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Patent # Description
2016/0375154 Gd(III)-Dithiolane Gold Nanoparticle Conjugates
Provided herein are compositions Gd(III)-dithiolane gold nanoparticle conjugates and methods of use thereof. In particular, compositions and method find use in...
2016/0375153 SYNTHESIS AND COMPOSITION OF AMINO ACID LINKING GROUPS CONJUGATED TO COMPOUNDS USED FOR THE TARGETED IMAGING OF...
The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a pteroyl ligand that binds...
2016/0375152 METHODS AND COMPOSITIONS RELATING TO IMPROVED LENTIVIRAL VECTORS AND THEIR APPLICATIONS
The present invention provides HIV-derived lentivectors which are safe, highly efficient, and very potent for expressing transgenes for human gene therapy,...
2016/0375151 ADENO-ASSOCIATED VIRUS VIRIONS WITH VARIANT CAPSID AND METHODS OF USE THEREOF
The present disclosure provides adeno-associated virus (AAV) virions with altered capsid protein, where the AAV virions exhibit greater infectivity of retinal...
2016/0375150 POLYMER-CYCLODEXTRIN-LIPID CONJUGATES
The invention comprises compounds, methods of making, and methods of using. A group of polymer-cyclodextrin-lipid conjugates having a center backbone and three...
2016/0375149 IN VIVO TARGETING OF CELLS WITH LIGAND-CONJUGATED PARTICLES
The invention provides compositions and methods for, inter alia, augmenting cell-based therapies in vivo by repeatedly stimulating target cells of interest...
2016/0375148 Compounds and Compositions for Treating EGFR Expressing Tumors
Provided are compounds for targeted immunotherapy. The compounds are useful in the treatment of EGFR expressing tumors/cancers. Also provided are compositions...
2016/0375147 MAYTANSINOID DERIVATIVES, CONJUGATES THEREOF, AND METHODS OF USE
Provided herein are maytansinoid derivatives, conjugates thereof, and methods of treating or preventing proliferative diseases with the same.
2016/0375146 Biologically Active Insulin Derivatives
A first aspect of the invention relates to a single chain insulin analogue comprising: (A) the A-chain of human or animal insulin, or an analogue or derivative...
2016/0375145 ETOPOSIDE AND DOXORUBICIN CONJUGATES FOR DRUG DELIVERY
The invention relates to improvements in the field of drug delivery. More particularly, the invention relates to polypeptides having a hydrolyzable covalent...
2016/0375144 METAP-2 INHIBITOR POLYMERSOMES FOR THERAPEUTIC ADMINISTRATION
Described herein are MetAP-2 inhibitors and compositions and formulations thereof, and more particularly compositions and formulations of MetAP-2 inhibitors...
2016/0375143 MIKTO-ARM BRANCHED POLYMERS
The invention relates to branched polymer comprising a support moiety and at least three homopolymer chains each covalently coupled to and extending from the...
2016/0375142 TARGETED THERAPEUTICS
The present invention provides pharmacological compounds including an effector moiety conjugated to a binding moiety that directs the effector moiety to a...
2016/0375141 ORAL DELIVERY SYSTEM FOR HEMOGLOBIN BASED OXYGEN CARRIERS
A process for making hemoglobin based oxygen carrier (HBOC) containing pharmaceutical composition suitable for oral delivery and the composition formed thereby...
2016/0375140 LONG-ACTING POLYMERIC DELIVERY SYSTEMS
Compositions comprised of a delivery vehicle or delivery system and an active agent dispersed within the delivery vehicle or system, wherein the delivery...
2016/0375139 COMPOSITION COMPRISING A POLYMER AND A BIOACTIVE AGENT AND METHOD OF PREPARING THEREOF
Amino acid based polymers and polymer blends. Compositions comprising at least one amino acid based polymer or polymer blend, at least one bioactive agent, and...
2016/0375138 CONSUMER GOODS PRODUCT COMPRISING FUNCTIONALISED LIGNIN OLIGOMER
The present invention relates to a consumer goods product comprising a consumer goods product ingredient and a functionalised lignin oligomer, wherein the...
2016/0375137 TARGETING LIPIDS
The present invention provides targeting lipids of structure L.sup.100-linker-L.sup.101 (CI), where L.sup.100 is a lipid, lipophile, alkyl, alkenyl or alkynyl, ...
2016/0375136 CARRIER COMPOSITION
The present invention relates to a carrier composition comprising a phosphate compound of an electron transfer agent and a polar aprotic solvent. Biologically...
2016/0375135 PHENYLALKYLCARBOXYLIC ACID DELIVERY AGENTS
The present invention provides phenylalkylcarboxylic acid compounds and compositions containing such compounds which facilitate the delivery of biologically...
2016/0375134 MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF SECRETED PROTEINS
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA...
2016/0375133 METHODS FOR PRODUCING HIGH CONCENTRATION LYOPHILIZED PHARMACEUTICAL FORMULATIONS
The present invention relates to methods of producing lyophilized pharmaceutical compositions comprising a high concentration of therapeutic protein or...
2016/0375132 HOMOGENOUS SUSPENSION OF IMMUNOPOTENTIATING COMPOUNDS AND USES THEREOF
The present invention generally relates to homogeneous suspensions of small molecule immune potentiators (SMIPs) that are capable of stimulating or modulating...
2016/0375131 METHODS OF RATIONAL NICOTINE HAPTEN DESIGN AND USES THEREOF
Provided herein are methods for rational design of nicotine haptens. More particularly, provided herein are methods for designing, selecting, and synthesizing...
2016/0375130 NOVEL IMMUNOTHERAPEUTIC COMPOSITION AND USES THEREOF
The present invention relates generally to an immunotherapeutic composition. More particularly, the present invention relates to an immunotherapeutic...
2016/0375129 DIMERIC SCAFFOLD PEPTIDES COMPRISING HIV-1 GP120 AND GP41 EPITOPES
The present invention relates to novel peptides and methods for inducing an immune response in a subject against an antigen and for treatment, diagnosis and...
2016/0375128 LIVE, ATTENUATED VACCINES AND METHODS OF MAKING AND USING
A live, attenuated HIV vaccine is provided, and methods of making a attenuated HIV vaccine are provided.
2016/0375127 Method of producing an inactivated lentivirus, especially HIV, vaccine, kit and method of use
A novel method for producing an immunogenic composition or vaccine comprising inactivated lentivirus, in particular inactivated HIV, wherein producer cells...
2016/0375126 AGENTS THAT ENGAGE ANTIGEN-PRESENTING CELLS THROUGH DENDRITIC CELL ASIALOGLYCOPROTEIN RECEPTOR (DC-ASGPR)
The present invention includes compositions and methods for making and using anti DC-ASGPR antibodies that can, e.g., activate DCs and other cells.
2016/0375125 THERAPIES, VACCINES, AND PREDICTIVE METHODS FOR INFECTIOUS SALMON ANEMIA VIRUS
The present invention provides therapies, vaccines, and predictive methods for infectious salmon anemia virus and provides compounds for diagnosing,...
2016/0375124 ALPHAVIRUS REPLICON PARTICLES MATCHED TO PROTEIN ANTIGENS AS IMMUNOLOGICAL ADJUVANTS
The immune response to an antigen of interest, especially one in purified form, can be significantly enhanced by the simultaneous administration of an...
2016/0375123 DENGUE VIRUS E-GLYCOPROTEIN POLYPEPTIDES CONTAINING MUTATIONS THAT ELIMINATE IMMUNODOMINANT CROSS-REACTIVE EPITOPES
Described herein are dengue virus E-glycoprotein polypeptides containing mutations that eliminate immunodominant cross-reactive epitopes associated with immune...
2016/0375122 PRRSV minor protein-containing recombinant viral vectors and methods of making and use thereof
The present invention encompasses recombinant porcine reproductive and respiratory syndrome virus (PRRSV) vaccines or compositions. In particular, the...
2016/0375121 ENGINEERED VESICLES COMPRISING ANTIGENIC PEPTIDES AND THE USES THEREOF AS MODULATORS OF IMMUNE RESPONSES
Disclosed herein are single nucleic acid constructs comprising a vector, wherein the vector comprises: a first nucleic acid sequence, wherein the first nucleic...
2016/0375120 SYNTHETIC OLIGOSACCHARIDES FOR MORAXELLA VACCINE
The present invention provides synthetic Moraxella catarrhalis lipooligosaccharide (LOS)-based oligosaccharides and conjugates containing various M....
2016/0375119 VECTORS FOR MOLECULE DELIVERY TO CD11b EXPRESSING CELLS
The invention relates to a novel use of a Bordetella adenylcyclase toxin in the manufacturing of vectors for targeting in vivo a molecule of interest,...
2016/0375118 MULTIVALENT PNEUMOCOCCAL POLYSACCHARIDE-PROTEIN CONJUGATE COMPOSITION
Provided is an immunogenic composition comprising 13 different polysaccharide-protein conjugates. Each of the conjugates comprises a capsular polysaccharide...
2016/0375117 METHODS AND COMPOSITIONS RELATING TO SYNTHETIC BETA-1,6 GLUCOSAMINE OLIGOSACCHARIDES
The invention relates to the compositions of synthetic oligo-.beta.-(1.fwdarw.6)-2-amino-2-deoxy-D-glu-copyranosides conjugated to carriers, and methods for...
2016/0375116 METHOD FOR TREATING STAGE IV MELANOMA
The present invention relates to a method of treating Stage IV melanoma in a subject. The method includes the step of administering to the subject a...
2016/0375115 PROSTATE-ASSOCIATED ANTIGENS AND VACCINE-BASED IMMUNOTHERAPY REGIMENS
The present disclosure provides (a) isolated immunogenic PAA polypeptides; (b) isolated nucleic acid molecules encoding immunogenic PAA polypeptides; (c)...
2016/0375114 NEWLY IDENTIFIED PEPTIDES FOR USE IN THE INDUCTION OF ORAL TOLERANCE IN YOUNG MAMMALS
The invention relates to newly identified peptides of that are capable of inducing tolerance to cow's milk, especially to .beta.-lactoglobulin. The peptides...
2016/0375113 COMPOSITIONS COMPRISING ENO1 AND THEIR USE IN METHODS OF TREATING OBESITY OR OVERWEIGHT AND REDUCING WEIGHT GAIN
The invention provides a method for reducing or preventing body weight gain in a subject comprising administering to the subject enolase 1 (Eno1). The...
2016/0375112 Reducing Adverse Side Effects of a Compound by a Neurotoxin
The present invention relates to methods and compositions for treating various side effects associated with the administration of one or more therapeutic...
2016/0375111 STABILIZED LIQUID AND LYOPHILIZED ADAMTS13 FORMULATIONS
The present invention relates to formulations of ADAMTS13 with enhanced or desirable properties. As such, the invention provides liquid and lyophilized...
2016/0375110 MODIFIED FACTOR IX, AND COMPOSITIONS, METHODS AND USES FOR GENE TRANSFER TO CELLS, ORGANS, AND TISSUES
The invention relates to modified Factor IX coding sequence, expression cassette, vectors such as viral (e.g., lenti- or adeno-associated viral) vectors, and...
2016/0375109 COMPOSITIONS AND METHODS FOR TREATING INTRACEREBRAL HEMORRHAGE
The disclosure provides compositions and methods for treating or preventing intracerebral hemorrhage (ICH) in a subject by administering a variant of FXa.
2016/0375108 Compositions and Methods of Use of Immunotoxins Comprising Ranpirnase (Rap) Show Potent Cytotoxic Activity
The present invention concerns methods and compositions for forming immunotoxin complexes having a high efficacy and low systemic toxicity. In preferred...
2016/0375107 FRAGILE HISTIDINE TRIAD (FHIT) COMPOSITIONS AND USES THEREOF
Provided herein are methods and compositions for the diagnosis, prognosis and treatment of a cancer associated disorders using the Fhit gene.
2016/0375106 DILUTE SURFACTANT OR ISOLATED SURFACTANT PROTEIN SOLUTION FOR THE REDUCTION OF SURFACE TENSION IN THE LUNG
In permeability lung edema, cardiogenic lung edema or neonatal respiratory distress, there is heterogeneous liquid distribution throughout the lungs. The...
2016/0375105 ALBUMIN NANOPARTICLES TO AUGMENT STEM CELL FUNCTION IN VIVO
The present invention relates to a product and method of using albumin nanoparticles for augmenting the function or effectiveness of stem cells or precursor...
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