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Patent # Description
2017/0002005 Carbazole and Carboline Compounds for Use in the Diagnosis, Treatment, Alleviation or Prevention of Disorders...
The present invention relates to novel compounds that can be employed in the diagnosis, treatment, alleviation or prevention of a group of disorders and...
2017/0002004 ADO-RESISTANT CYSTEAMINE ANALOGS AND USES THEREOF
The present disclosure is directed to methods for treating diseases for which cysteamine is indicated and compounds useful in such methods.
2017/0002003 DIAZABICYCLO[4.3.1]DECANE DERIVATIVES FOR TREATMENT OF PSYCHIATRIC DISORDERS
The present invention relates to diazabicyclo[4.3.1]decane derivatives, pharmaceutically acceptable salts of these compounds and pharmaceutical compositions...
2017/0002002 FUSED AMINO PYRIDINE AS HSP90 INHIBITORS
The present invention relates to HSP90 inhibitors containing fused amino pyridine core that are useful as inhibitors of HSP90 and their use in the treatment of...
2017/0002001 SOMATOSTATIN MODULATORS AND USES THEREOF
Described herein are compounds that are somatostatin modulators, methods of making such compounds, pharmaceutical compositions and medicaments comprising such...
2017/0002000 NOVEL 3,4-DISUBSTITUTED-1H-PYRROLO[2,3-b]PYRIDINES AND 4,5-DISUBSTITUTED-7H-PYRROLO[2,3-c]PYRIDAZINES AS LRRK2...
The present invention provides novel 3,4-disubstituted-1H-pyrrolo[2,3-b]pyridine derivatives and 4,5-disubstituted-7H-pyrrolo[2,3-c]pyridazine derivatives of...
2017/0001999 KEY INTERMEDIATES AND IMPURITIES OF THE SYNTHESIS OF APIXABAN: APIXABAN GLYCOL ESTERS
Object of the present invention is an improved process for the preparation of Apixaban, through new intermediates which undergo to a faster amidation reaction....
2017/0001998 SUBSTITUTED HETEROCYCLIC ACETAMIDES AS KAPPA OPIOID RECEPTOR (KOR) AGONISTS
The present invention relates to a series of substituted compounds having the general formula (I), including their stereoisomers and/or their pharmaceutically...
2017/0001997 OXEPAN-2-YL-PYRAZOL-4-YL-HETEROCYCLYL-CARBOXAMIDE COMPOUNDS AND METHODS OF USE
Oxepan-2-yl pyrazol-4-yl-heterocyclyl-carboxamide compounds of Formula I, including stereoisomers, geometric isomers, tautomers, and pharmaceutically...
2017/0001996 GLS1 INHIBITORS FOR TREATING DISEASE
Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: ...
2017/0001995 COMPOUNDS FOR THE TREATMENT OF CANCER
The present invention relates to a FoxM1 gene splicing modifier selected from a compound of formula (I) or of formula (VI) ##STR00001## wherein A and B are as...
2017/0001994 CYCLOPROPANAMINE COMPOUND AND USE THEREOF
The present invention provides a compound having a lysine-specific demethylase-1 inhibitory action, and useful as a medicament such as a prophylactic or...
2017/0001993 COMPOUNDS, COMPOSITIONS, AND METHODS FOR INCREASING CFTR ACTIVITY
The invention encompasses compounds such as compounds having the Formula (I) or (II), compositions thereof, and methods of modulating CFTR activity. The...
2017/0001992 COLORING COMPOUND AND TONER
This invention aims at providing a compound capable of providing a toner having high covering power and a toner having high covering power, which is achieved...
2017/0001991 COMPOUNDS, COMPOSITIONS, AND METHODS FOR INCREASING CFTR ACTIVITY
The disclosure encompasses compounds having e.g., Formula (Ia) or (Ib), compositions thereof, and methods of modulating CFTR activity. The disclosure also...
2017/0001990 PIPERIDINE-DIONE DERIVATIVES
The invention provides novel compounds having the general formula: ##STR00001## and tautomers and pharmaceutically acceptable salts thereof, wherein A.sup.1,...
2017/0001989 5-FLUORO-N-(PYRIDIN-2-YL)PYRIDIN-2-AMINE DERIVATIVES CONTAINING A SULFONE GROUP
The present invention relates to 5-fluoro-N-(pyridin-2-yl)pyridin-2-amine derivatives containing a sulfone group of general formula (I) as described and...
2017/0001988 PIPERIDINE AND PIPERAZINE DERIVATIVES AND THEIR USE IN TREATING VIRAL INFECTIONS AND CANCER
Disclosed are compounds of formula (I) (formula I), as antiviral agents, antineoplastic agents, pharmaceutical compositions comprising such compounds, and a...
2017/0001987 1-HETEROCYCLYL ISOCHROMANYL COMPOUNDS AND ANALOGS FOR TREATING CNS DISORDERS
Disclosed are compounds of Formula (I): ##STR00001## and pharmaceutically acceptable salts thereof, wherein A, R.sup.a, R.sup.1, R.sup.2, R.sup.3, R.sup.4,...
2017/0001986 INDAZOLES AND USE THEREOF
In one aspect, the present disclosure provides indazoles of Formula I: (I) and the pharmaceutically acceptable salts and solvates thereof, wherein R.sup.3,...
2017/0001985 USE OF BENZIMIDAZOLE-PROLINE DERIVATIVES
The present invention relates to compounds of the formula (I), wherein Ar.sup.1 and Ar.sup.2 are as described in the description and to their use as...
2017/0001984 CYCLOALKANE DERIVATIVES
Disclosed herein are therapeutic agents and/or preventive agents for pain or therapeutic agents and/or preventive agents for a sodium channel associated...
2017/0001983 TRPA1 MODULATORS
This disclosure relates to polycyclic heteroaromatic compounds useful as TRPA1 modulators, as well as compositions and methods of treating pain that include...
2017/0001982 OXINDOLE DERIVATIVES CARRYING AN AMINE-SUBSTITUTED PIPERIDYL-AZETIDINYL SUBSTITUENT AND USE THEREOF FOR...
The present invention relates to novel substituted oxindole derivatives of formula (I) wherein the variables are as defined in the claims and description; to...
2017/0001981 SULFONYL AMIDE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH
The present invention relates to a compound of the formula I ##STR00001## wherein R.sup.1 to R.sup.6, A, B, n and m are as defined herein. Such novel sulfonyl...
2017/0001980 Novel Cannabinergic Nitrate Esters and Related Analogs
Biologically active cannabinergic nitrate esters and related analogs, process of preparation, pharmaceutical compositions and their methods of use as...
2017/0001979 Piperidine compounds having multimodal activity against pain
The present invention relates to compounds having dual pharmacological activity towards both the sigma (.sigma.) receptor, and the .mu.-opiod receptor and more...
2017/0001978 PIPERIDINE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN
The present invention relates to compounds having dual pharmacological activity towards both the sigma (.sigma.) receptor, and the .mu.-opiod receptor and more...
2017/0001977 CRYSTALLINE FORMS OF AN ANDROGEN RECEPTOR MODULATOR
Described herein are amorphous and crystalline forms of the androgen receptor modulator ...
2017/0001976 SUBSTITUTED QUINAZOLINE COMPOUNDS AND USES THEREOF FOR MODULATING GLUCOCEREBROSIDASE ACTIVITY
Disclosed are new small molecules having a substituted quinazoline core structure and the uses thereof for modulating glucocerebrosidase activity. Also...
2017/0001975 1-(TRIAZIN-3-YL/PYRIDAZIN-3-YL)-PIPER(-AZINE)IDINE DERIVATIVES AND COMPOSITIONS THEREFOR FOR INHIBITING THE...
The present invention relates to compounds of formula I: ##STR00001## in which Y.sub.1, Y.sub.2, Y.sub.3, R.sub.1, R.sub.2a, R.sub.2b, R.sub.3a, R.sub.3b,...
2017/0001974 COMPOUND USEFUL FOR MANUFACTURING SALACINOL, METHOD FOR MANUFACTURING THE COMPOUND, METHOD FOR MANUFACTURING...
An object of the present invention is to provide a novel compound useful for manufacturing salacinol, a method for manufacturing the compound, a method for...
2017/0001973 PARTIALLY SATURATED TRICYCLIC COMPOUNDS AND METHODS OF MAKING AND USING SAME
The invention provides tricyclic compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making...
2017/0001972 METHOD FOR PURIFYING COMPOUND OR RESIN
The method according to the present invention is a method for purifying a compound represented by a specific formula (1) or a resin having a structure...
2017/0001971 DIRECT SYNTHESIS OF BIO-BASED ALKYL & FURANIC DIOL ETHERS, ACETATES, ETHER-ACETATES, AND CARBONATES
A method of preparing a glycol mono-ether or mono-acetate, or carbonate involving either one of two pathways from alkylene glycols, HMF or its reduction...
2017/0001970 Substituted benzohydrazide analogs as histone demethylase inhibitors
Benzohydrazide analogs, derivatives thereof, and related compounds, which are useful as inhibitors of lysine-specific histone demethylase, including LSD1 and...
2017/0001969 CRYSTALLINE FORMS OF TYROSINE KINASE INHIBITORS AND THEIR SALTS
The invention relates to various polymorphic forms and amorphous form of sodium 4-((3-(4-cyclohexylpiperazin-1-yl)-6-oxo-6H-anthra[1,9-cd]isoxazol- ...
2017/0001968 AMINOTRIAZOLE- AND AMINOTETRAZOLE-BASED KDM1A INHIBITORS AS EPIGENETIC MODULATORS
In some aspects, the present invention provides compounds of the formula (IV), wherein the variables are as defined herein, which may be used as inhibitors of...
2017/0001967 PIPERAZINE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN
The present invention relates to compounds having dual pharmacological activity towards both the sigma (.sigma.) receptor, and the .mu.-opioid receptor and...
2017/0001966 SOMATOSTATIN MODULATORS AND USES THEREOF
Described herein are compounds that are somatostatin modulators, methods of making such compounds, pharmaceutical compositions and medicaments comprising such...
2017/0001965 CRYSTALLINE FORMS OF A HISTONE DEACETYLASE INHIBITOR
This disclosure provides solid forms of 2-((2-chlorophenyl)(phenyl)amino)-N-(7-(hydroxyamino)-7-oxoheptyl)pyrimid- ine-5-carboxamide, and methods of...
2017/0001964 NEW SUBSTITUTED BIPHENYL ANALOGUES AS DUAL INHIBITORS OF AROMATASE AND SULFATASE
The present invention relates to new biphenyl derivatives of formula ##STR00001## These compounds acting as aromatase and sulfatase inhibitors, they are ...
2017/0001963 N-Substituted Imidazole Carboxylic Ester Chiral Compound Containing an Ether Side Chain, Its Preparation and...
The present invention relates to an N-substituted imidazole carboxylic ester chiral compound containing an ether side chain and to its preparation and...
2017/0001962 Processes for the Synthesis of Substituted Urea Compounds
The present invention concerns a process for preparing a compound having the Formula A: ##STR00001## or a pharmaceutically acceptable salt or derivative ...
2017/0001961 OXIME ETHER ACETATE COMPOUND, PREPARATION METHOD THEREFOR AND WEEDING APPLICATION THEREOF
The present invention discloses an oxime ether acetate compound containing a phenylpyridine moiety of formula (I), whose preparation method is as follows: (1)...
2017/0001960 BIPYRIDYL COMPOUND
There are provided a compound capable of being a novel ligand allowing regioselective borylation to be performed in the aromatic borylation reaction, and a...
2017/0001959 COMPOUNDS USEFUL AS CCR9 MODULATORS
The present invention relates to compounds useful as CCR9 modulators, to compositions containing them, to methods of making them, and to methods of using them....
2017/0001958 INHIBITORS OF MITOCHONDRIAL PYRUVATE DEHYDROGENASE KINASE ISOFORMS 1-4 AND USES THEREOF
The present disclosure relates to the identification of PDK inhibitors and their use in the treatment of diseases such as diabetes, cardiovascular disease and...
2017/0001957 RADIOIODINATED BIOCONJUGATION REAGENTS
This disclosure relates to radioiodinated compounds useful as bioconjugation reagents, and intermediates for making radioiodinated bioconjugation reagents.
2017/0001956 HYDROCARBYL CARBOXYBETAINE AND METHOD FOR PREVENTING HOFMANN ELIMINATION IN ALKALINE ENVIRONMENT
A Hydrocarbyl Carboxybetaine represented by Formula (1) is provided: ##STR00001## wherein, n.sub.1.gtoreq.0 and n.sub.2>0, A is a C1-C20 alkyl group when...
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