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Patent # Description
2016/0355839 TOMATO PLANTS WITH IMPROVED DISEASE RESISTANCE
The present disclosure provides tomato plants exhibiting resistance to Leveillula taurica (Lt) and lacking traits associated with linkage drag such as an...
2016/0355838 ANAEROBIC GERMINATION-TOLERANT PLANTS AND RELATED MATERIALS AND METHODS
The present invention provides methods and materials useful for improving early vigor of plants during germination. The methods and materials described herein...
2016/0355837 METHOD FOR PLANT IMPROVEMENT
The invention relates to the field of plant improvement, in particular of the improvement of yield for plants, by using a transgene containing a BETL promoter...
2016/0355836 MODIFIED PLANTS
Disclosed are improved plants that have increased yield. The plants show increased yield under low phosphate conditions and therefore require less fertilizer....
2016/0355835 METHODS OF MODULATING PLANT SEED AND NECTARY CONTENT
The present invention relates to methods of increasing the levels of at least one sugar in developing seeds in a plant, with the methods comprising inserting...
2016/0355834 POLYNUCLEOTIDES AND POLYPEPTIDES INVOLVED IN POST-TRANSCRIPTIONAL GENE SILENCING
This invention relates to isolated nucleic acid fragments encoding polypeptides involved in post-transcriptional gene silencing. The invention also relates to...
2016/0355833 Methods and Means for Obtaining Modified Phenotypes
Methods and means are provided for reducing the phenotypic expression of a nucleic acid of interest in eukaryotic cells by providing aberrant, preferably...
2016/0355832 NOVEL METHOD FOR THE PRODUCTION OF TRANSGENIC PLANTS
Mesocotyl meristem explants that contain multiple primary meristems are transformed via particle bombardment or Agrobacterium-mediated methods. Regeneration is...
2016/0355831 MORTIERELLA ALPINE URACIL AUXOTROPH WITH URA5 GENE KNOCKED OUT THROUGH HOMOLOGOUS RECOMBINATION, AND...
It relates to a Mortierella alpine ATCC32222 uracil auxotroph strain and a construction method thereof. In the present invention, Mortierella alpine ATCC32222...
2016/0355830 CORYNEBACTERIUM MICROORGANISM WITH IMPROVED ABILITY TO PRODUCE L-LYSINE AND METHOD FOR PRODUCING L-LYSINE USING...
A microorganism of the genus Corynebacterium with an improved ability to produce L-lysine in which a septum formation initiator protein is inactivated and a...
2016/0355829 RECOMBINANT MICROORGANISM FOR IMPROVED PRODUCTION OF FINE CHEMICALS
The present invention relates to a recombinant nucleic acid molecule, a recombinant microorganism, to a method for producing alanine and to the use of the...
2016/0355828 ORGANIC COMPOUNDS
The present invention relates to a novel selection system for use in a eukaryotic cell culture process and for expression of a recombinant product of interest....
2016/0355827 E. COLI PLASMID DNA PRODUCTION
General methods and strains of bacteria are described that dramatically simplify and streamline plasmid DNA production. In one preferred embodiment, endolysin...
2016/0355826 OLIGONUCLEOTIDE COMPOUNDS FOR TREATMENT OF PREECLAMPSIA AND OTHER ANGIOGENIC DISORDERS
This disclosure relates to novel targets for angiogenic disorders. Novel oligonucleotides are also provided. Methods of using the novel oligonucleotides for...
2016/0355825 TREATMENT OF DISEASE BY MODULATION OF SIRT6
An aspect of an embodiment of the invention relates to providing treatment of disease, in particular age-related disease, through increasing or decreasing the...
2016/0355824 METHOD FOR SELECTIVELY INHIBITING ACAT1 IN THE TREATMENT OF OBESITY, METABOLIC SYNDROME, AND ATHEROSCLEROSIS
The present invention features methods for preventing and treating three related diseases, diet-induced obesity, metabolic syndrome, and atherosclerosis, alone...
2016/0355823 CONTROL OF VARROA MITE INFESTATION
Nucleic acid agents for reducing or removing infestations of the Varroa destructor mite are described. Compositions comprising the nucleic acid agents and...
2016/0355822 INHIBITORY OLIGONUCLEOTIDES AND THEIR USE IN THERAPY
Inhibitory oligonucleotide having the general formula: X.sub.1CCN.sub.1N.sub.2N.sub.3X.sub.2N.sub.4N.sub.5GGGN.sub.6X.sub.3N.su- b.7 (I) are disclosed which can...
2016/0355821 SDF-1 binding nucleic acids and the use thereof in cancer treatment
The present invention is related to a nucleic acid molecule capable of binding to SDF-1, preferably capable of inhibiting SDF-1, whereby the nucleic acid...
2016/0355820 APTAMER CONSTRUCT
The present disclosure relates to aptamers and uses thereof, in particular, aptamers which specifically bind to CD133 and which are particularly useful in the...
2016/0355819 POTENT LNA OLIGONUCLEOTIDES FOR THE INHIBITION OF HIF-1A EXPRESSION
The present disclosure relates to an LNA oligonucleotide consisting of a sequence selected from the group consisting of ...
2016/0355818 METHOD OF FIXING AND EXPRESSING PHYSIOLOGICALLY ACTIVE SUBSTANCE
The present invention provides methods for retaining and expressing physiologically active substances in a target tissue-specific-manner, by administering the...
2016/0355817 RNAI AGENTS, COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING TRANSTHYRETIN (TTR) ASSOCIATED DISEASES
The present invention provides RNAi agents, e.g., double stranded RNAi agents, that target the transthyretin (TTR) gene and methods of using such RNAi agents...
2016/0355816 PROKARYOTIC RNAi-LIKE SYSTEM AND METHODS OF USE
Provided herein are methods for inactivating a target polynucleotide. The methods use a psiRNA having a 5' region and a 3' region. The 5' region includes, but...
2016/0355815 miR-29 Mimics and Uses Thereof
The present invention relates to synthetic oligonucleotide mimetics of miRNAs. In particular, the present invention provides double-stranded, ...
2016/0355814 MIR-155 INHIBITORS FOR TREATING CUTANEOUS T CELL LYMPHOMA (CTCL)
The present invention provides oligonucleotide inhibitors of miR-155 and compositions thereof. The invention further provides methods for treating cancer such...
2016/0355813 Polycomb-Associated Non-Coding RNAS
This invention relates to long non-coding RNAs (lncRNAs), libraries of those ncRNAs that bind chromatin modifiers, such as Polycomb Repressive Complex 2,...
2016/0355812 Compositions and Methods for Treating Liver Injury
Compositions and methods for detecting, inhibiting, treating, and/or preventing a liver disease or disorder such as cholestasis or fibrotic liver disease are...
2016/0355811 Antisense Oligonucleotides for Treatment of Spinal Muscular Atrophy
Various aspects of the present invention are directed to compounds targeted to various regions of the survival motor neuron 2 (SMN2) gene. Such compounds may...
2016/0355810 Modulation of Exon Recognition in Pre-mRNA By Interfering with the Secondary RNA Structure
The invention relates to oligonucleotides for inducing skipping of exon 51 of the dystrophin gene. The invention also relates to methods of inducing exon 51...
2016/0355809 MicroRNA-Based Methods and Assays for Osteosarcoma
Provided are methods and compositions useful in the diagnosis, treatment, and monitoring of osteosarcoma. Antisense to certain microRNA (miRNA) found to be...
2016/0355808 OLIGONUCLEOTIDE COMPOUNDS FOR TARGETING HUNTINGTIN mRNA
This disclosure relates to novel huntingtin targets. Novel oligonucleotides for the treatment of Huntington's disease are also provided.
2016/0355807 THERAPEUTIC AND DIAGNOSTIC MOLECULES
The present invention relates to methods for modulating angiogenesis, comprising administering to a subject, or cells or tissue derived therefrom: (i) one or...
2016/0355806 Polycomb-associated Non-Coding RNAs
This invention relates to long non-coding RNAs (lncRNAs), libraries of those ncRNAs that bind chromatin modifiers, such as Polycomb Repressive Complex 2,...
2016/0355805 Double Stranded Oligonucleotide Compounds Comprising Positional Modifications
Disclosed herein are double stranded RNA molecules which have been modified to exhibit one of the following, increased activity, enhanced nuclease stability,...
2016/0355804 MODULATION OF MICRORNA-138 FOR THE TREATMENT OF BONE LOSS
There is provided nucleic acids (mir-138Antimirs) for use in treating or preventing bone loss in a patient. Also there is provided a method for reducing the...
2016/0355803 METHODS OF SCREENING, SELECTING, AND IDENTIFYING CYTOTOXIC RECOMBINANT POLYPEPTIDES BASED ON AN INTERIM...
The present invention relates to methods of screening libraries of chimeric molecules comprising ribotoxic polypeptides, where screening is based on the...
2016/0355802 Compositions and Methods Of Use Thereof For Making Polypeptides With Many Instances Of Nonstandard Amino Acids
Compositions, systems, and methods for preparation of polypeptides having multiple iterations of non-standard amino acids are provided. The compositions and...
2016/0355801 NITRILASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM
The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are...
2016/0355800 Polypeptides Having Protease Activity
The present invention relates to isolated polypeptides having protease activity and isolated polynucleotides encoding the polypeptides. The invention also...
2016/0355799 POLYPEPTIDES HAVING CELLULASE ACTIVITY
The present disclosure relates to CBH II chimera fusion polypeptides, nucleic acids encoding the polypeptides, and host cells for producing the polypeptides.
2016/0355798 ENDONUCLEASES
The present invention provides an endonuclease I or enzymatically active fragment thereof wherein said endonuclease I has the sequence of SEQ ID No. 4 or a...
2016/0355797 SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION WITH OPTIMIZED FUNCTIONAL CRISPR-CAS SYSTEMS
The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are...
2016/0355796 COMPOSITIONS AND METHODS OF USE OF CRISPR-CAS SYSTEMS IN NUCLEOTIDE REPEAT DISORDERS
The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of...
2016/0355795 ENGINEERING OF SYSTEMS, METHODS AND OPTIMIZED GUIDE COMPOSITIONS WITH NEW ARCHITECTURES FOR SEQUENCE MANIPULATION
The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are...
2016/0355794 New Bifunctional Lipase Mutant and Uses Thereof in Flour Product Processing
The present invention provides a novel dual-function lipase variant and its application in processing of flour products. The amino acid sequence of the lipase...
2016/0355793 MATERIALS AND METHODS FOR USING AN ACYL-ACYL CARRIER PROTEIN THIOESTERASE AND MUTANTS AND CHIMERAS THEREOF IN...
A method of increasing production of fatty acids comprising introducing into a host and expressing therein an acyl-acyl carrier protein (ACP) thioesterase (TE)...
2016/0355792 ENGINEERED ORGANOPHOSPHORUS ACID ANHYDROLASES AND METHODS OF USE THEREOF
Genetically engineered organophosphorus acid anhydrolases (OPAA) with improved catalytic efficiency and relaxed stereospecificity are provided. The variants...
2016/0355791 FUSION PROTEIN FOR PROTEIN DETECTION, AND METHOD FOR DETECTING PROTEIN
A fusion protein for protein detection in which are fused: a protein domain including at least one among a C1 domain of protein G, a C2 domain of protein G,...
2016/0355790 INFLUENZA VIRUS REPLICATION BY INHIBITING MICRORNA LEC7C BINDING TO INFLUENZA VIRAL CRNA AND MRNA
A vector, composition and method to improve influenza virus replication by inhibiting miRNA lec-7C binding to influenza virus mRNA and/or cRNA.
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