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Patent # Description
2016/0368954 METHODS FOR TREATING DISORDERS THAT INVOLVE IMMUNOGLOBULIN A
Provided herein are FDC-SP polypeptides and methods of using such polypeptides. Methods include, but are not limited to, altering IgA concentration in a...
2016/0368953 BACTERIOCIN WITH NOVEL ACTIVITY
A bacteriocin produced constitutively by Streptococcus thermophilus strain 110 (NRRL B59671), thermophilin 110, kills and/or inhibits the growth Streptococcus...
2016/0368952 Proteins and nucleic acids useful in vaccines targeting staphylococcus aureus
The present invention relates to proteins and nucleic acids derived from Staphylococcus aureus as well as therapeutic and diagnostic uses of the proteins and...
2016/0368951 ANTIGEN CHIMERA, ANTIGEN COMPOSITION, VACCINE, METHOD OF PREPARING THE SAME AND CASSETTE THEREOF
The present invention provides an antigen chimera, comprising: a fusion protein of an antigen and a mucosal immune adjuvant protein monomer capable of forming...
2016/0368950 Immunogenic Compositions and Methods
Disclosed are immunogenic compositions and methods for their use in the formulation and administration of therapeutic and prophylactic pharmaceutical agents....
2016/0368949 INFLUENZA VIRUS RECOMBINANT PROTEINS
The present invention includes influenza Hemagglutinin protein fragments that fold properly when expressed in bacteria.
2016/0368948 IMMUNOGENIC WT-1 PEPTIDES AND METHODS OF USE THEREOF
This invention provides peptides, immunogenic compositions and vaccines comprising same, and methods of treating, reducing the incidence of, and inducing...
2016/0368947 NMDA Receptor Modulators and Uses Thereof
Disclosed are compounds having enhanced potency in the modulation of NMDA receptor activity. Such compounds are contemplated for use in the treatment of...
2016/0368946 TRIPEPTIDE EPOXY KETONE PROTEASE INHIBITORS
Provided herein are tripeptide epoxy ketone protease inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the...
2016/0368945 CHIRAL SPECIFIC BORON-CONTAINING COMPOUNDS AND THEIR USE IN TREATING CANCER OR AMYLOIDOSIS
Useful chiral specific boron-containing compounds, such as boronate, boronate esters, boranamines, borane diamines, boranamine thioesters, and boronic...
2016/0368944 LINKED PURINE PTERIN HPPK INHIBITORS USEFUL AS ANTIBACTERIAL AGENTS
The disclosure provides linked purine pterin compounds and analogues thereof that are novel HPPK inhibitors. The HPPK inhibitors described herein are compounds...
2016/0368943 SUBSTITUTED PURINE COMPOUNDS
The present invention relates to substituted purine compounds. The present invention also relates to pharmaceutical compositions containing these compounds and...
2016/0368942 ANTIBACTERIAL AMINOGLYCOSIDE ANALOGS
Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): ##STR00001## including stereoisomers, pharmaceutically...
2016/0368941 NOVEL METHODS OF ISOMERIZING CARBOHYDRATES
The invention provides a method of isomerizing a sugar into fructose using a calcium salt and an organic base. In certain embodiments, the sugar is glucose...
2016/0368940 Dithiolene Metal Complex Colorless IR Absorbers
The invention relates to the use of compounds of formulae (1) and/or (11) as colorless 1R absorbers wherein M is Ni, Pd, Pt, Au, Ir, Fe, Zn, W, Cu, Mo, In, Mn,...
2016/0368939 ORGANOMETALLIC 2-CYANO-2-AMINOBENZOATE-PROPYL DERIVATES AND THEIR USE AS ANTHELMINTICS
The invention relates to compounds characterized by a general formula (1), ##STR00001## wherein X is a group described by a general formula ...
2016/0368938 CO-CRYSTALS, SALTS AND SOLID FORMS OF TENOFOVIR ALAFENAMIDE
The present invention relates to co-crystals, salts and crystalline forms of tenofovir alafenamide and methods for preparation, use and isolation of such...
2016/0368937 PHOSPHONIUM COMPOUND, PREPARATION METHOD THEREOF, EPOXY RESIN COMPOSITION INCLUDING THE SAME, AND SEMICONDUCTOR...
A phosphonium compound, a method of preparing the same, an epoxy resin composition including the same, and a semiconductor device encapsulated with the same,...
2016/0368936 PROCESS FOR PREPARING DIALKYLPHOSPHINATE AND A PRODUCT THEREOF
The present provides a process for preparing dialkyl phosphinate, comprising: (1) firstly adding 0-99% of the total weight of phosphinic acids and/or salts...
2016/0368935 AZOLE SILANE COMPOUND, SURFACE TREATMENT SOLUTION, SURFACE TREATMENT METHOD, AND USE THEREOF
Objects are to provide a novel azole silane compound, a synthesis method thereof, and a silane coupling agent containing the azole silane compound as a...
2016/0368934 HYDRIDOSILAPYRROLES, HYDRIDOSILAAZAPYRROLES, THIASILACYCLOPENTANES, METHOD FOR PREPARATION THEREOF, AND...
Hydridosilapyrroles and hydridosilaazapyrrole are a new class of heterocyclic compounds having a silicon bound to carbon and nitrogen atoms within the ring...
2016/0368933 FUSED TRICYCLIC DUAL INHIBITORS OF CDK 4/6 AND FLT3
Compounds of Formula I are useful inhibitors of CDK 4, CDK6, and FLT3. Such compounds are useful in treating cancer and various other disease conditions....
2016/0368932 BUPRENORPHINE DIMER AND ITS USE IN TREATMENT OF GASTROINTESTINAL DISORDERS
The present invention provides a buprenorphine dimer compound, wherein the two buprenorphine portions are linked via an ethylene spacer, wherein the spacer is...
2016/0368931 PHARMACEUTICALLY ACTIVE DIMERS LINKED THROUGH PHENOLIC HYDROXYL GROUPS
Pharmaceutically active homo-dimers of opioid and other pharmaceutically active agents characterized by a single phenolic hydroxyl group wherein the respective...
2016/0368930 COMPOSITIONS AND METHODS FOR TREATING CANCER
K-Ras is the most frequently mutated oncogene in human cancer. Disclosed herein are compositions and methods for modulating K-Ras and treating cancer.
2016/0368929 MELAMPOMAGNOLIDE B DERIVATIVES
The present disclosure provides derivatives of melampomagnolide B (MMB), including carbonates, carbamates, and thiocarbamates. The derivatives may be...
2016/0368928 MELAMPOMAGNOLIDE B DERIVATIVES
The present disclosure provides derivatives of melampomagnolide B (MMB), including carbonates, carbamates, thiocarbamates, ester and amide derivatives of MMB....
2016/0368927 SYNTHESIS OF MAHANINE AND RELATED COMPOUNDS
Disclosed herein are methods of synthesizing mahanine and related compounds. The synthesis features an intramolecular aryl-alkyne isomerization, transition...
2016/0368926 SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF
Disclosed are compounds having enhanced potency in the modulation of NMDA receptor activity. Such compounds are contemplated for use in the treatment of...
2016/0368925 SUBSTITUTED 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE
The present invention provides a compound having the structure: ##STR00001## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, and R.sub.5 are each independently H,...
2016/0368924 PURINONE COMPOUNDS AS KINASE INHIBITORS
Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. In addition,...
2016/0368923 PYRIMIDINONES AS FACTOR XIA INHIBITORS
The present invention provides compounds of Formula (I): ##STR00001## or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the...
2016/0368922 2-OXO-1,3,8-TRIAZASPIRO[4.5]DECAN-3-YL] CARBOXYLIC ACID DERIVATIVES
The present invention provides compounds of Formula 1, ##STR00001## where A is selected from ##STR00002## and R1, R2 and R3 are defined in the specification, or a...
2016/0368921 SUBSTITUTED POLYCYCLIC CARBAMOLYPYRIDONE DERIVATIVE
This invention provides compounds having antiviral activities especially inhibiting activity for influenza virus, more preferably provides substituted...
2016/0368920 Imidazo[4,5-c]quinolin-2-one Compounds and Their Use in Treating Cancer
The specification generally relates to compounds of Formula (I): ##STR00001## and pharmaceutically acceptable salts thereof, where Q, R.sup.1, R.sup.2,...
2016/0368919 NOVEL PYRIDINE PYRAZINONES AS BET-FAMILY BROMODOMAIN INHIBITORS
Disclosed are novel pyridine pyrazinones or pharmaceutically acceptable salts thereof. Pharmaceutical compositions and the use of the compounds to treat...
2016/0368918 SYK INHIBITORS
The present disclosure relates to compounds that are Syk inhibitors and to their use in the treatment of various disease states, including cancer and...
2016/0368917 Bicyclic Heteroaryl Compounds
This invention relates to compounds of the general formula: ##STR00001## in which the variable groups are as defined herein, and to their preparation and use.
2016/0368916 PYRROLOPYRIDINES AS KINASE INHIBITORS
Compounds of Formula I are useful for inhibition of CHK1 and/or CHK2. Methods of using compounds of Formula I and stereoisomers and pharmaceutically acceptable...
2016/0368915 FUSED HETEROCYCLIC COMPOUND AND PEST CONTROL USE THEREOF
A fused heterocyclic compound is provided represented by the following formula (1) or an N-oxide thereof, wherein A.sup.1 represents NR.sup.5, oxygen or...
2016/0368914 FUSED TRICYCLIC UREA COMPOUNDS AS RAF KINASE AND/OR RAF KINASE DIMER INHIBITORS
Provided are certain fused tricyclic urea compounds and salts thereof, compositions thereof, and methods of use therefor.
2016/0368913 Methods of Making Diazaperopyrenium Dications and Uses Thereof
Methods of making diazaperopyrenium dications with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone, and uses thereof are provided.
2016/0368912 HALOGENATED PYRAZOLO[1,5-A]PYRIMIDINES, PROCESSES, USES, COMPOSITIONS AND INTERMEDIATES
The invention provides novel halogenated pyrazolo[1,5-a]pyrimidines of formula (I) wherein R, R.sub.1, X and Y have different meanings, and pharmaceutically...
2016/0368911 BENZOTHIOPHENE DERIVATIVES AS ESTROGEN RECEPTOR INHIBITORS
A compound of formula (I): ##STR00001## or a pharmaceutically acceptable salt thereof, compositions, combinations and medicaments containing said compounds and...
2016/0368910 INHIBITORS OF C-JUN-N-TERMINAL KINASE (JNK)
The present invention provides novel compounds according to Formula (I): ##STR00001## where Ring A, Ring B, X, L.sub.1, L.sub.2, R.sup.A, R.sup.C, R.sup.D, ...
2016/0368909 Novel Crystal Form of Dabrafenib Mesylate and Preparation Method Thereof
Disclosed are a novel crystal form of Dabrafenib mesylate and preparation method thereof. The novel crystal form of the present invention is more stable in...
2016/0368908 BENZIMIDAZOLE DERIVATIVES AS RLK AND ITK INHIBITORS
The present disclosure is directed to certain inhibitors of RLK and ITK of formula (I), pharmaceutical compositions comprising such compounds, and method of...
2016/0368907 PRMT5 INHIBITORS AND USES THEREOF
Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present...
2016/0368906 BICYCLIC HETEROCYCLIC DERIVATIVES AS BROMODOMAIN INHIBITORS
The present disclosure provides bicyclic heterocyclic derivatives of formula (I), which may be therapeutically useful, more particularly as bromodomain...
2016/0368905 ANTIVIRAL COMPOUNDS AND USES THEREOF
This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and...
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