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Patent # Description
2017/0015713 Fusion Protein Comprising Diphtheria Toxin Non-Toxic Mutant CRM197 or Fragment Thereof
Provided in the present invention are a diphtheria toxin non-toxic mutant CRM197 or a fragment thereof as an adjuvant in a fusion protein and the use thereof...
2017/0015712 COMPOSITIONS AND METHODS FOR TREATING, INCLUDING PREVENTING, PARVOVIRUS INFECTIONS AND RELATED DISEASES
Some embodiments of the invention include inventive polypeptides (e.g., mutant VP2 proteins) and virus-like particles made from the inventive polypeptides....
2017/0015711 MATERIALS AND METHODS FOR PRODUCING CLEAVED, HIV-1 ENVELOP GLYCOPROTEIN TRIMERS
Expression vectors and mammalian cell lines containing them are described that enable the recombinant production of HIV-1 envelope proteins, including SOSIP...
2017/0015710 CYCLIC PEPTIDE ANALOGS AND CONJUGATES THEREOF
Provided are cyclic peptide analogs, conjugates comprising such compounds, and pharmaceutical compositions comprising such compounds and conjugates, and...
2017/0015709 GLYCOPEPTIDE DERIVATIVES FOR THE PRESERVATION AND PROTECTION OF BIOLOGICAL MATERIALS AND MICROORGANISMS
The present invention relates to a compound of the following formula (I): in which at least one and only one group chosen among R.sup.5, R.sup.6 and R.sup.7 is...
2017/0015708 CHEMOKINE BINDING POLYPEPTIDES FOR TREATING AUTOIMMUNITY, AND INFLAMMATION
Novel polypeptides comprising a chemokine-binding peptide and an Fc fragment are disclosed. The polypeptides are capable of binding to certain chemokines so as...
2017/0015707 COVALENT GRANZYME B INHIBITORS
Covalent Granzyme B inhibitors, compositions that include the compounds, and methods for using the compounds. A method for treating cutaneous scleroderma,...
2017/0015706 PROLINE COMPOUNDS AS GRANZYME B INHIBITORS
Proline compounds as Granzyme B inhibitors, compositions that include the compounds, and methods for using the compounds. Methods for treating cutaneous...
2017/0015705 PYRROLE COMPOUNDS AS GRANZYME B INHIBITORS
Pyrrole compounds as Granzyme B inhibitors, compositions that include the compounds, and methods for using the compounds. Method for treating cutaneous...
2017/0015704 AMINOTHIAZOLES AND THEIR USES
The present application describes organic compounds of Formula (I) ##STR00001## and pharmaceutical compositions thereof, and their use for the treatment, ...
2017/0015703 THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHODS OF USE
Provided are methods of treating a cancer characterized by the presence of a mutant allele of IDH1/2 comprising administering to a subject in need thereof a...
2017/0015702 OPTIMIZED METHOD FOR ANTIBODY CAPTURING BY MIXED MODE CHROMATOGRAPHY
Herein is reported a method for the purification of an antibody directly captured from clarified cell culture supernatants using Streamline CST and/or Capto...
2017/0015701 LONG ACTING PROTEINS AND PEPTIDES AND METHODS OF MAKING AND USING THE SAME
Disclosed is a method for refolding a protein or peptide that does not contain essential disulfides and that contains at least one free cysteine residue. Also...
2017/0015700 COMPOUNDS WITH A COMBINED ANTIOXIDANT ACTIVITY AGAINST FREE RADICALS TOGETHER WITH AN ANTI-INFLAMMATORY ACTION,...
The invention relates to 2,4,6-octatrienoic acid derivative compounds having general formula (I) (CH.sub.3--CH.dbd.CH--CH.dbd.CH--CH.dbd.CH--CO--O--).sub.n--R...
2017/0015699 Partially Neutral Single-Stranded Oligonucleotide
The present invention relates to a detection unit comprising a solid surface and a partially neutral single-stranded oligonucleotide comprising a first...
2017/0015698 NUCLEIC ACID POLYHEDRA FROM SELF-ASSEMBLED VERTEX-CONTAINING FIXED-ANGLE NUCLEIC ACID STRUCTURES
Provided herein are compositions comprising nucleic acid structures comprising three or more arms arranged at fixed angles from each other, composites thereof...
2017/0015697 SPLICE SWITCHING OLIGOMERS FOR TNF SUPERFAMILY RECEPTORS AND THEIR USE IN TREATMENT OF DISEASE
The present invention relates to compositions and methods for preparing splice variants of TNFalpha receptor (TNFR) in vivo or in vitro, and the resulting TNFR...
2017/0015696 SOLID STATE FORMS OF SOFOSBUVIR
The present disclosure encompasses solid state forms of Sofosbuvir and pharmaceutical compositions thereof.
2017/0015695 PREPARATION OF MONOSACCHARIDES, DISACCHARIDES, TRISACCHARIDES, AND PENTASACCHARIDES OF HEPARINOIDS
The present invention provides preparations of monosaccharides, disaccharides, trisaccharides, and pentasaccharides of heparinoids. The present invention also...
2017/0015694 CARBOHYDRATE BINDERS AND MATERIALS MADE THEREWITH
A binder comprising a polymeric binder comprising the products of a carbohydrate reactant and nucleophile is disclosed. The binder is useful for consolidating...
2017/0015693 ACRYLAMIDE-BASED CONDUCTIVE COMPOUNDS, AND METHODS OF PREPARATION AND USES THEREOF
Acrylamide-based conductive compounds, and methods of making and using the acrylamide-based conductive compounds are disclosed. The acrylamide-based conductive...
2017/0015692 PROCESS FOR TREATING BLACK LIQUOR
The present invention relates to a method of membrane-filtrating a lignin containing composition in order to obtain a lignin fraction more suitable for further...
2017/0015691 Novel Benzoxaphosphole Compounds and a Process for Preparation Thereof
The present inventors prepared novel benzoxaphosphole compounds and shown a process for the synthesizing these novel compounds. The process of preparing the...
2017/0015690 TC-PTP INHIBITORS AS APC ACTIVATORS FOR IMMUNOTHERAPY
The invention encompasses the novel class of compounds represented by the Formula (I) below, which are inhibitors of the TC-PTP enzyme. The invention also...
2017/0015689 PYRIMIDINE DERIVATIVES
The present invention relates to compounds of formula (I) ##STR00001## or pharmaceutically acceptable salts thereof, wherein X, Y, Z, R.sup.1-R.sup.11, m, n, and...
2017/0015688 SUBSTITUTED BISPHENYL BUTANOIC PHOSPHONIC ACID DERIVATIVES AS NEP INHIBITORS
The present invention provides a compound of formula I; ##STR00001## or a pharmaceutically acceptable salt thereof, wherein R.sup.1, R.sup.2 and R.sup.3 are...
2017/0015687 ORGANIC TITANIUM DERIVATIVE AND PROCESS FOR THE PREPARATION THEREOF, INK CONTAINING THE DERIVATIVE AND CERAMIC...
Described is a production process for the preparation of an organic titanium derivative useful for the preparation of yellow inks for digital printing on...
2017/0015686 Substituted Bis Indenyl Metallocene Catalyst Compounds Comprising -Si-Si- Bridge
This invention relates to novel bridged bis indenyl metallocene catalyst compounds where the bridge is --((R.sup.15*).sub.2Si--Si(R.sup.15).sub.2)-- wherein,...
2017/0015685 ZIRCONIUM-89 OXINE COMPLEX AS A CELL LABELING AGENT FOR POSITRON EMISSION TOMOGRAPHY
The invention provides a method of preparing a .sup.89Zr-oxine complex of the formula. The invention also provides a method of labeling a cell with the...
2017/0015684 METHOD FOR PRODUCING 4-BORONO-L-PHENYLALANINE HAVING 18F ATOM INTRODUCED THEREINTO, AND PRECURSOR OF...
.sup.18F-labeled 4-boronophenylalanine (BPA) can be produced by preparing and further processing a precursor of .sup.18F-labeled BPA represented by the...
2017/0015683 PYRAZOLOPYRIMIDINE MACROCYCLES AS INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION
The disclosure generally relates to compounds of formula I, including compositions and methods for treating human immunodeficiency virus (HIV) infection. The...
2017/0015682 POLYMORPHIC MIXTURE OF RIFAXIMIN AND ITS USE FOR THE PREPARATION OF SOLID FORMULATIONS
A Rifaximin polymorphic mixture of .alpha./.beta. form in a relative ratio of 85/15.+-.3 and a process for its preparation. The polymorphic mixture of...
2017/0015681 IMIDAZOPYRIMIDINE MACROCYCLES AS INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION
The disclosure generally relates to compounds of formula I, including compositions and methods for treating human immunodeficiency virus (HIV) infection. The...
2017/0015680 N-AZASPIROCYCLOALKANE SUBSTITUTED N-HETEROARYL COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF SHP2
The present invention relates to compounds of formula I: ##STR00001## in which p, q, Y.sub.1, Y.sub.2, R.sub.1, R.sub.2a, R.sub.2b, R.sub.3a, R.sub.3b, R.sub.4a,...
2017/0015679 Novel Heterocyclic Derivatives as Modulators of Kinase Activity
The invention provides novel imidazol-piperidinyl derivatives of the formula (I) ##STR00001## in which R.sup.1, R.sup.2, W, X.sup.1, X.sup.2, X.sup.3, X.sup.4...
2017/0015678 BENZOXAZEPIN OXAZOLIDINONE COMPOUNDS AND METHODS OF USE
Described herein are benzoxazepin oxazolidinone compounds with phosphoinositide-3 kinase (PI3K) modulation activity or function having the Formula I...
2017/0015677 NEW TRICYCLIC QUINONE DERIVATIVE
This invention provides a compound represented by formula (1) or a pharmaceutically acceptable salt thereof. Specifically, the present invention provides a...
2017/0015676 PHOSPHONIC ACID CATALYST IN DEHYDRATIVE CYCLIZATION OF 5 AND 6 CARBON POLYOLS WITH IMPROVED COLOR AND PRODUCT...
A process for preparing materials derived from sugar alcohols such that the dehydration products exhibit better accountability and improved color to...
2017/0015675 SUBSTITUTED TRICYCLICS AND METHOD OF USE
The present invention provides for compounds of formula (I) ##STR00001## wherein X, Y, and R.sup.1 have any of the values defined in the specification, and...
2017/0015674 PROCESSES AND INTERMEDIATES FOR MAKING A JAK INHIBITOR
This invention relates to processes and intermediates for making {1-{1-[3-fluoro-2-(trifluoromethyl)isonicotinoyl]piperidin-4-yl}-3-[4-(7H- ...
2017/0015673 BROMODOMAIN INHIBITORS
The present invention provides for compounds of formula (I) wherein R.sup.x, X, Y, Y.sup.1, L.sup.1, A.sup.1, A.sup.2, A.sup.3, A.sup.4, A.sup.5, A.sup.6,...
2017/0015672 SUBSTITUTED PYRROLO[2,3-D]PYRIMIDINES FOR SELECTIVELY TARGETING TUMOR CELLS WITH FR-ALPHA AND FR-BETA TYPE...
Pyrrolo[2,3-d]pyrimidine derivatives, and pharmaceutical acceptable salts thereof, useful in therapeutically treating patients with cancer are disclosed. These...
2017/0015671 INHIBITORS OF BRUTON'S TYROSINE KINASE
Disclosed herein are amido compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. Also...
2017/0015670 DEUTERATED IBRUTINIB
The present invention in one embodiment provides a compound of Formula I: ##STR00001## or a pharmaceutically acceptable salt thereof, wherein the variables shown...
2017/0015669 HETEROARYLAMIDE INHIBITORS OF TBK1
The present invention provides compounds of formula 1: ##STR00001## which are useful as inhibitors of TBK-1, pharmaceutical compositions thereof, methods for...
2017/0015668 COMPOUNDS
The present invention relates to novel compounds that inhibit LRRK2 kinase activity, processes for their preparation, to compositions containing them and to...
2017/0015667 THIOL-X CLICK FOLDAMERS FOR POLYMER AFFINITY AND CATALYSIS LIBRARIES
Click thiol-X monomers and polymers containing such monomers are disclosed. The clickable sequence controllable monomers include an optionally protected thiol...
2017/0015666 ENHANCER OF ZESTE HOMOLOG 2 INHIBITORS
This invention relates to novel compounds according to Formula (I) which are inhibitors of Enhancer of Zeste Homolog 2 (EZH2), to pharmaceutical compositions...
2017/0015665 2,7-DIAZASPIRO[3.5]NONANE COMPOUNDS
The present invention relates to a compound of formula (I) or a stereoisomer, enantiomer, racemic, or tautomer thereof, Formula (I), wherein R.sup.1, R.sup.3,...
2017/0015663 PROCESS FOR THE PREPARATION OF APIXABAN AND INTERMEDIATES THEREOF
The present invention refers to novel process for the preparation of Apixaban. Further, the invention also related to a process for the preparation of...
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