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Patent # Description
2017/0008917 METHOD FOR PREPARING RACEMIC OR OPTICALLY ACTIVE alpha-GLYCEROPHOSPHORYLCHOLINE
A method of preparing racemic or optically active D or L-.alpha.-glycerophosphorylcholine in large amounts by subjecting choline phosphate or a salt thereof,...
2017/0008916 CARBONATE PRODRUGS AND METHODS OF USING THE SAME
The present invention provides carbonate prodrugs which comprise a carbonic phosphoric anhydride prodrug moiety attached to the hydroxyl or carboxyl group of a...
2017/0008915 ACID, SOLVENT, AND THERMAL RESISTANT METAL-ORGANIC FRAMEWORKS
The disclosure provides for thermal, solvent, and/or acid resistant metal organic frameworks and the use of these frameworks in devices and methods for gas...
2017/0008914 LANTHANUM COMPOUND, METHOD OF SYNTHESIZING LANTHANUM COMPOUND, LANTHANUM PRECURSOR COMPOSITION, METHOD OF...
A silicon-containing intermediate is synthesized by reacting a lanthanum tris[bis(trialkylsilyl)amide] complex with an alkylcyclopentadiene. A lanthanum...
2017/0008913 CONDENSED [1,4] DIAZEPINE COMPOUNDS AS AUTOTAXIN (ATX) AND LYSOPHOSPHATIDIC ACID (LPA) PRODUCTION INHIBITORS
Compounds of formula (I) ##STR00001## wherein R.sup.1, R.sup.2, A.sup.1 and A.sup.2 are as described herein, compositions including the compounds and methods of...
2017/0008912 BENZOTHIAZOLE MACROCYCLES AS INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION
The disclosure generally relates to compounds of formula I, including compositions and methods for treating human immunodeficiency virus (HIV) infection. The...
2017/0008911 2-Amino-6-Methyl-4,4a,5,6-Tetrahydropyrano[3,4-d][1,3]Thiazin-8a(8H)-yl-1,- 3-Thiazol-4-yl Amides
The present invention is directed to compounds, tautomers and pharmaceutically acceptable salts of the compounds which are disclosed, wherein the compounds...
2017/0008910 THIAZOLOPYRROLIDINE INHIBITORS OF ROR-GAMMA
Provided are novel compounds of Formula (I): pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the...
2017/0008909 PYRAZOLOPYRIMIDINE MACROCYCLES AS INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION
The disclosure generally relates to compounds of formula I, including compositions and methods for treating human immunodeficiency virus (HIV) infection. The...
2017/0008908 PYRIDIN-3-YL ACETIC ACID MACROCYCLES AS INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION
The disclosure generally relates to compounds of formula I, including compositions and methods for treating human immunodeficiency virus (HIV) infection. The...
2017/0008907 Compounds and Derivatives of 2H-Pyrido (3,2-b)(1, 4) Oxazin 3)4H)-Ones as raf Kinase and LRRK2 Inhibitors
The present invention provides oxazine compounds, method of using and method of making oxazine compounds and its pharmaceutical use.
2017/0008906 INHIBITORS OF HEPATITIS C VIRUS REPLICATION
The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the...
2017/0008905 COT MODULATORS AND METHODS OF USE THEREOF
The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.
2017/0008904 MDM2-BASED MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE
The description relates to MDM2 binding compounds, including bifunctional compounds comprising the same, which find utility as modulators of targeted...
2017/0008903 NOVEL PIPERIDINO-DIHYDROTHIENOPYRIMIDINE SULFOXIDES AND THEIR USE FOR TREATING COPD AND ASTHMA
Piperidino-dihydrothienopyrimidine sulfoxides of formula I ##STR00001## wherein: Ring A is a 6-membered aromatic ring optionally comprising one or two nitrogen...
2017/0008902 IMPROVED GLYCOL ACYLATION PROCESS WITH WATER-TOLERANT METAL TRIFLATES
A method for acid-catalyzed acylation of an isohexide is described. The method can enable direct alcohol acylation with carboxylic acids. In particular, the...
2017/0008901 SPIRO-OXAZOLONES
The present invention provides spiro-oxazolones, which act as V1a receptor modulators, and in particular as V1a receptor antagonists, their manufacture,...
2017/0008900 BICYCLIC COMPOUNDS AS AUTOTAXIN (ATX) AND LYSOPHOSPHATIDIC ACID (LPA) PRODUCTION INHIBITORS
Compounds of formula (I) ##STR00001## wherein R.sup.1, R.sup.2, A, W, m, n, p and q are as described herein, compositions including the compounds and methods of...
2017/0008899 BTK INHIBITORS
Provided are 6-5 membered fused pyridine ring compounds according to Formula (I) or pharmaceutically acceptable salts thereof, pharmaceutical compositions...
2017/0008898 Cyclic Amines
The present invention is directed to novel cyclic amines which inhibit the P2X.sub.7 receptor.
2017/0008897 PYRROLO[1,2-f][1,2,4]TRIAZINES USEFUL FOR TREATING RESPIRATORY SYNCITIAL VIRUS INFECTIONS
Provided herein are formulations, methods and substituted tetrahydrofuranyl-pyrrolo[1,2-f][1,2,4]triazine-4-amine compounds of Formula (I) for treating...
2017/0008896 HETEROARYL SYK INHIBITORS
The invention relates to new substituted heteroaryls of formula 1 wherein A is selected from the group consisting of N and CH D is selected from the group...
2017/0008895 USES OF DIAZEPANE DERIVATIVES
The present invention provides compounds of Formula (II) (e.g., compounds of Formula (I)), and pharmaceutically compositions thereof. Compounds of Formula (II)...
2017/0008894 COMPOUNDS AS MODULATORS OF ROR GAMMA
The present invention encompasses compounds of the formula (I) ##STR00001## wherein the variables are defined herein which are suitable for the modulation of...
2017/0008893 PROCESS AND INTERMEDIATES FOR THE SYNTHESIS OF 8-[-METHYL]-8-PHENYL-1,7-DIAZA-SPIRO[4.5]DECAN-2-ONE COMPOUNDS
This application discloses a process to synthesize 8-({1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy)-methyl]-8-pheny-1,7-diaza- spiro[4.5]decan-2-one comprising...
2017/0008892 PROCESS FOR PREPARATION OF SODIUM (2S, 5R)-6-(BENZYLOXY)-7-OXO-1,6-DIAZABICYCLO[3.2.1]OCTANE-2-CARBOXYLATE
A process for preparation of a compound of Formula (I) is disclosed. ##STR00001##
2017/0008891 APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES
Disclosed herein are compounds that inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating...
2017/0008890 SUBSTITUTED 4-AZAINDOLES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS
Substituted 4-azaindoles as NR2B receptor ligands. Such compounds may be used in NR2B receptor modulation and in pharmaceutical compositions and methods for...
2017/0008889 2,4-DISUBSTITUTED PHENYLENE-1,5-DIAMINE DERIVATIVES AND APPLICATIONS THEREOF, AND PHARMACEUTICAL COMPOSITIONS...
The present invention provides a class of 2,4-substituted phenylene-1,5-diamine derivatives, having an inhibiting effect on EGFR tyrosine kinases, and...
2017/0008888 HETEROCYCLIC COMPOUNDS
Provided herein are compounds of formula I and compositions containing the compounds. The compounds and compositions are useful in the methods of inhibiting...
2017/0008887 INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION
The disclosure generally relates to compounds of formula I, including compositions and methods for treating human immunodeficiency virus (HIV) infection. The...
2017/0008886 A PROCESS FOR THE PREPARATION OF APIXABAN AND ITS INTERMEDIATES
The present invention discloses the novel process for preparation of Apixaban intermediate formula (D), intermediate formula (E) and preparation of Apixaban...
2017/0008885 PYRROLO[3,2-C]PYRIDINE DERIVATIVES AS TLR INHIBITORS
The present invention provides a heterocyclic compound having a TLR7, TLR9, TLR7/8, TLR7/9 or TLR7/8/9 inhibitory action, which is useful as an agent for the...
2017/0008884 NOVEL CYSTEINE PROTEASE INHIBITORS AND USES THEREOF
The invention provides for novel cysteine protease inhibitors and compositions comprising novel cysteine protease derivatives. The invention further provides...
2017/0008883 SUBSTITUTED THIAZOLE OR OXAZOLE P2X7 RECEPTOR ANTAGONISTS
The present invention refers to novel substituted thiazole and oxazole compounds of formula (I) having P2X7 receptor (P2X7) antagonistic properties. The...
2017/0008882 PYRIDINES AND PYRIMIDINES AND USE THEREOF
The present disclosure provides pyridines and pyrimidines of Formula I and pharmaceutically acceptable salts and solvates thereof: wherein A, G, W.sup.1,...
2017/0008881 DIHYDROOXAZINE OR OXAZEPINE DERIVATIVES HAVING BACE1 INHIBITORY ACTIVITY
The present invention provides a compound which has an effect of inhibiting amyloid .beta. production, especially an effect of inhibiting BACE1, and which is...
2017/0008880 NEPRILYSIN INHIBITORS
In one aspect, the invention relates to compounds having the formula: ##STR00001## where R.sup.1, R.sup.2, R.sup.3, R.sup.4, and R.sup.5 are as defined in the...
2017/0008879 FUSED TRICYCLIC COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES
The present invention relates to novel Fused Tricyclic Compounds, compositions comprising at least one Fused Tricyclic Compound, and methods of using Fused...
2017/0008878 HETEROCYCLIC AMIDES AS KINASE INHIBITORS
Disclosed are compounds having the formula: ##STR00001## wherein X, Y, Z.sup.1, Z.sup.2, Z.sup.3, Z.sup.4, R.sup.5, R.sup.A, m, A. L, and B are as defined...
2017/0008877 BICYCLIC LACTAMS AND METHODS OF USE THEREOF
The invention provides novel compounds having the general formula I: ##STR00001## wherein R.sup.1, X, Z.sup.1, L, n, the A ring, the B ring, and the C ring are...
2017/0008876 Metal Chelate Compounds for Binding to the Platelet Specific Glycoprotein IIb/IIIa
The present invention is directed to compounds that bind to glycoprotein IIb/IIIa and can be used for diagnostic imaging, in particular magnetic resonance...
2017/0008875 OXINDOLE DERIVATIVES CARRYING A PIPERIDYL-SUBSTITUTED AZETIDINYL SUBSTITUENT AND USE THEREOF FOR TREATING...
The present invention relates to novel substituted oxindole derivatives of formula (I) wherein the variables are as defined in the claims and description; to...
2017/0008874 Method for Producing Sulfonyl Chloride Compound
An object of the present invention is to provide a production method of an intermediate used in the production method of a sulfonylpyrrole compound useful as a...
2017/0008873 COT MODULATORS AND METHODS OF USE THEREOF
The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.
2017/0008872 LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY INCLUDING THE SAME
A liquid crystal composition including at least one of the liquid crystal molecules represented by Chemical Formulas 1 to 3: ##STR00001##
2017/0008871 2-HYDROXYETHYL 2-OXO-1,3-DIOXOLANE-4-CARBOXYLATES, THEIR PREPARATION AND USE
2-hydroxyethyl 2-oxo-1,3-dioxolane-4-carboxylates of formula (I): ##STR00001## wherein one of R.sub.1 and R.sub.2 can be hydrogen. R.sub.1 and R.sub.2, if not...
2017/0008870 Methods for Obtaining Purified Cannabis Extracts and THCA Crystals
The present invention includes a method for obtaining a higher purity cannabinoid solvent extract from a plant which comprises cannabinoids and/or terpenes. A...
2017/0008869 PROCESS FOR THE PRODUCTION OF CANNABIDIOL AND DELTA-9-TETRAHYDROCANNABINOL
The present disclosure relates to the preparation of a cannabidiol compound or a derivative thereof. The cannabidiol compound or derivatives thereof can be...
2017/0008868 PROCESS FOR THE PRODUCTION OF CANNABIDIOL AND DELTA-9-TETRAHYDROCANNABINOL
The present disclosure relates to the preparation of a cannabidiol compound or a derivative thereof. The cannabidiol compound or derivatives thereof can be...
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