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Patent # Description
2016/0376604 SYSTEM FOR AUTOMATED EXPLANT PREPARATION AND METHOD OF USE
A system and method for the automated or semi-automated preparation of explants for transformation and transgenic engineering.
2016/0376603 METHOD OF TRANSFORMING CELLS
Use of an isolated Ensifer adhaerens strain OV14 deposited under NCIMB Accession Number 4177, or an isolated variant thereof characterised by a 16S rRNA gene...
2016/0376602 VECTORS FOR USE IN AN INDUCIBLE COEXPRESSION SYSTEM
The present invention provides expression vectors for use in an inducible coexpression system, capable of controlled induction of expression of each gene product.
2016/0376601 Hybrid immunoglobulins with moving parts
Hybrid immunoglobulins containing moving parts are provided as well as related compositions and methods of use and methods of production. In addition,...
2016/0376600 METHODS FOR ENHANCING MICROBIAL PRODUCTION OF SPECIFIC LENGTH FATTY ALCOHOLS IN THE PRESENCE OF METHANOL
The invention provides non-naturally occurring microbial organisms having a formaldehyde fixation pathway, a formate assimilation pathway, and/or a methanol...
2016/0376599 RNAi Inhibition of Alpha-ENaC Expression
The invention relates to compositions and methods for modulating the expression of alpha-ENaC, and more particularly to the downregulation of alpha-ENaC...
2016/0376598 Polycomb-Associated Non-Coding RNAS
This invention relates to long non-coding RNAs (lncRNAs), libraries of those ncRNAs that bind chromatin modifiers, such as Polycomb Repressive Complex 2,...
2016/0376597 METHOD OF TREATING INFLUENZA A
A method of treating Influenza A is disclosed. The method includes the step of administering a pharmaceutical composition including an oligonucleotide...
2016/0376596 COMPOSITIONS AND METHODS FOR INDUCING AN ENHANCED IMMUNE RESPONSE USING POXVIRUS VECTORS
Provided herein are recombinant poxviruses comprising heterologous or native nucleic acids specifying excess double-stranded RNA (dsRNA) early in infection,...
2016/0376595 PEPTIDE APTAMERS FOR MANIPULATING PROTEIN FUNCTION
Peptide aptamers and the methods to produce cassettes including the aptamers and manipulating them, are described. The peptide aptamer cassettes are useful to,...
2016/0376594 Modified L-Nucleic Acid
A modified L-nucleic acid, containing an L-nucleic acid part conjugated to a non-L-nucleic acid part is described. The conjugate has extended retention time in...
2016/0376593 CHEMICALLY MODIFIED POLYNUCLEOTIDES AND METHOD FOR PRODUCING CHEMICALLY MODIFIED POLYNUCLEOTIDES
The present invention relates to chemically-modified polynucleotides of formula (I): 5'-CONS-SEQ.ID.n-CONS-3' (I) containing one or more modified pyrimidines...
2016/0376592 Methods of Manipulating the Fate of Cells
A method of manipulating the fate of a cell, which comprises contacting the cell with at least one of (a) a cell fate-determining untranslated/noncoding RNA...
2016/0376591 iRNA AGENTS WITH BIOCLEAVABLE TETHERS
The invention relates to iRNA agents, which preferably include a monomer in which the ribose moiety has been replaced by a moiety other than ribose that...
2016/0376590 Methods and Compositions For The Specific Inhibition of Gene Expression by Double-Stranded RNA
The invention is directed to compositions and methods for selectively reducing the expression of a gene product from a desired target gene in a cell, as well...
2016/0376589 micro-RNA INHIBITOR
The invention provides a microRNA inhibitor that has two or more sequences complementary to the sequence of microRNA to be the target of inhibition, which two...
2016/0376588 MOLECULAR RE-ENGINEERING OF EXCITATION-INHIBITION BALANCE IN MEMORY CIRCUITS
Disclosed are memory-regulating agents and methods that target actin binding LIM protein family, member 3 (ABLIM3). Specifically, the disclosure provides...
2016/0376587 FUNCTIONALLY-MODIFIED OLIGONUCLEOTIDES AND SUBUNITS THEREOF
Functionally-modified oligonucleotide analogues comprising modified intersubunit linkages and/or modified 3' and/or 5'-end groups are provided. The disclosed...
2016/0376586 NUCLEIC ACID MOLECULE, EXPRESSION CASSETTE, EXPRESSION VECTOR, EUKARYOTIC HOST CELL, INDUCTION METHOD OF RNA...
Subjects of the invention are: nucleic acid molecule, expression cassette, expression vector, eukaryotic host cell, induction method of RNA interference in...
2016/0376585 OLIGONUCLEOTIDE-LIGAND CONJUGATES AND PROCESS FOR THEIR PREPARATION
The present invention relates to ligand conjugates of oligonucleotides (e.g., iRNA agents) and methods for their preparation. The ligands are derived primarily...
2016/0376584 METHOD AND APPARATUS FOR DUAL SOLID PHASE NUCLEIC ACID SYNTHESIS
Provided herein are methods and apparatuses for synthesizing nucleic acids having a predefined sequence through enzymatic elongation. In some embodiments, the...
2016/0376583 DIGITAL COUNTING OF INDIVIDUAL MOLECULES BY STOCHASTIC ATTACHMENT OF DIVERSE LABELS
Compositions, methods and kits are disclosed for high-sensitivity single molecule digital counting by the stochastic labeling of a collection of identical...
2016/0376582 MICRO RNA ISOLATION FROM BIOLOGICAL FLUID
The present disclosure provides methods and kits for isolating miRNAs from biological fluids.
2016/0376581 METHOD FOR THE PURIFICATION OF TARGETED NUCLEIC ACIDS FROM BACKGROUND NUCLEIC ACIDS
The present invention relates generally to the field of nucleic acid purification. In particular, provided herein are micro particles and micro particle...
2016/0376580 Method of Producing 1,5-Pentadiamine Using Lysine Decarboxylase Mutant Having Improved Thermal Stability
The present invention provides methods for producing 1,5-pentamethylenediamine ("1,5-PD") efficiently in a manner suitable for an actual production....
2016/0376579 NEW ENZYMES AND METHOD FOR PREPARING 4-HYDROXYL BENZYL ALCOHOL AND DERIVATIVES THEREOF
The present invention relates to a new enzyme able to produce 4-hydroxybenzyl alcohol from the amino acid tyrosine and the use thereof for producing...
2016/0376578 SHORT-ACTING FACTOR VII POLYPEPTIDES
Short-acting Factor VII peptides are disclosed. A shortened half-life is desirable for treatment of acute bleeding and similar disorders. Modification of the...
2016/0376577 FACTOR VII POLYPEPTIDES THAT ARE MODIFIED AND USES THEREOF
Nucleic acid encoding modified factor VII polypeptides, vectors and cells containing the nucleic acid, uses of the nucleic acids, methods of making the encoded...
2016/0376576 FLAVOR-IMPROVING ENZYME COMPOSITION, METHOD FOR SUPPRESSING OCCURRENCE OF UNPLEASANT ODOR, AND METHOD FOR...
A flavor-improving enzyme composition for reducing an unpleasant odor in a food or beverage is disclosed, the composition containing an enzyme exhibiting...
2016/0376575 PEPTIDE CAPABLE OF SILICA DEPOSITION AND USE THEREOF
A peptide for synthesizing silica and use thereof are provided. The peptide for synthesizing silica can polymerize silica from a silica precursor in an aqueous...
2016/0376574 MODIFIED GRAM POSITIVE BACTERIA AND USES THEREOF
The present invention relates to a gram positive bacterium, preferably a lactic acid bacterium (LAB) or Bifidobacterium, with increased stress resistance...
2016/0376573 FAGOPYRITOL SYNTHASE GENES AND USES THEREOF
The present invention relates to an isolated DNA molecule encoding a fagopyritol synthase. A method for producing a fagopyritol, an insulin mediator, an...
2016/0376572 FAGOPYRITOL SYNTHASE GENES AND USES THEREOF
The present invention relates to an isolated DNA molecule encoding a fagopyritol synthase. A method for producing a fagopyritol, an insulin mediator, an...
2016/0376571 FAGOPYRITOL SYNTHASE GENES AND USES THEREOF
The present invention relates to an isolated DNA molecule encoding a fagopyritol synthase. A method for producing a fagopyritol, an insulin mediator, an...
2016/0376570 O-Mannosyltransferase Deficient Filamentous Fungal Cells and Methods of Use Thereof
The present disclosure relates to compositions and methods useful for the production of heterologous proteins with reduced O-mannosylation in filamentous...
2016/0376569 GLYCOSYLTRANSFERASE GLYCOSYLATING FLAVOKERMESIC ACID AND/OR KERMESIC ACID
An isolated glycosyltransferase (GT) polypeptide capable of: (I): conjugating glucose to flavokermesic acid (FK); and/or (II): conjugating glucose to kermesic...
2016/0376568 THIENOPYRROLE COMPOUNDS AND USES THEREOF
Thienopyrrole compounds that may inhibit Oplophorus-derived luciferases are disclosed, as well as compositions and kits comprising the thienopyrrole compounds,...
2016/0376567 HERBICIDE-RESISTANT HYDROXYPHENYLPYRUVATE DIOXYGENASES
The present invention refers to method for producing a transgenic plant with increased herbicide tolerance or resistance as compared to a corresponding...
2016/0376566 Peroxygenase Variants
The present invention relates to peroxygenase variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs,...
2016/0376565 KETOREDUCTASE POLYPEPTIDES
The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme...
2016/0376564 Nucleic Acids and Polypeptides for Utilizing Plant Biomass
The present invention relates to novel nucleic acids, novel groups of polypeptides encoded by the polynucleotides, novel compositions, and methods of using the...
2016/0376563 Methods and Compositions for Treating Obesity
The present invention provides anti-ghrelin antibodies or antigen-binding molecules that are capable of degrading ghrelin and inhibiting ghrelin-mediated...
2016/0376562 Genetically stable oncolytic RNA virus, method of manufacturing and use thereof
In a method for manufacturing a modified enterovirus of ECHO 7 type by modification of native ECHO 7 virus, isolated by a known method from human feces and...
2016/0376561 Host Cells with Artificial Endosymbionts
The present invention is directed generally to eukaryotic host cells comprising artificial endosymbionts and methods of introducing artificial endosymbionts...
2016/0376560 METHOD FOR REJUVENATING CELLS
The invention relates to a method for reprogramming cells from aged donors or senescent cells to pluripotent cells that have lost marks of senescence. In...
2016/0376559 NUCLEAR RECEPTOR AND MUTANT THEREOF AND THE USE OF THE SAME IN THE REPROGRAMMING OF CELLS
According to the invention there is provided methods for inducing pluripotent stem cells in vitro, vectors and compositions for producing the same and methods...
2016/0376558 METHOD FOR INDUCING PLURIPOTENCY IN A HEMATOPOIETIC CELL
There is provided a method of inducing pluripotency in a hematopoietic cell. The method comprises providing a blood sample that has been collected from a...
2016/0376557 METHOD FOR INDUCING HUMAN CHOLANGIOCYTE DIFFERENTIATION
The invention relates to a method for inducing human cholangiocyte differentiation of progenitor cells called hepatoblasts. More specifically, the invention...
2016/0376556 KIDNEY-SPECIFIC TUMOR VACCINE DIRECTED AGAINST KIDNEY TUMOR ANTIGEN G-250
This invention provides an anti-cancer immunogenic agent(s) (e.g. vaccines) that elicit an immune response specifically directed against renal cell cancers...
2016/0376555 NOVEL METHODS TO REGENERATE HUMAN LIMBAL STEM CELLS
The invention disclosed herein provides systems and methods designed to facilitate human limbal stem/progenitor cell culture including a novel 3-dimensional...
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