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ANTI-MET IN COMBINATION WITH ANTI-VEGFR2 ANTIBODIES THERAPY FOR CANCER
The present invention provides preparation of medicaments for use in treating and methods of treating cancer selected from the group consisting of gastric...
ANTIBODY DRUG CONJUGATES (ADC) THAT BIND TO 158P1D7 PROTEINS
Antibody drug conjugates (ADC's) that bind to 158P1D7 protein and variants thereof are described herein. 158P1D7 exhibits tissue specific expression in normal...
MULTISPECIFIC NK ENGAGER PROTEINS
Multispecific proteins that bind and specifically redirect NK cells to lyse a target cell of interest are provided without non-specific activation of NK cells...
NOVEL ANTI-TRANSFERRIN RECEPTOR ANTIBODY THAT PASSES THROUGH BLOOD-BRAIN
Disclosed are novel anti transferrin receptor antibody that can pass through the blood-brain barrier, a fusion protein comprising a protein necessary to be...
4-1BB BINDING MOLECULES
The present disclosure provides isolated binding molecules that bind to human 4-1BB, nucleic acid molecules encoding an amino acid sequence of the binding...
Anti-BAFFR antibodies are formulated as lyophilisate or liquid formulation. The lyophilisates can be reconstituted to give a solution with a high concentration...
FULLY HUMAN ANTIBODIES AGAINST HUMAN 4-1BB
Fully human antibodies and antigen-binding portions thereof that bind to human 4-1BB and that allow binding of human 4-1BB to a human 4-1BB ligand. In one...
Antibodies, Uses & Methods
The present invention relates to anti-human OX4OL antibodies, new medical uses and methods.
METHODS AND COMPOSITIONS FOR TREATING SOLID TUMORS AND ENHANCING TUMOR
The present invention provides methods of treating and enhancing efficacy of immunotherapy for a solid tumor in a subject, comprising the step of contacting...
IDENTIFICATION OF CXCR8, A NOVEL CHEMOKINE RECEPTOR
Method of treating a subject for a disorder that correlates to increased CXCR8 signaling. The method includes disrupting the activation of receptor CXCR8 by...
ANTI-CLL-1 ANTIBODIES AND METHODS OF USE
The present invention relates to anti-CLL-1 antibodies including anti-CLL-1 antibodies comprising a CLL-1 binding domain and a CD3 binding domain (e.g.,...
ALPHA-V BETA-6 INTEGRIN-BINDING ANTIBODY FRAGMENTS
The present invention provides isolated, engineered multivalent antibody fragments that specifically bind .alpha..sub.V.beta..sub.6 integrin. In particular...
A METHOD OF INCREASING GIPCR SIGNALIZATION IN THE CELLS OF A SCOLIOTIC
There is provided a method of increasing GIPCR signalization in the cells of a subject in need thereof comprising administering to the subject an effective...
SOLUBLE MIC NEUTRALIZING MONOCLONAL ANTIBODY FOR TREATING CANCER
Disclosed are compositions and methods relating to antibodies that bind soluble Major Histocompatibility Complex class I chain-related (sMIC). Specifically,...
ANTI B7-H3 ANTIBODY
The present invention relates to an antibody having a therapeutic effect on a tumor. That is, the invention relates to an antibody which binds to B7-H3 to...
ANTI-CTLA-4 ANTIBODIES AND METHODS OF USE THEREOF
The instant disclosure provides antibodies that specifically bind to human CTLA-4 and antagonize CTLA-4 function. Also provided are pharmaceutical compositions...
HUMAN CD3 BINDING ANTIBODY
The invention is among others concerned with human CD3 binding antibodies comprising a heavy chain and light chain wherein said heavy chain comprises a...
BISPECIFIC CONSTRUCTS AND THEIR USE IN THE TREATMENT OF VARIOUS DISEASES
The present invention relates to bispecific constructs that specifically bind to cytotoxic T cells and, simultaneously, to IL5R-carrying target cells, as well...
Therapeutic Use of Anti-CD22 Antibodies for Inducing Trogocytosis
Disclosed are methods and compositions of anti-B cell antibodies, preferably anti-CD22 antibodies, for diagnosis, prognosis and therapy of B-cell associated...
HUMANIZED AND AFFINITY MATURED ANTIBODIES TO FcRH5 AND METHODS OF USE
The present invention relates to anti-FcRH5 antibodies, including anti-FcRH5 antibodies comprising an FcRH5 binding domain and a CD3 binding domain (e.g.,...
Compositions Comprising Antibodies to Lingo or Fragments Thereof
Endogenous LINGO-1 is a negative regulator for neuronal survival, axon regeneration, oligodendrocyte differentiation and myelination. Molecules that block...
COMPOSITIONS AND METHODS FOR TREATING OBESITY
The present invention provides anti-ghrelin antibodies or antigen-binding molecules that are capable of sequestering ghrelin and inhibiting ghrelin-mediated...
Treatment of Dermatological Pathologies
Skin inflammation in a human subject is reduced by administering to the subject a pharmaceutical composition that includes a pharmaceutically acceptable...
HUMAN ANTI-IL-32 ANTIBODIES
Provided are novel IL-32 binding molecules of human origin, particularly human anti-IL-32 antibodies as well as IL-32 binding fragments, derivatives and...
INHIBITION OF GRANULOCYTE COLONY STIMULATING FACTOR IN THE TREATMENT OF
The present invention relates to the discovery that granulocyte colony stimulating factor (G-CSF) as well as granulocyte colony stimulating factor receptor...
ANTI EOTAXIN-2 ANTIBODIES THAT RECOGNIZE ADDITIONAL CCR3-BINDING
Provided are isolated polyspecific antibodies directed to a unique epitope in the chemokine eotaxin 2. The antibodies bind additional CCR3-binding chemokines....
AMINO ACID SEQUENCES DIRECTED AGAINST THE ANGIOPOIETIN/TIE SYSTEM AND
POLYPEPTIDES COMPRISING THE SAME FOR THE...
The present invention relates to amino acid sequences that are directed against proteins from the group of the Angiopoietin/Tie family such as Tie1, Tie2,...
HUMANIZED ANTIBODIES SPECIFIC TO THE PROTOFIBRILLAR FORM OF THE
The present application relates to humanized antibodies specific to the protofibrillar form of the beta-amyloid peptide, and to the use of said antibodies in...
ANTIBODIES TO KALLIDIN AND DES-ARG9-KALLIDIN
The invention provides antibodies that specifically bind to Kallidin or des-Arg10-Kallidin. The invention also provides pharmaceutical compositions, as well as...
METHODS AND COMPOSITIONS FOR THE TREATMENT OF BETA-THALASSEMIA
Methods and compositions for the treatment of .beta.-thalassemia are provided. Methods and compositions restore or increase erythrocyte maturation in...
IMMUNOGLOBULIN-LIKE MOLECULES DIRECTED AGAINST FIBRONECTIN-EDA
The present invention is concerned with immunoglobulin (Ig)-like molecules or fragments thereof for use in treatment, prevention, or prevention of progression...
ANTI-COMPLEMENT FACTOR C1Q ANTIBODIES AND USES THEREOF
The present invention provides anti-C1q antibodies and methods of using the same.
Methods, compositions and kits for treating a subject using a recombinant
neutralizing binding protein
Methods, compositions and kits are provided for treating a subject exposed to or at risk for exposure to a disease agent using a pharmaceutical composition...
IGA MULTI-SPECIFIC BINDING MOLECULES
The present invention concerns IgA multi-specific binding molecules. In particular, the invention concerns multi-specific, including bispecific, binding...
The invention relates to a modified process for the purification of IgG, improving the yield of IgG per liter of starting material without compromising the...
NOVEL POLYVALENT IMMUNOTHERAPEUTICS OF HIGH SPECIFICITY BASED ON MODIFIED
ANTIBODIES AND A LYOPHILIZED...
The invention is related to the production and development of a lyophilized injectable formulation of modified antibodies or their variants, highly specific...
METHOD FOR OBTAINING THIN FIBRIL COLLAGEN BY CONTACTING NATIVE COLLAGEN
WITH AN ANTIBODY
A collagen material having a form of thin fibrils generally free of fibril-bundling proteogylcan interactions, and a method for providing the thin fibril...
METHODS AND COMPOSITIONS FOR THE INHIBITION OF TRPV4
TRPV4 activation increases vascular permeability and can be triggered by both chemical and mechanical cues. This activation of TRPV4 can contribute to a number...
NOVEL a4B7 PEPTIDE DIMER ANTAGONISTS
The invention relates to disulfide-rich dimer molecules which inhibit binding of .alpha.4.beta.7 to the mucosal addressin cell adhesion molecule (MAdCAM) in...
Novel peptides and combination of peptides for use in immunotherapy and
methods for generating scaffolds for...
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
TRIFUNCTIONAL T CELL-ANTIGEN COUPLER AND METHODS AND USES THEREOF
A trifunctional molecule comprising a target-specific ligand, a ligand that binds a protein associated with the TCR complex and a T cell receptor signaling...
TENEURIN C-TERMINAL ASSOCIATED PEPTIDES (TCAP) AND METHODS AND USES
The invention provides a novel family of biologically active neuropeptides and the nucleic aid molecules coding for same. The peptides are derived for the...
Melanocortin Receptor Ligands
The present invention is directed to compounds according to formula, (R.sup.2R.sup.3)-A.sup.1-c(A.sup.2-A.sup.3-A.sup.4-A.sup.5-A.sup.6-A.sup- ...
Glycosylated Polypeptide and Drug Composition Containing said Polypeptide
[Problem] To provide a glycosylated polypeptide having affinity to somatostatin receptors and, compared to somatostatins, having improved in-blood stability....
GLUCAGON AND GLP-1 CO-AGONIST COMPOUNDS
The present invention provides glucagon and GLP-1 co-agonist compounds that are useful in the treatment of type 2 diabetes, obesity, nonalcoholic fatty liver...
The embodiments relate to surface-binding peptides having the capability of binding to surfaces of biocompatible materials and can thereby be used to...
HJURP PEPTIDES AND VACCINES INCLUDING THE SAME
Isolated peptides derived from SEQ ID NO: 50 and fragments thereof that bind to an HLA antigen and induce cytotoxic T lymphocytes (CTL) and thus are suitable...
IL-17 Binding Compounds and Medical Uses Thereof
The present invention relates to new IL-17 inhibiting polypeptides, corresponding fusion proteins, compositions and medical uses thereof.
METHOD OF PREVENTIVELY TREATING A SUBJECT AT THE RISK OF DEVELOPING
INFECTIONS OF A RESPIRATORY VIRUS
A method of preventively treating a subject at the risk of developing infections of a respiratory virus is disclosed. The method includes a step of...
COMPOUND, USE, ANTI-TUMOR PHARMACEUTICAL COMPOSITION,GENE CONSTRCT FOR
POLYPEPTIDE EXPRESSION, PROCESS FOR THE...
The use of HspBP1 protein or part thereof for the preparation of an anti-tumor pharmaceutical composition, and its optional combination with one or more...