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Patent # Description
2017/0029524 HUMANIZED AND CHIMERIC MONOCLONAL ANTIBODIES TO CD99
Humanized or chimeric anti-CD99 monoclonal antibodies are provided. The antibodies bind to and neutralize human CD99, and find use in various therapeutic...
2017/0029523 STIMULATION VIA TLR4/MD-2 TO REVERSE TYPE 1 DIABETES
Disclosed are methods and compositions for treating Type I diabetes in a subject. Agents selected from a TLR4 agonist, a TLR4/MD-2 agonist, or a combination...
2017/0029522 METHODS FOR TREATING PROGRESSIVE MULTIPLE SCLEROSIS
The present invention concerns methods for treating progressive multiple sclerosis (MS) in a patient, and an article of manufacture with instructions for such...
2017/0029521 STABLE IgG4 ANTIBODIES
The present invention relates to stabilized IgG4 antibodies, to methods of producing such antibodies and to uses of such antibodies as a medicament. In a main...
2017/0029520 COMPOSITIONS AND METHODS FOR USE IN ORGAN TRANSPLANTATION
The present disclosure provides, inter alia, methods for treating an individual in need of an organ transplantation, such as a renal transplantation, by...
2017/0029519 Fn14 Binding Proteins and Uses Thereof
The present disclosure provides proteins comprising antibody antigen binding domains that bind to Fn14 and uses thereof. The present disclosure also provides...
2017/0029518 ANTI-BCMA ANTIBODIES
This invention provides antibodies that recognize the B Cell Maturation Antigen (BCMA) and that bind naive B cells, plasma cells, and/or memory B cells. The...
2017/0029517 ANTIBODIES AGAINST HUMAN CSF-1R AND USES THEREOF
The present invention relates to antibodies against human CSF-1R (anti-CSF-1R antibody), methods for their production, pharmaceutical compositions containing...
2017/0029516 ANTI HUMAN INTERLEUKIN-1 RECEPTOR ACCESSORY PROTEIN (IL1 RAP) ANTIBODIES AND USES THEREOF
The present disclosure provides an antibody or an antigen-binding fragment thereof with binding specificity for human interleukin-1 receptor accessory protein...
2017/0029515 METHOD OF INHIBITION OF LEUKEMIC STEM CELLS
A method for inhibition of leukemic stem cells expressing IL-3R.alpha. (CD123), comprises contacting the cells with an antigen binding molecule comprising a Fc...
2017/0029514 ANTI-CD123 ANTIBODIES AND CONJUGATES AND DERIVATIVES THEREOF
The present invention generally relates to antibodies, antigen-binding fragments thereof, polypeptides, and immunoconjugates that bind to CD123 antigen (the...
2017/0029513 Methods of Improving or Accelerating Physical Recovery After Surgery for Hip Fracture
The disclosure relates to uses and regimens for accelerating/improving physical recovery in a patient with disuse atrophy triggered by reduced mobility due to...
2017/0029512 ANTIBODY CONSTRUCTS FOR EGFRVIII AND CD3
The present invention relates to a bispecific antibody construct comprising a first binding domain which binds to human EGFRVIII on the surface of a target...
2017/0029511 TRKB OR TRKC AGONIST COMPOSITIONS AND METHODS FOR THE TREATMENT OF OTIC CONDITIONS
Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with TrkB or TrkC agonist compositions and formulations...
2017/0029510 PDGF RECEPTOR BETA BINDING POLYPEPTIDES
The present invention provides binding polypeptides (e.g., antibodies or fragments thereof) that specifically bind to a target antigen (e.g., a human antigen,...
2017/0029509 Methods For Inhibiting The Binding Of Endosialin To Ligands
The invention provides methods for inhibiting the interaction of endosialin with endosialin ligands. The inhibition is effectuated on the genetic level, by...
2017/0029508 Reducing Systemic Regulatory T Cell Levels or Activity for Treatment of Disease and Injury of the CNS
The present specification discloses a pharmaceutical composition comprising an active agent that causes reduction of the level of systemic immunosuppression in...
2017/0029507 ANTIGEN BINDING CONSTRUCTS TO CD8
Antigen binding constructs that bind to CD8, for example antibodies, including antibody fragments (such as scFv, minibodies, and cys-diabodies) that bind to...
2017/0029506 Immunoglobulins Binding Human Vgamma9 Vdelta2 T Cell Receptors
The invention is in the field of medicine and relates to immunology, and relates in particular to human V.gamma.9V.delta.2 T cell receptor binding ...
2017/0029505 MULTIMERIC FC PROTEINS
The invention relates to multimeric proteins which bind to human Fc receptors. The invention also relates to therapeutic compositions comprising the proteins,...
2017/0029504 ANTI-PVRIG ANTIBODIES AND METHODS OF USE
The present invention is directed to anti-PVRIG antibodies and methods of using same.
2017/0029503 ANTI-SIGLEC-15 ANTIBODIES AND USES THEREOF
This disclosure relates to anti-Siglec-15 antibodies and uses thereof, in particular in the treatment of leukaemia, such as acute myeloid leukaemia.
2017/0029502 ANTIBODY CONSTRUCTS FOR MSLN AND CD3
The present invention relates to a bispecific antibody construct comprising a first binding domain which binds to human MSLN on the surface of a target cell...
2017/0029501 ANTI-EPHRINB2 ANTIBODIES AND METHODS USING SAME
The invention provides anti-EphrinB2 antibodies, and compositions comprising and methods of using these antibodies.
2017/0029500 USE OF INHIBITORS OF LEUKOTRIENE B4 RECEPTOR BLT2 FOR TREATING ASTHMA
The present invention relates to the use of inhibitors of leukotriene B4 receptor BLT2 for treating asthma. More particularly, the present invention relates to...
2017/0029499 METHODS FOR TREATING HEPCIDIN-MEDIATED DISORDERS
Methods for treating hepcidin-mediated disorders are provided.
2017/0029498 USES OF A DUAL V REGION ANTIBODY-LIKE PROTEIN
Uses of a dual V region antibody-like protein or a fragment of a dual V region antibody-like region.
2017/0029497 IMMUNOGLOBULINS
The present invention discloses humanised anti-IL-18 antibodies, methods of manufacture, and methods of treatment with said antibodies. Further disclosed are...
2017/0029496 Anti-IL-12 Antibodies and Compositions
Isolated anti-IL-12 antibodies, nucleic acids encoding antibodies or antibody portions, vectors, host cells, and methods of making are useful for production of...
2017/0029495 Human Antibodies that Bind Human TNF-Alpha and Methods of Preparing the Same
Methylglyoxal (MGO)-modified recombinant TNF-alpha antibodies (e.g., Adalimumab) are identified. MGO modification decreases binding between Adalimumab and...
2017/0029494 Antigen Binding Constructs
The present invention is directed to antigen binding constructs comprising one or two epitope binding domains separated by a single chain Fc region of an...
2017/0029493 ANTIBODIES AGAINST HUMAN ANGIOPOIETIN 2
The present invention relates to antibodies against human Angiopoietin 2 (anti-ANG-2 antibodies), methods for their production, pharmaceutical compositions...
2017/0029492 HUMAN ANTIBODIES TO HUMAN DELTA LIKE LIGAND 4
The present invention provides methods of treating, ameliorating, or inhibiting tumor growth, cancer, or pathological angiogenesis by administering to a...
2017/0029491 ABSCOPAL EFFECT OF USPIO THERANOSIS AND IMMUNOTHERAPY FOR CANCER TREATMENT
The invention disclosed herein concerns abscopal effect of USPIO theranosis and immunotherapy using the same for cancer treatment.
2017/0029490 SULFONAMIDE-CONTAINING LINKAGE SYSTEMS FOR DRUG CONJUGATES
Sulfonamide-containing linkage systems for release of payload compounds from an attached targeting moiety in drug conjugates. The conjugates have the formula...
2017/0029489 HUMAN MONOCLONAL ANTIBODY WITH SPECIFICITY FOR DENGUE VIRUS SEROTYPE 1 E PROTEIN AND USES THEREOF
Compositions and methods for the treatment or prevention of Dengue virus infection in a vertebrate subject are provided. In particular, human neutralizing...
2017/0029488 Human Antibodies to Respiratory Syncytial Virus F Protein and Methods of Use Thereof
The present invention provides fully human antibodies that bind to respiratory syncytial virus F protein, compositions comprising the antibodies and methods of...
2017/0029487 SELECTIVE INHIBITORS OF C-FOS AND THEIR ANTIPROLIFERATIVE PROPERTIES
Selective inhibitor of c-Fos and their antiproliferative properties The invention relates to selective inhibitor of c-Fos for use in the prevention and/or...
2017/0029486 NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST ESOPHAGEAL CANCER AND OTHER CANCERS
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2017/0029485 HUMAN TIM-3 FUSION PROTEIN CAPABLE OF BLOCKING TIM-3 SIGNALING PATHWAY
The present invention provides a human Tim-3-Ig fusion protein which can block Tim-3 signal pathway, and said Ig fusion protein comprises Tim-3 protein, human...
2017/0029484 ISOLATED T CELL RECEPTORS AND METHODS OF USE THEREFOR
Provided are isolated TCRs, TCR-like molecules, and portions thereof that bind to phosphopeptide-HLA-A2 complexes. The isolated TCRs, TCR-like molecules, or...
2017/0029483 MURINE ANTI-NY-ESO-1 T CELL RECEPTORS
The invention provides an isolated or purified T cell receptor (TCR) having antigenic specificity for NY-ESO-1. Also provided are related polypeptides,...
2017/0029482 NOVEL PURIFICATION PROCESS OF GONADOTROPIN
The present invention provides an improved method for the purification of desired gonadotropin from a crude mixture containing at least one contaminating...
2017/0029481 Compounds That Bind to the Erythropoietin Receptor
The present invention provides mimetics of erythropoietin that bind to the erythropoietin receptor and that are suitable for use in pharmaceutical...
2017/0029480 CHIMERIC FIBROBLAST GROWTH FACTOR 21 PROTEINS AND METHODS OF USE
The present invention relates to a chimeric protein that includes an N-terminus coupled to a C-terminus, where the N-terminus includes a portion of a paracrine...
2017/0029479 Modified FGF-21 Polypeptides Comprising an Internal Deletion and Uses Thereof
Modified FGF-21 polypeptides and uses thereof are provided, for example, for the treatment of diseases associated with fibrosis. Modified FGF-21 polypeptides...
2017/0029478 High Molecular Weight, Post-Translationally Modified Protein Brushes
Disclosed are protein brushes that mimic mucin in physical and functional characteristics. The protein brushes have a variable number of tandem repeats similar...
2017/0029477 Fusion Molecules
The present invention relates to fusion molecules that have binding specificity for pyoverdine type I, II and III and pyochelin and can be used in various...
2017/0029475 MSP NANOPORES AND USES THEREOF
Provided herein are mutant single-chain Mycobacterium smegmatis porin (Msp) and uses thereof.
2017/0029474 POLYPEPTIDE AND ANTI-TUMOR AGENT
Provided is a polypeptide comprising an R domain of CRM197 and comprising one or more amino acid substitutions or deletions at positions selected from the...
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