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Patent # Description
2017/0015662 6-ARYL-4-PHENYLAMINO-QUINAZOLINE ANALOGS AS PHOSPHOINOSITIDE-3-KINASE INHIBITORS
The present invention relates to 6-aryl-4-phenylamino quinazolines of formula I wherein, R and R'' are as herein described. The present invention particularly...
2017/0015661 HETEROAROMATIC DERIVATIVES AND THEIR USE AS PHARMACEUTICALS
The invention relates to the compounds (I) and their acids and bases salts: wherein: Formula (I) the dotted line indicates a double bond; X is N or C--R.sub.1...
2017/0015660 SIGMA-2 RECEPTOR LIGAND DRUG CONJUGATES AS ANTITUMOR COMPOUNDS, METHODS OF SYNTHESIS AND USES THEREOF
Methods and compositions for treating cancers such as pancreatic cancer and synovial sarcoma are disclosed. Compounds comprising a sigma-2 receptor-binding...
2017/0015659 Prodrugs of NH-Acidic Compounds
The invention provides a method of sustained delivery of a lactam, imide, amide, sulfonamide, carbamate or urea containing parent drug by administering to a...
2017/0015658 HEPATITIS B CORE PROTEIN ALLOSTERIC MODULATORS
The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of...
2017/0015657 COMPOUND HAVING SELECTIVE EP2 AGONIST ACTIVITY
A compound represented by general formula (I) wherein all symbols are as defined in the specification, a salt or N-oxide of the compound, or a solvate or...
2017/0015656 NOVEL COMPOUNDS
The invention is directed to certain novel compounds. Specifically, crystalline forms of ...
2017/0015655 HETEROCYCLIC COMPOUND
The present invention provide a heterocyclic compound having a HDAC inhibitory action, and useful for the treatment of autoimmune diseases and/or inflammatory...
2017/0015654 PYRIDAZINE COMPOUND
The present provides a pyridazine compound having an inhibiting effect on Stearoyl-CoA desaturase (SCD) (in particular, SCD1). The present provides a compound...
2017/0015653 DIHYDROPYRIDINONE MGAT2 INHIBITORS FOR USE IN THE TREATMENT OF METABOLIC DISORDERS
The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as...
2017/0015652 Coumarin-based compounds and related methods
The present invention generally relates to coumarin-based compounds that can be used for the labeling of biological molecules, as well as related synthetic and...
2017/0015651 SUBSTITUTED 2-AZABICYCLES AND THEIR USE AS OREXIN RECEPTOR MODULATORS
The present invention is directed to compounds of Formula I: ##STR00001## wherein X is N or CR.sub.1; Y is N or CR.sub.2; R.sub.1 is H, alkoxy, halo, triazolyl,...
2017/0015650 BICYCLIC AZA COMPOUNDS AS MUSCARINIC M1 RECEPTOR AND/OR M4 RECEPTOR AGONISTS
This invention relates to compounds that are agonists of the muscarinic M1 receptor and/or M4 receptor and which are useful in the treatment of muscarinic...
2017/0015649 N-Thio-anthranilamid compounds and their use as pesticides
N-Thio-anthranilamid compounds of formula (I) ##STR00001## wherein A is A.sup.1 ##STR00002## wherein the variables and the indices are as defined per the...
2017/0015648 TETRAZOLONE-SUBSTITUTED DIHYDROPYRIDINONE MGAT2 INHIBITORS
The present invention provides compounds of Formula (I): a stereoisomer, a tautomer, a pharmaceutically acceptable salt, a polymorph, a solvate thereof,...
2017/0015647 SELECTIVE MATRIX METALLOPROTEINASE INHIBITORS
The invention provides compounds, compositions, and methods for the treatment of diseases, disorders, or conditions that are modulated by matrix...
2017/0015646 PROCESSES AND INTERMEDIATES FOR THE PREPARATIONS OF ISOMER FREE PROSTAGLANDINS
Novel processes for the preparation of a compound of Formula I-2 substantially free of the 5,6-trans isomer: ##STR00001## wherein ##STR00002## R.sub.2,...
2017/0015645 SUBSTITUTED PYRAN DERIVATIVES
Certain 3,6-disubstituted and 2, 4, 5-trisubstituted pyran derivatives that exhibit potent activity on monoamine transport systems are provided. The 3, 6 and...
2017/0015644 TRICYCLIC PRODRUGS
Prodrugs (I) and (Ia) of galiellactone, and derivatives thereof, are provided by reacting the parent compound, e.g. galiellactone, with a thiol. Such drugs may...
2017/0015643 USE OF CARBOXYLIC ACIDS AND FURANIC MOLECULES FOR ESTERIFICATION
A process for recovering and using an organic/carboxylic acid or furanic molecule by means of making an ester of a free carboxylic acid or furanic molecule...
2017/0015642 CONVERSION OF FRUCTOSE-CONTAINING FEEDSTOCKS TO HMF-CONTAINING PRODUCT
The present invention relates generally to processes for converting fructose-containing feedstocks to a product comprising 5-(hydroxymethyl)furfural (HMF) and...
2017/0015641 DICARBOXYLIC ACID COMPOUND
It is an object of the present invention to provide a medicament for preventing or treating hyperphosphatemia. Solution: A compound represented by a general...
2017/0015640 USE OF ARYLALKANOLAMINES AS SIGMA-1 RECEPTOR ANTAGONISTS
The present invention relates to the use of arylalkanolamine compounds with sigma-1 receptor antagonist activity. In particular, the said arylalkanolamine...
2017/0015639 METHOD FOR PRODUCING POLYMERIZABLE COMPOUND
Provided is a method for producing a polymerizable compound represented by a formula (I) comprising: a step (1) that reacts a compound represented by a formula...
2017/0015638 Use of N-(1,3,4-Oxadiazol-2-yl)arylcarboxamides or their salts for controlling unwanted plants in areas of...
Use of N-(1,3,4-Oxadiazol-2-yl)arylcarboxamides of formula (I) or salts thereof ##STR00001## with R, X, A, and Z having the meaning as defined in the...
2017/0015637 NOVEL HETEROARYL BUTANOIC ACID DERIVATIVES
The present invention describes novel heteroaryl butanoic acid derivatives that are good drug candidates especially with regard to leukotriene A4 hydrolase...
2017/0015636 HIGH-PRESSURE REACTOR FOR THE SYNTHESIS OF MELAMINE
Reactor for the synthesis of melamine from urea, in accordance with the high-pressure non-catalytic process, comprising: a vertical reactor body (1), at least...
2017/0015635 DISUBSTITUTED TRIAZOLE ANALOGS
The present invention relates to disubstituted triazoles, their synthesis, and their use as anti-cancer compounds. In particular, compounds of Formula (I) are...
2017/0015634 DISUBSTITUTED 5-FLUORO PYRIMIDINE DERIVATIVES CONTAINING A SULFONDIIMINE GROUP
The present invention relates to 5-fluoro pyrimidine derivatives containing a sulfondiimine group of general formula (I) as described and defined herein, and...
2017/0015633 PYRIMIDONE CARBOXAMIDE COMPOUNDS AS PDE2 INHIBITORS
Disclosed are pyrimidine carboxamide compounds of formula (I) which are useful as therapeutic agents for the treatment of central nervous system disorders...
2017/0015632 METHOD FOR PRODUCING CARBOXAMIDES
The present invention relates to a process for the preparation of carboxamide derivatives of formula (I) as described herein starting from a pyrazole carbonyl...
2017/0015631 PKM2 MODULATORS AND METHODS FOR THEIR USE
Compounds having activity as PKM2 activators are disclosed. The compounds have the following structure (I): ##STR00001## including stereoisomers, tautomers,...
2017/0015630 CONSTRAINED TRICYCLIC SULFONAMIDES
Tricyclic chemical modulators of protein phosphatase 2A are disclosed. The compounds are useful to treat cancer, age-onset proteotoxicity, stress-induced...
2017/0015629 AZEPANE DERIVATIVES AND METHODS OF TREATING HEPATITIS B INFECTIONS
Provided herein are compounds useful for the treatment of HBV infection in a subject in need thereof, pharmaceutical compositions thereof, and methods of...
2017/0015628 METHODS FOR THE PREPARATION OF INDACATEROL AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF
The invention relates to new and improved processes for the preparation of Indacaterol and pharmaceutically acceptable salts thereof as well as intermediates...
2017/0015627 PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING
The invention provides novel inhibitors of hedgehog signaling that are useful as a therapeutic agents for treating malignancies where the compounds have the...
2017/0015626 TWO-PHOTON-ABSORBING COMPOUND
A two-photon-absorbing compound which is excellent in water-solubility, is excited by two-photon absorption in a near-infrared wavelength region, and emits a...
2017/0015625 SULFONAMIDES DERIVED FROM TRICYCLYL-2-AMINOCYCLOALKANOLS AS ANTICANCER AGENTS
A genus of arylsulfonamide derivatives of aminocycloalkanols is disclosed. The compounds are of the following genus: ##STR00001## The compounds induce FOXO1...
2017/0015624 METHOD FOR CRYSTALLIZATION OF 2-AMINO-2-[2-[4-(3-BENZYLOXYPHENYLTHIO)-2-CHLOROPHENYL]-ETHYL]-1,3-PROPAN- ...
A method for highly efficiently preparing high purity crystals of 2-amino-2-[2-[4-(3-benzyloxyphenylthio)-2-chloro-phenyl]-ethyl]-1,3-propa- nediol...
2017/0015623 CYCLOPROPENE AMINO ACIDS AND METHODS
The invention relates to a polypeptide comprising an amino acid having a cyclopropene group wherein said cyclopropene group is joined to the amino acid via a...
2017/0015622 CATALYSTS, METHODS, AND SYSTEMS FOR PREPARING CARBAMATES
Methods, systems and kits for preparing carbamates as well as catalysts for preparing the carbamates, are disclosed. The methods for preparing carbamate can...
2017/0015621 TWO-STEP AND ONE-POT PROCESSES FOR PREPARATION OF ALIPHATIC DIISOCYANATES
The present invention relates to using a two-step (thermolysis) or one-pot process to prepare aliphatic diisocyanates from aliphatic diamines and diaryl...
2017/0015620 PROCESS FOR THE PREPARATION OF EXAMETAZIME
The present invention provides an improved process for the preparation of exametazime, which is used as ligand in preparation of technetium-99m complex. ...
2017/0015619 NEPRILYSIN INHIBITORS
In one aspect, the invention relates to compounds having the formula: ##STR00001## where R.sup.1-R.sup.5 and X are as defined in the specification, or a ...
2017/0015618 DIARYL AMINE ANTIOXIDANTS PREPARED FROM BRANCHED OLEFINS
Diaryl amines are selectively alkylated by reaction with branched olefins, which olefins are capable of forming tertiary carbonium ions and can be conveniently...
2017/0015617 USE OF POLYAMINOISOPRENYL DERIVATIVES IN ANTIBIOTIC OR ANTISEPTIC TREATMENT
The present invention relates to the use of polyaminoisoprenyl derivatives in antibiotic or antiseptic treatment of bacteria including those presenting...
2017/0015616 REFINING METHOD OF ORGANIC AMINE
Provided are a method of refining a reaction solution including a carbonate of 1,5-diaminopentane, which is produced by fermentation, through a decarbonation...
2017/0015615 MOLDED CATALYST FOR USE IN MANUFACTURE OF METHYL METHACRYLATE, AND METHOD FOR MANUFACTURE OF METHYL...
The present invention provides a molded catalyst for use in the manufacture of methyl methacrylate, for manufacturing methyl methacrylate from a starting...
2017/0015614 PRODUCTION OF ALPHA-HYDROXY CARBOXYLIC AIDS AND ESTERS FROM HIGHER SUGARS USING TANDEM CATALYST SYSTEMS
The present disclosure is directed to methods and composition used in the preparation of alpha-hydroxy carboxylic acids and esters from higher sugars using a...
2017/0015613 SHORT CONTACT, ELEVATED TEMPERATURE MEG RECLAMATION
Monoethylene glycol (MEG) may be reclaimed by a process that includes contacting a MEG-water-salt stream with a heat transfer fluid and then flash separating...
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