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Patent # Description
2017/0016067 Biomarkers For Endometriosis
The presence of certain auto antibodies and miRNAs indicates that a subject has endometriosis. The auto-antibodies recognise antigens listed in Table 1. The...
2017/0016066 BAG3 AS A TARGET FOR THERAPY OF HEART FAILURE
Compositions are directed to BCL2-associated athanogene 3 (BAG3) molecules and agents which modulate expression of BAG3 molecules. Pharmaceutical composition...
2017/0016065 Nucleic Acid Probe and Method of Detecting Genomic Fragments
Provided herein, among other things, is a method of processing a nucleic acid sample. In some embodiments, the method comprises a) hybridizing a sample...
2017/0016064 Method for reducing dephasing during cluster DNA sequencing
A method for nucleic acid sequencing, comprising: exposing a plurality of clusters of a plurality of template polynucleotide strands to a series of flows of a...
2017/0016063 METHODS FOR SEQUENCING NUCLEIC ACIDS
Provided herein are methods and compositions for the sequencing of long nucleic acids, such as DNA. The methods and compositions are suited for the spatial...
2017/0016062 SEQUENCING METHODS AND KITS
A method for detecting rare genomic variants in a population of cells is disclosed. The method can detect de novo mutations in bacteria and analyze the impact...
2017/0016061 Sequencing Method Using Magnifying Tags
The present invention provides a method of sequencing all or part of a target nucleic acid molecule by determining the sequence of a portion of said nucleic...
2017/0016060 DISPOSABLE, INTEGRATED MICROFLUIDIC CARTRIDGE AND METHODS OF MAKING AND USING SAME
The disclosed embodiments concern microfluidic cartridges for detecting biological reactions. In some embodiments, the microfluidic cartridges are configured...
2017/0016059 UNIVERSAL CONTROLS FOR SEQUENCING ASSAYS
The present invention relates to a positive and negative control and an extraction control, respectively, for sequencing assays. The present application...
2017/0016058 APPARATUS FOR USE IN ISOTHERMAL AMPLIFICATION
A method of monitoring amplification of a nucleic acid by providing a nucleic acid and an amplification mixture using the kit of isothermal reagents to a pH...
2017/0016057 Complexity Management of Genomic DNA
The presently claimed invention provides for novel methods and kits for reducing the complexity of a nucleic acid sample by providing non-gel based methods for...
2017/0016056 ACCURATE DETECTION OF RARE GENETIC VARIANTS IN NEXT GENERATION SEQUENCING
The invention relates to a method for analyzing a target nucleic acid fragment, comprising generating a first strand using one strand of the target as a...
2017/0016055 NUCLEIC ACID PRODUCTION AND SEQUENCE ANALYSIS
A method for producing a nucleic acid molecule from a template nucleic acid sequence and a linking unit attached to a primer, which method comprises a step of...
2017/0016054 DETECTING INCREASE OR DECREASE IN THE AMOUNT OF A NUCLEIC ACID HAVING A SEQUENCE OF INTEREST
A method of detecting copy number variations in foetal or tumour DNA within a sample of circulating cell-free DNA includes carrying out amplification of DNA...
2017/0016053 SIMULTANEOUS QUANTIFICATION OF GENE EXPRESSION IN A USER-DEFINED REGION OF A CROSS-SECTIONED TISSUE
The present invention relates to, among other things, probes, compositions, methods, and kits for simultaneous, multiplexed detection and quantification of...
2017/0016052 MICROARRAY BASED SAMPLE DETECTION SYSTEM
A microarray assembly for detection of a target molecule is disclosed. The microarray assemblies comprise an array chamber having a microarray located therein...
2017/0016051 DNA Methylation Detection
The present invention relates to a method for detecting methylation of a target oligonucleotide molecule. The method comprises obtaining an electrical change...
2017/0016050 NOVEL AZO COMPOUND, USE THEREOF AND METHOD FOR PREPARING SAME
The present invention provides a novel azo compound having a quenching ability for the material that exhibits a luminescent phenomenon at an excited energy...
2017/0016049 DETECTION OF A TARGET NUCLEIC ACID SEQUENCE USING TWO DIFFERENT DETECTION TEMPERATURES
The present invention relates to detection of a target nucleic acid sequence in a sample using two different detection temperatures. The present invention...
2017/0016048 COMPOSITIONS AND METHODS FOR ENRICHING POPULATIONS OF NUCLEIC ACIDS
This disclosure provides methods and compositions that are useful for enriching a particular population of nucleic acids (a "population of interest") within a...
2017/0016047 ENRICHING A SAMPLE OF CIRCULATING CELL-FREE NUCLEIC ACIDS
A method of enriching a sample of circulating cell-free DNA for DNA derived from a foetus or from a tumour includes carrying out amplification of DNA such that...
2017/0016046 Methods and Compositions for Isolating Polynucleotides
Methods of isolating target double-stranded polynucleotides with internal single-stranded regions are provided. Compositions and kits comprising ...
2017/0016045 SYSTEM AND METHOD FOR CONTAMINATION TESTING OF HIGH-TOUCH SURFACES
Methods and materials as may be utilized to provide consistent contamination testing of surfaces are described. The methods are based upon the designation of...
2017/0016044 TEST STRIP AND APPARATUS FOR MEASURING THE CONTENT OF ALCOHOL IN BLOOD, OR OF ANY OTHER SUBSTANCE IN BLOOD, AND...
A test strip for measuring the blood alcohol content from blood includes a base material and two electrodes attached to it and a reaction area connected to...
2017/0016043 SYSTEM AND METHOD FOR IMPROVED TRANSIENT PROTEIN EXPRESSION IN CHO CELLS
The present invention is directed generally to systems and methods suitable for high level expression of recombinant proteins in suspension CHO cells. In...
2017/0016042 BINDING FUSION PROTEINS, BINDING FUSION PROTEIN-DRUG CONJUGATES, XTEN-DRUG CONJUGATES AND METHODS OF MAKING AND...
The present invention relates to binding fusion protein compositions comprising targeting moieties linked to extended recombinant polypeptide (XTEN), binding...
2017/0016041 STABILIZED REDUCING AGENTS AND METHODS USING SAME
The disclosure provides stabilized reducing agents and methods for using them in sample preparation. Stabilized reducing agents described herein provide...
2017/0016040 CHEMOENZYMATIC SYNTHESIS OF HEPARIN AND HEPARAN SULFATE ANALOGS
The present invention provides a one-pot multi-enzyme method for preparing UDP-sugars from simple sugar starting materials. The invention also provides a...
2017/0016039 METHODS AND STRAINS FOR PRODUCING BIOPRODUCTS IN AUREOBASIDIUM PULLULANS
The present disclosure provides methods for producing bioproducts from novel genetically altered strains of Aureobasidium pullulans. Methods and materials for...
2017/0016038 METABOLICALLY ENGINEERED ORGANISMS FOR THE PRODUCTION OF ADDED VALUE BIO-PRODUCTS
The present invention relates to genetically engineered organisms, especially microorganisms such as bacteria and yeasts, for the production of added value...
2017/0016037 Method for Increasing the Solubility of Methionine by Mineral Addition and Acid Treatment
The present invention relates to a method for enhancing the solubility of methionine. More particularly, the present invention relates to a method for...
2017/0016036 METHOD FOR CULTURING MICROALGAE OF THE AURANTIOCHYTRIUM GENUS IN A CULTURE MEDIUM WITHOUT CHLORIDE AND WITHOUT...
A method for culturing a protist of the Aurantiochytrium mangrovei genus. The genus is characterized genetically and by virtue of the lipid profile thereof....
2017/0016035 GENETICALLY ENGINEERED METHYLOTROPHS FOR THE PRODUCTION OF PHA BIOPOLYMERS AND C3, C4, AND C5 BIOCHEMICALS FROM...
Methods and genetically engineered hosts for the production of 3-carbon, 4-carbon and 5-carbon products, polymers and copolymers in methylotrophic bacteria are...
2017/0016034 Host cells and methods for producing diacid compounds
The present invention provides for a genetically modified host cell and related methods and materials for the biocatalytic production of an ...
2017/0016033 Mutant Microorganism Comprising Gene Encoding Methylmalonyl-CoA Reductase and Use Thereof
Provided herein is a mutant microorganism containing a methylmalonyl-CoA reductase-encoding gene having an activity of converting methylmalonyl-CoA to...
2017/0016032 METHOD FOR PRODUCING 1,3-PROPANEDIOL USING MICROORGANISM VARIANT WITH DELETION OF 2,3-BUTANEDIOL SYNTHETIC GENE
The present invention relates to a method for producing 1,3-propanediol using a mutant microorganism lacking a 2,3-butanediol synthetic gene, and more...
2017/0016031 OPTIMIZED BIOGAS (BIOMETHANE) PRODUCTION FROM ANAEROBIC REACTORS
An improved process and apparatus for producing biogas having a high methane content from a feed or substrate. Feed material is injected into a reactor having...
2017/0016030 NOVEL DNA-BINDING PROTEINS AND USES THEREOF
Disclosed herein are polypeptides, polynucleotides encoding, cells and organisms comprising novel DNA-binding domains, including TALE DNA-binding domains. Also...
2017/0016029 Protein with Recombinase Activity for Site-Specific DNA-Recombination
The invention relates to the use of a protein with recombinase activity to catalyze a site-specific DNA recombination and a method for producing a...
2017/0016028 Production of Lentiviral Vectors
A high-volume gene therapy vector manufacturing process which produces a recombinant gene therapy vector which is able to transform host cells even when they...
2017/0016027 DELIVERY METHODS AND COMPOSITIONS FOR NUCLEASE-MEDIATED GENOME ENGINEERING
The present disclosure is in the field of genome engineering, particularly targeted modification of the genome of a cell.
2017/0016026 CHIMERIC NUCLEIC ACID MOLECULES WITH NON-AUG TRANSLATION INITIATION SEQUENCES AND USES THEREOF
The present disclosure relates to nucleic acid vaccine compositions and methods for preventing or treating pathological conditions, such as cancer or...
2017/0016025 METHOD FOR GENERATING T-CELLS COMPATIBLE FOR ALLOGENIC TRANSPLANTATION
The present invention pertains to engineered T-cells, method for their preparation and their use as medicament, particularly for immunotherapy. The engineered...
2017/0016024 PRP8 NUCLEIC ACID MOLECULES TO CONTROL INSECT PESTS
This disclosure concerns nucleic acid molecules and methods of use thereof for control of insect pests through RNA interference-mediated inhibition of target...
2017/0016023 SNAP25 NUCLEIC ACID MOLECULES TO CONTROL INSECT PESTS
This disclosure concerns nucleic acid molecules and methods of use thereof for control of insect pests through RNA interference-mediated inhibition of target...
2017/0016022 MODIFIED GENE CONFERRING VIRUS RESISTANCE
The present invention relates to modified RDR1 gene capable of conferring virus resistance to a plant and/or increasing virus resistance in a plant, which...
2017/0016021 RECOMBINANT CONSTRUCT, RECOMBINANT MICROORGANISM, RECOMBINANT PLANT CELL AND METHOD OF PROVIDING PLANT WITH...
Provided is a strategy for generating transgenic plants with concurrent resistance to DNA and RNA viruses at one construction, so as to develop an RNA-directed...
2017/0016020 Powdery Mildew Resistance Providing Genes in Cucumis Sativus
The present invention relates to powdery mildew resistance providing genes of the Cucumis family, and especially Cucumis sativus, wherein said resistance is...
2017/0016019 Plants Having Enhanced Pathogen Resistance and Methods of Modulating Pathogen Resistance in Plants
The present invention relates to methods of modifying pathogen resistance in plants and plants having modified pathogen resistance. In particular, the present...
2017/0016018 HPPD VARIANTS AND METHODS OF USE
In the present invention, HPPD enzymes and plants containing them showing a full tolerance against several classes of HPPD-inhibitors are described. A set of...
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