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Patent # Description
2017/0008967 ANTI-TLR4 ANTIBODIES AND USES THEREOF
Disclosed are antibodies that specifically bind Toll-like Receptor 4 (TLR-4), and to methods of using the anti-TLR4 antibodies as therapeutics and diagnostic...
2017/0008966 Anti-CD38 Antibodies for Treatment of Light Chain Amyloidosis and Other CD28-Positive Hematological Malignancies
The present invention relates to methods of treatment of light chain amyloidosis and other CD38-positive hematological malignancies with anti-CD38 antibodies.
2017/0008965 ANTI-PROLACTIN RECEPTOR ANTIBODY FORMULATIONS
Provided are a wide concentration range, especially high concentration, substantially salt-free anti-prolactin receptor antibody formulations that are...
2017/0008964 ANTIBODY DRUG CONJUGATES
The present invention relates to anti-FGFR2 antibodies, antibody fragments, antibody drug conjugates, and their uses for the treatment of cancer.
2017/0008963 TREATMENT OF CANCER USING HUMANIZED ANTI-EGFRvIII CHIMERIC ANTIGEN RECEPTOR
The invention provides compositions and methods for treating diseases associated with expression of EGFRvIII. The invention also relates to chimeric antigen...
2017/0008962 THERAPEUTIC PEPTIDES
The present disclosure provides, in part, compositions comprising peptides immunospecifically binds to defined binding partners, wherein the peptides comprise...
2017/0008961 Improved Methods for the Treatment of Vascularizing Cancers
The invention concerns therapeutic compositions for the treatment of vascularizing cancers, especially, glioblastoma. In particular, the invention is directed...
2017/0008960 TCR Complex Immunotherapeutics
Single chain fusion proteins that specifically bind to a TCR complex or a component thereof, such as TCR.alpha., TCR.beta., or CD3.epsilon., along with...
2017/0008959 AGER-PEPTIDES AND USE THEREOF
The present invention relates to the identification, functionality and use of domains from the N terminus of the receptor for Advanced Glycation End Products...
2017/0008958 ONCOSTATIN M RECEPTOR ANTIGEN BINDING PROTEINS
The invention provides anti-oncostatin M receptor-.beta. (OSMR) antigen binding proteins, e.g., antibodies and functional fragments, derivatives, muteins, and...
2017/0008957 ANTIBODY THERAPEUTICS WITH LOCAL ACTIVITY IN THE DIGESTIVE TRACT
This invention provides methods and compositions of antibody therapeutics that are therapeutically effective in the digestive tract or below the mucosal...
2017/0008956 COMPOSITIONS AND METHODS FOR INCREASING MUSCLE MASS AND MUSCLE STRENGTH BY SPECIFICALLY ANTAGONIZING GDF8 AND...
The present invention provides compositions and methods which involve specifically antagonizing GDF8 and Activin A. In certain embodiments, compositions are...
2017/0008955 HUMANIZED BETA-AMYLOID BINDING MOLECULES AND USES THEREOF
Provided herein are humanized antibodies or antigen-binding fragments thereof, that can bind to a cyclic peptide comprising the amino acid sequence SNK,...
2017/0008954 Monoclonal Antibodies that Modulate Immunity to MTB and Enhance Immune Clearance
The invention is directed to compositions and methods for stimulating, enhancing or modulating the immune system of a patient before or after infection by a...
2017/0008953 METHODS OF TREATING AND PREVENTING STAPHYLOCOCCUS AUREUS INFECTIONS AND ASSOCIATED CONDITIONS
The present invention relates to methods and compositions for preventing and treating Staphylococcus aureus in a subject. Therapeutic compositions of the...
2017/0008952 MEANS AND METHODS FOR PRODUCING STABLE ANTIBODIES
The invention provides means and methods for selecting and producing stable antibodies against an antigen of interest, using stable ex vivo B cell cultures.
2017/0008951 FUSION PROTEINS COMPRISING IGG2 HINGE DOMAINS
The present invention relates to biologically active fusion proteins containing the IgG2 hinge as a multimerization domain capable of multimerizing proteins,...
2017/0008950 HYBRID IMMUNOGLOBULIN CONTAINING NON-PEPTIDYL LINKAGE
The present invention provides a compound having the structure: A-B-----Z wherein A is a biologically active structure of the compound; wherein Z is a protein...
2017/0008949 Use of the binding domain of a subunit of a multi-subunit structure for targeted delivery of pharmaceutically...
Herein is reported the use of a conjugate of a subunit of a multi-subunit structure and one biologically active entity for targeted delivery of the ...
2017/0008948 METHOD OF PRODUCING RECOMBINANT HIGH MOLECULAR WEIGHT vWF IN CELL CULTURE
Among other aspects, the present invention relates to cell culture conditions for producing high molecular weight vWF, in particular, highly multimericWF with...
2017/0008947 Expression of Chimeric Polypeptide with Variable Lymphocyte Receptors on Immune Cells and Uses for Treating Cancer
This disclosure relates to recombinant cellular expression of chimeric proteins with peptide sequences derived from lymphocyte receptors and uses for treating...
2017/0008946 MIMETIC PEPTIDES AND THEIR USE IN MEDICINE
The present invention concerns the field of ion channels, and in particular relates to peptides which are suitable for use in the treatment of conditions where...
2017/0008945 Novel Insulin Derivatives and the Medical Uses Hereof
The present invention is in the therapeutic fields of drugs for medical conditions relating to diabetes. More specifically the invention relates to novel...
2017/0008944 Exendin-4 Derivatives as Selective Peptidic Dual GLP-1/Glucagon Receptor Agonists
The present invention relates to dual GLP-1/glucagon receptor agonists and their medical use, for example in the treatment of disorders of the metabolic...
2017/0008943 STABLE GLUCAGON ANALOGUES AND USE FOR TREATMENT OF HYPOGLYCAEMIA
The invention relates to derivatives of glucagon analogues comprising the substitutions Imp1 and His3, a substituent having three to ten negatively charged...
2017/0008942 IL-22 POLYPEPTIDES AND IL-22 Fc FUSION PROTEINS AND METHODS OF USE
The invention relates to IL-22 polypeptides, IL-22 Fc fusion proteins and IL-22 agonists, composition comprising the same, methods of making and methods of...
2017/0008941 METHOD FOR PURIFYING PEGylated ERYTHROPOIETIN
Herein is reported a method for the purification of a protein comprising erythropoietin and a single poly (ethylene glycol) residue from reaction by-products...
2017/0008940 Mucin Derived Polypeptides
The present technology relates to isolated MUC17, Muc3 or MUC3 derived polypeptides and polynucleotides encoding the same. The MUC17, Muc3 or MUC3 derived...
2017/0008939 NON-NARCOTIC CRMP2 PEPTIDES TARGETING SODIUM CHANNELS FOR CHRONIC PAIN
Disclosed herein are isolated polypeptides capable of preventing collapsin response mediator protein 2 (CRMP2)-small ubiquitin-like modifier (SUMO)ylation...
2017/0008938 POLYMER PARTICLES AND USES THEREOF
The present invention relates to polymer particles and uses thereof. In particular the present invention relates to functionalised polymer particles, processes...
2017/0008937 COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING CLOSTRIDIUM INFECTION
Clostridium difficile is a leading cause of antibiotic-associated infection in hospitals worldwide. There is a need for a vaccine to Clostridium difficile that...
2017/0008936 Polypeptide Libraries With A Predetermined Scaffold
Populations of polypeptide variants based on a common scaffold, each polypeptide in the population comprising the scaffold amino acid sequence EXXXAXXEIX...
2017/0008935 MUTATED SALMONELLA ENTERIACA
A novel, mutated Salmonella enterica serovar Typhimurium vaccine is generated and imparts protective immunity in vaccinated animals for a range of S. enterica...
2017/0008934 BACTERIALLY FORMED MICROCIN S, A NEW ANTIMICROBIAL PEPTIDE, EFFECTIVE AGAINST PATHOGENIC MICROORGANISMS, E.G....
The present invention relates to a new isolated polypeptide nominated microcin S, isolated nucleic acid molecules encoding the microcin S polypeptide and...
2017/0008933 MODIFIED MENINGOCOCCAL FHBP POLYPEPTIDES
Modified meningococcal fHbp polypeptides with increased stability.
2017/0008932 USPA2 PROTEIN CONSTRUCTS AND USES THEREOF
The present invention relates to compositions comprising Moraxella catarrhalis (M. catarrhalis) Ubiquitous surface protein A2 (UspA2). More particularly, the...
2017/0008931 Melanocortin-1 Receptor-Specific Cyclic Hexapeptides
Melanocortin receptor-specific cyclic hexapeptides of the formula ##STR00001## where R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8 and...
2017/0008930 STABILIZED ALPHA HELICAL PEPTIDES AND USES THEREOF
Novel polypeptides and methods of making and using the same are described herein. The polypeptides include cross-linking ("hydrocarbon stapling") moieties to...
2017/0008929 SOCS MIMETICS FOR THE TREATMENT OF DISEASES
The subject invention concerns peptide mimetics of SOCS proteins and methods of use. In one embodiment, a peptide mimetic of the invention binds to a SOCS1 and...
2017/0008928 NOVEL PEPTIDES AND PEPTIDE DERIVATIVES AND USES THEREOF
The invention relates to cholecystokinin (CCK) derivatives of the general formula I: P-L-X1-X2-X3-Gly-Trp-X6-DMeAsp-X8-NH.sub.2, wherein P is Chem. 1:...
2017/0008927 ARTIFICIAL CATALYST SYSTEM SUBSTITUTABLE FOR IN VIVO ACYLATION FUNCTION
An artificial catalyst system substitutable for an in vivo histone acylation function has been successfully established by such an approach of synthetic...
2017/0008926 RARE EARTH MATERIAL-BINDING PEPTIDE AND USE THEREOF
A binding agent is capable of binding to rare earth materials such as rare earths and inorganic compounds thereof. A rare earth material-binding agent includes...
2017/0008925 AROMATIC-CATIONIC PEPTIDES AND USES OF SAME
The disclosure provides aromatic-cationic peptide compositions and methods of preventing or treating disease using the same. The methods comprise administering...
2017/0008924 PYRROLIDINE CARBOXAMIDO DERIVATIVES AND METHODS FOR PREPARING AND USING THE SAME
Pyrrolidine carboxamido derivatives, optical isomers thereof, and salts thereof that are able to prevent, improve, and/or treat inflammatory conditions,...
2017/0008923 SOLUTION PHASE SYNTHESIS AND CRYSTALLIZATION OF BETA-TURN PEPTIDOMIMETIC CYCLIC SALTS
The present disclosure relates to methods of preparing and crystallizing .beta.-turn cyclic peptidomimetic salts of formula I: ##STR00001## where R.sub.1,...
2017/0008922 BRANCHED CHAIN-CONTAINING AROMATIC COMPOUND
The present invention provides a particular branched chain-containing aromatic compound. The branched chain-containing aromatic compound of the present...
2017/0008921 C-3 NOVEL TRITERPENONE WITH C-28 REVERSE AMIDE DERIVATIVES AS HIV INHIBITORS
The invention relates to C-3 novel triterpenone with C-28 reverse amide derivatives, related compounds, and pharmaceutical compositions useful for the...
2017/0008920 MAMMALIAN METABOLITES OF STEROIDS
Described herein, in certain embodiments, are steroidal derivatives, methods of making such compounds, pharmaceutical compositions and medicaments comprising...
2017/0008919 CRYSTALLINE FORM OF OXAZOLIDINONE ANTIBIOTICS AND PREPARATION METHOD, COMPOSITION AND USE THEREOF
The present invention relates to a novel crystal form of oxazolidinone antibiotics. The new crystalline form has advantages in the aspects of solubility,...
2017/0008918 NOVEL CYP-EICOSANOID DERIVATIVES
The present invention relates to compounds according to general formula (I) which are analogues of epoxymetabolites produced by cytochrome P450 (CYP) enzymes...
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