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Patent # Description
2016/0367704 COMPLEXES OF RNA AND CATIONIC PEPTIDES FOR TRANSFECTION AND FOR IMMUNOSTIMULATION
The present invention relates to a complexed RNA, comprising at least one RNA complexed with one or more oligopeptides, wherein the oligopeptide, which has the...
2016/0367703 DIAGNOSIS AND TREATMENT OF MULTIPLE SULFATASE DEFICIENCY AND OTHER SULFATASE DEFICIENCIES
This invention relates to methods and compositions for the diagnosis and treatment of Multiple Sulfatase Deficiency (MSD) as well as other sulfatase...
2016/0367702 COMPOSITIONS COMPRISING SYNTHETIC POLYNUCLEOTIDES ENCODING CRISPR RELATED PROTEINS AND SYNTHETIC SGRNAs AND...
The present invention relates to compositions comprising and methods of using synthetic polynucleotides, e.g., modified mRNA, encoding CRISPR related proteins...
2016/0367701 Compositions for in vivo Expression of Therapeutic Sequences in the Microbiome
Compositions for a phage particle are disclosed. The phage particle is non-replicating and includes at least one heterologous nucleic acid sequence that is...
2016/0367700 AMPHIPHILIC CYCLODEXTRIN-BASED GLYCODENDRIMERS
The present application provides an amphiphilic cyclodextrin-based compound of the formula I: R-G-D-A (I) wherein R is one or more hydrophilic groups; G is one...
2016/0367699 NOVEL LINKERS FOR ANTIBODY-DRUG CONJUGATES AND RELATED COMPOUNDS, COMPOSITIONS, AND METHODS OF USE
Provided herein are antibody-cytotoxin antibody-drug conjugates and related compounds, such as linker-cytotoxin conjugates and the linkers used to make them,...
2016/0367698 CYTOTOXIC BENZODIAZEPINE DERIVATIVES
The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds of formula...
2016/0367697 VARIANT TARGET BINDING AGENTS AND USES THEREOF
The present invention provides variant target binding agents and methods relating to the use of such binding agents for the prophylaxis or treatment of cancers...
2016/0367696 DRUG CONJUGATE COMPOSITION
The invention provides a liquid composition and a lyophilized composition comprising a therapeutically effective amount of a conjugate comprising an antibody...
2016/0367695 POLYPEPTIDE CONSTRUCTS AND USES THEREOF
The present invention provides a polypeptide construct comprising a peptide or polypeptide signaling ligand linked to an antibody or antigen binding portion...
2016/0367694 PEPTIDE HAVING CANCER SELECTIVE TRANSLOCATION FUNCTION AND USE THEREOF
The present invention relates a peptide having cancer selective translocation function, and the use thereof, and more particularly to a VEGF-binding protein...
2016/0367693 Selective Arylation of Dichalcogenides in Biomolecules
Disclosed are chemical transformations for the conjugation of unprotected peptide biomolecules. The processes feature several significant advantages over...
2016/0367692 TARGETED DELIVERY OF ANTIMICROBIAL AGENTS
A cationic antimicrobial peptide (CAMP) conjugate is disclosed. The CAMP conjugate may be made by identifying a suitable carrier peptide; identifying a...
2016/0367691 TARGETED ENZYME COMPOUNDS AND USES THEREOF
The present invention is related to the one-step synthesis of enzyme conjugates and methods for treating or preventing MPS-II by administering such conjugates....
2016/0367690 CURCUMIN-PEPTIDE CONJUGATES AND FORMULATIONS
Disclosed here are compositions comprising a curcuminoid-peptide complex. Also disclosed are therapeutic compositions comprising a curcuminoid-peptide complex...
2016/0367689 Use of Pegylated IL-10 to Treat Cancer
Provided are methods of treatment for tumors. In particular, methods are provided for use of a chemically modified IL-10 to treat tumors.
2016/0367688 RAMAN-ACTIVE POLYMER PARTICLES AND METHODS FOR SYNTHESIZING THEREOF
An exemplary Raman-active nanoparticle can be provided, which can include, for example, a hydrophilic cyclopropenium cation, and one or more copolymers derived...
2016/0367687 SITE-SPECIFIC DELIVERY OF NUCLEIC ACIDS BY COMBINING TARGETING LIGANDS WITH ENDOSOMOLYTIC COMPONENTS
The invention relates to compositions and methods for site-specific delivery of nucleic acids by combining them with targeting ligands and endosomolytic...
2016/0367686 ALKENYL SUBSTITUTED 2,5-PIPERAZINEDIONES, COMPOSITIONS, AND USES THEREOF
Provided herein are compounds of Formula (I), and salts thereof, wherein each instance of R.sup.L is independently optionally substituted C.sub.6-C.sub.40...
2016/0367685 DUPA-INDENOISOQUINOLINE CONJUGATES
A targeting ligand-cytotoxic drug conjugate, for example, a DUPA-Indenoisoquinoline conjugate, is useful for treating cancers, e.g., prostate cancer.
2016/0367684 HYALURONAN CONJUGATES WITH PHARMACEUTICALLY ACTIVE SUBSTANCES, METHODS AND COMPOSITIONS
A method for manufacturing a hyaluronan conjugate comprises providing hyaluronan in solution or gel form, reacting the hyaluronan in solution or gel form with...
2016/0367683 ENHANCING THE IN-VIVO EFFICIENCY OF PARTICLE DELIVERY THROUGH NON-COVALENT INTERACTION WITH RED BLOOD CELL...
The present invention relates to the production of modified microscale and nanoscale particles that have enhanced in vivo delivery characteristics. The...
2016/0367682 NANOSCALE PLATINUM COMPOUNDS AND METHODS OF USE THEREOF
The invention is directed to biocompatible conjugated polymer nanoparticles including a copolymer backbone, a plurality of sidechains covalently linked to said...
2016/0367681 BIODEGRADABLE POLYESTERAMIDE COPOLYMERS FOR DRUG DELIVERY
The present invention relates to a poly (ester amide) (PEA) having a chemical formula described by structural formula (IV), ##STR00001## wherein m+p varies...
2016/0367680 POLYLACTIDE COMPOSITIONS AND USES THEREOF
The present invention provides compositions and methods relating to polylactides which may be used for drug delivery (e.g., parenteral delivery), wherein an...
2016/0367679 Polymer Compositions in Biomedical Applications
The present invention relates to biomedically useful compositions of C2-C3 linked polyethers of 1,6:2,3-dianhydrohexopyranose derivatives combined with...
2016/0367678 BOLAAMPHIPHILIC COMPOUNDS, COMPOSITIONS AND USES THEREOF
Bolaamphiphilic compounds are provided according to formula I: ##STR00001## where HG.sup.1, HG.sup.2 and L.sup.1 are as defined herein. Provided bolaamphilphilic...
2016/0367677 LIPID NANODISCS AND NANORODS AS MODULATORS OF CLOTTING FACTOR FUNCTION IN VIVO
The present invention includes composition and methods of using a lipid nanodisk or nanotube composition comprising a lipid composition of phosphatidylserine...
2016/0367676 PETROLATUM-BASED DELIVERY SYSTEMS AND FOR ACTIVE INGREDIENTS
The present disclosure is broadly concerned with petrolatum-based compositions as a suspension matrix for the active ingredients. The disclosure is also...
2016/0367675 REDUCED-VISCOSITY CONCENTRATED PROTEIN FORMULATIONS
The present application concerns concentrated protein formulations with reduced viscosity, which arc particularly suitable for subcutaneous administration. The...
2016/0367674 COMBINATION ARTEMISININ AND CHEMILUMINESCENT PHOTODYNAMIC THERAPY AND USES THEREFOR
Photodynamic therapy-based methods of treating diseases such as cancer and malaria are disclosed. These methods include administering 5-aminolevulinic acid...
2016/0367673 AGGLOMERATING MAGNETIC ALKOXYSILANE-COATED NANOPARTICLES
The present invention relates to a method for producing a suspension of agglomerates of magnetic alkoxysilane-coated metal nanoparticles, wherein an aqueous...
2016/0367672 METHODS AND SYSTEMS FOR TREATING TUMORS
The invention relates methods and systems of using a nanoparticle and near infrared radiation to treat, prevent, reduce the likelihood of having, reduce the...
2016/0367671 Nanoparticle Composition for Use in Targeting Cancer Stem Cells and Method for Treatment of Cancer
There is provided a nanoparticle composition comprising a central core portion including magnetic nanoparticles adapted to act as a heat source and a...
2016/0367670 FRACTIONATED RADIOTHERAPY AND CHEMOTHERAPY WITH AN OXYGEN THERAPEUTIC
A fluorocarbon emulsion in water for use in fractionated radiotherapy and chemotherapy, wherein said fluorocarbon comprises between 4 and 8 carbon atoms.
2016/0367669 TARGETING MICROBUBBLES
This invention related to manufactured microbubbles, as well as methods of using manufactured microbubbles, for example, in medicinal applications. The...
2016/0367668 SYSTEMS AND METHODS FOR TREATMENT OF DISEASE VIA APPLICATION OF MECHANICAL FORCE BY CONTROLLED ROTATION OF...
The present disclosure describes systems, apparatus, and methods for application of dynamic magnetic field (DMF) treatment to direct movement, and specifically...
2016/0367667 Compositions and Methods for Diagnosing and Treating Cancer
An isolated antibody that specifically binds to an extracellular domain of human DLL4 and affects growth of a tumor comprising cancer stem cells is described....
2016/0367666 SELF-BUFFERING PROTEIN FORMULATIONS
The invention herein described, provides, among other things, self-buffering protein formulations. Particularly, the invention provides self-buffering...
2016/0367665 SELF-BUFFERING PROTEIN FORMULATIONS
The invention herein described, provides, among other things, self-buffering protein formulations. Particularly, the invention provides self-buffering...
2016/0367664 IL2Rbeta/Common Gamma Chain Antibodies
Anti-CD122 and/or .gamma.c antibodies and fragments thereof are disclosed. Also disclosed are compositions comprising such antibodies and fragments, and uses...
2016/0367663 Combination therapies for heme malignancies with Anti-CD38 antibodies and survivin inhibitors
The present invention relates to combination therapies for heme malignancies with anti-CD38 antibodies and survivin inhibitors.
2016/0367662 COMBINATIONS OF TRAMETINIB, PANITUMUMAB AND DABRAFENIB FOR THE TREATMENT OF CANCER
A novel combination comprising a B-Raf inhibitor, particularly N-{3-[5-(2-Amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2- ...
2016/0367661 NLRP6 Inflammasome Intestinal Epithelium Mucus Secretion
The present invention provides a composition and method for treating or preventing a disease or disorder associated with intestinal microbiota.
2016/0367660 COMPOSITIONS WITH REDUCED DIMER FORMATION
The present invention relates to the use of a non-reducing carbohydrate or carbohydrate derivative and at least one agent which inhibits dimer formation in a...
2016/0367659 VIRAL PEPTIDES
A composition comprising one or more peptides selected from the group consisting of SEQ ID NOs 1 to 76; and/or comprising one or more polynucleotide sequences...
2016/0367658 AVIRULENT, IMMUNOGENIC FLAVIVIRUS CHIMERAS
Chimeric flaviviruses that are avirulent and immunogenic are provided. The chimeric viruses are constructed to contain amino acid mutations in the...
2016/0367657 LIVE ATTENUATED VIRUS VACCINES FOR LA CROSSE VIRUS AND OTHER BUNYAVIRIDAE
The invention relates to vaccine compositions including CEV serogroup immunogens, attenuated and inactivated viruses of the CEV serogroup and chimeric...
2016/0367656 METHOD FOR THE PRODUCTION OF RECOMBINANT VIRUS, DNA CONSTRUCTS, RECOMBINANT VIRUS AND VACCINE COMPOSITIONS
The purpose of the present invention is the production of recombinant virus through the cloning and expression of sequences of coding nucleotides of the whole...
2016/0367655 Immunogenic Compositions
The present invention provides compositions comprising a Chlamydial major outer membrane protein (referenced herein as "MOMP"), from at least one Chlamydial...
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