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Patent # Description
2017/0000905 DEVICE AND METHOD OF PERSONALIZED MEDICINE
The field of this invention is personalized medicine. A tissue sample is taken from a patient, optionally amplified, and injected into animals, such as mice in...
2017/0000904 PHARMACOLOGICALLY INDUCED TRANSGENE ABLATION SYSTEM
The present invention relates to gene therapy systems designed for the delivery of a therapeutic product to a subject using replication-defective virus...
2017/0000903 CRYSTALLINE CELLULOSE GEL-BASED CRYPTANDS, SURFACE ACTIVE AGENTS, EMULSIONS AND VESICLES
Crystalline cellulose gels useful in the stabilization of emulsions, including nanoemulsions, and for acting as cryptands or clathrates, and methods for their...
2017/0000902 EGFR-TARGETED NANOPARTICLES
Described herein are carrier nanoparticles comprising a polymer containing a polyol coupled via a boronic ester to a polymer containing a boronic acid,...
2017/0000901 DLL3 MODULATORS AND METHODS OF USE
Novel modulators, including antibodies and derivatives thereof, and methods of using such modulators to treat proliferative disorders are provided.
2017/0000900 ANTI-CD37 IMMUNOCONJUGATE AND ANTI-CD20 ANTIBODY COMBINATIONS
Methods of administering immunoconjugates that bind to CD37 (e.g., IMGN529) in combination with antibodies that bind to CD20 are provided. The methods comprise...
2017/0000899 RECEPTOR-TARGETED NANOPARTICLES FOR ENHANCED TRANSCYTOSIS MEDIATED DRUG DELIVERY
Receptor-targeted nanoparticles (R-NPs) are provided for selective transport into and through targeted tissues of therapeutic, prophylactic and diagnostic...
2017/0000898 Therapeutic Biologic for Treatment of Hepatocellular Carcinoma
The invention provides, inter alia, conjugates comprising a coagulating agent conjugated to an antibody, where the antibody specifically binds an extracellular...
2017/0000897 MONOMETHYLVALINE COMPOUNDS CAPABLE OF CONJUGATION TO LIGANDS
Auristatin peptides, including MeVal-Val-Dil-Dap-Norephedrine (MMAE) and MeVal-Val-Dil-Dap-Phe (MMAF), were prepared and attached to Ligands through various...
2017/0000896 PRO-DRUG FORM (P2PDOX) OF THE HIGHLY POTENT 2-PYRROLINODOXORUBICIN CONJUGATED TO ANTIBODIES FOR TARGETED...
Disclosed are methods, compositions and uses of conjugates of prodrug forms of 2-pyrrolinodoxorubicin (P2PDox) with antibodies or antigen-binding fragments...
2017/0000895 LONG ACTING LUTEINIZING HORMONE (LH) COMPOUND
The present invention relates to a long acting biologically active luteinizing hormone (LH) compound comprising an LH agonist linked to a pharmaceutically...
2017/0000894 COMPOSITIONS AND METHODS FOR MODIFYING THE SURFACE OF CELLS AND METHODS OF USE
Described herein are compounds, compositions and methods for modification of the surface of a living cell with a therapeutically relevant targeting moiety....
2017/0000893 COMPOUNDS FOR TARGETING DRUG DELIVERY AND ENHANCING siRNA ACTIVITY
Here described are compounds consisting of the structure (targeting molecule).sub.m-linker-(targeting molecule).sub.n, wherein the targeting molecule is a retinoid or...
2017/0000892 STABILIZING COMPOSITION FOR BIOLOGICAL MATERIALS
Dry stabilizing compositions for bioactive materials include sugars and hydrolyzed proteins, and may be formed into tablets or other forms providing enhanced...
2017/0000891 FOOD COMPOSITION
A food composition comprising astaxanthin (A), a powder (B) of a sucrose fatty acid ester that is powdery at 25.degree. C. and has an HLB value of 10 or more,...
2017/0000890 PHARMACEUTICAL FORMULATION FOR ADMINISTRATION OF MEDICINES
The formulation of medicines based on healthy, natural, gluten-free, lactose-free excipients without coloring agents or artificial preservatives is provided.
2017/0000889 STABLE BROMFENAC OPHTHALMIC SOLUTION
The present invention provides a stable, aqueous solution comprising a non-steroidal anti-inflammatory drug (NSAID) such as bromfenac or a pharmacologically...
2017/0000888 NANOSTRUCTURED GELS CAPABLE OF CONTROLLED RELEASE OF ENTRAPPED AGENTS
Self-assembled gel compositions including a gelator, e.g., an enzyme-cleavable gelator, e.g., having a molecular weight of 2500 or less, are described. The...
2017/0000887 UNIFORM CORE-SHELL TIO2 COATED UPCONVERSION NANOPARTICLES AND USE THEREOF
An upconversion nanoparticle (UCN) coated with a layer of semiconductor material is disclosed. The UCN core acts as a nanotransducer to convert near infrared...
2017/0000886 MESENCHYMAL STEM CELLS FOR TARGETED CANCER THERAPY
An isolated polynucleotide comprising the element of: a promoter element that drives expression of the C--C motif ligand 5 ("a CCL5 promoter") operatively...
2017/0000885 METHODS OF TREATING CANCER USING ANTI-OX40 ANTIBODIES AND PD-1 AXIS BINDING ANTAGONISTS
The invention provides methods of treating or delaying progression of cancer in an individual comprising administering to the individual an anti-human OX40...
2017/0000884 STAT3 PHOSPHORYLATION DURING GRAFT-VERSUS-HOST DISEASE
Compositions and methods to reduce the risk of graft versus host disease (GVHD) in a subject receiving hematopoietic stem cell transplantation (HSCT). Also...
2017/0000883 SUPERANTIGEN POST-EXPOSURE THERAPY
The present invention relates to a post-exposure therapeutic against superantigen-mediated disease in a subject.
2017/0000882 Genetically Detoxified Pertussis Vaccine that Maintains Intrinsic Adjuvant Activity
The invention is directed to a method for the production of a pertussis vaccine and, in particular, a detoxified pertussis vaccine comprising detoxified...
2017/0000881 ENHANCING THE T-CELL STIMULATORY CAPACITY OF HUMAN ANTIGEN PRESENTING CELLS IN VITRO AND IN VIVO AND ITS USE IN...
We provide new methods of in vitro or in vivo enhancing the T-cell stimulatory capacity of human DCs and the use thereof in cancer vaccination. The method...
2017/0000880 MILK-BASED PROTEIN HYDROLYSATES AND INFANT FORMULAE AND NUTRITIONAL COMPOSITIONS MADE THEREOF
A composition including protein hydrolysates derived from milk is obtained by the treatment of enzymes derived from microorganisms. A trypsin-like enzyme and a...
2017/0000879 Compositions and Methods for the Treatment or Prevention of Hepatitis B Virus Infection
Disclosed are yeast-based immunotherapeutic compositions, hepatitis B virus (HBV) antigens, and fusion proteins for the treatment and/or prevention of HBV...
2017/0000878 CONSTRAINED IMMUNOGENIC COMPOSITIONS AND USES THEREFOR
A stable immunogenic or vaccine composition comprising a complex or polyhedra comprising same comprising an antigen of a pathogen or other antigen against...
2017/0000877 MONOVALENT H5 VACCINE
The present invention relates to a monovalent H5N1 vaccine. More specifically, the present invention relates to the development of a monovalent H5 vaccine...
2017/0000876 METHOD FOR THE VACCINATION AGAINST HIV
The present invention relates to novel compositions of active agents and methods for the treatment of HIV infection and AIDS. In particular, the present...
2017/0000875 TOXOID PREPARATION AND USES THEREOF
The present invention relates to toxoid preparations comprising a non-disrupted and/or a non-denatured toxin associated with a particulate vector that...
2017/0000874 NOVEL MENINGOCOCCAL CONJUGATE VACCINE FOR GROUPS A, C, Y AND W135 AND A PREPARATION METHOD THEREOF
The present invention provides a meningococcal conjugate vaccine for groups A, C, Y and W135, which is a tetravalent conjugate vaccine comprising...
2017/0000873 Dimethyl Fumarate and Vaccination Regimens
Provided herein is a method of treating or preventing a disease or disorder (e.g., MS) in a subject in need thereof, comprising (a) administering to the...
2017/0000872 INACTIVATED BACTERIAL CELL FORMULATION
The invention relates to the use of lactic acid-producing bacteria to boost the immune system.
2017/0000871 COMPOSITION FOR TREATING PROSTATE CANCER (PCa)
The present invention relates to an active (immunostimulatory) composition comprising at least one RNA preferably an mRNA, encoding at least two (preferably...
2017/0000870 COMBINATION THERAPY FOR IMMUNOSTIMULATION
The present invention relates to a method for immunostimulation in a mammal which comprises a. administration of at least one mRNA containing a region which...
2017/0000869 Compositions and Methods for Treating Immunological Dysfunction
The present invention is directed to methods of lymphotherapy to treat cancer, infection and autoimmune disease.
2017/0000868 COMPOSITIONS AND METHODS FOR COMBINATION THERAPY WITH DENGUE VIRUS AND DENDRITIC CELLS
Described herein are compositions and methods for treating cancer through the combination of tumor antigen-pulsed dendritic cells and Dengue Virus. The...
2017/0000867 VACCINE COMPOSITIONS AND METHODS FOR RESTORING NKG2D PATHWAY FUNCTION AGAINST CANCERS
The present invention provides compositions and methods for treating cancer in a subject by eliciting an immune response against a MIC polypeptide.
2017/0000866 METHOD FOR EMULSIFYING A TRIEPITOPE PEPTIDE WITH MONTANIDE AND KITS FOR PERFORMING THE SAME
The present invention relates to a method for preparing a vaccine formulation with an optimized polypeptide comprising three epitopes and MONTANIDE as...
2017/0000865 DNA Vaccines Encoding Heat Shock Proteins
A method of treating a T cell-mediated inflammatory autoimmune disease by administering to an individual in need thereof an immunogenic composition comprising...
2017/0000864 COMPOSITIONS, METHODS AND USES OF ALPHA 1-ANTITRYPSIN FOR EARLY INTERVENTION IN BONE MARROW TRANSPLANTATION AND...
Embodiments of the present invention relate to compositions and methods for treatment of subjects in need of or having a bone marrow transplant. Certain...
2017/0000863 THERAPEUTIC AGENT FOR DISC HERNIATION
The present invention provides a therapeutic agent for disc herniation, which has extremely few adverse side effects, can achieve a prolonged pain-ameliorating...
2017/0000862 ENGINEERED CHIMERIC PEGYLATED ADI AND METHODS OF USE
Provided are chimeric arginine deiminases, including pegylated chimeric arginine deiminases, and related compositions and methods of use thereof, including...
2017/0000861 PHARMACEUTICAL COMPOSITION WITH IMPROVED STABILITY CONTAINING FACTOR VII FUSION PROTEIN
The present invention provides a pharmaceutical composition with improved stability, comprising a fusion protein comprising factor VII(FVII) and transferrin,...
2017/0000860 ULTRAPURE HYPOALLERGENIC SOLUTIONS OF SACROSIDASE
One aspect provides an ultrapure, hypoallergenic sacrosidase. Another aspect provides a solution of sacrosidase in about 1:1 glycerol/water having an enzymatic...
2017/0000859 NON-NATURAL RIBONUCLEASE CONJUGATES AS CYTOTOXIC AGENTS
The present invention is directed toward the delivery of a toxic protein to pathogenic cells, particularly cancer cells. In preferred embodiments, the toxic...
2017/0000858 COMPLEXES OF RNA AND CATIONIC PEPTIDES FOR TRANSFECTION AND FOR IMMUNOSTIMULATION
The present invention relates to a complexed RNA, comprising at least one RNA complexed with one or more oligopeptides, wherein the oligopeptide, which has the...
2017/0000857 NEW TARGET FOR DIABETES TREATMENT AND PREVENTION
The present invention relates to the identification of ALMS1 as the missing player involved in the regulation of the insulin-mediated glucose uptake through...
2017/0000856 DIETARY SUPPLEMENTS AND FORMULATIONS
Provided are dietary supplements, formulations, kits and methods for administration to an individual with type II diabetes or at risk of developing type II...
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