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SGK1 INHIBITORS FOR TREATMENT OF PROSTATE CANCER
The present invention encompasses the recognition that reproducible and detectable changes in the level and or activity of SGK1 are associated with incidence...
TREATMENT OF PROGRESSIVE NEURODEGENERATIVE DISEASE WITH IBUDILAST
Compositions and methods for treating progressive neurodegenerative diseases, and their associated symptoms by administration of ibudilast ...
INHALABLE AZTREONAM LYSINATE FORMULATION FOR TREATMENT AND PREVENTION OF
PULMONARY BACTERIAL INFECTIONS
A method and a composition for treatment of pulmonary bacterial infections caused by gram-negative bacteria suitable for treatment of infection caused by...
The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; ##STR00001## a method for manufacturing the compounds of...
Methods of Reducing Mammographic Breast Density and/or Breast Cancer Risk
The present disclosure is directed to generally methods for treating mammographic breast density and/or breast stiffness in a patient in need thereof, such as...
Treatment of Multidrug-Resistant Nephrotic Syndrome (MDR-NS) in Children
The present disclosure provides compositions and methods for treating multidrug-resistant nephrotic syndrome (MDR-NS) in pediatric subjects comprising...
DIARYL AND ARYLHETEROARYL UREA DERIVATIVES AS MODULATORS OF THE 5-HT2A
SEROTONIN RECEPTOR USEFUL FOR THE...
The present invention relates to certain pyrazole derivatives of Formula (I) and pharmaceutical compositions thereof that modulate the activity of the...
METHOD FOR INHIBITING TUMOR METASTASIS
A leukotriene C4 and D4 antagonist is used to inhibit tumor metastasis by acting to inhibit tumor cell adhesion to endothelial cells, therby preventing tumor...
SOLID DISPERSION OF INDIRUBIN
The invention described herein provides a solid dispersion of Indirubin, a pharmaceutical composition comprising the solid dispersion of Indirubin, a process...
SELF-EMULSIFYING FORMULATIONS OF DIM-RELATED INDOLES
Disclosed herein are self-emulsifying compositions and formulations of Diindolylmethane ("DIM") and certain derivatives of DIM, their uses and methods of...
NEW SOMATOSTATIN RECEPTOR SUBTYPE 4 (SSTR4) AGONISTS
3-aza-bicyclo[3.1.0]hexane-6-carboxylic acid amide derivatives which are agonists of somatostatin receptor subtype 4 (SSTR4), useful for preventing or treating...
Vildagliptin Formulation Process Under Inert Gas Atmosphere
The present invention relates to a process for preparing a pharmaceutical composition of vildagliptin under oxygen free inert gas atmosphere. The present...
Pharmaceutical Formulations of Vildagliptin
The present invention relates to a pharmaceutical formulation comprising therapeutically effective amount of vildagliptin or pharmaceutically acceptable salt...
COMPOUNDS FOR THE TREATMENT OF MYCOBACTERIAL INFECTIONS
The invention relates to compounds of Formula I or a pharmaceutically acceptable salt, ester or prodrug thereof: ##STR00001##
The invention relates to a complex of an anthocyanidin and a methylated .beta.-cyclodextrin which can be formulated as an aqueous solution and as a solid, and...
SYSTEMS, METHODS, AND FORMULATIONS FOR TREATING CANCER
A method and compositions for treating cancer is described using at least two epigenetic modifiers. In various embodiments, hyperbaric oxygen therapy and...
PHARMACEUTICAL COMPOSITION COMPRISING EFFECTIVE DOSE OF POMIFERIN FOR
The present invention provides a compound of formula (I) as a SERCA inhibitor for treating cancers, a pharmaceutical composition comprising said compound, and...
COMPOSITION FOR TREATMENT OF DYSLIPIDEMIA AND INFLAMMATION
The present invention provides compositions that are substantially niacin free for treating dyslipidemia and/or inflammation in a subject. Compositions of the...
METHODS OF TREATING CANCER
The present invention provides methods and compositions for treating non-small-cell lung cancer (NSCLC) by administering a) a composition comprising...
Drug Combination for Treatment of Proliferative Diseases
Angiogenesis inhibitory drug combination obtained according to a specific algorithm, preferably a FSC, in which an initial combination of drugs is iteratively...
SARMS AND METHOD OF USE THEREOF
This invention is directed to substituted acylanilide compounds and uses thereof in treating muscular dystrophies such as Duchenne muscular dystrophy and...
SARMS AND METHOD OF USE THEREOF
This invention is directed to substituted acylanilide compounds and uses thereof in improving or preserving lung function and cardiac function in a subject...
COMPOSITIONS COMPRISING POLYUNSATURATED FATTY ACID MONOGLYCERIDES OR
DERIVATIVES THEREOF AND USES THEREOF
There are provided compositions comprising ##STR00001## Such compositions can also further comprise various components such as lipids (for example fatty acids,...
RETINAL DERIVATIVES AND METHODS FOR THE USE THEREOF FOR THE TREATMENT OF
Compositions of and methods for using synthetic retinal derivatives as retinoid replacements and opsin agonists are provided.
CONTROLLED RELEASE PHARMACEUTICAL COMPOSITIONS COMPRISING A FUMARIC ACID
The present invention relates to controlled release pharmaceutical compositions comprising fumaric acid ester(s) as active substance(s). The compositions are...
METHODS OF TREATING MIXED DYSLIPIDEMIA
The present disclosure relates to, inter alia, methods of treating mixed dyslipidemia with ethyl eicosapentaenoate.
Compositions Containing Very Long Chain Saturated Fatty Acids and Methods
A fatty acid composition comprising at least one purified very long chain saturated fatty acid (VLC-SFA) having a chain length in a range of from about 28...
ENDOPROSTHESIS HAVING AND ACTIVE SUSBTANCE COATING
The present invention relates to an endoprosthesis with a drug coating comprising or consisting of at least one antibiotic agent and at least one further...
Treatment of intrahepatic cholestatic diseases
Treatment of intrahepatic cholestatic diseases by therapy with MBX-8025 or an MBX-8025 salt.
ANTI-CHOLESTEROLEMIC COMPOUNDS AND METHODS OF USE
The present invention provides novel compounds with hypocholesteremic activity from crude Embilica officinialis (EO) extracts and methods of use. The invention...
MITOCHONDRIAL DELIVERY OF 3-BROMOPYRUVATE
A mitochondria targeted gold nanoparticle (T-3-BP-AuNP) decorated with 3-bromopyruvate (3-BP) and delocalized lipophilic triphenylphosphonium (TPP) cations to...
METHODS OF TREATING CANCER USING RAD51 SMALL MOLECULE STIMULATORS
Methods of killing or inhibiting the growth cancer cells and tumors and of treating cancer by administering compounds that stimulate the activity of RAD51....
HIGH CONCENTRATION LOCAL ANESTHETIC FORMULATIONS
A transdermal topical anesthetic formulation, which can be used to ameliorate or inhibit pain, has been developed. In the preferred embodiment, the topical...
COMPOSITION AND METHOD FOR ENHANCING WOUND HEALING
The invention relates to a composition for enhancing wound healing and/or for reducing pain and inflammation, comprising a first active ingredient and a second...
COMPOSITIONS AND METHODS FOR INCREASING THE METABOLIC LIFETIME OF
DEXTROMETHORPHAN AND RELATED PHARMACODYNAMIC...
This disclosure relates to methods administering various compounds in conjunction with dextromethorphan to a human being. Dosage forms, drug delivery systems,...
METHODS OF ENHANCING IMMUNITY IN A COMPANION ANIMAL
Disclosed herein are methods for enhancing the immune response of a companion animal, comprising administering to a companion animal a composition comprising...
CANNABINOID RECEPTOR TREATMENTS
The present invention includes methods and compositions for treating a transplant recipient by administration of a CB.sub.2 receptor agonist either alone or in...
ZEAXANTHIN FOR TUMOR TREATMENT
A composition comprising a pharmaceutically effective amount of zeaxanthin or its derivative for use in treating a malignant tumor and a method of using a...
Pramipexole-Containing Transdermal Patch for Treatment of
The purpose of the present invention is to provide a nonaqueous tape that is stable and has high percutaneous absorption performance, and that contains...
WATER-DISPERSIBLE AMORPHOUS PARTICLES AND METHOD FOR PREPARING SAME
The present invention pertains to spherical water-dispersible amorphous particles having a particle diameter of 10-990 nm and a PDI of 0.01-0.5, wherein the...
ENGINEERED FLUORINATED BIOMATERIALS
Provided are protein polymers providing the dual functionality of delivery and imaging. The protein polymers comprise a coiled-coil domain of the cartilage...
ORAL VIRUS VACCINE
The present disclosure relates to a polymer-coated virus particle for an oral virus vaccine, a method of preparing the same, and a composition comprising the...
TREATING SOFT TISSUE VIA CONTROLLED DRUG RELEASE
Methods for inhibiting tissue ossification or calcification in a subject, comprising administering a therapeutically effective amount of BMP I inhibitor-loaded...
Formulations of Nonopioid and Confined Opioid Analgesics
The preferred exemplary embodiments in the present application provide formulations and methods for the delivery of drugs, particularly drugs of abuse, having...
DRY COATED TABLET
Provided is a dry coated tablet showing high stability of the active ingredient (proton pump inhibitor, acetylsalicylic acid), which stably and rapidly...
Spray Drying Process for Production of Powders with Enhanced Properties
An improved spray drying method for production of amorphous solid dispersions with enhanced bulk density and material attributes comprising the introduction of...
This invention relates to pharmaceutical formulations comprising particles with a substantially non-hygroscopic inner crystalline core and an outer coating...
DRUG CARRIER AND MANUFACTURING METHOD THEREOF
A drug carrier and a manufacturing method thereof are provided. The drug carrier includes a hydrophilic group, a hydrophobic group and an organic dye. The...
STABLE PHARMACEUTICAL COMPOSITION OF CLOPIDOGREL FREE BASE FOR ORAL AND
The present disclosure provides ready-to-use, oil/water emulsion compositions with mean droplet size (intensity-average, nm) of 100-500 nm, where the oil phase...
HIGH DELIVERY RATES FOR LIPID BASED DRUG FORMULATIONS, AND METHODS OF
Provided is a method of preparing lipid based drug formulations with low lipid/drug ratios using coacervation techniques. Also provided are methods of...