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Patent # Description
2016/0376354 HUMAN ISLET AMYLOID POLYPEPTIDE (HIAPP) SPECIFIC ANTIBODIES AND USES THEREOF
Provided are novel human islet amyloid polypeptide, also known as amylin and IAPP and proIAPP respectively, specific antibodies as well as fragments,...
2016/0376353 HUMANIZED, ANTI-N2 ANTIBODIES
The present invention encompasses humanized antibodies that specifically bind N2 peptide, methods for the preparation thereof and methods for the use thereof.
2016/0376352 HUMANIZED ANTI-TAU(pS422) ANTIBODIES AND METHODS OF USE
The invention provides humanized anti-human Tau(pS422) antibodies and methods of using the same.
2016/0376351 ANTI-TAU ANTIBODIES AND METHODS OF USE
The invention provides anti-Tau antibodies and methods of using the same.
2016/0376350 ANTI SERUM ALBUMIN FAB-EFFECTOR MOIETY FUSION CONSTRUCT, AND THE PREPARING METHOD THEREOF
The present invention relates to antigen-binding fragment (Fab) and a Fab-effector fusion protein or (poly)peptide comprising thereof. The Fab of the present...
2016/0376349 Compositions For diagnosis and Therapy of diseases associated with aberrant expression of Futrins (R-Spondins)...
The present invention relates to a composition useful for the diagnosis of diseases associated with aberrant expression of the genes encoding the secreted...
2016/0376348 METHODS AND COMPOSITIONS RELATED TO SOLUBLE MONOCLONAL VARIABLE LYMPHOCYTE RECEPTORS OF DEFINED ANTIGEN SPECIFICITY
Disclosed are compositions and methods related to variable lymphocyte receptors (VLRs). More particularly, disclosed are a variety of antigen specific...
2016/0376347 ANTI-INFLUENZA ANTIBODY
The present invention relates to an antibody that confers protection against influenza virus infection. More specifically, it relates to an anti-neuraminidase...
2016/0376346 Fc FUSION PROTEINS COMPRISING NOVEL LINKERS OR ARRANGEMENTS
The application provides Fc fusion proteins having novel arrangements. In one embodiment, the application provides Fc fusion proteins comprising a .sup.10F3...
2016/0376345 FIBRONECTIN-BASED BINDING MOLECULES AND USES THEREOF
The invention provides fibronectin type III (Fn3)-based binding molecules that bind to a specific target antigen. The invention further provides bispecific...
2016/0376344 FACTOR VIII COMPOSITIONS AND METHODS OF MAKING AND USING SAME
The present invention relates to compositions comprising factor VIII coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic...
2016/0376343 NOVEL IL-17R-ECD MUTANTS
A protein comprising an amino acid sequence having at least 97% homology to SEQ ID NO: 1. The amino acid sequence comprises valine at position 60, glycine at...
2016/0376342 STABLE LIQUID FORMULATION OF FUSION PROTEIN WITH IgG Fc DOMAIN
A stable liquid formulation includes a fusion protein having an Fc domain of a human immunoglobulin G (IgG), in particular, a protein in which an Fc domain of...
2016/0376341 TGF-BETA RECEPTOR TYPE II VARIANTS AND USES THEREOF
In certain aspects, the present disclosure relates to polypeptides comprising a truncated, ligand-binding portion of the extracellular domain of T.beta.RII...
2016/0376340 Diagnosis and therapy of Multiple Sclerosis
The serotonin receptor 5HT2A (5HT2aR) and membrane NADPH oxidases (NOX enzymes) are found to be a target of autoantibodies present in Multiple Sclerosis...
2016/0376339 DECOY PEPTIDES INHIBITING BINDING OF AMIGO2 AND 3-PHOSPHOINOSITIDE-DEPENDENT KINASE 1
The present invention provides a decoy peptide or polypeptide capable of inhibiting the binding of AMIGO2 and 3-phosphoinositide-dependent kinase 1 (PDK1), and...
2016/0376338 HEAT-SENSING PROTEIN SWITCHES AND USES THEREOF
A region of the TRPV1 protein that functions as a temperature switch (FIG. 1) has been identified, and can be expressed, purified and applied in combination...
2016/0376337 PEPTIDES AND COMPOSITIONS FOR TREATMENT OF JOINT DAMAGE
The present invention provides new protease resistant polypeptides, as well as compositions and methods for treating, ameliorating or preventing conditions...
2016/0376336 NOVEL ENGINEERED POTENT CYTOTOXIC STAPLED BH3 PEPTIDES
Compositions comprising peptide sequences with high cytotoxicity to cancer cell lines are provided. Pharmaceutical compositions comprising peptide sequences...
2016/0376335 POLYMERS CONTAINING MULTIVALENT AMYLOID-BETA-BINDING D-PEPTIDES AND THEIR USE
The invention relates to novel multivalent polymeric amyloid-beta-binding substances composed of several interconnected substances which per se already have...
2016/0376334 POSITIVE MODULATOR OF BONE MORPHOGENIC PROTEIN-2
Compounds of the present invention of formula I and formula II are disclosed in the specification and wherein the compounds are modulators of Bone Morphogenic...
2016/0376333 Polypeptides to Inhibit Epstein Barr Viral Protein BHRF1 and B Cell Lymphoma Family Proteins
The present invention provides designed polypeptides that selectively bind to and inhibit Epstein Barr protein BHFR1, and B cell lymphoma family proteins, and...
2016/0376332 CYAN-EXCITABLE ORANGE-RED FLUORESCENT PROTEINS AND BIOLUMINESCENT RESONANCE ENERGY TRANSFER SYSTEMS
Engineered orange-red fluorescent proteins with enhanced fluorescent properties, obtained by mutagenesis of mNeptune2, are disclosed. In particular, the...
2016/0376331 ELECTROACTIVE BIOPOLYMER OPTICAL AND ELECTRO-OPTICAL DEVICES AND METHOD OF MANUFACTURING THE SAME
A method of manufacturing a biopolymer optical device includes providing a polymer, providing a substrate, casting the polymer on the substrate, and...
2016/0376330 MATING FACTOR ALPHA PRO-PEPTIDE VARIANTS
The present invention is related to Mating Factor .alpha. pro-peptide variants useful for the recombinant expression of polypeptides comprising a GLP-1 peptide...
2016/0376329 Glucoprotein for Stimulation of the Immunological System
Several glucoproteins were isolated from the water extract of mushroom Trametes Versicolor using Fast Protein Liquid Chromatography Gel Filtration. The...
2016/0376328 PROTEINS COMPRISING AMINO-TERMINAL PROXIMAL SHIGA TOXIN A SUBUNIT EFFECTOR REGIONS AND CELL-TARGETING...
The present invention provides proteins comprising immunoglobulin-type binding regions for cell-type specific targeting and Shiga toxin A Subunit effector...
2016/0376327 Fusobacterium polypeptides and methods of use
The present invention provides isolated polypeptides isolatable from a Fusobacterium spp. Also provided by the present invention are compositions that include...
2016/0376326 MODIFIED BACTERIAL COLLAGEN-LIKE PROTEINS
The present disclosure relates to recombinant or synthetic collagen-like proteins comprising at least one triple-helical domain and wherein the collagen-like...
2016/0376325 USE OF AAV-EXPRESSED M013 PROTEIN AS AN ANTI-INFLAMMATORY THERAPEUTIC
Disclosed are methods and compositions for preventing, treating, and/or ameliorating one or more symptoms of inflammation in a mammal. In particular, viral...
2016/0376324 POLYNUCLEOTIDES FOR TREATING ONCOGENIC VIRAL POLYPEPTIDE POSITIVE TUMORS
This document relates to polynucleotides encoding antigenic polypeptides to induce an immune response to oncogenic viral polypeptides. Also provided are...
2016/0376323 ADENO-ASSOCIATED VIRUS VIRIONS WITH VARIANT CAPSID AND METHODS OF USE THEREOF
The present disclosure provides adeno-associated virus (AAV) virions with altered capsid protein, where the AAV virions exhibit greater infectivity of retinal...
2016/0376322 Derivative Peptide Compounds and Methods of Use
The present invention provides synthetic peptide compounds and uses thereof for therapy and diagnostics of complement-mediated diseases, such as inflammatory...
2016/0376321 A NOVEL SARS IMMUNOGENIC COMPOSITION
Embodiments of the disclosure concern immunogenic compositions and methods for treating or preventing Severe acute respiratory syndrome (SARS). The...
2016/0376320 ANTI-MICROBIAL PEPTIDES AND METHOD FOR DESIGNING NOVEL ANTI-MICROBIAL PEPTIDES
Disclosed herein are novel anti-microbial peptides with inhibitory activity against M. tuberculosis and streptococcus bacteria. Additionally, a method for...
2016/0376319 COLLAGEN IMAGING COMPOSTIONS
Compounds and methods for imaging and/or assessing collagen are described. The compounds can include collagen binding peptides.
2016/0376318 POLYPEPTIDE, DNA MOLECULE ENCODING THE POLYPEPTIDE, VECTOR, PREPARATION METHOD AND USE
A polypeptide, a DNA molecule encoding the polypeptide, a vector, a preparation method and a use therefor are disclosed. The polypeptide comprises an amino...
2016/0376317 NOVEL IMMUNOTHERAPY AGAINST SEVERAL TUMORS INCLUDING NEURONAL AND BRAIN TUMORS
The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the...
2016/0376316 NOVEL IMMUNOTHERAPY AGAINST SEVERAL TUMORS INCLUDING NEURONAL AND BRAIN TUMORS
The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the...
2016/0376315 NOVEL IMMUNOTHERAPY AGAINST SEVERAL TUMORS INCLUDING NEURONAL AND BRAIN TUMORS
The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the...
2016/0376314 NOVEL IMMUNOTHERAPY AGAINST SEVERAL TUMORS INCLUDING NEURONAL AND BRAIN TUMORS
The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the...
2016/0376313 NOVEL IMMUNOTHERAPY AGAINST SEVERAL TUMORS INCLUDING NEURONAL AND BRAIN TUMORS
The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the...
2016/0376312 NOVEL IMMUNOTHERAPY AGAINST SEVERAL TUMORS INCLUDING NEURONAL AND BRAIN TUMORS
The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the...
2016/0376311 PEPTOIDS AND METHODS FOR TREATING ALZHEIMER'S DISEASE
Provided herein are peptoids capable of inhibiting or reversing amyloid .beta. (A.beta.) fibril or plaque production. The peptoids form a helical structure...
2016/0376310 PEPTIDE DOMAINS THAT BIND SMALL MOLECULES OF INDUSTRIAL SIGNIFICANCE
Described herein are small peptide domains and consensus sequences that bind small target molecules of industrial importance, e.g., metals such as nickel,...
2016/0376309 AROMATIC-CATIONIC PEPTIDES AND USES OF SAME
The disclosure provides compositions and methods relating to aromatic-cationic peptides. The methods comprise administering to the subject an effective amount...
2016/0376308 SYNTHETIC PEPTIDE AMIDES AND DIMERS THEREOF
The invention relates to synthetic peptide amide ligands of the kappa opioid receptor and particularly to agonists of the kappa opioid receptor that exhibit...
2016/0376307 IAP ANTAGONISTS
There are disclosed compounds that modulate the activity of inhibitors of apoptosis (IAPs), pharmaceutical compositions containing said compounds and methods...
2016/0376306 N-Terminally Modified Linear and Branched Polyamine Conjugated Peptidomimetics as Antimicrobials Agents
N-terminally modified linear and branched polyamine conjugated peptidomimetics as antimicrobials agents. The invention relates to therapeutically viable...
2016/0376305 COMPOSITIONS CONTAINING HC-HA/PTX3 COMPLEXES AND METHODS OF USE THEREOF
Provided herein are methods for the production of native and reconstituted hyaluronan (HA) complexes containing pentraxin-3 (PTX3) and heavy chain 1 (HC1) of...
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