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Patent # Description
2016/0362458 MODIFIED MICROBIAL TOXIN RECEPTOR FOR DELIVERING AGENTS INTO CELLS
We described a novel system of targeted cell therapy with a protein toxin, such as anthrax toxin, that has been modified to re-direct it to a desired cell...
2016/0362457 Immunogenic Proteins and Compositions
The invention provides proteins and compositions for the treatment and prevention of Streptococcus agalactiae (Group B streptococcus; GBS)
2016/0362456 MODIFIED MICROORGANISMS FOR CHEMICAL PRODUCTION
The present invention relates to increasing xylose utilization in industrial microbe by inducing mutations in the regulator genes, crp and xylR. Thus the...
2016/0362455 INFLUENZA VIRUS VACCINES AND USES THEREOF
The present disclosure provides influenza hemagglutinin stem domain polypeptides comprising (a) an influenza hemagglutinin HA1 domain that comprises an HA1...
2016/0362454 Identification and Attenuation of the Immunosuppressive Domains in Fusion Proteins of Enveloped RNA Viruses
The present invention relates to enveloped RNA viruses. The invention in particular relates to the generation of superior antigens for mounting an immune...
2016/0362453 RECOMBINANT BINDING PROTEINS AND THEIR USE
New designed ankyrin repeat domains with binding specificity for serum albumin, recombinant binding proteins comprising at least two designed ankyrin repeat...
2016/0362452 SYNTHETIC PEPTIDE FOR REPRESSING TRANSCRIPTION AND/OR GENE EXPRESSION FROM A BINDING SITE OF INTEREST
A synthetic peptide includes an amino acid sequence that: has 70-75%, 75-80%, 80-85%, 85-90%, 90-95% or 95-100% homology with an RpoN box of Region III of an...
2016/0362451 SELF-ASSEMBLING PEPTIDE COMPOSITIONS
The present disclosure provides peptide compositions (e.g., of self-assembling peptides) with particular attributes (e.g., peptide identity, peptide...
2016/0362450 SYNTHETIC PEPTIDE AMIDES
The invention relates to synthetic peptide amide ligands of the kappa opioid receptor and particularly to agonists of the kappa opioid receptor that exhibit...
2016/0362449 SYNTHESIS OF BORONIC ESTER AND ACID COMPOUNDS
The invention relates to the synthesis of boronic ester and acid compounds. More particularly, the invention provides improved synthetic processes for the...
2016/0362448 METHODS FOR REDUCING CHROMATIN CONTENT IN PROTEIN PREPARATIONS BY TREATMENT WITH ALKYL CATIONS
A method of reducing aggregate content in a preparation having a target protein includes contacting the preparation with an alkyl cation to form a mixture, and...
2016/0362447 METHODS FOR REDUCING AGGREGATE CONTENT OF PROTEIN PREPARATIONS BY TREATMENT WITH ARYL ANIONS
A method of reducing the aggregate content in a preparation having a target protein includes contacting the preparation with an aryl anion to form a mixture...
2016/0362446 ANTIBODY PURIFICATION PROCESS
A method of purifying a target antibody includes contacting a cell culture harvest or a protein preparation including at least one target antibody with at...
2016/0362445 SOLID PHASE PEPTIDE SYNTHESIS VIA SIDE CHAIN ATTACHMENT
The present application discloses peptides and peptaibols of high purity may be obtained by solid phase peptide synthesis using as the starting resin hydroxy...
2016/0362444 Method for Treating Diabetes
This application is directed to the use of steroid compounds for the selective inhibition of the enzyme PTP1B in a mammal for the treatment of diabetes.
2016/0362443 Method For DHEA Enanthate Processing
A method is provided for producing dehydroepiandrosterone (DHEA) enanthate. The method comprises placing a portion of unprocessed DHEA into a solvent, such as...
2016/0362442 Method For DHEA Enanthate Processing
A method is provided for producing dehydroepiandrosterone (DHEA) enanthate. The method comprises placing a portion of unprocessed DHEA into a solvent, such as...
2016/0362441 CYCLIC DINUCLEOTIDES FOR CYTOKINE INDUCTION
A cyclic dinucleotide compound of Formula (I): ##STR00001## wherein X.sub.1 is H or F; X.sub.2 is H or F; at least one among X.sub.1 and X.sub.2 is a fluorine...
2016/0362440 Synthesis of Protected 3'-Amino Nucleoside Monomers
Orthogonally protected 3'-amino nucleoside monomers and efficient methods for their synthesis are described. The methods employ selective protection of the...
2016/0362439 CYCLIC PEROXIDES AS PRODRUGS FOR SELECTIVE DELIVERY OF AGENTS
Disclosed herein, inter alia, are prodrug compositions and methods of using the same for treatment and detection of disease. Specifically, disclosed herein is...
2016/0362438 5-FORMYLCYTOSINE SPECIFIC CHEMICAL LABELING METHOD AND RELATED APPLICATIONS
The present invention relates to a 5-formylcytosine specific chemical labeling method and related applications in aspects such as sequencing, detection,...
2016/0362437 Method for Producing Lentztrehalose A, Compound Useful for the Method, and Method for Producing the Compound
A method for producing a compound represented by Structural Formula (1), including: introducing benzyl group into trehalose to produce at least one of compound...
2016/0362436 SIALIC ACID DERIVATIVES
Sialic acid derivatives of the formula (I) ##STR00001##
2016/0362435 PROCESS FOR ISOLATING FERMENTABLE SUGARS FROM THE ACID HYDROLYZATE OF A MATERIAL CONTAINING CELLULOSE,...
The present invention provides a process for isolating fermentable sugars from the acid hydrolyzate of a material containing cellulose, hemicellulose and...
2016/0362434 METHODS AND COMPOUNDS FOR ENHANCING CONTRAST IN MAGNETIC RESONANCE IMAGING (MRI)
The present application relates to methods and compounds for enhancing contrast in magnetic resonance imaging. The methods comprise administering compounds of...
2016/0362433 ETHER COMPOUNDS FOR TREATMENT OF COMPLEMENT MEDIATED DISORDERS
Compounds, methods of use, and processes for making inhibitors of complement factor D comprising Formula I, or a pharmaceutically acceptable salt or...
2016/0362432 PHOSPHONATE COMPOUNDS FOR TREATMENT OF COMPLEMENT MEDIATED DISORDERS
Compounds, methods of use, and processes for making inhibitors of complement factor D comprising Formula I, or a pharmaceutically acceptable salt or...
2016/0362431 Carbidopa And L-Dopa Prodrugs And Methods Of Use
The present disclosure relates to (a) carbidopa prodrugs, (b) pharmaceutical combinations and compositions comprising a carbidopa prodrug and/or an L-dopa...
2016/0362430 MODIFIED OPIOIDS CONTAINING SILICON
A modified opioid is provided comprising modified morphine molecules, wherein for each morphine molecule, one or more carbon atoms are replaced with silicon...
2016/0362429 HALOGEN FREE SYNTHESIS OF AMINOSILANES BY CATALYTIC DEHYDROGENATIVE COUPLING
Compounds and method of preparation of Si--X and Ge--X compounds (X.dbd.N, P, As and Sb) via dehydrogenative coupling between the corresponding unsubstituted...
2016/0362428 Synthesis and Isolation of Crystalline Alkali Metal Arene Radical Anions
Certain embodiments are directed to a composition comprising a complex of the general formula [M(crown ether)(solvent).sub.n][arene.sup.-.cndot.], wherein M is...
2016/0362427 BRIDGED BICYCLIC KALLIKREIN INHIBITORS
Provided herein are kallikrein modulating compounds, pharmaceutical compositions comprising the same, and uses thereof.
2016/0362426 PROCESS FOR THE SYNTHESIS OF A PHOSPHOINOSITIDE 3-KINASE INHIBITOR
The present application is directed to processes and intermediates for making (S)-7-(1-((9H-purin-6-yl)amino)ethyl)-6-(3-fluorophenyl)-3-methyl-- ...
2016/0362425 CRYSTALLINE FORMS OF A PI3K INHIBITOR
The present invention is related to crystalline forms of (S)-7-(1-(9H-purin-6-ylamino)ethyl)-6-(3-fluorophenyl)-3-methyl-5H-thiazo- lo[3,2-a]pyrimidin-5-one...
2016/0362424 SALTS OF (S)-7-(1-(9H-PURIN-6-YLAMINO)ETHYL)-6-(3-FLUOROPHENYL)-3-METHYL-5- H-THIAZOLO[3,2-A]PYRIMIDIN-5-ONE
The present invention relates to salt forms of the phosphoinositide 3-kinase (PI3K) inhibitor ...
2016/0362423 7-OXO-THIAZOLOPYRIDINE CARBONIC ACID DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF...
The present invention relates to a compound having the general formula (A), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph,...
2016/0362422 BROAD SPECTRUM BETA-LACTAMASE INHIBITORS
Broad spectrum beta-lactamase inhibitors. Certain inhibitors also exhibit potent antibiotic activity in addition to beta-lactamase inhibition. Compounds of the...
2016/0362421 FUSED HETEROCYCLIC COMPOUNDS AS ION CHANNEL MODULATORS
The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including...
2016/0362420 Antiparasitic Compositions and Methods Utilizing Substituted 5,5,7,7-Tetramethyl-...
The present disclosure relates generally to systems, methods, and compounds for therapeutic use against parasitic infections. More particularly, the disclosure...
2016/0362419 POLYMORPHOUS FORMS OF RIFAXIMIN, PROCESSES FOR THEIR PRODUCTION AND USE THEREOF IN THE MEDICINAL PREPARATIONS
Crystalline polymorphous forms of the rifaximin (INN) antibiotic named rifaximin .delta. and rifaximin .epsilon. useful in the production of medicinal...
2016/0362418 CARBOXAMIDE-SUBSTITUTED XANTHENE DYES
Carboxamide-substituted xanthene dyes, reactive dyes, and the use of such dyes as a labeling reagent are disclosed. Specifically, a carboxamide-substituted dye...
2016/0362417 Process for the Preparation of 5-Fluorotryptophol
The present invention relates to a process for the preparation of 5-fluorotryptophol as well as a process for the preparation of ...
2016/0362416 ANTIVIRAL COMPOUNDS
The disclosure is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such...
2016/0362415 POLYMORPHIC FORMS OF NALTREXONE
This invention relates to the discovery of novel polymorphic forms of naltrexone, including solvates, hydrates, anhydrous and other crystalline forms and...
2016/0362414 MACROCYCLES AS FACTOR XIA INHIBITORS
The present invention provides compounds of Formula (I): ##STR00001## or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein all...
2016/0362413 POLYMORPHIC FORM OF ALCAFTADINE, COMPOSITION AND PROCESS
The present invention relates to novel polymorphic forms of alcaftadine, processes of preparing novel polymorphic forms of alcaftadine and pharmaceutical...
2016/0362412 IDO Inhibitors
Presently provided are IDO inhibitors and pharmaceutical compositions thereof, useful for modulating an activity of indoleamine 2,3-dioxygenase; treating...
2016/0362411 PROCESSES FOR MAKING PONATINIB AND INTERMEDIATES THEREOF
Methods are disclosed for making 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methylpiperazin- -1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide,...
2016/0362410 PYRAZOLO[1,5-A]PYRIMIDINE-5,7-DIAMINE COMPOUNDS AS CDK INHIBITORS AND THEIR THERAPEUTIC USE
The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain ...
2016/0362409 N2-PHENYL-PYRIDO[3,4-D]PYRIMIDINE-2, 8-DIAMINE DERIVATIVES AND THEIR USE AS MPS1 INHIBITORS
The present invention relates to compounds of formula I: ##STR00001## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are all as defined herein. The compounds of...
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