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Patent # Description
2016/0362408 ARYL- AND HETARYL-SUBSTITUTED IMIDAZO[1,2-A]PYRIDINE-3-CARBOXAMIDES AND USE THEREOF
The present application relates to novel aryl- and hetaryl-substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for preparation thereof, to the use...
2016/0362407 HETEROCYCLIC INHIBITORS OF ERK1 AND ERK2 AND THEIR USE IN THE TREATMENT OF CANCER
The present application provides novel heterocyclic compounds and pharmaceutically acceptable salts thereof. Also provided are methods for preparing these...
2016/0362406 HETEROCYCLIC INHIBITORS OF ERK1 AND ERK2 AND THEIR USE IN THE TREATMENT OF CANCER
The present application provides novel heterocyclic compounds and pharmaceutically acceptable salts thereof. Also provided are methods for preparing these...
2016/0362405 HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF
Provided herein are heterocyclic compounds for treatment of CSF1R, FLT3, KIT, and/or PDGFR.beta. kinase mediated diseases. Also provided are pharmaceutical...
2016/0362404 NEW COMPOUNDS
The present invention encompasses compounds of general formula (1) ##STR00001## wherein A, B, X, R.sup.l to R.sup.3 are defined as in claim 1, which are suitable...
2016/0362403 NOVEL DISUBSTITUTED 3,4-DIAMINO-3-CYCLOBUTENE-1,2-DIONE COMPOUNDS FOR USE IN THE TREATMENT OF...
Methods for preparing disubstituted 3,4-diamino-3-cyclobutene-1,2-dione compounds that correspond to general formula (I) are described. Also described are...
2016/0362402 NOVEL COMPOUNDS HAVING ANTI-ALLODYNIC AND ANTIHYPERALGESIC ACTIVITY
The present invention relates to molecules of formula (I) where R1=--SO.sub.3H, --PO.sub.3H, --PO.sub.2(OH).sub.2, --OPO.sub.2H.sub.2, --NHSO.sub.3H,...
2016/0362401 PROCESS FOR TOTAL SYNTHESIS OF FLAVONOID COMPOUNDS AND ISOMERS THEREOF
The present invention relates to the a process for total synthesis of flavonoid compounds of general formula I and isomers thereof ##STR00001## wherein R.sub.1...
2016/0362400 AVANAFIL PREPARATION METHOD
Disclosed is a method for preparing avanafil (I) by using cytosine as the starting material. The preparation steps comprise: using cytosine as the raw...
2016/0362399 ARYL, HETEROARYL, AND HETEROCYCLIC COMPOUNDS FOR TREATMENT OF COMPLEMENT MEDIATED DISORDERS
Compounds, methods of use, and processes for making inhibitors of complement factor D comprising Formula I, or a pharmaceutically acceptable salt or...
2016/0362398 AMIDE COMPOUNDS FOR TREATMENT OF COMPLEMENT MEDIATED DISORDERS
Compounds, methods of use, and processes for making inhibitors of complement factor D comprising Formula I, or a pharmaceutically acceptable salt or...
2016/0362397 COMPOUNDS TARGETING PROTEINS, COMPOSITIONS, METHODS, AND USES THEREOF
The present invention provides modulators of protein function, to restore protein homeostasis, including cytokine, aiolos, and/or ikaros activity, and...
2016/0362396 QUINAZOLINES AS POTASSIUM ION CHANNEL INHIBITORS
A compound of formula I ##STR00001## wherein A, X, Y, Z, R.sub.1 and R.sub.24 are described herein. The compounds are useful as inhibitors of potassium channel...
2016/0362395 INDOLE, INDAZOLE AND BENZIMIDAZOLE ARYLAMIDES AS P2X3 AND P2X2/3 ANTAGONISTS
Compounds of the formula I: ##STR00001## or a pharmaceutically acceptable salt thereof, wherein, X, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are as defined...
2016/0362394 CARBAMATE-SUBSTITUTED OXINDOLE DERIVATIVES AND USE THEREOF FOR THE TREATMENT OF VASOPRESSIN-DEPENDENT DISEASES
The present invention relates to novel carbamate-substituted oxindole derivatives, pharmaceutical compositions comprising them, and their use for the treatment...
2016/0362393 ENDOPARASITE CONTROL AGENT
The present invention is intended to provide a novel parasiticide, antiprotozoal or other endoparasite control agents which are effective for controlling...
2016/0362392 GLUCAGON RECEPTOR MODULATORS
The present invention provides a compound of Formula (I) ##STR00001## or a pharmaceutically acceptable salt thereof wherein R.sup.1, R.sup.2, R.sup.3, A.sup.1,...
2016/0362391 Improved Process for the Preparation of Pomalidomide and its Purification
Methods of synthesizing pomalidomide are disclosed. Further, methods of purifying pomalidomide from a reaction mixture are also disclosed.
2016/0362390 TRICYCLIC INHIBITORS OF HIF-2-ALPHA AND USES THEREOF
Compounds comprising a fused tricylic core that modulate HIF-2.alpha. activity, pharmaceutical compositions containing these chemical entities, and methods of...
2016/0362389 SYNTHETIC INTERMEDIATE OF 1-(2-DEOXY-2-FLUORO-4-THIO- -D-ARABINOFURANOSYL)CYTOSINE, SYNTHETIC INTERMEDIATE OF...
A compound represented by a formula [1D] as shown below (wherein R.sup.1A, R.sup.1B, R.sup.2A, R.sup.2B, R.sup.3A and R.sup.3B represent a hydrogen atom, an...
2016/0362388 CHEMILUMINESCENT METHODS AND REAGENTS FOR ANALYTE DETECTION
The present invention relates to chemiluminescent method and regent to detect analyte. One aspect of the current invention relates to using enzyme substrate...
2016/0362387 PART-STREAM DISTILLATION
A continuous process for the preparation of propylene oxide, comprising (a) reacting propene, optionally admixed with propane, with hydrogen peroxide in a...
2016/0362386 CYSTINE DIAMIDE ANALOGS FOR THE PREVENTION OF CYSTINE STONE FORMATION IN CYSTINURIA
Cystine analogs that improve the solubility of L-cystine in urine for treatment of cystinuria and which have the structure: ##STR00001## and pharmaceutically...
2016/0362385 METHOD FOR PRODUCING 1,4-BENZOXAZINE COMPOUND
The present invention provides an industrially advantageous method for producing a 1,4-benzoxazine compound useful as a medicine while avoiding safety and...
2016/0362384 TRIAZOLE-BASED READER MOLECULES AND METHODS FOR SYNTHESIZING AND USE THEREOF
Triazole-based molecules, methods of making and using the same are provided. Triazole-based molecules may be used as reading molecules and incorporated into or...
2016/0362383 ETHYNYL DERIVATIVES
The present invention relates to compounds that may be used in the treatment or prevention of disorders relating to allosteric modulation of the mGluR4...
2016/0362382 BENZAMIDE DERIVATIVES
Disclosed are benzamide derivatives useful in slowing the expansion of cancer cells.
2016/0362381 NOVEL PROCESS FOR PREPARING ENZALUTAMIDE
The present invention provides a process for the efficient preparation of enzalutamide.
2016/0362380 METHOD FOR DECARBOXYLATION OF AMINO ACIDS VIA IMINE FORMATION
The present application provides methods for decarboxylation of amino acids via imine formation with a catalyst under pressurized, heated, conditions in either...
2016/0362379 POLYMORPHS OF 3-DIFLUOROMETHYL-1-METHYL-1 H-PYRAZOLE-4-CARBOXYLIC ACID ...
The present invention relates to solid forms of the fungicide of formula (I): compositions comprising the solid forms and methods of their use as fungicides.
2016/0362378 MCT4 INHIBITORS FOR TREATING DISEASE
Disclosed herein are compounds and compositions useful in the treatment of MCT4 mediated diseases, such as proliferative and inflammatory diseases, having the...
2016/0362377 R-7-(3-AMINOMETHYL-4-METHOXYIMINO-3-METHYL-PYRROLIDIN-1-YL)-1-CYCLOPROPYL-- ...
Disclosed herein are R-7-(3-aminomethyl-4-methoxyimino-3-methyl-pyrrolidin-1-yl)-1-cyclopropyl- -6-fluoro-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid...
2016/0362376 SULFONAMIDE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALT THEREOF
The present invention aims to provide a novel low-molecular-weight compound having an orexin agonist activity, which is expected to be useful as a superior...
2016/0362375 Iodine(III)-Mediated Radiofluorination
A process for fluorination of aromatic compounds employing iodonium ylides and applicable to radiofluorination using .sup.18F is described. Processes,...
2016/0362374 PIPERIDINE COMPOUNDS, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME AND ITS USE
Piperidine compounds and pharmaceutically useful salts thereof, a pharmaceutical composition including an effective amount of the racemic or enantiomerically...
2016/0362373 Pro-Neurogenic Compounds
This technology relates generally to compounds and methods for stimulating neurogenesis (e.g., post-natal neurogenesis, including post-natal hippocampal and...
2016/0362372 PRO-NEUROGENIC COMPOUNDS
This invention relates generally to stimulating neurogenesis (e.g., post-natal neurogenesis, e.g., post-natal hippocampal neurogenesis) and protecting from...
2016/0362371 NOVEL TRICYCLIC COMPOUNDS AND PREPARATION THEREOF
The present invention provides novel tricyclic compound of Formula I or its stereoisomer or ester or pharmaceutically acceptable salts and preparation thereof...
2016/0362370 NUCLEAR RECEPTOR MODULATORS
The invention provides compounds of Formula (I) ##STR00001## pharmaceutically acceptable salts, thereof wherein the variable are defined herein. The compounds of...
2016/0362369 METHOD FOR PRODUCING OPTICALLY ACTIVE AZETIDINONE COMPOUND
There is provided a novel and stereoselective method for producing an optically active azetidinone compound. An optically active azetidinone compound of...
2016/0362368 NOVEL ANILINE DERIVATIVE, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND USE THEREOF
[Problem] The present invention provides a novel compound having an S1P.sub.1 receptor antagonistic activity. [Solution] The present invention provides a compound...
2016/0362367 Industrial Methods for Producing Arylsulfur Pentafluorides
Industrial methods for producing arylsulfur pentafluorides are disclosed. Methods include reacting arylsulfur halotetrafluoride with hydrogen fluoride in the...
2016/0362366 Industrial Methods for Producing Arylsulfur Pentafluorides
Industrial methods for producing arylsulfur pentafluorides are disclosed. Methods include reacting arylsulfur halotetrafluoride with hydrogen fluoride in the...
2016/0362365 Industrial Methods for Producing Arylsulfur Pentafluorides
Industrial methods for producing arylsulfur pentafluorides are disclosed. Methods include reacting arylsulfur halotetrafluoride with hydrogen fluoride in the...
2016/0362364 (3-ALKYLTHIO)PROPENOIC ACID-DERIVED COMPOUNDS AND THEIR APPLICATION IN COSMETICS
The present invention relates to compounds of general formula (I): ##STR00001## wherein Y, R.sub.1, R.sub.2 and R.sub.3 are as defined in the specification. The...
2016/0362363 A PROCESS FOR THE REMOVAL OF SODIUM FROM DI-SULFIDE OIL
In the present disclosure there is provided a process for obtaining di-sulfide oil having sodium level below 0.1 ppm wherein a stream comprising di-sulfide oil...
2016/0362362 COMPOSITIONS, METHODS, AND SYSTEMS FOR THE SYNTHESIS AND USE OF IMAGING AGENTS
The present invention generally relates to novel synthetic methods, systems, kits, salts, and precursors useful in medical imaging. In some embodiments, the...
2016/0362361 NITRONE COMPOUNDS AND THEIR USE IN PERSONAL CARE
Provided are compounds and compositions thereof that are useful as antioxidants in personal care formulations. The compounds are of the Formula I: ...
2016/0362360 UREA PRODUCTION PLANT
Disclosed is a plant for the production of urea. The plant comprises conventional sections for synthesis and recovery, for evaporation and condensation, for...
2016/0362359 POROUS COORDINATION POLYMER AND APPLICATION THEREFOR
An object of the present invention is to provide a novel porous coordination polymer having superhydrophobicity. The present invention relates to a porous...
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