/0347731 DAPAGLIFLOZIN CRYSTALLINE FORM AND PREPARATION METHOD THEREOF
A crystalline form of dapagliflozin represented by formula (I) is provided. The crystalline form has a characteristic absorption peak in an X-ray powder...
2016/0347730 Methods of Producing Cancer Compounds
Provided herein are methods of making the compound of Formula I: ##STR00001## and certain intermediates involved in such process.
2016/0347729 MULTIFUNCTIONAL PRIMARY AMINE, PROCESS FOR ITS PREPARATION, AND USE THEREOF
The invention relates to a hydrophilically modified multifunctional amine AC which has more than one primary amino group per molecule, and at least one group...
2016/0347728 ANTIBACTERIAL COMPOUNDS
The present invention relates to the following compounds for use in the treatment of a bacterial infection ##STR00001## wherein the integers are as defined in...
2016/0347727 NEAR-INFRARED FLUORESCENT NERVE CONTRAST AGENTS AND METHODS OF USE THEREOF
The instant invention provides near-infrared fluorescent nerve contrast agents and methods of using them.
2016/0347726 METHOD FOR PRODUCING PURIFIED COMPOUND
A method for producing a purified compound represented by the formula (II), comprising; obtaining a reaction mixture containing a compound represented by the...
2016/0347725 INHIBITORS OF PAXILLIN FUNCTION AND RELATED COMPOSITIONS AND METHODS
This disclosure relates to small molecule inhibitors of paxillin and paxillin binding, and related compositions and methods of treatment.
2016/0347724 HETEROCYCLIC COMPOUND
A fused heterocyclic compound having an enteropeptidase inhibitory action and use of the compound as a medicament for treatment or prophylaxis of obesity,...
2016/0347723 METHOD OF REFINING VALSARTAN COMPRISING MORE THAN OR EQUAL TO 10% D-ISOMERS
The present invention relates to a method of refining valsartan comprising more than or equal to 10% D-isomers, the method comprising: adding a solvent to...
2016/0347722 NOVEL SALTS AND CO-CRYSTALS OF LESINURAD
Novel salts and cocrystals of lesinurad, processes for their preparation, pharmaceutical compositions comprising these new salt forms and co-crystals, and use...
2016/0347721 Formation of N-Protected bis-3,6-(4-aminoalkyl)-2,5,diketopiperazine
The disclosed embodiments detail improved methods for the synthesis of diketopiperazines from amino acids. In particular improved methods for the...
2016/0347720 NOVEL PROCESSES
This invention relates to methods of making a compound of formula (I) and intermediates for same ##STR00001## the compounds of formula (I) being useful for...
2016/0347719 (N-(CYANOMETHYL)-4-(2-(4-MORPHOLINOPHENYLAMINO)PYRIMIDIN-4-YL)BENZAMIDE
The present invention relates to stable novel salt forms of N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)benzamide that are suitable for the...
2016/0347718 ROSUVASTATIN CALCIUM AND PROCESS FOR PRODUCING INTERMEDIATE THEREOF
An object of the present invention is to provide a novel method capable of producing rosuvastatin calcium and intermediates therefor efficiently, inexpensively...
2016/0347717 TETRASUBSTITUTED ALKENE COMPOUNDS AND THEIR USE
Disclosed herein are compounds, or pharmaceutically acceptable salts thereof, and methods of using the compounds for treating breast cancer by administration...
2016/0347716 Water-Soluble Pyrazole Derivatives as Corrosion Inhibitors
Disclosed are nitrogen-containing heterocyclic compounds of relatively low aquatic toxicity and methods of using the heterocyclic compounds as corrosion...
2016/0347715 Toll-Like Receptor 8 Agonists
Compounds described herein can be used for therapeutic purposes. The compounds can be TLR agonists, such as TLR8 agonists. The compounds can be included in...
2016/0347714 HISTONE DEMETHYLASE INHIBITORS
The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted amidopyridine...
2016/0347713 2-Aminopyridine-based Selective Neuronal Nitric Oxide Synthase Inhibitors
Aminopyridine compounds, as can be used in conjunction with methods for modulation of nitric oxide synthase activity.
2016/0347712 (-)-(2R,3S)-2-AMINO-3-HYDROXY-3-PYRIDIN-4-YL-1-PYRROLIDIN-1-YL-PROPAN-1-ON- E (L)-(+) TARTRATE SALT, ITS METHOD...
The present invention is directed to (-)-(2R,3S)-2-amino-3-hydroxy-3-pyridin-4-yl-1-pyrrolidin-1-yl-propan-1-o- ne (L)-(+) tartrate salt, a pharmaceutical...
2016/0347711 PROCESS INTERMEDIATES AND METHODS FOR THE PREPARATION OF PROCESS INTERMEDIATES FOR THE SYNTHESIS OF ARGATROBAN...
Methods are provided for the synthesis of key intermediates for the synthesis of Argatroban monohydrate, ethyl ...
2016/0347710 1-ALPHA,25-DIHYDROXY-24,24-DIFLUORO-19-NOR-VITAMIN D3 ANALOGS AND THEIRPHARMACEUTICAL USES
Disclosed are 1.alpha.,25-dihydroxy-24,24-difluoro-2-methylene-19-nor-vitamin D analogs and their pharmaceutical uses. These new vitamin D analogs are ...
2016/0347709 ACID GENERATOR COMPOUNDS AND PHOTORESISTS COMPRISING SAME
Acid generator compounds are provided that are particularly useful as a photoresist composition component. In one preferred aspect, acid generators are...
2016/0347708 ANTIBACTERIAL AGENTS: N(ALPHA)-AROYL-N-ARYL-PHENYLALANINAMIDES
The invention provides compounds having activity as bacterial RNA polymerase inhibitors and antibacterial agents, as well as compositions comprising the...
2016/0347707 CATALYST, AND METHOD FOR PRODUCING OXIDATION PRODUCT
A novel catalyst is provided which enables efficient production of an oxidation product by using an oxygen-induced oxidation reaction of an organic substrate....
2016/0347706 Methods of Producing Cancer Compounds
Provided herein are methods of making the compound of Formula I: ##STR00001## and certain intermediates involved in such process.
2016/0347705 STABLE SOLID FORMS OF ENCLOMIPHENE AND ENCLOMIPHENE CITRATE
The present invention refers to new solid forms of Enclomiphene citrate and Enclomiphene base, processes for preparing thereof and uses.
2016/0347704 PHOTOLABILE PRO-FRAGRANCES
The invention relates to specific ketones of formula (I) which act as photolabile pro-fragrances. The invention further relates to detergents or cleaning...
2016/0347703 FULLERENE DERIVATIVE, FLUORORESIN COMPOSITION, AND LUBRICANT
A fullerene derivative of the present invention has a fullerene skeleton and a plurality of perfluoropolyether chains in a molecule, wherein the ...
2016/0347702 SINGLE-POT SYNTHESIS OF DIALKYL CARBONATES USING CATALYST FROM NATURAL RESOURCE
The present invention relates to a single-pot method for preparing dialkyl carbonates, the method comprises reaction of alkylene oxide with aliphatic or cyclic...
2016/0347701 METHOD FOR PRODUCING CARBONATES
In an embodiment, a method of producing carbonate can comprise: reacting a feed comprising carbon monoxide and chlorine in a tube of a reactor to produce a...
2016/0347700 PROCESS FOR OXIDATION OF ALKYL AROMATIC COMPOUND TO AROMATIC CARBOXYLIC ACID
The present disclosure provides a process for oxidation of p-xylene to terephalic acid. Recovery of fluid medium and valuable chemicals in carried out using...
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