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Patent # Description
2017/0002105 POLYMERS INCORPORATING HYDROXYL GROUP-CONTAINING METHYLSTYRENE
Vulcanizates with desirable properties can be obtained from compounds incorporating polymers that include hydroxyl group-containing .alpha.-methylstyrene...
2017/0002104 AMINOSILANE TERMINAL MODIFIER TO WHICH FUNCTIONAL GROUP HAS BEEN INTRODUCED, METHOD FOR PRODUCING...
Disclosed are an end-modified conjugated diene-based polymer configured such that the end of a conjugated diene-based polymer is coupled with an ...
2017/0002103 MODIFIED CONJUGATED DIENE POLYMER, MODIFIED RUBBER COMPOSITION COMPRISING SAME, AND METHOD FOR PREPARING...
Disclosed are a modified conjugated diene-based polymer represented by specific Chemical Formula and a method of preparing the same.
2017/0002102 METHOD FOR PRODUCING RUBBER PARTICLES WITH REDUCED COAGULATION TENDENCY, METHOD FOR PRODUCING PNEUMATIC TIRE,...
Provided is a method for producing rubber particles with a reduced coagulation tendency. The present invention relates to a method for producing rubber...
2017/0002101 RUBBER COMPOSITION, MODIFIED POLYMER, AND TIRE
An object of the present invention is to provide a modified polymer that can realize a rubber composition having excellent low heat build-up and that has...
2017/0002100 DEPOLYMERISATION OF POLYSACCHARIDES AND RELATED PRODUCTS
Procedure for depolymerising polysaccharides using UV-vis light irradiation catalyzed by a radical photoinitiator. The polysaccharides obtained with the...
2017/0002099 Methods for Purifying Polysaccharides and Pharmaceutical Compositions and Medical Devices Containing the Same
Methods for removing endotoxin from naturally occurring materials, such as polysaccharides (e.g., agarose and/or carrageenan) are described herein....
2017/0002098 MODIFIED BIOPOLYMERS AND METHODS OF PRODUCING AND USING THE SAME
Modified biopolymers, such as, charge-modified biopolymers, cross-linked biopolymers, and cross-linked, charge-modified biopolymers are provided along with...
2017/0002097 MULTI-SPECIFIC BINDING PROTEINS
This invention generally relates to multi-specific binding proteins. The invention also relates to methods of making such proteins and to methods of using such...
2017/0002096 CONJUGATION METHODS
This invention describes a method of conjugating a cell binding agent such as an antibody with an effector group (e.g., a cytotoxic agent) or a reporter group...
2017/0002095 CANCER SPECIFIC GLYCANS AND USE THEREOF
The present invention describes glycans, which are specifically expressed by certain cancer cells, tumours and other malignant tissues. The present invention...
2017/0002094 PLASMA KALLIKREIN BINDING PROTEINS AND USES THEREOF IN TREATING HEREDITARY ANGIOEDEMA
Provided herein are plasma kallikrein binding proteins such as antibodies binding to active plasma kallikrein and methods of using such proteins in treating...
2017/0002093 INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF...
Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements...
2017/0002092 INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF...
Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements...
2017/0002091 INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF...
Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements...
2017/0002090 LIGAND-CYTOTOXIC DRUG CONJUGATE, PREPARATION METHOD THEREOF, AND USES THEREOF
Ligand-cytotoxic drug conjugates, pharmaceutical compositions, preparation methods, and pharmaceutical uses thereof are provided. More specifically, a...
2017/0002089 ANTI-MCAM ANTIBODIES AND ASSOCIATED METHODS OF USE
The invention provides anti-MCAM antibodies that inhibit the ability of human MCAM to bind a laminin alpha-4 chain. The invention also provides pharmaceutical...
2017/0002088 COMPOSITIONS AND METHODS FOR THE DETECTION DIAGNOSIS AND THERAPY OF HEMATOLOGICAL MALIGNANCIES
Disclosed are methods and compositions for the detection, diagnosis, prognosis, and therapy of hematological malignancies, and in particular, B cell leukemias,...
2017/0002087 MOBILIZING ANTI-TUMOR IMMUNITY BY TARGETING CHEMERIN RECEPTOR CCRL2
Chemerin is a chemoattractant that selectively directs intra-tumor recruitment of CMKLR1+ cells. Blockade of CCRL2 from binding to chemerin in non-neoplastic...
2017/0002086 ANTIBODIES AND IMMUNOCONJUGATES
The invention provides immunoconjugates and methods of using the same.
2017/0002085 METHODS OF USING ANTI-LGR5 ANTIBODIES
Provided herein are methods of using anti-LGR5 antibodies, for example, for treating a hedgehog-related disease including basal cell carcinoma.
2017/0002084 MONOCLONAL ANTIBODIES DIRECTED TO CD20
The invention provides antibody to canine or feline or equine antigens. Specifically, antibodies directed to canine CD20 which have been caninized or felinized...
2017/0002083 Antibodies, Uses & Methods
The present invention relates to anti-human OX40L antibodies, new medical uses and methods.
2017/0002082 ACTIVATABLE ANTIBODIES THAT BIND INTERLEUKIN-6 RECEPTOR AND METHODS OF USE THEREOF
The invention relates generally to activatable antibodies that include a masking moiety (MM), a cleavable moiety (CM), and an antibody (AB) that specifically...
2017/0002081 ANTIBODY AGAINST THE CSF-1R
The present invention provides antibodies specific for the CSF-1R, compositions comprising said antibodies and methods of treatment using such compositions.
2017/0002080 Antibodies With Modified Affinity To FcRn That Promote Antigen Clearance
An objective of the present invention is to provide methods for facilitating antigen-binding molecule-mediated antigen uptake into cells, methods for...
2017/0002079 ST2 ANTIGEN BINDING PROTEINS
Described herein are compositions and methods related to antigen binding proteins that bind to human ST2, including antibodies. In particular embodiments, the...
2017/0002078 FORMULATION FOR ANTI-ALPHA4BETA7 ANTIBODY
Methods for inducing clinical remission of ulcerative colitis in a human patient are described comprising administration of an antibody that has binding...
2017/0002077 COMBINATION TREATMENT FOR MULTIPLE SCLEROSIS
The present application provides evidence that a combined blockade against alpha-4 integrin and MCAM is more effective than against either molecule alone. In...
2017/0002076 TARGETING AGENT ANTIBODY CONJUGATES AND USES THEREOF
Methods, compositions and uses are provided for bispecific antibodies comprising one or more unnatural amino acids. The bispecific antibodies may bind to two...
2017/0002075 ANTIBODIES TO RECEPTOR OF ADVANCED GLYCATION END PRODUCTS (RAGE) AND USES THEREOF
The present application relates to isolated proteins, particularly monoclonal antibodies, in particular CDR-grafted, humanized antibodies which bind to RAGE...
2017/0002074 ANTI-CD33 ANTIBODIES AND IMMUNOCONJUGATES
The invention provides anti-CD33 antibodies and immunoconjugates and methods of using the same.
2017/0002073 COMPOSITIONS AND METHODS FOR MODULATING AN IMMUNE RESPONSE
Described herein are compositions for increasing IL-12 production comprising IgG or a fragment thereof or a variant thereof and uses of said compositions for...
2017/0002072 Compositions and Methods for Treating Cancer
The invention provides compositions and methods for treating ovarian cancer. Specifically, the invention relates to administering a genetically modified T cell...
2017/0002071 Arthritis Treatment
Administration of a monoclonal Ab (mAb) that specifically targets IL-1.alpha. is useful to treating articular and extra-articular symptoms of arthritis.
2017/0002070 HUMAN IL-23 ANTIGEN BINDING PROTEINS
Antigen binding proteins that bind to human IL-23 protein are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the...
2017/0002069 Polypeptides
There is provided inter alia a polypeptide comprising an immunoglobulin chain variable domain which binds to TNF-alpha, wherein the immunoglobulin chain...
2017/0002068 ANTI AMPHIREGULIN ANTIBODIES, COMPOSITIONS COMPRISING SAME AND USES THEREOF
A method of determining the suitability of a subject to a treatment with an anti-amphiregulin antibody, wherein the subject has a cancer selected from the...
2017/0002067 Anti-C5a Binding Moieties With High Blocking Activity
The present invention relates to binding moieties that specifically bind to a conformational epitope of C5a, in particular human C5a. Preferred binding...
2017/0002066 Antibodies With Modified Affinity To FcRn That Promote Antigen Clearance
An objective of the present invention is to provide methods for facilitating antigen-binding molecule-mediated antigen uptake into cells, methods for...
2017/0002065 USE OF VHH ANTIBODIES FOR THE PREPARATION OF PEPTIDE VECTORS FOR DELIVERING A SUBSTANCE OF INTEREST AND THEIR...
Use of a variable fragment (VHH antibody) of a camelid single-chain antibody for the preparation of a peptide vector for delivering a substance of interest...
2017/0002064 VH4 ANTIBODIES AGAINST GRAY MATTER NEURON AND ASTROCYTE
Monoclonal antibodies exhibiting an VH4 signature associated with multiple sclerosis (MS) and clinically isolated syndrome have been produced and sequenced....
2017/0002063 ANTIBODIES AGAINST STAPHYLOCOCCUS AUREUS AND USES THEROF
The invention relates to the field of immunology and vaccine development. In particular, it relates to antibodies and fragments thereof against Staphylococcus...
2017/0002062 COMPOSITION AND METHODS BASED ON NEUTRALIZING ANTIBODIES DELIVERED INTRANASALLY FOR ENHANCED THERAPEUTIC EFFICACY
The present invention provides methods for treatment or prophylaxis of viruses, particularly influenza virus, by administration of agents, particularly...
2017/0002061 scFV ANTIBODY LIBRARY
The invention provides libraries of antibody molecules, libraries of nucleic acids encoding antibody molecules, methods of producing said libraries, and...
2017/0002060 POLYNUCLEOTIDES FOR THE IN VIVO PRODUCTION OF ANTIBODIES
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides encoding an antibody, variant or...
2017/0002059 NOVEL EUKARYOTIC CELLS AND METHODS FOR RECOMBINANTLY EXPRESSING A PRODUCT OF INTEREST
The disclosure pertains to novel eukaryotic cell suitable for recombinant production of a product of interest, wherein the effect of the expression product of...
2017/0002058 COMPOSITIONS AND METHODS THAT INVOLVE PROTEIN SCAFFOLDS THAT SPECIFICALLY BIND TO HEPATOCYTE GROWTH FACTOR RECEPTOR
This disclosure describes a non-naturally occurring protein scaffold that specifically binds to hepatocyte growth factor receptor (MET) and methods of using...
2017/0002057 COMPOSITIONS CONTAINING FUSION PROTEIN OF ALBUMIN AND ANALOGS THEREOF, METHODS FOR MAKING AND USING THE SAME
The invention is related to fusion proteins of human somatostatin (e.g., SST-14 or SST-28) and human serum albumin, comprising a region at least 85% homologous...
2017/0002056 FUSION PROTEIN INHIBITING ANGIOGENESIS OR GROWTH AND USE THEREOF
Provided are a fusion protein inhibiting angiogenesis or vascular growth, coding sequence thereof, vector comprising the coding sequence, host cell,...
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