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Patent # Description
2017/0007717 DUOCARMYCIN ADCS FOR USE IN TREATMENT OF ENDOMETRIAL CANCER
The present invention relates to duocarmycin-containing antibody-drug conjugates (ADCs) for use in the treatment of human solid tumours expressing HER2,...
2017/0007716 ANTIBODY-DRUG CONJUGATES AND IMMUNOTOXINS
The present invention relates to conjugates, in particular antibody-drug conjugates and immunotoxins, having the formula I: A-(L-D)p (I) or a pharmaceutically...
2017/0007715 MULTISPECIFIC ANTIGEN-BINDING MOLECULES AND USES THEREOF
The present invention provides multispecific antigen-binding molecules and uses thereof. The multispecific antigen-binding molecules comprise a first...
2017/0007714 ANTIBODY-DRUG CONJUGATES AND IMMUNOTOXINS
The present invention relates to conjugates, in particular antibody-drug conjugates and immunotoxins, having the formula I: A-(L-D)p (I) or a pharmaceutically...
2017/0007713 IMMUNOGENIC GLYCOPROTEIN CONJUGATES
The present invention relates generally to glycoconjugates comprising a saccharide covalently conjugated to a carrier protein through a spacer containing...
2017/0007712 GLYCOPEGYLATION METHODS AND PROTEINS/PEPTIDES PRODUCED BY THE METHODS
The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a...
2017/0007711 PEGYLATED GROWTH HORMONE ANTAGONISTS
A composition that is a human growth hormone receptor antagonist comprising human growth hormone receptor antagonist G120K, wherein at least one amino acid of...
2017/0007710 TARGETED DRUG PHOSPHORYLCHOLINE POLYMER CONJUGATES
The present invention provides random copolymers containing phosphorylcholine and one or more functional agents, and methods of preparing such random copolymers.
2017/0007709 GLYCOAMINO ACID AND USE THEREOF
An object of the present invention is to provide an amino acid precursor which shows improvement in the properties (particularly water-solubility, stability in...
2017/0007708 GLYCOTARGETING THERAPEUTICS
Several embodiments of the present disclosure relate to glycotargeting therapeutics that are useful in the treatment of transplant rejection, autoimmune...
2017/0007707 Derivatives of GLP-1 Like Peptides, and Uses Thereof
The invention relates to derivatives of GLP-1 like peptides which are C-terminally extended analogues of native GLP-1. The derivatives comprise two side...
2017/0007706 Sialic Acid Derivatives For Protein Derivatisation And Conjugation
Derivatives are synthesized of starting materials, usually polysaccharides, having sialic acid at the reducing terminal end, in which the reducing terminal...
2017/0007705 SEMI-SOLID DELIVERY VEHICLE AND PHARMACEUTICAL COMPOSITIONS
A semi-solid delivery vehicle contains a polyorthoester and an excipient, and a semi-solid pharmaceutical composition contains an active agent and the delivery...
2017/0007704 CARRIER AND PHARMACEUTICAL COMPOSITIONS FOR INTRASINAL DELIVERY AND USES THEREOF
Disclosed are carrier compositions for local administration of one or more active pharmaceutical ingredients to a subject in need of treatment. The carrier...
2017/0007703 COMPOSITION FOR ACCELERATING PENETRATION THROUGH SKIN, PREPARATION FOR TRANSDERMAL ADMINISTRATION, AND SKIN...
The present invention provides a skin penetration-accelerating composition that eliminates the need for forming a drug into a particle structure and...
2017/0007702 TRIALKYL CATIONIC LIPIDS AND METHODS OF USE THEREOF
The present invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel, trialkyl, cationic...
2017/0007701 PHARMACEUTICAL COMPOSITIONS
A pharmaceutical solution for a medication delivery apparatus, especially a metered dose inhaler, is described. The pharmaceutical solution comprises: (a) a...
2017/0007700 COMPOSITIONS AND METHODS FOR BORON NEUTRON CAPTURE THERAPY
Provided herein are compositions and methods for boron neutron capture therapy. In particular, the disclosure relates to therapy using liposomal ...
2017/0007699 SONOSENSITIZER COMPOSITION CONTAINING TITANIUM OXIDE NANOPARTICLE AS ACTIVE INGREDIENT, COMPOSITION FOR...
The present invention relates to a sonosensitizer composition containing titanium dioxide nanoparticles as an active ingredient, a composition for preventing...
2017/0007698 METHODS AND COMPOSITIONS FOR TREATING CANCER AND INFECTIOUS DISEASES
The invention relates to compositions comprising a CD4 lymphocyte depleting agent; and methods of using the compositions to treat, prevent, reduce the severity...
2017/0007697 POTENTIATING IMMUNE RESPONSE AGAINST CANCER
A method of potentiating an immune response against a cancer, non-cancerous tumor or both in a patient is provided. The method includes administering...
2017/0007696 SUPRAMOLECULAR HYDROGEL OF FMLF-BASED MOLECULES AND USE THEREOF
The invention relates to the application of peptides that can self-assemble to form supramolecular nanofibrils and hydrogels, hydrogel compositions containing...
2017/0007695 PEPTIDE/Beta-1,3-GLUCAN COMPLEX AND PRODUCTION METHOD THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING...
This peptide/.beta.-1,3-glucan complex includes .beta.-1,3-glucan and a peptide/polynucleotide conjugate in which an antigenic peptide is bonded covalently to...
2017/0007694 METHODS AND COMPOSITIONS FOR THE STABILIZATION OF PROTEINS
The present disclosure relates to buffer-stabilized protein compositions and methods of making the same. The disclosed compositions and methods provide a means...
2017/0007693 PD1 AND PDL1 ANTIBODIES AND VACCINE COMBINATIONS AND USE OF SAME FOR IMMUNOTHERAPY
Disclosed herein is a vaccine comprising an antigen and PD1 antibody and/or PDL1 antibody. Also disclosed herein is a method for enhancing an immune response...
2017/0007692 IMMUNOMODULATORY COMPOUNDS
The present invention is based on the finding that in addition to interfering with or blocking, preventing and/or inhibiting the interaction between a pathogen...
2017/0007691 COMPOSITION FOR INDUCING PROLIFERATION OR ACCUMULATION OF REGULATORY T CELLS
It was found that bacteria belonging to the genus Clostridium induce accumulation of regulatory T cells (Treg cells) in the colon. Moreover, the present...
2017/0007690 METHODS AND COMPOSITIONS FOR THE STABILIZATION OF ANTHRAX RECOMBINANT PROTECTIVE ANTIGEN
The present disclosure relates to buffer-stabilized anthrax recombinant protective antigen (rPA) compositions and methods of making the same. The disclosed...
2017/0007689 METHODS AND COMPOSITIONS FOR NANOEMULSION VACCINE FORMULATIONS
The present disclosure relates to nanoemulsion vaccine compositions and methods of making and using the same. The disclosed compositions and methods provide a...
2017/0007688 VACCINE DELIVERY SYSTEMS USING YEAST CELL WALL PARTICLES
The present invention generally relates to compositions and methods for delivering a vaccine. The compositions and methods disclosed herein are particularly...
2017/0007687 PEPTIDE VACCINE THERAPY FOR TREATMENT OF FRa-EXPRESSING TUMORS
Provided are methods for inducing and maintaining protective immunity against a tumor expressing FR.alpha. in a subject, comprising the administration of one...
2017/0007686 Adoptive Cellular Therapy Using an Agonist of Retinoic Acid Receptor-Related Orphan Receptor Gamma & Related...
The invention relates to medical therapy using an agonist of the retinoic acid receptor-related orphan receptor gamma (ROR.gamma.) and provides adoptive...
2017/0007685 TUMORS EXPRESSING IgG1 Fc INDUCE ROBUST CD8 T CELL RESPONSES
A lymphoma cell line was engineered to express surface IgG1 Fc. These tumor cells were taken up rapidly by DCs, leading to enhanced cross-presentation of...
2017/0007684 BIFUNCTIONAL CONJUGATE COMPOSITIONS AND ASSOCIATED METHODS
Bifunctional conjugate compositions are provided comprising a Signal-1 moiety bound to a first polymer carrier, wherein the combined size of the Signal-1...
2017/0007683 TOLEROGENIC COMPOSITIONS COMPRISING AND USES THEREOF
The present invention is directed to polypeptides and compositions thereof useful for the prevention of treatment of allergic disorders, in particular atopic...
2017/0007682 Multivalent Stable Vaccine Composition and Methods of Making Same
Stable immunogenic composition capable of eliciting a robust and durable immune response yielding a measurable increase in neutralizing antibodies at least 200...
2017/0007681 METHODS AND COMPOSITIONS USED IN TREATING INFLAMMATORY AND AUTOIMMUNE DISEASES
Methods of treating neuroinflammation by administration of a selective protein C activator, such as recombinant human WE thrombin and optionally one or more of...
2017/0007680 Lysosomal Targeting Peptides and Uses Thereof
The present invention provides further improved compositions and methods for efficient lysosomal targeting based on the GILT technology. Among other things,...
2017/0007679 CRISPR/CAS-RELATED METHODS AND COMPOSITIONS FOR TREATING HIV INFECTION AND AIDS
CRISPR/CAS-related compositions and methods for treatment of a subject at risk for or having a HIV infection or AIDS are disclosed.
2017/0007678 COMPOSITIONS AND METHODS TO PROMOTE WOUND HEALING
Compositions and methods to promote wound healing are described. The compositions and methods up-regulate X-box binding protein 1 (XBP1) and/or...
2017/0007677 PHARMACEUTICAL COMPOSITION FOR CANCER TREATMENT AND PHARMACEUTICAL PREPARATION FOR CANCER TREATMENT CONTAINING...
The invention provides a novel anticancer therapeutic having a high effect against solid cancers, lacking the side effects of chemotherapeutics, and being...
2017/0007676 MATRIX GEL
The present invention relates to a gel having a three dimensional matrix structure and a drug in the form of a solid contained within the three dimensional...
2017/0007675 STABLE PEPTIDE FORMULATIONS AND METHODS FOR PREPARATION
Disclosed is a stable formulation for parenteral injection, as well as methods for its use and preparation, that includes a peptide or a salt thereof that has...
2017/0007674 METHOD FOR PREVENTING OR REDUCING POSTOPERATIVE PULMONARY COMPLICATIONS
The present invention relates to methods for preventing or reducing the incidence of postoperative pulmonary complications in surgical patients after an...
2017/0007673 THERAPEUTIC AGENT FOR RHINITIS
The problem to be solved by the present invention is to provide an effective and safe therapeutic preparation for rhinitis, which not only has significant...
2017/0007672 COMPOSITIONS AND METHODS FOR TREATING NEUTROPENIA
The invention relates methods of using a retinoid agonist and a G-CSF or an analog thereof to treat, prevent, reduce the likelihood of having, reduce the...
2017/0007671 FORMULA OF NEUREGULIN PREPARATION
The present invention provides a pharmaceutical preparation for treating a cardiovascular disease. Particularly, the present invention provides a formula of a...
2017/0007670 Method of Treating Intraocular Tissue Pathologies
Nerve Growth Factor (NGF), in the form of a preparation to be administered over ocular surface, is suggested as being suitable for therapy and/or prophylaxis...
2017/0007669 PEPTIDE-MEDIATED DELIVERY OF ACTIVE AGENTS ACROSS THE BLOOD-BRAIN BARRIER
Provided herein are methods for transporting an infectious agent (e.g., a virus) across the blood-brain barrier (BBB). For example, the methods provided herein...
2017/0007668 Pharmaceutical Composition Comprising Stem Cells Treated with NOD2 Agonist or Culture Thereof for Prevention...
The present invention relates to a pharmaceutical composition for the prevention or treatment of immune disorders and inflammatory diseases, comprising stem...
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