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Patent # Description
2017/0002355 cGAP-PNA MULTIVALENT PEPTIDE NUCLEIC ACID LIGAND DISPLAY
Described herein are compositions composed of peptide nucleic acid strands. In some aspects the peptide nucleic acid strands are complementary to at least a...
2017/0002354 MIRNA MODULATORS OF THERMOGENESIS
Provided are novel methods and compositions for the modulation of thermogenesis. Such methods are particularly advantageous in that they allow for the...
2017/0002353 Methods and Compositions Related To miR-21 and miR-29A, Exosome Inhibition And Cancer Metastasis
The present invention provides materials and methods related to the discovery that tumor secreted miR-21 and miR-29a can function by binding as ligands to...
2017/0002352 Inhibitors of thioredoxin-interacting protein (TXNIP) for therapy
Described is a compound capable of reducing or inhibiting (a) the biological activity of thioredoxin-interacting protein (TXNIP) or (b) the expression of the...
2017/0002351 COMPOSITIONS AND METHODS FOR REDUCING C/EBP HOMOLOGOUS PROTEIN ACTIVITY IN MYELOID-DERIVED SUPPRESSOR CELLS
Provided are compositions and methods of use thereof that modulate C/EBP homologous stress-related protein (Chop) activity in Myeloid-derived Suppressor Cells...
2017/0002350 TAILED MIRTRON EFFECTORS FOR RNAI-MEDIATED GENE SILENCING
The present invention relates to an isolated mirtron capable of binding a target nucleic acid, wherein the isolated mirtron comprises: a) a stem loop structure...
2017/0002349 SMALL RNA, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF IN PHARMACEUTICALS FOR SPECIFICALLY...
Disclosed in the present invention are a method for specifically up-regulating gene expression through targeting core promoter using small RNAs (including...
2017/0002348 MICRORNAS THAT SILENCE TAU EXPRESSION
This invention relates to the treatment and prevention of Alzheimer's disease (AD), tangle-predominant dementia (TPD) and other diseases associated with...
2017/0002347 Compositions and Methods for Making Selenocysteine Containing Polypeptides
Non-naturally occurring tRNA.sup.Sec and methods of using them for recombinant expression of proteins engineered to include one or more selenocysteine residues...
2017/0002346 PICHIA PASTORIS SURFACE DISPLAY SYSTEM
This disclosure relates to novel Pichia pastoris display systems, e.g., display systems featuring the Pichia pastoris strains (such as SuperMan5) with...
2017/0002345 METHODS FOR EFFICIENT, EXPANSIVE, USER-DEFINED DNA MUTAGENESIS
The presently disclosed subject matter provides methods for the creation of one or more user-defined mutations that can be located anywhere in a target...
2017/0002344 ISOLATION OF MICRONICHES FROM SOLID-PHASE AND SOLID SUSPENSION IN LIQUID PHASE MICROBIOMES USING LASER INDUCED...
A method for printing materials by: providing a receiving substrate; providing a target substrate having a photon-transparent support, a photon absorbent...
2017/0002343 METHOD OF ATTACHING A CELL-OF-INTEREST TO A MICROTUBE
A method of attaching a cell or a membrane-coated particle-of-interest to a microtube is provided. The method comprising: co-electrospinning two polymeric...
2017/0002342 GRANULES COMPRISING ISOMALTULOSE SYNTHASE
The invention provides granules comprising A) at least one enzyme selected from at least one of the groups selected from transferases of EC 2, hydrolases of EC...
2017/0002341 HETEROLOGOUS EXPRESSION OF FUNGAL CELLOBIOHYDROLASE 2 GENES IN YEAST
The present invention provides for heterologous expression of polypeptides encoded by wild-type and codon-optimized cbh2 genes from the organisms Cochliobolus...
2017/0002340 ALPHA-AMYLASE VARIANTS
The invention relates to a variant of a parent Termamyl-like alpha-amylase, which variant exhibits altered properties, in particular reduced capability of...
2017/0002339 Methods and Compositions for Sequences Guiding Cas9 Targeting
The present invention is directed to methods and compositions for genome editing and DNA targeting of proteins.
2017/0002338 OMEGA-TRANSAMINASE OF R CONFIGURATION AND USES THEREOF
An omega-transaminase of R-configuration is provided. The omega-transaminase of R-configuration has the amino acid sequence as shown in SEQ ID NO: 2, or has at...
2017/0002337 Fusion Enzymes
The present disclosure relates to recombinant proteins having N-acetylglucosaminyltransferase activity. The present disclosure further relates to methods for...
2017/0002336 MODIFIED GLUCOSYLTRANSFERASES FOR PRODUCING BRANCHED ALPHA-GLUCAN POLYMERS
Glucosyltransferase enzymes are disclosed herein that produce branched alpha-glucan polymer. Also disclosed, for example, are polynucleotides encoding these...
2017/0002335 GLUCOSYLTRANSFERASE AMINO ACID MOTIFS FOR ENZYMATIC PRODUCTION OF LINEAR POLY ALPHA-1,3-GLUCAN
Reactions comprising water, sucrose, and one or more glucosyltransferase enzymes are disclosed herein. Glucosyltransferase enzymes used in these reactions...
2017/0002334 DIRECT EVOLUTION OF A REGIOSELECTIVE HALOGENASE FOR INCREASED THERMOSTABILITY
Compounds and methods are providing involving RebH variants with improved properties. directed evolution based on random mutagenesis was employed to generate a...
2017/0002333 KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF AZETIDINONE
The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase...
2017/0002332 METHOD FOR PURIFYING ENVELOPED VIRUSES OR VIRAL VECTORS
The invention relates to a process for purifying enveloped viruses. The process of the invention is useful for recovering at a large scale enveloped viruses...
2017/0002331 CYTOTOXIC ANTIBODY
An antibody that binds a glycosylated protein is disclosed, wherein the glycosylation comprises the glycan motif Fuc.alpha.1-2Gal.beta.1-3GlcNAc1-3Gal.beta.1...
2017/0002330 ENGINEERED ADULT-LIKE HUMAN HEART TISSUE
A cardiac organoid containing 3-D matter of adult human heart tissue.
2017/0002329 GENERATING CARDIAC PROGENITOR CELLS FROM PLURIPOTENT STEM CELLS USING ISOXAZOLE OR ISOXAZOLE LIKE COMPOUNDS
This disclosure provides a chemically modified induced pluripotent stem (iPS) cell derived from parental cells and methods for generating the chemically...
2017/0002328 METHOD FOR HARVESTING STEM AND PROGENITOR CELLS AND METHOD OF TREATMENT OF KIDNEY DISEASE AND NEUROLOGICAL DISEASE
A method of generating one of podocyte progenitor cells and neural stem/progenitor cells comprising the steps of collecting a urine specimen from a patient;...
2017/0002327 DIRECTED DIFFERENTIATION AND MATURATION OF PLURIPOTENT CELLS INTO HEPATOCYTE LIKE CELLS BY MODULATION OF...
Provided are improved methods using Glycogen synthase kinase 3 (GSK3) inhibitors by which endodermal cells, notable endodermal cells derived from human...
2017/0002326 Purification of Cell Mixtures Using Molecular Beacons Targeting Cell Specific RNA
This disclosure is in the area of research and therapeutics. In certain embodiments, it provides methods to assist in the purification of cell mixtures, e.g.,...
2017/0002325 GENERATION OF CARDIOMYOCYTES FROM HUMAN PLURIPOTENT STEM CELLS
Methods for generating high-yield, high-purity cardiomyocyte progenitors or cardiomyocytes from pluripotent cells are described. Wnt/.beta.-catenin signaling...
2017/0002324 SURFACE ENERGY DIRECTED CELL SELF ASSEMBLY
The present disclosure provides a method of fabricating cell, such as stem cell, arrays on a carrier where the surface energy of the carrier has been modified...
2017/0002323 METHOD FOR PREPARING TISSUE, PARTICULARLY ADIPOSE TISSUE, FOR TRANSPLANTATION FROM LOBULAR FAT EXTRACTED BY...
A method of preparing adipose tissue for transplantation, from lobular fat extracted, for instance, by liposuction, said fat consisting of a fluid component...
2017/0002322 METHODS OF GENERATING NATURAL KILLER CELLS
Provided herein are methods of producing natural killer cells using a two-step expansion and differentiation method. Also provided herein are methods of...
2017/0002321 METHODS AND COMPOSITIONS FOR GENERATING AN IMMUNE RESPONSE BY INDUCING CD40 AND PATTERN RECOGNITION RECEPTOR...
Provided are methods for activating an antigen-presenting cell and eliciting an immune response by inducing an inducible pattern recognition receptor adapter,...
2017/0002320 Protein markers associated bone marrow stem cell differentiation into early progentior cells
A novel cytosolic 58 kd phosphoprotein induced during bone marrow stem cell (BM) differentiation into dendritic cells (DC) during in vitro cultivation with the...
2017/0002319 Master Transcription Factors Identification and Use Thereof
Provided herein are methods for identifying master transcription factors (TFs) in a cell type of interest and for transdifferentiation of a somatic cell, e.g.,...
2017/0002318 APPLICATION OF LAMININ TO CORNEAL ENDOTHELIAL CELL CULTURE
The present invention provides a method of culturing corneal endothelial cells. More specifically, the present invention provides a composition for culturing...
2017/0002317 CONVERSION OF NON-NEURONAL CELLS INTO NEURONS
The subject invention concerns materials and methods for conversion of non-neuronal cells into neurons. The subject invention also concerns methods for...
2017/0002316 TRANS-DIFFERENTIATION OF DIFFERENTIATION CELLS
The present invention comprises methods and compositions related to trans-differentiating differentiated cells, the methods comprising bringing said cells into...
2017/0002315 CELL-SEEDING AND -CULTURING DEVICE
Provided is a device for seeding cells in a plurality of cell arrangement areas in a simple manner and a short period of time. A seeding and culturing device...
2017/0002314 METHODS RELATING TO PLURIPOTENT CELLS
The technology described herein relates to methods, assays, and compositions relating to causing a cell to assume a more pluripotent state, e.g. without...
2017/0002313 COMPOSITIONS AND METHODS OF OBTAINING AND USING ENDODERM AND HEPATOCYTE CELLS
The invention provides for efficient methods for generating populations of endoderm cells and/or differentiated cells derived from endoderm cells (e.g.,...
2017/0002312 COMPOSITIONS AND METHODS FOR FLOWABLE ALLOGRAFT TISSUE
The present technology provides methods for preparing a flowable amniotic composition derived from amniotic membrane of humans. Various embodiments of the...
2017/0002311 METHOD FOR PRODUCING CULTURE MEDIUM COMPOSITION
The present invention provides a production method of a medium composition, including previously removing divalent metal cations contained in a polymer...
2017/0002310 Efficient Bottom-Improving Bacillus and Compound Bottom-Improving Microbial Agent Prepared From the Same and...
The applicant provides a strain of Bacillus tequilensis ZSGD5, with accession number of the deposit of CCTCC NO.: M 2014004, deposited at the China Center for...
2017/0002309 BIOLOGICAL YEAST, METHOD FOR OBTAINING SAME AND USES THEREOF
The present invention relates to a method for producing yeast. It relates in particular to a method for producing biological yeast, comprising the use of...
2017/0002308 DEVICE FOR SEPARATING CELLS IN FLUID
The present disclosure provides a device for separating cells in fluid, comprising a first driving pump, a separation column, a detection column, a second...
2017/0002307 Imaging Apparatus, Imaging System and Incubator
An imaging apparatus comprises: a culture container including an accommodation space for accommodating a sample carrier carrying biological samples in a...
2017/0002306 Gas Recirculation System for an Incubated Controlled Environment
A gas recirculation system for an incubated controlled environment, the system comprising: a first mixing box; a second mixing box in fluid communication with...
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