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COMBINATIONS COMPRISING POSITIVE ALLOSTERIC MODULATORS OR ORTHOSTERIC
AGONISTS OF METABOTROPIC GLUTAMATERGIC...
The present invention relates to combinations comprising a positive allosteric modulator ("PAM") of metabotropic glutamatergic receptor subtype 2 ("mGluR2") or...
Methods and Compositions for Treating Cancers having Acquired Resitance to
prior Chemotherapeutic and Targeted...
This invention provides methods and compositions useful for treating early and late stage metastatic cancer to prevent or treat acquired resistance due to gene...
PHARMACEUTICAL COMPOSITIONS OF SITAGLIPTIN
The present invention relates to stable oral pharmaceutical compositions of sitagliptin base and processes for the preparation thereof.
COMPLEX GRANULE FORMULATION HAVING IMPROVED STABILITY COMPRISING
LEVOCETIRIZINE AND MONTELUKAST
The present invention relates to a complex granule formulation comprising a first granular part comprising levocetirizine or its pharmaceutically acceptable...
Naloxone Single Agent and Multilayer Tablets
The present invention relates to a solid oral pharmaceutical composition comprising naloxone, or a pharmaceutical acceptable salt thereof, as an active...
ABUSE-PROOFED ORAL DOSAGE FORM
The present invention relates to an abuse-proofed, oral dosage form with controlled opioid-release for once daily administration, characterised in that it...
BENZOQUINOLINE INHIBITORS OF VESICULAR MONOAMINE TRANSPORTER 2
The present invention relates to new benzoquinoline inhibitors of vesicular monoamine transporter 2 (VMAT2), pharmaceutical compositions thereof, and methods...
ONCOGENIC ROS1 AND ALK KINASE INHIBITOR
A compound suitable for treating cancer, in particular NSCLC, inhibits activity of oncogenic ROS1 kinase and ALK kinase. The compound has certain structural...
ONCOGENIC ROS1 KINASE INHIBITOR
The present invention provides a compound that inhibits activity of oncogenic ROS1, a composition comprising said compound. The present invention also provides...
METHOD OF INHIBITING MUTANT C-KIT
The present invention includes a method of reducing or inhibiting the kinase activity of C-KIT mutant tyrosine kinase activity in a cell or a subject, and the...
Novel Crystal Form
A novel crystalline form of a compound is disclosed.
METHODS AND OPHTHALMIC DEVICES USED IN THE TREATMENT OF OCULAR ALLERGIES
Ophthalmic devices and methods of treating allergic conjunctivitis are disclosed herein.
NICOTINAMIDE DERIVATE IN THE TREATMENT OF ACUTE CORONARY SYNDROME
The use of a nicotinamide derivative in the treatment acute coronary syndrome (ACS) and pharmaceutical compositions used in such treatment.
THERAPEUTIC AND DIAGNOSTIC METHODS
The invention relates to methods of treating diseases, particularly cancers, that respond favorably to the inhibition of Nicotinamide phosphoribosyltransferase...
COMPOSITIONS OF TOLPERISONE
The present disclosure relates to tolperisone, or a pharmaceutically acceptable salt or hydrate thereof, with 10 ppm 2-methyl-1-(4-methylphenyl)-propenone...
CANCER TREATMENTS USING COMBINATIONS OF TYPE 2 MEK AND ERK INHIBITORS
The present invention provides, inter alia, methods, kits, and pharmaceutical compositions for treating or ameliorating the effects of a cancer in a subject in...
Compositions and Methods for Treating Nocturnal Acid Breakthrough and
Other Related Disorders
The present invention relates to, inter alia, pharmaceutical compositions comprising an acid labile proton pump inhibitor and a buffering agent; to methods for...
COMPOSITIONS AND METHODS FOR THE TREATMENT AND MANAGEMENT OF STEATOSIS IN
Compositions and methods for the treatment and management of steatosis are disclosed.
Provided is a patch preparation that has improved adhesion to an adherend so as to enable a drug, especially, a systemically active drug to be stably and...
Methods and Compositions for Controlling Ectoparasites
A method for inhibiting hatching of an ectoparasite egg, the method comprising exposing the ectoparasite egg to at least one metal chelating agent and/or...
RON INHIBITORS FOR USE IN PREVENTING AND TREATING BONE LOSS
Provided herein are methods for inhibiting osteolysis or treating osteoporosis in a subject in need thereof, the method including administering to the subject...
USE OF CHEMICAL COMPOUNDS THAT CAN INHIBIT THE TOXIC ACTIVITY OF
SPHINGOMYELINASE D FROM VENOMS OF LOXOSCELES...
The present invention relates preferably to the use of 4-bromo-N-[(E)-(2-methyl-1H-indol-3-yl)methyleneamino]benzenesulphonamide and...
ENDOPARASITE CONTROL AGENT
The present invention is intended to provide a novel parasiticide, antiprotozoal or other endoparasite control agents which are effective for controlling...
The invention provides compounds of formula (I): ##STR00001## wherein R.sup.1-R.sup.3, n, and W have any of the values defined in the specification, and salts...
METHODS OF TREATING NEUROLOGICAL DISORDERS
The present invention provides methods of treating epilepsy and other neurological disorders. The methods generally involve administering to an individual in...
Administering an agent containing isoleucine and threonine as active ingredients is effective for the prophylaxis or improvement of frailty in an elderly...
COMPOSITION COMPRISING A DIINDOLYLMETHANE AND A RETINOID TO TREAT A SKIN
Provided is a composition for use in treating a skin condition, the composition comprising: (a) a first component comprising a substituted or unsubstituted...
COMPOSITIONS AND METHODS FOR TREATMENT OF NEURODEGENERATIVE DISEASE
Compounds, compositions, kits and methods for treating conditions related to neurodegeneration or ocular disease, are disclosed.
AZETIDINE ESTROGEN RECEPTOR MODULATORS AND USES THEREOF
Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds...
USES OF SESQUITERPENE LACTONE COMPOUNDS AND THEIR DERIVATIVES IN DRUGS
The present invention relates to the uses of sesquiterpene lactone compounds and their derivatives in preparing drugs. It belongs to the field of drug...
Use of Lappaol F to Inhibit Tumor Cell Growth
Provided is a method for inhibiting the growth of tumor cells comprising administering to an individual in need of treatment, a composition comprising a...
USE OF NARINGENIN IN PREPARING DRUGS FOR PREVENTING AND/OR TREATMENT
ABDOMINAL AORTIC ANEURYSM
Naringenin is used for preparing products for preventing and/or treating abdominal aortic aneurysms. The products include drugs and/or health care products....
GRANULATE CONTAINING CANNABINOID, METHOD FOR ITS MANUFACTURE AND ORAL
DOSAGE UNIT COMPRISING SUCH GRANULATE
The present invention relates to a granulate comprising granules made up of 40-99 wt. % of lactose particles and 1-60 wt. % of a binding component that holds...
XANTHONE-RICH PLANT EXTRACTS OR COMPOUNDS THEREFROM FOR MODULATING
DISEASES OF THE CENTRAL NERVOUS SYSTEM AND...
The invention relates to a method of treatment and/or prophylaxis of a disease or disorder of the central nervous system comprising administering to a mammal...
MAST CELL STABILIZERS FOR LUNG DISEASE TREATMENT
Methods for the treatment of lung diseases with mast cell stabilizers are provided.
MAST CELL STABILIZERS TREATMENT FOR SYSTEMIC DISORDERS
Methods for the treatment of systemic disorders treatable with mast cell stabilizers, including mast cell related disorders, are provided.
METHODS OF TREATING FIBROTIC DISEASES USING TETRAHYDROCANNABINOL-11-OIC
This invention is in the field of medicinal chemistry and relates to novel compounds, and pharmaceutical compositions and methods of use thereof for the...
METHOD AND COMPOSITION FOR PREVENTING AND TREATING VIRAL INFECTIONS
A method and composition for treating viral infections using a combination of naturally occurring compounds is provided. The method includes administering to a...
Treating or Preventing Nephrogenic Diabetes Insipidus
In certain embodiments, the disclosure relates to methods of treating or preventing nephrogenic diabetes insipidus comprising administering an effective amount...
Improved delivery of poorly water soluble drugs with aphafetoprotein
stabilized with metal ions
The invention discloses a novel significantly improved carrier protein for pharmaceutical applications: metal ion-stabilized alfa-fetoprotein, AFP. The...
Solid Nanoparticle Formulation of Water Insoluble Pharmaceutical
Substances With Reduced Ostwald Ripening
The present invention belongs to the fields of pharmacology, medicine and medicinal chemistry. The present invention provides novel pharmaceutical compositions...
Compositions Including Androgen Receptor Degradation (ARD) Enhancers and
Methods of Prophylactic or Therapeutic...
The present invention includes methods and compositions useful for treating and preventing skin disorders, hair loss and other skin disorders. The compositions...
INDUCTION OF ARTERIOGENESIS
The present invention inter alia relates to a method of promoting collateral circulation comprising the step of exposing a subject to a therapeutically...
EFFICACY OF DIETARY DHA-PHOSPHOLIPID FOR BRAIN DHA AND DPA ACCRETION IN
The invention pertains to the use of a dietary DHA comprising phospholipid (PL-DHA) for increasing the amount of DPA or the amount of DHA and DPA in tissues...
USE OF A COMPOSITION COMPRISING FISH OIL AND JUICE FOR THE TREATMENT OF
The present invention provides use of a composition comprising fish oil with low totox value and juice in an oil-in-water emulsion in treatment/resolution of...
COMPOSITIONS AND METHODS FOR ENHANCING NEUROGENESIS IN ANIMALS
The invention provides methods for enhancing neurogenesis in an animal. In one embodiment, a method for enhancing neurogenesis in an animal can comprise...
TOPICAL COMPOSITION FOR PAIN RELIEF
The composition comprises 0.5% to 10% by weight of a neuropathic analgesic; 0.5% to 10% by weight of a muscle relaxant; 0.5% to 20% by weight of an...
COMPOUNDS AND METHODS FOR TREATING ABERRANT ADRENOCORTICAL CELL DISORDERS
Methods and compositions are provided for treatment of disorders associated with aberrant adrenal cortex cell behavior, including (but not limited to)...
METHODS OF TREATING MUSCLE CRAMPING AND RELATED COMPOSITIONS
Described herein are compositions comprising capsaicin and methods of treating muscle cramping in a subject, comprising orally administering to the subject a...
PROTOTYPICAL ANALGESIC PROFILE OF N-STEARYL DOPAMINE (NS-DA)
The present invention discloses the prototypical profile of N-Stearyl dopamine (NS-DA) against the anticancer drugs induced neuropathic pain (ADINP). Indeed,...