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Methods of Preparing a Catalyst
A method comprising a) calcining a silica support at temperature in the range of from about 100.degree. C. to about 500.degree. C. to form a precalcined silica...
NOVEL ANIONIC POLYMERIZATION INITIATOR AND METHOD FOR PREPARING CONJUGATED
DIENE-BASED POLYMER USING SAME
Disclosed are an anionic polymerization initiator, which is a reaction product of an organometallic compound and a compound including an alkyl chain having a...
CONTROLLED RADICAL POLYMERIZATION
A process of polymerization of a vinylic monomer uses a polymerization regulator/initiator that is a compound represented by Formula I. ##STR00001##
MODIFIED CONJUGATED DIENE-BASED POLYMER, PREPARATION METHOD THEREFOR, AND
RUBBER COMPOSITION CONTAINING SAME
Disclosed are a modified conjugated diene-based polymer represented by specific Chemical Formula, a method of preparing the same, and a rubber composition...
POLYMERS FUNCTIONALIZED WITH HETEROCYCLIC NITRILE COMPOUNDS
A method for preparing a functionalized polymer, the method comprising the steps of preparing a reactive polymer and reacting the reactive polymer with a...
Conjugates of Oligomer of Hyaluronic Acid or of a Salt Thereof, Method of
Preparation Thereof and Use Thereof
The invention relates to conjugates of hyaluronic acid oligomer according to the general formulae I, II III or IV, or a salt thereof, the method of preparation...
Compositions And Methods For Modulating And Redirecting Immune Responses
Provided herein are methods of modulating and redirecting an immune response. Compositions and methods for killing targeted cells in a cell population are also...
ANTI-FIBULIN-3 ANTIBODIES AND USES THEREOF
Embodiments described herein provide anti-fibulin-3 antibodies, recombinant proteins that bind specifically to fibulin-3, compositions and the treatment...
NUCLEIC ACIDS ENCODING HUMAN ANTIBODIES TO SIALYL-LEWIS A
The present invention provides compositions for the production of an antibody or functional fragment thereof directed against Sialyl-Lewis.sup.a (sLe.sup.a)....
COMBINATION THERAPY COMPRISING ANTI-ANGIOGENESIS AGENTS AND OX40 BINDING
The invention provides compositions and methods for treating cancers. The method comprises administering an anti-angiogenesis agent and an OX40 binding agonist.
ANTIBODY POLYPEPTIDES THAT ANTAGONIZE CD40
Antibody polypeptides that specifically bind a novel epitope of human CD40 are provided. The antibody polypeptides do not exhibit CD40 agonist activity. The...
MULTIVALENT AND MULTISPECIFIC DR5-BINDING FUSION PROTEINS
The disclosure relates generally to molecules that specifically engage death receptor 5 (DR5), a member of the TNF receptor superfamily (TNFRSF). More...
ANTIBODIES AGAINST HUMAN CSF-1R AND USES THEREOF
The present invention relates to antibodies against human CSF-1R (CSF-1R antibody), methods for their production, pharmaceutical compositions containing said...
HUMAN ANTIGEN BINDING PROTEINS THAT BIND BETTA-KLOTHO, FGF RECEPTORS AND
The present invention provides compositions and methods relating to or derived from antigen binding proteins activate FGF21-mediated signaling. In embodiments,...
INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR -SPECIFIC ANTIBODIES AND USES
The blood-brain barrier (BBB) prevents transport of molecules larger than 500 Daltons from blood to brain. Receptor-mediated transcytosis (RMT) facilitates...
INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR -SPECIFIC ANTIBODIES AND USES
The blood-brain barrier (BBB) prevents transport of molecules larger than 500 Dal tons from blood to brain. Receptor-mediated transcytosis (RMT) facilitates...
CD86 ANTAGONIST MULTI-TARGET BINDING PROTEINS
This disclosure provides a multi-specific fusion protein composed of a CD86 antagonist binding domain and another binding domain that is an IL-10 agonist, an...
DEFINED COMPOSITION GENE MODIFIED T-CELL PRODUCTS
Aspects of the invention described herein, concern approaches to make genetically modified T-cells comprising a chimeric antigen receptor for human therapy. In...
PRODUCTION OF CYTOTOXIC ANTIBODY-TOXIN FUSION IN EUKARYOTIC ALGAE
Methods and compositions are disclosed to engineer chloroplast comprising heterologous genes encoding target binding domain fused to a eukaryotic toxin and...
The present invention provides an anti-blood coagulant capable of selectively suppressing a pathological blood coagulation reaction without increasing the risk...
The present disclosure provides compositions and methods relating to antibodies that specifically bind to human erythropoietin. The disclosure provides nucleic...
BINDING PROTEINS AGAINST VEGF, PDGF, AND/OR THEIR RECEPTORS
Binding proteins that bind one or more of VEGF, PDGF and/or their receptors, including antibodies, CDR-grafted antibodies, humanized antibodies, binding...
TREATMENT OF PAROXYSMAL NOCTURNAL HEMOGLOBINURIA PATIENTS BY AN INHIBITOR
Eculizumab, a humanized monoclonal antibody against C5 that inhibits terminal complement activation, showed activity in a preliminary 12-week open-label trial...
METHODS FOR TREATING COMPLEMENT-ASSOCIATED DISORDERS
The present disclosure relates to, inter alia, compositions containing an inhibitor of human complement and use of the compositions in methods for treating or...
Agents, Uses and Methods for the Treatment of Synucleinopathy
The invention relates to novel monoclonal anti-alpha-synuclein antibodies. The antibodies can be used for treating a synucleinopathy such as Parkinson's...
Antibodies Specific for Hyperphosphorylated Tau and Methods of Use Thereof
The present invention relates to a novel class of monoclonal antibody that specifically binds the phosphorylated serine 396 residue on pathological...
The invention provides antibodies that specifically bind to transthyretin (TTR). The antibodies can be used for treating or effecting prophylaxis of diseases...
ANTIBODIES TO SERICIN AND METHODS AND KITS USING SAME
The present invention relates to antibodies that bind to a polypeptide at an epitope in the amino acid sequence of SEQ ID NO: 1 (e.g., a sericin polypeptide)....
ANTI-GLUCOSAMINIDASE PASSIVE IMMUNIZATION FOR STAPHYLOCOCCUS AUREUS
The present invention is directed to a monoclonal antibody that binds specifically to a Staphylococcus aureus glucosaminidase and inhibits in vivo growth of S....
Compositions and Methods for Treating and Preventing Staphylococcus Aureus
Antibodies having Fab regions that specifically bind to Staphylococcus aureus protein A are capable of mediating opsinization of Staphylococcus aureus bacteria...
BINDING MOLECULES AGAINST CHIKUNGUNYA VIRUS AND USES THEREOF
The invention relates to binding molecules against Chikungunya virus, which are able of neutralizing Chikungunya virus infectivity, and which can be used with...
METHOD FOR PURIFYING IMMUNOGLOBULIN
The present invention relates to a method for purifying an immunoglobulin, and more particularly, to a method for purifying an immunoglobulin, which comprises:...
COMPOSITIONS AND METHODS FOR PREPARING A SUBJECT FOR ORGAN OR NON-ORGAN
Embodiments of the present invention illustrate methods of preventing transplantation rejection. In certain embodiments, a subject in need of an organ or...
POLYPEPTIDE COMPOSITIONS WITH TYPE VII COLLAGEN FIBRONECTIN TYPE III-LIKE
REPEATS AND TREATMENT METHODS FOR...
Disclosed are compositions and methods for accelerating wound closure and preventing inhibiting or reducing scarring or fibrosis. The methods of the present...
Factor VIII Fusion Protein
The present invention relates to modified coagulation factors. In particular, the present invention relates to conjugated Factor VIII molecules fused to a...
Novel Substitution Mutant Receptors and Their Use in an Ecdysone
Receptor-Based Inducible Gene Expression System
This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More...
METHODS FOR ENGINEERING T-CELL RECEPTORS
The present invention provides a method for engineering a T-cell receptor domain polypeptide comprising at least one modification in a structural loop region...
The present invention relates to compositions, methods and kits for delivery of active agents (X) to cells or tissues that express proteoglycans. More...
PURIFYING INSULIN USING CATION EXCHANGE AND REVERSE PHASE CHROMATOGRAPHY
IN THE PRESENCE OF AN ORGANIC MODIFIER...
A process is described for purifying insulin and insulin analogs that comprises high-pressure liquid chromatography with an acidic cation exchange medium...
Growth Hormone Receptor Agonists
We disclose growth hormone fusion proteins that have increased in vivo stability and activity; nucleic acid molecules encoding said proteins and methods of...
RECOMBINANT HUMAN INTERFERON-LIKE PROTEINS
This application relates to recombinant human interferon-like proteins. In one embodiment a recombinant protein created by gene shuffling technology in...
SUPERAGONISTS AND ANTAGONISTS OF INTERLEUKIN-2
Novel human interleukin-2 (IL-2) muteins or variants thereof, and nucleic acid molecules and variants thereof are provided. Methods for producing these muteins...
CHEMOKINE-IMMUNOGLOBULIN FUSION POLYPEPTIDES, COMPOSITIONS, METHOD OF
MAKING AND USE THEREOF
This application is directed to chemokine-immunoglobulin fusion polypeptides and chemokine-polymer conjugates. The fusion polypeptides and conjugates can be...
CLAUDIN-6-SPECIFIC IMMUNORECEPTORS AND T CELL EPITOPES
The present invention provides Claudin-6-specific immunoreceptors (T cell receptors and artificial T cell receptors (chimeric antigen receptors; CARs)) and T...
CHIMERIC POLYPEPTIDE COMPRISING THE FRAGMENT B OF SHIGA TOXIN AND PEPTIDES
OF THERAPEUTIC INTEREST
The invention pertains to methods for using chimeric polypeptides of the formula: B-X wherein B represents the B fragment of Shiga toxin or a functional ...
PRO-APOPTOTIC RAS AND RAF PEPTIDES
The invention relates to pro-apoptotic peptides, useful in cancer treatment, and to chimeric peptides comprising a cell penetrating peptide linked to a...
METHODS AND COMPOSITIONS COMPRISING TAU OLIGOMERS
Tau protein has a causative role in Alzheimer's disease and multiple other neurodegenerative disorders exhibiting tau histopathology collectively termed...
STABILIZED ANTI-MICROBIAL PEPTIDES
The present invention provides methods of designing and making structurally stabilized anti-microbial peptides for the prophylaxis and treatment of infection....
COBALAMIN ACQUISITION PROTEIN AND USE THEREOF
The present invention relates to a cobalamin acquisition protein, compositions containing the cobalamin acquisition protein, and the use of such compositions.
Synthetic Polypeptide Having A Xylose Import Activity
This disclosure provides methods and compositions related to microbial gene expression. In one aspect, a synthetic polypeptide having a xylose import activity.