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Patent # Description
2016/0354488 AAV-Mediated Subcellular Targeting of Heterologous Rhodopsins in Retinal Ganglion Cells
Microbial type rhodopsins, such as the light-gated cation-selective membrane channel, channelrhodopsin-2 (Chop2/ChR2) or the ion pump halorhodopsin (HaloR) are...
2016/0354487 COMPOSITIONS AND METHODS OF USE OF CRISPR-CAS SYSTEMS IN NUCLEOTIDE REPEAT DISORDERS
The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of...
2016/0354486 BINDING MOLECULE CONJUGATES
The present invention concerns methods for identifying, producing, and engineering binding molecule conjugates, and to the conjugates produced. In particular,...
2016/0354485 1-(CHLOROMETHYL)-2,3-DIHYDRO-1H-BENZO[E]INDOLE DIMER ANTIBODY-DRUG CONJUGATE COMPOUNDS, AND METHODS OF USE AND...
The invention provides antibody-drug conjugates comprising an antibody conjugated to a 1-(chloromethyl)-2,3-dihydro-1H-benzo[e]indole (CBI) dimer drug moiety...
2016/0354484 COMPOSITIONS FOR INDUCING ANTIGEN-SPECIFIC TOLERANCE
Peptides that specifically bind erythrocytes are described. These are provided as peptidic ligands having sequences that specifically bind, or as antibodies or...
2016/0354483 COMPOUNDS, CONJUGATES AND COMPOSITIONS OF EPIPOLYTHIODIKETOPIPERAZINES AND POLYTHIODIKETOPIPERAZINES
The present application provides, among other things, compounds, compositions and methods for treating various diseases including cancer.
2016/0354482 PHARMACEUTICAL COMPOSITIONS COMPRISING MACROLIDE DIASTEREOMERS, METHODS OF THEIR SYNTHESIS AND THERAPEUTIC USES
The disclosure relates to compositions comprising diastereomer of a macrolide exhibiting improved therapeutic profile in the context of inhibiting cell...
2016/0354481 MASS PRODUCTION OF READY-TO-USE SUSPENSIONS OF FIBRINOGEN-COATED ALBUMIN SPHERES FOR THE TREATMENT OF...
A composition and a method effective in the production of the composition. The composition is a ready-to-use aqueous suspension in large and small quantities...
2016/0354480 ACTIVATED NEUROTENSIN MOLECULES AND THE USES THEREOF
The present invention relates to activated neurotensin, pharmaceutical compositions comprising the same, and the uses thereof. The compounds and compositions...
2016/0354479 FUNCTIONALIZED POLYPEPTIDES
The invention provides functionalized polypeptides, especially therapeutic polypeptides (e.g., scFv), comprising a linker sequence that can be rapidly and...
2016/0354478 AMINE PEGYLATION METHODS FOR THE PREPARATION OF SITE-SPECIFIC PROTEIN CONJUGATES
Examples include a method of making a protein-PEG conjugate. The method may include providing an aqueous protein solution. The aqueous protein solution may...
2016/0354477 CONJUGATES OF TUMOR NECROSIS FACTOR INHIBITORS TO FUNCTIONALIZED POLYMERS
This document relates to conjugates of TNF inhibitors or derivatives thereof and functionalized (e.g., mono- or bi-functional) polymers (e.g., polyethylene...
2016/0354476 TARGETED THERAPEUTIC NUCLEOSIDES AND THEIR USE
Provided herein are compounds comprising one or more therapeutic nucleosides and one or more targeting groups. In certain embodiments, the compounds further...
2016/0354475 Acid-Labile Lipophilic Prodrugs of Cancer Chemotherapeutic Agents
The present application discloses an acid labile lipophilic molecular conjugate of cancer chemotherapeutic agents and methods for reducing or substantially...
2016/0354474 ANIONIC POLYPLEXES FOR USE IN THE DELIVERY OF NUCLEIC ACIDS
The present invention provides an anionic polyplex formed from a nucleic acid and an anionic polymer and further comprising a cation, which can be in the form...
2016/0354473 Cosmetic and Pharmaceutical Foam
The invention relates to an alcohol-free cosmetic or pharmaceutical foam carrier comprising water, a hydrophobic solvent, a foam adjuvant agent, a ...
2016/0354472 USE OF HUMAN SERUM ALBUMIN TO DECREASE ANTIGENICITY OF THERAPEUTIC PROTEINS
Provided herein are therapeutic compositions that include albumin (such as human serum albumin) and therapeutic proteins, such as a modified proaerolysin...
2016/0354471 Pine Bark Extract and Black Pepper Essential Oil with Anti-Inflammatory and Anti-Arthritic Action and Method of...
A gel for topical application, comprising of: about 37.0 percent by weight of deionized water; about 0.3 percent by weight of acrylate crosspolymer; about 0.05...
2016/0354470 SUSTAINED-RELEASE DRUG CARRIER COMPOSITION
The present invention provides compositions for extended release of an active ingredient, comprising a lipid-saturated matrix formed from a biodegradable...
2016/0354469 Composition, its preparation and method of use in treating skin disorders
This invention pertains to a zafirlukast-containing composition, a method of preparing the composition, and a method for treating certain skin disorders using...
2016/0354468 (BACTERIO)CHLOROPHYLL PHOTOSENSITIZERS FOR TREATMENT OF EYE DISEASES AND DISORDERS
An ophthalmic composition is provided, comprising chlorophyll or bacteriochlorophyll compounds for photodynamic treatment (PDT) of diseases, disorders and...
2016/0354467 SYSTEMS AND METHODS FOR INTERIOR ENERGY-ACTIVATION FROM AN EXTERIOR SOURCE
A method and a system for producing a change in a medium. The method places in a vicinity of the medium at least one energy modulation agent. The method...
2016/0354466 HYPERTHERMIA TARGETING COMPOSITIONS, DEVICES, AND METHODS FOR CANCER THERAPY
A method of cancer hyperthermia therapy includes placing a device including an exogenously-excitable polymeric material at a cancer hyperthermia therapy site...
2016/0354465 Methods for Treating Pressure Induced Optic Neuropathy, Preventing Neuronal Degeneration and Promoting Neuronal...
This invention relates to methods for promoting neuronal survival and regeneration using LINGO-1 antagonists and TrkB agonists. Additionally, the invention...
2016/0354464 COMPOSITIONS AND METHODS FOR MODULATING AN IMMUNE RESPONSE
The invention generally features compositions and methods for modulating an immune response. In particular embodiments, such compositions and methods modulate...
2016/0354463 ALLERGEN FRAGMENTS
The present invention relates to a peptide derived from the ragweed pollen allergen Amb a (1) and comprising (6 to 50) amino acid residues and pharmaceutical...
2016/0354462 Vaccine and Therapeutic Delivery System
The present invention relates to a new vaccine delivery system. In particular, the present invention includes compositions and methods of integrally...
2016/0354461 SIV AND HIV VACCINATION USING RHCMV- AND HCMV-BASED VACCINE VECTORS
Particular aspects provide for use of the .beta.-herpesvirus Cytomegalovirus (CMV: e.g., RhCMV and HCMV) as a uniquely evolved "vector" for safely initiating...
2016/0354460 LIVE-ATTENUATED VIRUS AND METHODS OF PRODUCTION AND USE
Presented herein are live-attenuated viruses and methods of generating thereof from a parental virus through a plurality of nucleotide substitutions in the...
2016/0354459 PLASMIDS AND METHODS FOR PEPTIDE DISPLAY AND AFFINITY-SELECTION ON VIRUS-LIKE PARTICLES OF RNA BACTERIOPHAGES
The present invention relates to a system and method for controlling peptide display valency on virus-like particles (VLPs), especially including MS2 VLPs. In...
2016/0354458 TILAPIA LAKE VIRUS VACCINES
The present invention relates to vaccine compositions comprising attenuated strain of Tilapia Lake Virus (TiLV) for protecting tilapia fish against infection...
2016/0354457 INJECTABLE VACCINES AGAINST MULTIPLE MENINGOCOCCAL SEROGROUPS
An injectable immunogenic composition comprising capsular saccharides from at least two of serogroups A, C, W135 and Y of Neisseria meningitidis, wherein said...
2016/0354456 METHODS FOR IDENTIFYING TUMOR-SPECIFIC POLYPEPTIDES
The present invention provides methods for identifying tumor-specific polypeptides, polypeptides so identified, and methods for their use
2016/0354455 CHIMERIC NUCLEIC ACID MOLECULES WITH NON-AUG TRANSLATION INITIATION SEQUENCES AND USES THEREOF
The present disclosure relates to nucleic acid vaccine compositions and methods for preventing or treating pathological conditions, such as cancer or...
2016/0354454 METHODS FOR INDUCTION OF ANTIGEN-SPECIFIC IMMUNE TOLERANCE
Peptides that specifically bind erythrocytes are described. These are provided as peptidic ligands having sequences that specifically bind, or as antibodies or...
2016/0354453 COMPOSITIONS FOR GENERATING IMMUNE TOLERANCE BY TARGETING ERYTHROCYTES
Peptides that specifically bind erythrocytes are described. These are provided as peptidic ligands having sequences that specifically bind, or as antibodies or...
2016/0354452 MATERIALS AND METHODS FOR THE DEVELOPMENT OF AN ANTIGEN-SPECIFIC IMMUNE NON-RESPONSIVENESS STATE
The present invention provides materials and methods for making a subject non-responsive to an antigen. Methods of the invention may comprise contacting the...
2016/0354451 METHOD OF PROVIDING PATIENT SPECIFIC IMMUNE RESPONSE IN AMYLOIDOSES AND PROTEIN AGGREGATION DISORDERS
A treatment of Alzheimer's disease and other disorders involving protein misfolding or aggregation is provided by enhancing or sustaining an antibody response...
2016/0354450 Method for Treating Adhesive Capsulitis
The invention relates to the discovery that collagenase injections are effective in lyse the collagenous adhesions in the shoulder and treat the disorder,...
2016/0354449 ANTIDOTES FOR FACTOR XA INHIBITORS AND METHODS OF USING THE SAME
The present invention relates antidotes to anticoagulants targeting factor Xa. The antidotes are factor Xa protein derivatives that bind to the factor Xa...
2016/0354448 COMPOSITIONS COMPRISING SULFORAPHANE OR A SULFORAPHANE PRECURSOR AND A MUSHROOM EXTRACT OR POWDER
The present disclosure relates to the synergistic combination of a sulforaphane precursor, an enzyme capable of converting the sulforaphane precursor to...
2016/0354447 CARDIAC FIBROBLAST-DERIVED EXTRACELLULAR MATRIX AND INJECTABLE FORMULATIONS THEREOF FOR TREATMENT OF ISCHEMIC...
Compositions and methods using an engineered cardiac fibroblast-derived 3-dimensional extracellular matrix (ECM) are disclosed. The ECM includes the structural...
2016/0354446 Formulation for Regeneration of Bone, Cartilage, Teeth, and Periodontium and Treatment of Tumors and Cysts
The present invention provides a formulation comprising a corticosteroid and an insulin analog. Also provided is a formulation comprising a corticosteroid, an...
2016/0354445 PHARMACEUTICAL COMPOSITION FOR USE IN THE TREATMENT OF A NEURODEGENERATIVE DISEASE
The present invention refers to a pharmaceutical composition for use in the treatment of a neurodegenerative disease.
2016/0354444 COMPOSITIONS AND METHODS FOR THE TREATMENT OF SEXUAL DYSFUNCTION
Described herein are pharmaceutical compositions for the treatment of sexual dysfunction in an individual. In some embodiments, the pharmaceutical composition...
2016/0354443 Replacement Therapy for Natriuretic Peptide Deficiencies
Use and methods of use of natriuretic peptide mimetics which bind to and activate natriuretic peptide receptor A in patients with a defect, condition,...
2016/0354442 THERAPEUTIC METHOD OF INDUCING MITOCHONDRIAL BIOGENESIS TO TREAT SKIN AND MUSCLE PATHOLOGIES
A method of inducing mitochondrial biogenesis in a mammal is provided. The method comprises the step of administering to the mammal an interleukin-15 or...
2016/0354441 NON-SURGICAL, LOCALIZED DELIVERY OF COMPOSITIONS FOR PLACENTAL GROWTH FACTORS
Described herewith are compositions comprising placental growth factors and methods for non-surgical, localized delivery thereof. The composition is delivered...
2016/0354440 METHODS FOR TREATING METABOLIC DISORDERS USING FGF
The method provides methods and compositions for treating metabolic disorders such as impaired glucose tolerance, elevated blood glucose, insulin resistance,...
2016/0354439 BLOCKADE OF CCL18 SIGNALING VIA CCR6 AS A THERAPEUTIC OPTION IN FIBROTIC DISEASES AND CANCER
The present invention relates to an isolated soluble CCR6 receptor polypeptide capable of binding to CCL18 and/or CCL20 and to a method for quantifying the...
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