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Patent # Description
2016/0376304 SEPARATION OF BISPECIFIC ANTIBODIES AND BISPECIFIC ANTIBODY PRODUCTION SIDE PRODUCTS USING HYDROXYAPATITE...
The present invention is directed to methods comprising the use of hydroxyapatite chromatography to separate a bispecific antibody from a solution that also...
2016/0376303 GLYCYRRHETINIC ACID DERIVATIVE AND USE THEREOF
A novel glycyrrhetinic acid derivative. The glycyrrhetinic acid derivative is represented by the following general formula. ##STR00001##
2016/0376302 N-ALKYL 2-(DISUBSTITUTED)ALKYNYLADENOSINE-5-URONAMIDES AS A2A AGONISTS
The present invention provides N-alkyl 2-(disubstituted)alkynyladenosine-5'-uronamides and derivatives thereof and pharmaceutical compositions containing the...
2016/0376301 PURIFICATION OF STAPHYLOCOCCUS AUREUS TYPE 5 AND TYPE 8 CAPSULAR SACCHARIDES
The invention provides a method for releasing capsular polysaccharide from S. aureus type 5 or type 8 cells, comprising the step of treating the cells with...
2016/0376300 PROCESS FOR DEPOLYMERIZATION OF LIGNIN BY LACCASES
A method for depolymerization of lignin includes oxidizing non-phenolic lignin by putting into presence, in at least one solvent, non-phenolic lignin, laccase,...
2016/0376299 Novel Complex and Preparation Method of Poly(Alkylene Carbonate) Using the Same
The present invention is directed to a novel complex synthesized from a Salen-type ligand. The novel complex contains a quaternary ammonium salt. The present...
2016/0376298 PROTOTYPE SYSTEMS OF THERANOSTIC BIOMARKERS FOR IN VIVO MOLECULAR MANAGEMENT OF CANCER
The present invention relates to a theranostic system comprising a beacon and a compound selected from the group consisting of a quinazoline-based tyrosine...
2016/0376297 Phosphorous Derivatives as Kinase Inhibitors
The invention features compounds of the general formula: ##STR00001## in which the variable groups are as defined herein, and to their preparation and use.
2016/0376296 BIOCOMPATIBLE FLAVONOID COMPOUNDS FOR ORGANELLE AND CELL IMAGINING
Flavonoid compounds may be prepared that are selective for certain cell organelles, and may be used as biological imaging agents. Organelles that may be imaged...
2016/0376295 PRODRUGS OF PYRIDONE AMIDES USEFUL AS MODULATORS OF SODIUM CHANNELS
The invention relates to prodrug compounds of formula I: ##STR00001## wherein R.sup.2, R.sup.3, R.sup.5, R.sup.7 and X are as defined herein. The invention also...
2016/0376294 COMPOUNDS USEFUL IN THE SYNTHESIS OF HALICHONDRIN B ANALOGS
In general, the invention features compounds useful for the synthesis of analogs of halichondrin B, such as eribulin or pharmaceutically acceptable salts...
2016/0376293 NICKEL PRE-CATALYSTS AND RELATED COMPOSITIONS AND METHODS
Described herein are nickel pre-catalysts and related compositions and methods. The nickel pre-catalysts may be activated to form catalysts which may be...
2016/0376292 METHODS FOR FORMING PROTECTED ORGANOBORONIC ACIDS
Described are methods of forming protected boronic acids that provide in a manner that is straightforward, scalable, and cost-effective a wide variety of...
2016/0376291 IMIDAZOLO-, OXAZOLO-, AND THIAZOLOPYRIMIDINE MODULATORS OF TRPV1
Certain TRPV1-modulating imidazolo-, oxazolo-, and thiazolopyrimdine compounds are described. The compounds may be used in pharmaceutical compositions and...
2016/0376290 Imidazothiazole Derivatives as Modulators of TNF Activity
A series of substituted imidazo[2,1-b]thiazole derivatives, and analogues thereof, being potent modulators of human TNF.alpha. activity, are accordingly of...
2016/0376289 NOVEL BICYCLIC OR TRICYCLIC HETEROCYCLIC COMPOUND
The present invention provides a novel bicyclic or tricyclic heterocyclic compound represented by the formula (I) ##STR00001## wherein ring A is an optionally...
2016/0376288 MACROCYCLIC BENZODIAZEPINE DIMERS, CONJUGATES THEREOF, PREPARATION AND USES
Macrocyclic benzodiazepine dimers having a structure represented by formula I ##STR00001## where A and B are independently according to formulae Ia or Ib ...
2016/0376287 Chemical Compounds
Provided are a series of novel pyridine or pyrimidine derivatives which inhibit CDK9 and may be useful for the treatment of hyperproliferative diseases. In...
2016/0376286 Pyrimidin-4-one derivatives and their use in the tratement, amelioration or prevention of a viral disease
The present invention relates to a compound having the general formula II, optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph,...
2016/0376285 METHOD FOR PRODUCING CARBOXYLIC ACID ANHYDRIDE, METHOD FOR PRODUCING CARBOXYLIC IMIDE, AND METHOD FOR...
A method for producing a carboxylic acid anhydride includes heating a composition containing a specific compound in a solvent to yield the carboxylic acid...
2016/0376284 TAXANE COMPOUNDS, COMPOSITIONS AND METHODS
The present invention provides a method for the preparation of orally available pentacyclic taxane compounds, as well as intermediates useful in their...
2016/0376283 TBK/IKK INHIBITOR COMPOUNDS AND USES THEREOF
The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as TBK/IKK.epsilon. inhibitors.
2016/0376282 PORPHYRIN CONTAINING COVALENT ORGANIC FRAMEWORKS AND PROCESS FOR THE PREPARATION THEREOF
Disclosed herein is novel highly stable, crystalline porphyrin containing covalent organic frameworks and their synthesis using Schiff base reaction which are...
2016/0376281 BRUTON'S TYROSINE KINASE INHIBITORS
The present invention provides compounds useful as inhibitors of Btk, compositions thereof, and methods of using the same.
2016/0376280 Substituted 7-Azabicycles And Their Use As Orexin Receptor Modulators
The present invention is directed to compounds of Formula I: ##STR00001## wherein A is phenyl, naphthalenyl, pyridyl, quinolinyl, isoquinolinyl, imidazopyridyl,...
2016/0376279 FXR AGONISTS AND METHODS FOR MAKING AND USING
Novel FXR agonists are disclosed, embodiments of a method of making the same, and of a composition comprising them are disclosed herein. Also disclosed are...
2016/0376278 FUSED PYRAZOLE DERIVATIVE HAVING AUTOTAXIN INHIBITORY ACTIVITY
The present invention provides a compound of formula (1), wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4a, R.sup.4b, R.sup.5a and R.sup.5b are as defined in the...
2016/0376277 NOVEL HETEROCYCLIC COMPOUNDS
The present invention relates to heterocyclic compounds of the general formula (I) their pharmaceutically acceptable salts, pharmaceutically acceptable...
2016/0376276 Imidazotriazine Derivatives as Modulators of TNF Activity
A series of substituted imidazo[1,2-b][1,2,4]triazine derivatives of formula (I), being potent modulators of human TNFa activity, are accordingly of benefit in...
2016/0376275 Imidazopyridazine Derivatives as Modulators of TNF Activity
A series of substituted imidazo[1,2-b]pyridazine derivatives of formula (I), being potent modulators of human TNFa activity, are accordingly of benefit in the...
2016/0376274 POLYMORPHIC FORMS OF (S)-2-(1-(9H-PURIN-6-YLAMINO)PROPYL)-5-FLUORO-3-PHENYLQUINAZOLIN-4(3H)-ON- E
Polymorphs of (S)-2-(1-(9H-purin-6-ylamino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-on- e, compositions thereof, methods for their preparation, and methods...
2016/0376273 Novel Inhibitors of Phosphodiesterase Type 5 and their Therapeutic Uses
Disclosed is a compound represented by formula (I) or a pharmaceutically acceptable salt thereof as an inhibitor of phosphodiesterase type 5 and its...
2016/0376272 FACTOR XIa INHIBITORS
The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said...
2016/0376271 P2X7 MODULATORS
The present invention is directed to compounds of Formulas (I, IIa and IIb): ##STR00001## The invention also relates to pharmaceutical compositions comprising ...
2016/0376270 PROCESS OF PREPARING 3-(3-(4-(1-AMINOCYCLOBUTYL)PHENYL)-5-PHENYL-3H-IMIDAZO[4,5-B]PYRIDIN-2-YL- ...
The present invention is directed to a processes for the synthesis of 3-(3-(4-(1-aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl- ...
2016/0376269 NOVEL SALTS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS
The present invention discloses salts of a Compound 1: ##STR00001## useful in the prophylaxis and/or treatment of inflammatory conditions, autoimmune diseases,...
2016/0376268 Fused Tricyclic Imidazole Derivatives As Modulators of TNF Activity
A series of fused tricyclic imidazole derivatives, in particular dihydro-1H-cyclopenta[4,5]imidazo[1,2-a]pyridine derivatives, and analogues thereof, being...
2016/0376267 5-HYDROXY-4-(TRIFLUOROMETHYL)PYRAZOLOPYRIDINE DERIVATIVE
A compound represented by the general formula (I) or a pharmacologically acceptable salt thereof has an excellent LCAT-activating effect and is useful as an...
2016/0376266 ANTI-ALPHAVBETA1 INTEGRIN COMPOUNDS AND METHODS
Provided herein, inter alia, are methods and compositions for inhibiting .alpha.v.beta.1 integrin and for treating fibrosis.
2016/0376265 PREPARATION OF N-MONOFLUOROALKYL COMPOUNDS
The present invention relates to an improved synthesis of N-monofluoroalkyl tropanes using fluoroalkyl iodide. The invention also provides the use of such...
2016/0376264 QUINOLINONE-CARBOXAMIDE COMPOUNDS AS 5-HT4 RECEPTOR AGONISTS
The invention provides novel quinolinone-carboxamide 5-HT.sub.4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising...
2016/0376263 BITTER TASTE MODIFIERS INCLUDING SUBSTITUTED ...
The present invention includes compounds and compositions known to modify the perception of bitter taste, and combinations of said compositions and compounds...
2016/0376262 NOVEL PYRIDINE DERIVATIVES
The invention relates to a compound of formula (I) ##STR00001## wherein A and R.sup.1 to R.sup.4 are defined as in the description and in the claims. The...
2016/0376261 BENZIMIDAZOLE DERIVATIVES AS BROMODOMAIN INHIBITORS
This application relates to chemical compounds which may act as inhibitors of, or which may otherwise modulate the activity of, a bromodomain-containing...
2016/0376260 Slow Release of Organoboronic Acids in Cross-Coupling Reactions
A method of performing a chemical reaction includes reacting a compound selected from the group consisting of an organohalide and an organo-pseudohalide, and a...
2016/0376259 Methods for Preparing Oltipraz
The invention provides improved methods of synthesizing oltipraz, which result in higher overall yield and better purity of the desired product.
2016/0376258 1,2-NAPHTHOQUINONE BASED DERIVATIVE AND METHOD OF PREPARING THE SAME
Disclosed are a compound represented by Formula (1), or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, tautomer, enantiomer, or...
2016/0376257 FATTY ACID SYNTHASE INHIBITORS
This invention relates to triazolones and triazolones for the modulation, notably the inhibition of the activity or function of fatty acid synthase (FAS)....
2016/0376256 SULFONYL PIPERIDINE DERIVATIVES AND THEIR USE FOR TREATING PROKINETICIN MEDIATED DISEASES
The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof ##STR00001## in which q, R.sup.11, R.sup.12, R.sup.13 and...
2016/0376255 QUINOLONE INHIBITORS OF LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2
The present invention relates to new quinolone inhibitors of lipoprotein-associated phospholipase A2 activity, pharmaceutical compositions thereof, and methods...
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