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HYDROGEL BASED ON .gamma.-POLYGLUTAMIC ACID AND .epsilon.-POLYLYSINE
CROSSLINKED POLYMER, AND PREPARATION...
A hydrogel based on a cross-linked .gamma.-polyglutamic acid and .epsilon.-polylysine polymer is obtained by cross-linking of .gamma.-polyglutamic acid with...
WOUND CARE COMPOSITIONS
Glass-based particles of a biocompatible material which comprises 40 to about 80 wt % borate (B.sub.2O.sub.3) intermixed into a carrier which is an ointment,...
AUTONOMOUSLY POWERED VAPOUR RELEASE DEVICE
The present invention is directed to an autonomously powered vapor dispensing device comprising an intermediate basin which allows the volatile liquid...
[Problem] Provided is a decontamination system which does not require large scale equipment such as large diameter ducts or anti-condensation heaters, while...
VACUUM EXHAUST SYSTEM OF STERILIZER
The present invention relates to a vacuum exhaust system of a sterilizer, comprising: a sterilization chamber; a first vacuum pump connected to one side of the...
LED structure and luminaire for continuous disinfection
A LED structure, a lighting fixture and a method of providing white light illumination. The LED structure comprises a substrate; a light emitting area defined...
METHOD AND APPARATUS UTILIZING UV-A AND UV-C FOR TREATMENT OF TEXTILE
The present invention discloses a method and corresponding apparatus utilizing UV-A and UV-C for treatment of textile materials. The method comprises the steps...
TIN-117M SOMATOSTATIN RECEPTOR BINDING COMPOUNDS AND METHODS
Tin-117m somatostatin analogues or antagonist are used to treat tumors and symptoms associated with these tumors which express somatostatin receptors, such as...
IN-VIVO INTRAVASCULAR BLOOD REPLACING LIQUID, IN-VIVO INTRAVASCULAR BLOOD
REPLACING LIQUID FORMULATION, AND...
An in-vivo intravascular blood replacing liquid of the present invention is injected into a blood vessel to replace blood at an intravascular portion to be...
MALTOL-COATED MAGNETITE NANOPARTICLES, COMPOSITIONS AND METHODS COMPRISING
The present invention relates to maltol-coated magnetite nanoparticles, pharmaceutical compositions comprising same, and methods for using same as contrast...
DENDRONIZED METALLIC OXIDE NANOPARTICLES, A PROCESS FOR PREPARING THE SAME
AND THEIR USES
Dendronized metallic oxide nanoparticles, a process for preparing the same and their uses.
FLUORESCENT CONJUGATED POLYMERS WITH A BODIPY-BASED BACKBONE AND USES
The present invention provides various fluorescent conjugated polymers with a BODIPY-based backbone. The invention also provides methods of using the polymers...
POLYMERIC SYSTEMS AND USES THEREOF IN THERANOSTIC APPLICATIONS
Polymeric systems useful for theranostic applications are disclosed. The polymeric systems comprise a fluorescent or fluorogenic moiety and a therapeutically...
The invention relates to a water-based biocompatible non-cytotoxic preparation for the selective staining of internal limiting membrane (ILM) and/or epiretinal...
Method of Treating or Retarding the Development of Blindness
A method for treating an ocular disorder characterized by the defect or absence of a normal gene in the ocular cells of a human or animal subject involves...
TARGETED DRUG DELIVERY THROUGH AFFINITY BASED LINKERS
The current invention discloses targeted drug delivery conjugates comprising a targeting moiety linked to a drug via a molecule having an affinity for the...
ANTIBODY-DRUG CONJUGATES AND USES THEREOF
The present invention relates to therapeutic immunoconjugates comprising SN-38 attached to an antibody or antigen-binding antibody fragment. The antibody may...
ANTI-NOTCH3 ANTIBODIES AND ANTIBODY-DRUG CONJUGATES
The present invention provides for anti-Notch3 antibodies, anti-Notch3 antibody-drug conjugates and methods for preparing and using the same.
DUOCARMYCIN ADCS SHOWING IMPROVED IN VIVO ANTITUMOR ACTIVITY
The present invention relates to duocarmycin-containing antibody-drug conjugates (ADCs) for use in the treatment of human solid tumours and haematological...
AURISTATIN-ANTIBODY CONJUGATES AND USES THEREOF
Disclosed herein are auristatin-antibody conjugates and compositions thereof. The auristatin-antibody conjugates and compositions may be used for treating...
SPLICEOSTATIN ANALOGS AND METHOS FOR THEIR PREPARATION
The present invention is directed to novel cytotoxic spliceostatin analogs and derivatives, to antibody drug conjugates thereof, and to methods for using the...
CONJUGATES OF CYSTEINE ENGINEERED ANTIBODIES
The invention relates to novel cell-binding agent-cytotoxic agent conjugates, wherein the cell-binding agent (CBA) is covalently linked to the cytotoxic agent...
PHARMACEUTICAL COMPOSITIONS FOR HIGH-CAPACITY TARGETED DELIVERY
Provided herein are aptamers and pharmaceutical compositions comprising the same. In some embodiments, the aptamer selectively binds a protein of interest such...
OLIGOSACCHARIDES COMPRISING AN AMINOOXY GROUP AND CONJUGATES THEREOF
The invention provides methods for the synthesis of oligosaccharides comprising an aminooxy group. The invention further provides oligosaccharides comprising...
The present invention provides pharmacological compounds including an effector moiety conjugated to a binding moiety that directs the effector moiety to a...
HYBRID ANTICANCER PRODRUG SIMULTANEOUSLY PRODUCING CINNAMALDEHYDE AND
QUINONE METHIDE AND METHOD FOR PREPARING SAME
The present invention relates to a hybrid anticancer prodrug simultaneously producing cinnamaldehyde and quinone methide. The hybrid anticancer prodrug...
VEHICLE COMPOSITIONS ESSENTIALLY FREE OF PHARMACEUTICALLY ACTIVE AGENTS
FOR THE IMPROVED TREATMENT OF ACNE AND...
The present invention related to the use of a pharmaceutical composition which is essentially free of pharmaceutically active agents for the treatment of human...
COMPOSITIONS AND METHODS FOR BIRDS
Compositions and methods are disclosed for providing beneficial effects to animals, such as reducing harmful pathogens and increasing performance. In one...
Implantable Polymeric Device for Sustained Release of Sufentanil
Extended release of sufentanil is provided by implanting a device containing sufentanil into a mammal or human being. The device may include a solid...
POLOXAMER-BASED INTRALESIONAL INJECTIONS FOR THE DELIVERY OF
Intralesional injections including poloxamer compounds and anticancer drugs are disclosed. The combination of the poloxamer-based composition with...
SWINE VIRUS VACCINES THAT ARE LIQUID STABLE
The present invention is drawn to liquid stable swine vaccines that comprise a live porcine virus. The invention is also drawn to the manufacture of such...
STABILIZED HYPOHALOUS ACID SOLUTIONS
The present invention provides a stabilized hypohalous acid solution (or formulation thereof), which may be conveniently packaged for sale, or stored for later...
CELL ENERGY THERAPEUTICS
The invention in suitable embodiments is directed to cell energy therapeutics enabled by ultrabright fluorescent molecules and emitting photons of a luminance...
Singlet Oxygen-Labile Linkers and Methods of Production and Use Thereof
Activatable compositions that include at least one functional moiety and at least one cleavable linker directly or indirectly linked to the at least one...
IMMUNOGLOBULIN PREPARATION AND STORAGE SYSTEM FOR AN IMMUNOGLOBULIN
The present invention relates to an immunoglobulin preparation comprising immunoglobulin in a mass-volume percentage of at least 4%, wherein the concentration...
CHIMERIC ANTIGEN RECEPTOR (CAR) SIGNALLING SYSTEM
The present invention relates to a chimeric antigen receptor (CAR) signalling system comprising; (i) a receptor component comprising an extracellular...
ANTI-TUMOR COMPOSITIONS AND USES THEREOF
The present invention provides a composition for raising an immune response against a tumor. The composition comprises at least one tumor antigen, a...
Fusion Protein Comprising Diphtheria Toxin Non-Toxic Mutant CRM197 or
Provided in the present invention are a diphtheria toxin non-toxic mutant CRM197 or a fragment thereof as an adjuvant in a fusion protein and the use thereof...
VACCINE COMPRISING AMB A 1 PEPTIDES FOR USE IN THE TREATMENT OF RAGWEED
The present invention relates to compositions for preventing or treating allergy to ragweed by tolerisation. The compositions are based on combinations of...
CYTOMEGALOVIRUS VACCINES AND METHODS OF PRODUCTION
Methods of increasing diversity in cytomegalovirus vaccines through the selection of cell type in which the virus is propagated, and the use of cytomegalovirus...
MPER-LIPOSOME CONJUGATES AND USES THEREOF
The present invention relates to peptides and compositions suitable for use in inducing anti-HIV-1 antibodies. The compositions comprise HIV-1 gp41 membrane...
The present disclosure provides vaccine compositions for prophylaxis and treatment of Zika virus infections comprising Zika virus antigens in immunogenic...
METHODS FOR PREVENTING AND TREATING STAPHYLOCOCCUS AUREUS COLONIZATION,
INFECTION, AND DISEASE
The invention provided herein relates to a method of preventing a Staphylococcus aureus colonization and/or infection by administering a Streptococcus...
COMPOSITIONS AND METHODS OF PREPARING LEPTOSPIRA
The present invention includes compositions and methods of preparing flagellar-coiling protein 1 (Fcp1)-deficient Leptospira bacterium. In one aspect, the...
NOVEL TREATMENT METHOD
There is provided according to the invention a method of treating a mammal suffering from or susceptible to an immune reaction to drug treatment comprising the...
PROSTATE CANCER VACCINE
Androgen receptor-based vaccines for eliciting an immune reaction in vivo against cells expressing androgen receptor are disclosed. The vaccines are useful in...
MUCIN ANTIGEN VACCINE
Provided are expression vectors for generating an immune response to a mucin. The vectors comprise a transcription unit encoding a secretable polypeptide, the...
COMBINATION OF VACCINATION AND OX40 AGONISTS
The present invention relates to a vaccine/agonist combination comprising an RNA vaccine comprising at least one RNA comprising at least one open reading frame...
ENOLASE 1 (ENO1) COMPOSITIONS AND USES THEREOF
The invention provides compositions comprising Eno1 and a muscle targeting peptide, e.g, as a fusion protein, for delivery of Eno1 to a muscle. The Eno1 may...
SUMOYLATION OF SERCA2A AND CARDIOVASCULAR DISEASE
Methods for treating cardiovascular disease, and in particular heart failure, are provided comprising administering a therapeutically effective amount of a...