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Patent # Description
2017/0007617 INTRAVENOUS FORMULATIONS OF A LATE SODIUM CURRENT INHIBITOR
An intravenous pharmaceutical composition or kit comprising 4-(pyrimidin-2-ylmethyl)-7-(4-(trifluoromethoxy)phenyl)-3,4-dihydrobenzo[- f][1,4]oxazepin-5(2H)-one...
2017/0007616 ANTIMICROBIAL FORMULATIONS AND APPLICATIONS THEREOF
Described herein are new approaches to antimicrobial therapy, which includes the development of new combinations of antibiotic agents as well as their use for...
2017/0007615 Antibacterial Compounds
The present disclosure relates to a novel combination of compounds, their use as antibacterials, compositions comprising them and methods for treating or...
2017/0007614 Autotaxin inhibitors
The present invention relates to novel compounds that are autotaxin inhibitors, processes for their preparation, pharmaceutical compositions and medicaments...
2017/0007613 Apilimod Compositions and Methods for Using Same
The present invention relates to methods for treating cancer with apilimod and related compositions and methods.
2017/0007612 PROCESS FOR THE PREPARATION OF A SOLID, ORALLY ADMINISTRABLE PHARMACEUTICAL COMPOSITION
The present invention relates to a process for the preparation of a solid, orally administrable pharmaceutical composition, comprising ...
2017/0007611 INHIBITORS OF BRUTON'S TYROSINE KINASE
Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. Methods for the...
2017/0007610 NOVEL HETEROBICYCLIC COMPOUNDS AS KAPPA OPIOID AGONISTS
The present invention relates to novel compounds of the general formula (I), which are selective and peripherally acting KOR agonist, their tautomeric forms,...
2017/0007609 PERIPHERALLY ACTING OPIOID COMPOUNDS
The invention relates to a compound of Formula I, II, III, IV or a pharmaceutically acceptable ester or prodrug thereof: ##STR00001##
2017/0007608 ACTIVATORS OF PYRUVATE KINASE M2 AND METHODS OF TREATING DISEASE
The invention described herein features methods, compositions, and kits that utilize activators of pyruvate kinase M2 (PKM2) for the treatment or amelioration...
2017/0007607 SOLID PREPARATION
The present invention provides a solid preparation excellent in disintegration property and preservation stability. The present invention relates to a solid...
2017/0007606 FGFR INHIBITOR FOR USE IN THE TREATMENT OF HYPOPHOSPHATEMIC DISORDERS
The present invention relates generally to 3-(2,6-Dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-ph- enylamino]-pyrimid-4-yl}-1-methyl-urea or...
2017/0007605 Method of Optimizing the Treatment of Philadelphia-positive Leukemia with Abl Tyrosine Kinase Inhibitors
The present invention provides a method of treating Philadelphia positive (Ph+) leukemia, such as Philadelphia chromosome positive acute lymphoblastic leukemia...
2017/0007604 1-PYRAZOLYL-3-(4-((2-ANILINOPYRIMIDIN-4 -YL) OXY) NAPTHTHALEN-1 - YL) UREAS AS P38 MAP KNASE INHIBITORS
There are provided compounds of formula (I) which are inhibitors of the family of p38 mitogen-activated protein kinase enzymes, and to their use in therapy,...
2017/0007603 LIVER X RECEPTOR MODULATORS
Provided herein are novel compounds and pharmaceutically acceptable salts thereof that are liver X receptor modulators. Also provided are compositions...
2017/0007602 PHARMACEUTICAL DOSAGE FORMS
The present invention relates to solid pharmaceutical dosage forms comprising the drug substance ...
2017/0007601 PYRIMIDINE FGFR4 INHIBITORS
Provided herein are compounds of Formula I useful as FGFR4 inhibitors, as well as methods of use of the same.
2017/0007600 ACOUSTIC MIXING FOR AUTO GRANULATION
A process for acoustically mixing a bulk drug substance involves the application of acoustic energy to drive an accelerative force in a mixing vessel...
2017/0007599 METHODS FOR TREATING NEUROBLASTOMA
Substituted indazole derivatives of formula (I) or formula 2.(I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for...
2017/0007598 COMPOSITIONS FOR AFFECTING WEIGHT LOSS
Disclosed are compositions for affecting weight loss comprising a first compound and a second compound, where the first compound is an opioid antagonist and...
2017/0007597 PERIPHERAL OPIOID RECEPTOR ANTAGONISTS AND USES THEREOF
The present invention provides a compound of formula I: ##STR00001## wherein X.sup.-, R.sup.1, and R.sup.2 are as defined herein, and compositions thereof.
2017/0007596 TREATMENT OF MULTIPLE SCLEROSIS WITH COMBINATION OF LAQUINIMOD AND FLUPIRTINE
This invention provides a method of treating a subject afflicted with multiple sclerosis or presenting a clinically isolated syndrome comprising administering...
2017/0007595 NSD3 INHIBITORS FOR TREATMENT OF CANCERS
The present invention relates to the use of NSD3i inhibitors for the treatment of cancer. In particular, the present invention relates to methods, kits and...
2017/0007594 THERAPEUTIC COMPOSITION AND CONFIGURATION
A system intended to be employed for therapeutic purposes incorporates an active ingredient (e.g., a source of nicotine). Representative forms of nicotine...
2017/0007593 MUSCARINIC ANTAGONISTS AND COMBINATIONS THEREOF FOR THE TREATMENT OF AIRWAY DISEASE IN HORSES
The invention relates to the field of medicine, in particular to the field of veterinary medicine. The invention specifically relates to muscarinic antagonists...
2017/0007592 METHODS FOR STABILIZING OXIDATIVELY UNSTABLE COMPOSITIONS
Ophthalmic compositions and methods of preparing such compositions are disclosed.
2017/0007591 Composition to Mitigate Spikes in Blood Sugar
Compositions comprising therapeutically effective amounts of quercetin, myricetin and chlorogenic acid are improved by the addition of one or multiple...
2017/0007590 ANTIPROLIFERATIVE COMPOUNDS AND METHODS OF USE THEREOF
Compounds of formula I for treating, preventing or managing cancer are disclosed. Also disclosed are methods of treating, preventing or managing cancer, such...
2017/0007589 Compositions For Treating Retinal Degeneration And Methods of Production and Use Thereof
Compositions for use in methods of treating and/or inhibiting a pathologic ocular condition, as well as methods of producing and using same, are disclosed.
2017/0007588 SMALL MOLECULE INHIBITORS OF XBP1 SPLICING
Small molecule inhibitors of XBP1 splicing by IRE1.alpha. are provided, as well as methods for their use in treating or preventing cancer (e.g., endocrine...
2017/0007587 LPT-723 AND IMMUNE CHECKPOINT INHIBITOR COMINATIONS AND METHODS OF TREATMENT
The present invention provides, inter alia, a composition containing a compound of formula (I): ##STR00001## or a pharmaceutically acceptable salt thereof,...
2017/0007586 PHARMACEUTICAL COMPOSITIONS COMPRISING PRASUGREL AND CYCLODEXTRIN DERIVATIVES AND METHODS OF MAKING AND USING...
The present invention is directed to pharmaceutical compositions comprising prasugrel and a cyclodextrin derivative, and methods of making and using the same.
2017/0007585 USE OF FK506 FOR THE TREATMENT OF PULMONARY ARTERIAL HYPERTENSION
A method for reducing pulmonary hypertension in a mammal that employs FK506 is provided. In certain embodiments, the method comprises administering FK506 to a...
2017/0007584 STABLE VETERINARY ANTHELMINTIC FORMULATIONS
Described herein are stable veterinary formulations and methods of treatment and use, comprising at least one macrocyclic lactone and levamisole as active...
2017/0007583 Neurodegenerative Therapies
The present invention provides a compound of formula (I) wherein: Y represents a C or N atom which may be substituted or form a cyclic group with R''' but may...
2017/0007582 Use of Dipeptidyl Peptidase IV Effectors for Normalizing the Blood Glucose Level in Mammals
The present invention comprises the use of activity-reducing effectors of dipeptidyl peptidase (DP IV) and DP IV-analogous enzyme activity in the blood of a...
2017/0007581 CAI-BASED SYSTEMS AND METHODS FOR THE LOCALIZED TREATMENT OF OCULAR AND OTHER DISEASES
The subject invention provides CAI compounds and formulations thereof, and methods for their use in the localized treatment of non-life threatening diseases....
2017/0007580 VELIPARIB IN COMBINATION WITH CARBOPLATIN FOR THE TREATMENT OF TRIPLE NEGATIVE BREAST CANCER
The invention relates to a method for the treatment of triple negative breast cancer in a subject, comprising administering to the subject an effective amount...
2017/0007579 SUBSTITUTED ALIPHANES, CYCLOPHANES, HETERAPHANES, HETEROPHANES, HETERO-HETERAPHANES AND METALLOCENES USEFUL FOR...
The present disclosure provides substituted aliphanes, cyclophanes, heteraphanes, heterophanes, hetero-heteraphanes and metallocenes, of Formula I D-M-D ...
2017/0007578 Genotype Specific Methods for Treating Human Subjects Using 4-Methylpyrazole
Provided herein are methods of administering 4-methylpyrazole (4-MP), or physiologically acceptable salts thereof, to subjects of genetic subpopulations...
2017/0007577 METHOD OF TREATING OR INHIBITING THE DEVELOPMENT OF BRAIN INFLAMMATION AND SEPSIS
A leukotriene C4 and D4 antagonist is used to treat or inhibit brain inflammation and sepsis by acting to inhibit increased capillary permeability and white...
2017/0007576 PHARMACEUTICAL COMPOSITION FOR TOPICAL ADMINISTRATION
The present invention relates to a pharmaceutical composition for topical administration comprising a compound of formula I, ...
2017/0007575 Ready to Use Ketorolac Formulations
Disclosed in certain embodiments is a pharmaceutical composition for parenteral administration comprising: an aqueous solution comprising ketorolac or a...
2017/0007574 PERIPHERAL KAPPA OPIOID RECEPTOR AGONISTS FOR UREMIC PRURITUS IN DIALYSIS PATIENTS
The invention provides a method of prevention, inhibition or treatment of uremic pruritus in a dialysis patient by administering an effective amount of a kappa...
2017/0007573 METHOD OF TREATING CANCER WITH COMBINATIONS OF HISTONE DEACETYLASE INHIBITORS (HDAC1) SUBSTANCES
A method for treating cancer is described using combination therapies comprising the use of hyperbaric oxygen with histone deacetylase inhibitors, with and...
2017/0007572 THERAPEUTIC AGENTS CONTAINING CANNABIS FLAVONOID DERIVATIVE FOR OCULAR DISORDERS
The present invention provides a cannabis-based flavonoid pharmaceutical composition including any one or more selected from the group of Apigenin, Cannflavin...
2017/0007571 Composition of a Spray-Dried Powder for Pulmonary Delivery of a Long Acting Neuraminidase Inhibitor (LANI)
The present invention is related to pharmaceutical formulations and methods of treating a subject afflicted with the influenza virus, the method includes...
2017/0007570 PREPARATIONS OF TAXANES FOR INTRAVENOUS ADMINISTRATION AND THE PREPARATION METHOD THEREOF
The invention relates to a preparation of taxanes for intravenous administration consisting of a drug solution and an emulsion. The drug solution consists of...
2017/0007569 COMPOSITIONS AND METHODS FOR PREPARATION OF POORLY WATER SOLUBLE DRUGS WITH INCREASED STABILITY
The present invention provides stable pharmaceutical compositions of poorly water soluble pharmaceutical agents and stabilizing agents which function to...
2017/0007568 USE OF COMPOSITION CONTAINING IRON (II) AMINO ACID CHELATE IN PREPARATION OF DRUG FOR AMELIORATING DIABETES
The present invention provides a use of a composition containing a ferrous amino acid chelate for the preparation of a pharmaceutical used in diabetes...
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