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Patent # Description
2016/0368904 SUBSTITUTED BENZOFURANYL AND BENZOXAZOLYL COMPOUNDS AND USES THEREOF
The invention generally relates to substituted benzofuranyl and substituted benzoxazolyl compounds, and more particularly to a compound represented by...
2016/0368903 SUBSTITUTED OXOPYRIDINE DERIVATIVES AND USE THEREOF IN THE TREATMENT OF CARDIOVASCULAR DISORDERS
The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the...
2016/0368902 CRYSTALLINE PHARMACEUTICAL AND METHODS OF PREPARATION AND USE THEREOF
Novel crystalline polymorphic forms, Forms A, B, C, D, and E of a compound of Formula I, which has been found to be a potent inhibitor of LFA-1, are disclosed....
2016/0368901 CRYSTALLINE FORM OF (S)-(2-(6-CHLORO-7-METHYL-1H-BENZO[D]IMIDAZOL-2-YL)-2-METHYLPYRROLIDIN-1 ...
The invention relates to crystalline forms of (S)-(2-(6-chloro-7-methyl-1H-benzo[d]imidazol-2-yl)-2-methylpyrrolidin-1-- ...
2016/0368900 PLANT GROWTH REGULATING COMPOUNDS
The present invention relates to novel heterocyclic derivatives of Formula (I), to processes and intermediates for preparing them, to plant growth regulator...
2016/0368899 DNA-PK INHIBITORS
The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said...
2016/0368898 2-PYRIDYLOXY-4-METHYL OREXIN RECEPTOR ANTAGONISTS
The present invention is directed to 2-pyridyloxy-4-methyl compounds which are antagonists of orexin receptors. The present invention is also directed to uses...
2016/0368897 Pyrazoline Dihydroquinolones, Pharmaceutical Compositions, and Uses
This disclosure relates to pyrazoline dihydroquinolone derivates, pharmaceutical compositions, and uses. In certain embodiments, the compounds are selective...
2016/0368896 INHIBITOR OF p38 MAP KINASE
A compound of formula (XV): ##STR00001## wherein R.sub.1 represents an amino group, a protected amino group or nitro group; or a salt thereof. The compound is a...
2016/0368895 PULMONARY HYPERTENSION TREATING AGENT
[Problem] The present invention addresses the problem of providing a compound that is useful for preventing or treating diseases associated with malfunctioning...
2016/0368894 SUBSTITUTED AMINO TRIAZOLES USEFUL AS ACIDIC MAMMALIAN CHITINASE INHIBITORS
Disclosed are amino triazole compounds substituted by a carboxylate functional group or an bioisosteric polar functional group. Compounds having the...
2016/0368893 CYCLIC SULFONE AND SULFOXIMINE ANALOGS AND USES THEREOF
The present disclosure relates to cyclic sulfones and sulfoximines that are HIF-2a inhibitors and methods of making and using them for treating cancers. In...
2016/0368892 MOLECULES AND COMPOSITIONS THAT INHIBIT GRAM NEGATIVE BACTERIA AND THEIR USES
Antivirulence strategies to combat Pseudomonas aeruginosa, are described. One strategy encompasses synthesis of a series of compounds that inhibit the...
2016/0368891 Cyclic Ketone Peroxide Composition
A composition comprising at least two trimeric cyclic ketone peroxides: a trimeric cyclic methyl ethyl ketone peroxide (3MEK-cp) of formula (I) and at least...
2016/0368890 PALLADIUM/SILVER CO-CATALYZED TANDEM REACTIONS SYNTHESIS OF PHENYLACETOPHENONE DERIVATIVES BY...
This invention relates to the quick and efficient synthesis of anti-tumor or anti-cancer compounds. More particularly, it relates to the quick and efficient...
2016/0368889 TREPROSTINIL DERIVATIVE COMPOUNDS AND METHODS OF USING SAME
Compounds represented by formulae I, II, III, and IV including pro-drugs for treprostinil and prostacyclin analogs. Uses include treatment of pulmonary...
2016/0368888 Process Involving Cross Metathesis of Olefins
A method of forming a macrocyclic musk compound comprising the steps of:-- i) cross-metathesizing a first olefin and a second olefin in the presence of a...
2016/0368887 METHOD FOR PRODUCING 2,3,5-TRIMETHYL BENZOQUINONE BY OXIDATION OF 2,3,6-TRIMETHYLPHENOL
The invention relates to a method for producing 2,3,5-trimethyl benzoquinone or a compound containing 2,3,5-trimethyl benzoquinone, the method comprising the...
2016/0368886 MULTITARGET HEDGEHOG PATHWAY INHIBITORS AND USES THEREOF
The present invention concerns compounds that selectively inhibit the activity of the Hedgehog (Hh) pathway, their preparation and uses thereof. The compounds...
2016/0368885 MALEATE OF ANTI-PRION COMPOUND, METHOD FOR PRODUCING SAME, AND PHARMACEUTICAL COMPOSITION THEREOF
An object of the present invention is to provide an anti-prion compound that has high crystallinity and is highly stable in the crystalline form and to provide...
2016/0368884 Vortioxetine Pyroglutamate
The present invention provides vortioxetine pyroglutamate salt and pharmaceutical compositions comprising said salt.
2016/0368883 ISOXAZOLINE DERIVATIVES AS INSECTICIDES
The present invention relates to compounds formula (I): ##STR00001## wherein P is P1, P2, heterocyclyl or heterocyclyl substituted by one to five Z; ...
2016/0368882 PROCESS FOR MANUFACTURING PYRIMIDINE SULFAMIDE DERIVATIVES
The invention relates to a process for manufacturing the compound of formula I ##STR00001## wherein R is H, (C.sub.1-C.sub.6)alkyl or benzyl, or a salt thereof,...
2016/0368881 THERAPEUTIC COMPOUNDS
Compounds of Formula I: or salts thereof are disclosed. Also disclosed are pharmaceutical compositions comprising a compound of Formula I, processes for...
2016/0368880 PROCESSES FOR THE PREPARATION OF PESTICIDAL COMPOUNDS
The present application provides processes for making pesticidal compounds and compounds useful both as pesticides and in the making of pesticidal compounds.
2016/0368879 PHOTOACID GENERATOR, AND RESIN COMPOSITION FOR PHOTOLITHOGRAPHY
Provided is a non-ionic photoacid generator (A) expressed by general formula (1). R1 and R2 each independently represents an alkyl group having 1-18 carbons or...
2016/0368878 REDUCTION-TRIGGERED ANTIBACTERIAL SIDEROMYCINS
A compound is provided, comprising: an Fe(III)-binding or an Fe(III)-bound siderophore; one or more optional linker covalently bound to the siderophore; a...
2016/0368877 2-Aminoquinoline-Based Compounds for Potent and Selective Neuronal Nitric Oxide Synthase Inhibition
Various 2-aminoquinoline compounds as can be used, in vivo or in vitro, for selective inhibition of neuronal nitric oxide synthase.
2016/0368876 METHOD FOR PREPARATION OF 6-TRIFLUOROMETHYLPYRIDINE-3-CARBOXYLIC ACID DERIVATIVES FROM TRIFLUOROACETYLACETIC ACID
The invention discloses a method for the preparation of 6-trifluoromethylpyridine-3-carboxylic acid derivatives (I) from trifluoroacetylacetic acid (II) and...
2016/0368875 METHODS OF MAKING NETUPITANT AND INTERMEDIATES THEREOF
Methods are disclosed for the preparation of netupitant and pharmaceutically acceptable salts thereof which are novel, easily reproducible, environmentally...
2016/0368874 1,4-SUBSTITUTED PIPERIDINE DERIVATIVES
Described herein are 1,4-substituted piperidine compounds according to Formula I that have demonstrated activity as fatty acid synthase inhibitors. Also...
2016/0368873 Optically Active Form of Mepenzolate, and Ameliorating Agent for Chronic Obstructive Pulmonary Disease Which...
An optically active form of mepenzolate bromide is provided. An agent for ameliorating chronic obstructive pulmonary disease that contains the optically active...
2016/0368872 COMPOUNDS AND METHODS FOR TREATING CANCERS
Provided are carbazole and carbazole-like compounds (e.g., pyridoindole and pyrrolodipyridine compounds. The compounds can be used to selectively kill cancer...
2016/0368871 CRYSTALLINE COMPOUNDS
The present invention relates to crystalline forms of (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane hydrochloride and compositions comprising the same...
2016/0368870 OLEFIN SUBSTITUTED OXINDOLES HAVING AMPK ACTIVITY
The present invention relates to compounds of formula (I), which have valuable pharmacological properties, in particular are activators of AMPK and which are...
2016/0368869 COMPOSITIONS AND METHODS FOR INHIBITION OF CATHEPSINS
This invention is directed to compound of Formula I and methods of using these compounds in the treatment of conditions in which modulation of a cathepsin,...
2016/0368868 N-(1-CYANO-2-HYDROXY-1-METHYL-ETHYL)-4-(TRIFLUOROMETHYLSULFANYL)BENZAMIDE DERIVATIVES FOR USE AS NEMATOCIDAL DRUGS
The invention relates to compounds characterized by a general formula (1), ##STR00001## wherein T is S, SO or SO.sub.2, and R is hydrogen or CO--R'...
2016/0368867 THROMBOXANE RECEPTOR ANTAGONISTS
The invention relates to novel chemical entities that act as thromboxane (TX) A.sub.2 receptor, or T prostanoid receptor (TP), antagonists and to their use in...
2016/0368866 PROCESS FOR FLUORINATION OF SULPHONYL HALIDE COMPOUNDS
The preparation is described of a compound of formula (I) comprising an --SO.sub.2F function by reacting a compound of formula (II) with a fluorinating agent...
2016/0368865 GEMINI SURFACTANTS AND METHODS FOR THEIR PREPARATION AND USE
Disclosed herein are gemini surfactants, and methods for making and using these gemini surfactants. These gemini surfactants may be incorporated in paints and...
2016/0368864 BIOINSPIRED CATALYSIS USING OLIGOUREA HELICAL FOLDAMERS
The present description provides oligourea catalysts, a polar helical oligomeric strands, and methods for catalyzing reactions with polar helical oligomeric...
2016/0368863 NOVEL GEMINI SURFACTANT AND THEIR USE
Disclosed herein are gemini surfactants, and methods for making and using these gemini surfactants. These gemini surfactants may be incorporated in paints and...
2016/0368862 COMPOSITIONS AND METHODS OF TREATMENT USING A BCAT1 INHIBITOR
The present invention is directed to compounds and methods that inhibit the cytosolic form of BCAT1.
2016/0368861 COMPOSITIONS AND METHODS RELATED TO THE PRODUCTION OF ACRYLONITRILE
Disclosed herein are a catalyst and method useful in the process of converting sugars to acrylonitrile.
2016/0368860 AMIDE DERIVATIVE
The present invention provides a useful medicament for the treatment and/or prophylaxis of a disease associated with the enhancement of OPN production...
2016/0368859 PROCESS FOR THE SYNTHESIS OF AGOMELATINE
Process for the industrial synthesis of the compound of formula (I): ##STR00001##
2016/0368858 LEVALBUTEROL SALT
Levalbuterol L-tartrate affords crystals possessing properties desirable for use in a metered dose inhaler.
2016/0368857 (HETERO)ARYL CYCLOPROPYLAMINE COMPOUNDS AS LSD1 INHIBITORS
The invention relates to (hetero)aryl cyclopropylamine compounds, including particularly the compounds of formula (I) as described and defined herein, and...
2016/0368856 REDUCTIVE PREPARATION OF TERTIARY DIMETHYLAMINES FROM NITRILES
This disclosure describes a low temperature process for the preparation of dimethyl amines from nitriles via reductive amination. In some embodiments, the...
2016/0368855 TREPROSTINIL DERIVATIVES AND COMPOSITIONS AND USES THEREOF
The present disclosure provides treprostinil derivatives that can act as prodrugs of treprostinil. The treprostinil derivatives can be used to treat any...
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