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Patent # Description
2016/0355539 SELECTIVE SOLVENT FREE PHOSPHORYLATION
A synthetic process is provided for the preparation of phosphorylated analogs of nicotinamide riboside ("NR") having the formula (I), or salts thereof, and...
2016/0355538 PROCESS FOR PREPARING A NOVEL CRYSTALLINE FORM OF EMAMECTIN BENZOATE AND USE THE SAME
A crystalline modification V of emamectin benzoate, exhibiting at least 3 of the following reflexes in an X-ray powder diffractogram recorded using ...
2016/0355537 TRIOXACARCINS AND USES THEREOF
The present invention relates to trioxacarcin compounds of the formula: ##STR00001## or pharmaceutically acceptable forms thereof; wherein R.sup.1, R.sup.2, ...
2016/0355536 METHOD FOR PRODUCING THIOLANE SKELETON-TYPE GLYCOCONJUGATE, AND THIOLANE SKELETON-TYPE GLYCOCONJUGATE
There is provided a production method of a compound represented by the following formula (II) through a step of reacting a compound represented by the...
2016/0355535 FATTY ACID DERIVATIVES OF LIGNIN AND USES THEREOF
The present disclosure provides fatty acid derivatives of lignin with improved properties such as workability and other physical properties. These derivatives...
2016/0355534 IRIDIUM (III) BASED PHOSPHORS BEARING PINCER CARBENE AND PYRAZOLYL CHELATES
The present invention provides a class of iridium (III) based phosphors bearing both pincer carbene and pyrazolyl chelates. Differing from the conventional...
2016/0355533 Crystalline Fosaprepitant Dicyclohexylamine Salt And Its Preparation
The present invention provides dicyclohexylamine salt of fosaprepitant (fosaprepitant DCHA), a process for preparing fosaprepitant DCHA, and a use of...
2016/0355532 STABILIZED FORM OF TETROFOSMIN AND ITS USE
The present invention provides a stabilized form of Tetrofosmin, which is stable at room temperature as well as in contact with oxygen, and a non-radioactive...
2016/0355531 Pharmaceutical Process and Intermediates
The present disclosure provides for processes and intermediates in the large-scale manufacture of the compound of formula (I) or hydrates thereof. ##STR00001##
2016/0355530 HEPATITIS C INHIBITORS AND USES THEREOF
This disclosure relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and...
2016/0355529 PYRIDONE DERIVATIVES AS ACID SECRETION INHIBITORS AND PROCESS FOR PREPARATION THEREOF
The present invention relates to the preparation of stable pyridone disulphide derivatives having general formula (I) and its stereoisomers, which are useful...
2016/0355528 INHIBITORS OF HIV REPLICATION
The present invention relates to novel 2,3,4-substituted 5,6,7,8-tetrahydro[1]benzothieno[2,3-b]pyridine compounds and pharmaceutically acceptable salts...
2016/0355527 COMPOUNDS AS TYROSINE KINASE MODULATORS
The present invention is directed to novel compounds of Formula I. The compounds of the present invention are potent tyrosine kinase modulators, and are...
2016/0355526 PROCESS FOR THE INDUSTRIAL SYNTHESIS OF SORDIDIN
The present invention relates to a process for preparing sordidin, comprising a step of preparing 4-(2-ethyl-1,3-dioxolan-2-yl)pentan-2-one by means of a...
2016/0355525 PROCESS FOR PREPARATION OF DARUNAVIR
The present invention provides a process for the preparation of darunavir or solvates or a pharmaceutically acceptable salt thereof substantially free of...
2016/0355524 PHILLYGENOL SULPHATE AND DERIVATIVE THEREOF, AND PREPARATION METHOD AND APPLICATION THEREOF
The present invention provides a forsythiaside sulfate derivatives as represented by the following formula, the preparation method and antiviral application...
2016/0355523 CELL-PERMEABLE, CELL-COMPATIBLE, AND CLEAVABLE LINKERS FOR COVALENT TETHERING OF FUNCTIONAL ELEMENTS
Provided herein are cell-permeable, cell-compatible, and chemoselectively-cleavable linkers for tethering (e.g., covalently) functional elements (e.g., a...
2016/0355522 SPIRO-OXAZOLONES
The present invention provides spiro-oxazolones, which act as V1a receptor modulators, and in particular as V1a receptor antagonists, their manufacture,...
2016/0355521 BICYCLIC UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF PAIN
Compounds of Formula I: or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C and X are as...
2016/0355520 Tricyclic Compounds Having Cytostatic and/or Cytotoxic Activity and Methods of Use Thereof
The present invention provides tricyclic compounds having cytostatic and cytotoxic activity in a single molecule having receptor tyrosine kinase(s),...
2016/0355519 HIV INHIBITING BICYCLIC PYRIMIDINE DERIVATIVES
HIV replication inhibitors of formula ##STR00001## N-oxides, pharmaceutically acceptable addition salts, quaternary amines or stereoisomeric forms thereof,...
2016/0355518 MICROBIOCIDAL HETEROBICYCLIC DERIVATIVES
Compounds of the formula I wherein Y--X, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, A.sup.1, A.sup.2, A.sup.3, Ra and n are as...
2016/0355517 BICYCLIC HETEROARYL UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS AS TRKA KINASE INHIBITORS
Compounds of Formula I or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C and X are as...
2016/0355516 NITROGEN CONTAINING COMPOUNDS AND THEIR USE AS ANTIBACTERIAL AGENTS
Compounds of Formula (I), their preparation, and use in preventing or treating a bacterial infection are disclosed. (I) ##STR00001##
2016/0355515 COMPOSITIONS AND METHODS FOR TREATMENT OF CANCER
The present invention relates to pyrroloquinolinyl-pyrrolidine-2,5-dione compounds in combination with chemotherapeutic agents. The present invention provides...
2016/0355514 PYRIDINYL AND PYRIMIDINYL SULFOXIDE AND SULFONE DERIVATIVES
Disclosed are certain pyridinyl and pyrimidinyl sulfoxide and sulfone compounds, pharmaceutical compositions comprising such compounds and methods of treatment...
2016/0355513 COMPOSITIONS AND USES THEREOF
Provided are solid dispersions, solid molecular complexes, salts and crystalline polymorphs involving propane-1-sulfonic acid ...
2016/0355512 INHIBITORS OF INFLUENZA VIRUSES REPLICATION
Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological...
2016/0355511 NOVEL 1-SUBSTITUTED INDAZOLE DERIVATIVE
A medicament for treating diseases associated with cholinergic properties in the central nervous system (CNS) and/or peripheral nervous system (PNS), diseases...
2016/0355510 1 -(5-TERT-BUTYL-2-ARYL-PYRAZOL-3-YL)-3-[2-FLUORO-4-[(3-OXO-4H-PYRIDO[2, 3-B]PYRAZIN-8-YL)OXY]PHENYL]UREA...
The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain ...
2016/0355509 Imidazopyridine Derivatives as Modulators of TNF Activity
A series of substituted 3H-imidazo[4,5-c]pyridine derivatives of formula (I), being potent modulators of human TNFa activity, are accordingly of benefit in the...
2016/0355508 POLYCYCLIC ESTROGEN RECEPTOR MODULATORS AND USES THEREOF
Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds...
2016/0355507 4-HYDROXY-3-(HETEROARYL)PYRIDINE-2-ONE APJ AGONISTS
The present invention provides compounds of Formula (I): ##STR00001## wherein all variables are as defined in the specification, and compositions comprising any...
2016/0355506 CRYSTALLINE SALT FORM OF (S)-(2-(6-CHLORO-7-METHYL-1H-BENZO[D]IMIDAZOL-2-YL)-2-METHYLPYRROLIDIN-1-- ...
The invention relates to a crystalline form of (S)-(2-(6-chloro-7-methyl-1H-benzo[d]imidazol-2-yl)-2-methylpyrrolidin-1-- ...
2016/0355505 NOVEL COMPOUNDS
A compound of formula (I): ##STR00001## or a salt thereof; which is an inhibitor of spleen tyrosine kinase (SYK) and therefore potentially of use in treating ...
2016/0355504 HETEROARYL INHIBITORS OF SUMO ACTIVATING ENZYME
Disclosed are compounds of formula (I); or a pharmaceutically acceptable salt thereof; wherein Y, Ra, Ra', Rc, Rf, X2, Rd, Rd', Re, Re'2, m, and G have the...
2016/0355503 NITROGEN HEXACYCLE COMPOUNDS AS INHIBITORS OF p97 COMPLEX
Nitrogen hexacycle compounds having an arylalkyl amine substituent at the P4 position and a substituted 5:6 bicyclic group at the P2 position of the nitrogen...
2016/0355502 CATHEPSIN CYSTEINE PROTEASE INHIBITORS
This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and...
2016/0355501 NITROGENOUS HETEROCYCLIC DERIVATIVES AND THEIR APPLICATION IN DRUGS
The present invention relates to the field of medicine, provided herein are novel nitrogenous heterocyclic compounds, their preparation methods and their uses...
2016/0355500 INTERMEDIATE COMPOUNDS AND PROCESS FOR THE PREPARATION OF EFINACONAZOLE
The present invention relates to a process for the preparation of (2R,3R)-2-(2,4-difluorophenyl)-3-(4-methylene-1-piperidinyl)-1-(1H-1,2,4-- ...
2016/0355499 TRPV1 ANTAGONISTS INCLUDING DIHYDROXY SUBSTITUENT AND USES THEREOF
The invention relates to compounds of formula IA ##STR00001## and pharmaceutically acceptable derivatives thereof, compositions comprising an effective amount of...
2016/0355498 INHIBITORS OF BRUTON'S TYROSINE KINASE
Disclosed herein are reversible and irreversible inhibitors of Bruton's tyrosine kinase (Btk). Also disclosed are pharmaceutical compositions that include the...
2016/0355497 THIOPYRANOSE COMPOUND AND METHOD FOR PRODUCING SAME
There is provided a production method of a thiopyranose compound represented by the following Formula (2) by reacting a compound represented by the following...
2016/0355496 CHROMENE DERIVATIVES AND THEIR ANALOGS AS WNT PATHWAY ANTAGONISTS
Compounds of formula (IIc); wherein X.sup.3 and X.sup.4 independently from each other are N or CR.sup.8 wherein R.sup.8 may be same or different; Y.sup.1,...
2016/0355495 PREPARATION METHOD OF CHIRAL MULTIPLE SUBSTITUTED TETRAHYDROPYRAN
An organocatalytic kinetic resolution of racemic secondary nitroallylic alcohols via Michael/acetalization sequence to give fully substituted ...
2016/0355494 FUSED HETEROCYCLIC COMPOUND
A fused heterocyclic compound having an enteropeptidase inhibitory action and use of the compound as a medicament for treatment or prophylaxis of obesity,...
2016/0355493 CAFFEIC ACID DERIVATIVES FOR ANTI-ANGIOGENESIS
The present invention develops a series of methyl caffeate derivatives having biological activity in anti-angiogenesis. The present invention suggests that the...
2016/0355492 Methods of Making Sulfurized Derivatives
This disclosure relates to sulfurized derivatives made from functionalized monomers. The disclosure relates to lubricants, functional fluids, fuels,...
2016/0355491 GAMMA-BUTYROLACTONE COMPOSITION AND METHOD FOR PRODUCING SAME
An object of the present invention is to provide high-purity gamma-butyrolactone (GBL) capable of preventing occurrence of reaction other than the object at...
2016/0355490 VINYL-CONTAINING COMPOUNDS AND PROCESSES FOR MAKING THE SAME
The present invention provides a process for forming vinyl-containing compounds including the steps of: a) reacting in a nitrogen atmosphere a dicarboxylic...
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