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Patent # Description
2016/0362708 Cell-Free Protein Synthesis Driven Metabolic Engineering
Disclosed are cell-free systems for metabolic engineering, methods for cell-free metabolic engineering, kits for preparing the disclosed systems, and kits for...
2016/0362707 PROCESSING MATERIALS
Biomass feedstocks (e.g., plant biomass, animal biomass, and municipal waste biomass) are processed to produce useful products, such as fuels. For example,...
2016/0362706 METHODS AND SYSTEMS FOR PRODUCING PRODUCTS USING ENGINEERED IRON OXIDIZING BACTERIA AND COPPER METAL
Methods and systems for producing a particular biofuel or a particular chemical using genetically modified iron-oxidizing bacteria (IOB) and copper as a redox...
2016/0362705 Methods for Nuclear Reprogramming Using Synthetic Transcription Factors
The current disclosure provides methods for reprogramming mammalian somatic cells by regulating the expression of endogenous cellular genes. Cellular...
2016/0362704 ISOLATED POLYNUCLEOTIDES AND POLYPEPTIDES AND METHODS OF USING SAME FOR INCREASING PLANT YIELD, BIOMASS, GROWTH...
Provided are isolated polynucleotides encoding a polypeptide at least 80% homologous to the amino acid sequence selected from the group consisting of SEQ ID...
2016/0362703 METHODS OF IMPROVING DROUGHT TOLERANCE AND SEED PRODUCTION IN RICE
The invention provides for compositions and methods for producing plants that have higher yield in drought conditions by manipulating the G-proteins such as...
2016/0362702 PLANTS WITH INCREASED YIELD AND METHOD FOR PRODUCING SAID PLANTS
The invention relates to a method for increasing the yield and biomass of a plant, by means of an increase in the expression of the L-aspartate oxidase in the...
2016/0362701 Effect of PpeGID1c on Vegetative Growth of Fruit Trees
The genetic basis for a recessive dwarf trait (dw) in peach (Prunus persica) was determined. Using a sequencing-based bulk-segregant mapping strategy, dw was...
2016/0362700 REVERSIBLE GENIC MALE STERILITY IN COMPOSITAE
The present invention relates to plants of the Compositae family exhibiting a reversible genic male sterility trait, characterised in that the genic male...
2016/0362699 PLANT CELL COMPRISING MUTATION INTRODUCED IN TARGET DNA, AND METHOD FOR PRODUCING THE PLANT CELL
It has been found that a marker gene, which is inserted in the genomic DNA via homologous recombination, and to both ends of which nuclease recognition sites...
2016/0362698 Method for Stable Gene-Amplification in a Bacterial Host Cell
A bacterial host cell is disclosed including at least two copies of an amplification unit in its genome, the amplification unit including: i) at least one copy...
2016/0362697 METHODS AND SYSTEMS FOR ENGINEERING BACTERIAL SYSTEMS TO SHIELD TOXICITY DURING NON-NATIVE PROTEIN EXPRESSION...
The invention described herein relates to methods, systems, compositions and cells to provide one or more toxic non-native proteins in a cell, wherein the one...
2016/0362696 MODIFIED MICROORGANISM WITH IMPROVED BIOMASS SEPARATION BEHAVIOUR
The present invention relates to a modified microorganism having, compared to its wild-type, a reduced activity of the enzyme that is encoded by the wcaJ-gene....
2016/0362695 Methods and Compositions for Neuroprotection
Disclosed herein are methods and kits useful for providing neuroprotection to neurons in the inner ear and to methods of treating inner ear diseases and...
2016/0362694 METHODS AND COMPOSITIONS FOR THE DIAGNOSIS, CLASSIFICATION, AND TREATMENT OF CANCER
Some embodiments of the present technology relate to methods and compositions for the diagnosis and treatment of cancer. Some embodiments include methods and...
2016/0362693 Reagents and Methods for Treating Cancer
This invention describes a genetic system for targeting the EVI1 gene in mammalian cells. The EVI1 gene is an oncogenic transcription factor that, when...
2016/0362692 TREATMENT OF RETINITIS PIGMENTOSA
A method of treating or preventing retinitis pigmentosa, wherein the method comprises administering an adeno-associated virus (AAV) vector comprising a...
2016/0362691 TRIPTOLIDE DERIVATIVES AND PREPARATION METHOD AND USE THEREOF
Tripyolide-nucleic acid aptamer derivatives, a preparation method and use thereof are shown. The structure of the triptolide-nucleic acid aptamer derivatives...
2016/0362690 NOVEL POLYNUCLEOTIDES AND METHODS FOR INHIBITING CANCER CELLS
The present invention provides methods of inhibiting or reducing the growth of cancer cells in a subject, by administering a therapeutic effective amount of...
2016/0362689 DIFFERENTIALLY EXPRESSED MICRORNA MOLECULES FOR THE TREATMENT AND DIAGNOSIS OF CANCER
A significant challenge in cancer research field is to define molecular features that distinguish cancer stem cells from normal stem cells. In this study,...
2016/0362688 COMPOSITIONS AND METHODS OF USING MICRORNA INHIBITORS
The present invention provides compositions and methods of making and using microRNA inhibitors. In a particular embodiment, the invention features...
2016/0362687 METHODS AND COMPOSITIONS FOR MODULATING ALPHA-1 ANTITRYPSIN EXPRESSION
Disclosed herein are methods for decreasing A1AT mRNA and protein expression and treating, ameliorating, preventing, slowing progression, or stopping...
2016/0362686 COMPOSITION INCLUDING RCC1-REGULATING SUBSTANCE FOR REDUCING SENESCENCE OF CELL OR SUBJECT AND METHOD OF...
A method of controlling senescence in a cell by inhibiting regulator of chromosome condensation 1 (RCC1) gene expression or RCC1 protein activity in the cell.
2016/0362685 IN VIVO PRODUCTION OF SMALL INTERFERING RNAS THAT MEDIATE GENE SILENCING
The invention provides engineered RNA precursors that when expressed in a cell are processed by the cell to produce targeted small interfering RNAs (siRNAs)...
2016/0362684 POOLED METHOD FOR HIGH THROUGHPUT SCREENING OF TRANS FACTORS AFFECTING RNA LEVELS
Provided herein are methods directed to multiplexed detection of the modulation of transcriptional activity using perturbation elements.
2016/0362683 Recombinant Fusion Proteins and Libraries from Immune Cell Repertoires
Disclosed herein are methods and compositions for generating a repertoire of recombinant fusion polypeptides from immune cells, and uses thereof.
2016/0362682 Recombinant Fusion Proteins and Libraries from Immune Cell Repertoires
Disclosed herein are methods and compositions for generating a repertoire of recombinant fusion polypeptides from immune cells, and uses thereof.
2016/0362681 Recombinant Fusion Proteins and Libraries from Immune Cell Repertoires
Disclosed herein are methods and compositions for generating a repertoire of recombinant fusion polypeptides from immune cells, and uses thereof.
2016/0362680 COMPOSITIONS AND METHODS FOR NEGATIVE SELECTION OF NON-DESIRED NUCLEIC ACID SEQUENCES
The present invention provides methods, compositions and kits for the generation of next generation sequencing (NGS) libraries in which non-desired...
2016/0362679 Immunoglobulin Variable Region Libraries
Antigen-specific immunoglobulin V-regions are identified from a library of nucleic acids amplified using polymerase chain reaction using leader ...
2016/0362678 USE OF MICROVESICLES IN DIAGNOSIS AND PROGNOSIS OF MEDICAL DISEASES AND CONDITIONS
The presently disclosed subject matter is directed to methods of aiding diagnosis, prognosis, monitoring and evaluation of a disease or other medical condition...
2016/0362677 SYSTEM AND METHOD FOR PROCESSING AND DETECTING NUCLEIC ACIDS
A system and method for processing and detecting nucleic acids from a set of biological samples, comprising: a capture plate and a capture plate module...
2016/0362676 METHOD FOR MODIFYING NUCLEIC ACIDS
The present invention pertains to: a method for modifying a nucleic acid contained in a sample, said method including a step for bringing the sample into...
2016/0362675 COMPOSITIONS OF PROKARYOTIC PHENYLALANINE AMMONIA-LYASE VARIANTS AND METHODS OF USING COMPOSITIONS THEREOF
Provided herein are phenylalanine ammonia-lyase (PAL) variants produced by prokaryotes, wherein such prokaryotic PAL variant has a greater ...
2016/0362674 BETA-LACTAMASES WITH IMPROVED PROPERTIES FOR THERAPY
This invention relates to, in part, compositions of beta-lactamases and methods of using these enzymes in, for example, gastrointestinal tract (GI tract)...
2016/0362673 Compositions and Methods for Modulating Hemostasis
Factor Xa variants and methods of use thereof are disclosed.
2016/0362672 COAGULATION FACTOR IX COMPOSITIONS AND METHODS OF MAKING AND USING SAME
The present invention relates to compositions comprising factor IX coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic...
2016/0362671 PLASMID-ENCODED NEUROTOXIN GENES IN CLOSTRIDIUM BOTULINUM SEROTYPE A SUBTYPES
The present invention provides a novel isolated plasmid, wherein the plasmid is a native plasmid found in unique C. botulinum type A strains and encode either...
2016/0362670 PH20 POLYPEPTIDE VARIANTS, FORMULATIONS AND USES THEREOF
Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also...
2016/0362669 THERMOPHILIC ETHANOL-RESISTANT -GLUCOSIDASE AND ENCODING GENE AND APPLICATION THEREOF
The present invention discloses thermophilic ethanol-resistant .beta.-glucosidase and an encoding gene and application thereof. The amino acid sequence of the...
2016/0362668 CRISPR HYBRID DNA/RNA POLYNUCLEOTIDES AND METHODS OF USE
The present disclosure provides DNA-guided CRISPR systems; polynucleotides comprising DNA, RNA and mixtures thereof for use with CRISPR systems; and methods of...
2016/0362667 CRISPR-Cas Compositions and Methods
Class 2 CRISPR-Cas nucleoprotein complexes are disclosed comprising a Class 2 CRISPR-Cas protein, a CRISPR-Cas associated polynucleotide lacking a spacer...
2016/0362666 Phytase Variants
The present invention relates to a phytase which has at least 74% identity to a phytase derived from Citrobacter braakii and comprises at least one alteration...
2016/0362665 Phospholipase C Mutant And Use Thereof
The present application provides mutants of wild type phospholipase C (PLC) specific to phosphatidylcholine from Bacillus cereus. The related mutations include...
2016/0362664 MODIFIED POLYMERASES FOR IMPROVED INCORPORATION OF NUCLEOTIDE ANALOGUES
The invention relates to modified polymerase enzymes which exhibit improved incorporation of nucleotide analogues bearing substituents at the 3' position of...
2016/0362663 DIACYLGYLCEROL ACYL TRANSFERASE (DGA1) POLYNUCLEOTIDES, AND METHODS OF INCREASING YEAST CELL LIPID PRODUCTION...
DGA1 catalyzes the final enzymatic step for converting acyl-CoA and 1,2-diacylglycerol to triacylglycerols (TAG) and CoA in yeast. Disclosed are methods for...
2016/0362662 Modified Leucine Dehydrogenase
The present invention provides a means and method useful for measurement of a total branched-chain amino acid concentration. Specifically, the present...
2016/0362661 ENRICHED POPULATIONS OF CARDIOMYOCYTE LINEAGE CELLS FROM PLURIPOTENT STEM CELLS
The invention provides methods for depleting extraneous phenotypes from a mixed population of cells comprising the in vitro differentiated progeny of primate...
2016/0362660 METHOD OF REPAIRING DAMAGED CHONDROCYTES VIA LOW-DOSE IRRADIATION
The present invention relates to a method for inhibiting an inflammatory response in chondrocytes, and dedifferentiation or destruction of chondrocytes by...
2016/0362659 METHOD OF PRODUCING ERYTHROCYTES WITHOUT FEEDER CELLS
Provided herein are methods of producing erythrocytes from hematopoietic cells, particularly hematopoietic cells from placental perforate in combination with...
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