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Patent # Description
2017/0029473 EVOLUTION OF BT TOXINS
The disclosure provides amino acid sequence variants of Bacillus thuringiensis (Bt) toxins and methods of producing the same. Some aspects of this disclosure...
2017/0029472 FUSION PROTEINS AND COMBINATION VACCINES COMPRISING HAEMOPHILUS INFLUENZAE PROTEIN E AND PILIN A
The present invention relates to compositions comprising Haemophilus influenzae Protein E and Pilin A. More particularly, the present application relates to...
2017/0029471 PCV2 ORF2 PROTEIN VARIANT AND VIRUS LIKE PARTICLES COMPOSED THEREOF
Vaccination methods to control PCV2 infection with different PCV2 subtypes are disclosed. Specifically, a PCV2 subtype b (PCV2b) ORF2 proteins or immunogenic...
2017/0029470 FUSION PROTEINS FOR USE AS IMMUNOGENIC ENHANCERS FOR INDUCING ANTIGEN-SPECIFIC T CELL RESPONSES
A fusion protein for use as an immunogen enhancer for enhancing antigen-specific T cell responses is disclosed. The fusion protein comprises: (a) an...
2017/0029469 CYCLOSPORIN ANALOGS
Disclosed herein are novel analogs of cyclosporin, pharmaceutical compositions containing them, and methods for their use in the treatment of dry eye and other...
2017/0029468 AGONISTS OF GUANYLATE CYCLASE USEFUL FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS, INFLAMMATION, CANCER AND...
The invention provides novel guanylate cyclase-C agonist peptides and their use in the treatment of human diseases including gastrointestinal disorders,...
2017/0029467 METHOD OF PRODUCING BIVALIRUDIN
The present disclosure provides a method of producing bivalirudin using a peptide fragment or peptide fragments on solid phase peptide synthesis that...
2017/0029466 PEPTIDES WHOSE UPTAKE BY CELLS IS CONTROLLABLE
A generic structure for the peptides of the present invention includes A-X-B-C, where C is a cargo moiety, the B portion includes basic amino acids, X is a...
2017/0029465 PEPTIDES AND METHODS OF USING SAME
We describe peptides and their uses for the treatment of autoimmune, inflammatory and metabolic diseases.
2017/0029464 VIRAL VECTOR FOR THE TARGETED TRANSFER OF GENES IN THE BRAIN AND SPINAL CORD
The invention relates to novel peptides, polypeptides or proteins which bind specifically to brain cells and/or to the spinal cord. The peptides, polypeptides,...
2017/0029463 SAA-DOMAIN-SPECIFIC ANTIBODIES AND PEPTIDE ANTAGONISTS AND USE THEREOF TO TREAT INFLAMMATORY DISEASES
Isolated SAA peptides, fusion proteins and compositions comprising such are provided as are domain-specific SAA antibodies. Methods of treating sepsis and...
2017/0029462 VIRUS REMOVAL MEMBRANE
A virus removal membrane is formed from a hydrophilized synthetic polymer, in which, when a solution containing gold colloids having a diameter of 20 nm is...
2017/0029461 HEPARIN AFFINITY TAG AND APPLICATIONS THEREOF
In one aspect, affinity tags for recombinant protein purification are described herein which, in some embodiments, can mitigate or overcome disadvantages of...
2017/0029460 LIMONIN EXTRACTION METHOD
A limonin extraction method, comprising the following steps: step one, raw material extracting or juicing: directly soaking raw material in water or using a...
2017/0029459 Novel 7-Dehydrocholesterol Derivatives and Methods Using Same
The present invention provides, in certain aspects, novel 7-dehydrocholesterol (7DHC) derivatives that are useful in treating or preventing cancer, as well as...
2017/0029458 NOVEL TRITERPENE-GLYCOSIDES AS SWEETENERS OR SWEETENER ENHANCERS
Suggested are triterpene-glycoside compounds, which are obtainable by the extraction of Momordica grosvenorii (Siraitia grosvenori) which are useful as a...
2017/0029457 METHODS FOR THE SYNTHESIS OF FUNCTIONALIZED NUCLEIC ACIDS
Described herein are methods for the synthesis of derivatives of thiosulfonate reagents. Said reagents have utility for the synthesis of phosphorothiotriesters...
2017/0029456 NUCLEOTIDES FOR THE TREATMENT OF LIVER CANCER
Provided herein are compounds, compositions and methods for the treatment of liver cancer such as hepatocellular carcinoma, cholangiocarcinoma, or biliary...
2017/0029455 URACYL SPIROOXETANE NUCLEOSIDES
The present invention relates to compounds of the formula I: ##STR00001## including any possible stereoisomers thereof, wherein R.sup.9 has the meaning as...
2017/0029454 NKT CELL LIGANDS AND METHODS OF USE
Alpha-glycosylceramide compounds capable of activating NKT cells and compositions thereof are disclosed. Methods for activating NKT cells, methods of...
2017/0029453 BIS(PHOSPHINE)-CARBODICARBENE CATALYST COMPLEXES AND METHODS OF USING THE SAME
An organometallic complex of a tridentate bis(phosphine)-carbodicarbene ligand and a transition metal, is described. In some embodiments the ligand has the...
2017/0029452 PHENANTHROLINE PHOSPHONIC ACID DERIVATIVE AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
The present invention relates to a novel phenanthroline phosphonic acid compound and a pharmaceutical salt thereof, as well as an application of the compound...
2017/0029451 BRANCHED CHAIN ACYCLIC NUCLEOSIDE PHOSPHONATE ESTERS AND METHODS OF SYNTHESIS AND USES THEREOF
The present invention is directed to branched chain nucleoside phosphonate ester compounds and methods of synthesis thereof. The present invention is also...
2017/0029450 ANTHRACENE-9, 10-DIONE DIOXIME COMPOUND PRODRUGS AND THEIR USES
Chemical agents, such as disulfonamide derivatives of fluorene, anthracene, xanthene, dibenzosuberone and acridine, and similar heterocyclic ring structures;...
2017/0029449 METHOD FOR ACQUIRING ONE OR A PLURALITY OF RECYCLABLE MATERIALS FROM SEEDS
A method for acquiring at least one or a plurality of recyclable materials, in particular phytic acid, from a native material quantity containing phytic acid...
2017/0029448 POLYCATIONIC METHYL PHOSPHOLIPIDS FOR IMPROVEDDELIVERY OF NUCLEIC ACIDS TO EUKARYOTIC CELLS
New cationic lipids are provided that are useful for delivering macromolecules, such as nucleic acids, into eukaryotic cells. The lipids can be used alone, in...
2017/0029447 HYDROXIDE-CATALYZED FORMATION OF SILICON-OXYGEN BONDS BY DEHYDROGENATIVE COUPLING OF HYDROSILANES AND ALCOHOLS
The present disclosure is directed to methods for dehydrogenatively coupled hydrosilanes and alcohols, the methods comprising contacting an organic substrate...
2017/0029446 Process Of Synthesizing Diisopropylamino-Disilanes
Chemical processes comprise selectively synthesizing diisopropylamino-disilanes and reduction of chloride in amin-osilanes, and the compositions comprise the...
2017/0029445 ASYMMETRIC AUXILIARY GROUP
To provide a chiral reagent or a salt thereof. The chiral reagent has following chemical formula (I). In the formula (I), G.sup.1 and G.sup.2 are independently a...
2017/0029444 BORON-DIPYRROMETHENE FLUORESCENCE PROBES AND MANUFACTURING METHOD AND USE THEREOF
The present invention provides a difluoroboron dipyrromethene fluorescent probe having a structure represented by the following general formula I, and a...
2017/0029443 POLYMORPHIC FORMS AND CO-CRYSTALS OF A C-MET INHIBITOR
Provided herein are novel polymorphic forms and co-crystals of a compound useful in the treatment, prevention, or amelioration of cancer. In particular, the...
2017/0029442 HETEROCYCLIC COMPOUNDS AND USES THEREOF
The present invention relates to pharmaceutical compounds, compositions and methods, especially as they are related to compositions and methods for the...
2017/0029441 AMIDO-SUBSTITUTED IMIDAZOPYRIDAZINES USEFUL IN THE TREATMENT OF HYPER-PROLIFERATIVE AND/OR ANGIOGENESIS DISORDERS
The present invention relates to amido-substituted imidazopyridazine compounds of general formula (I): in which A, E, R2, R3, R4 and n are as defined in the...
2017/0029440 PIPERIDINE/PIPERAZINE DERIVATIVES
The invention further relates to a DGAT inhibitor of formula ##STR00001## including any stereochemically isomeric form thereof, wherein A represents CH or N; the...
2017/0029439 NOVEL MACROCYCLIC COMPOUNDS
The present invention relates to novel macrocyclic compounds of general formula (I) as described and defined herein, and methods for their preparation, their...
2017/0029438 POLYCYCLIC CARBAMOYLPYRIDONE DERIVATIVE HAVING HIV INTEGRASE INHIBITORY ACTIVITY
The present invention is to provide a novel compound (I) shown below, having the anti-virus activity, particularly the HIV integrase inhibitory activity, and a...
2017/0029437 Compositions and Methods for Treating Neoplasia, Inflammatory Disease and Other Disorders
The invention features compositions and methods for treating or preventing a neoplasia. More specifically, the invention provides compositions and methods for...
2017/0029436 NEOSORAPHENS
The present invention relates to compounds according to general formula (I); to compositions, including a pharmaceutical formulation and a combination...
2017/0029435 CORTISTATIN ANALOGUES AND SYNTHESES AND USES THEREOF
Provided herein are compounds of Formula (A), (B), (C), (D) and (E), pharmaceutically acceptable salts, quaternary amine salts, and N-oxides thereof, and...
2017/0029434 PHOSPHONIC ACID CATALYST IN DEHYDRATIVE CYCLIZATION OF 5 AND 6 CARBON POLYOLS WITH IMPROVED COLOR AND PRODUCT...
A process for preparing cyclic dehydration products from sugar alcohols is described. The process involve using a mixed-acid catalyst reaction mixture...
2017/0029433 TRANSFER HYDROGENATION OF CYCLOPAMINE ANALOGS
Provided herein is a process for the transfer-hydrogenation of ketone analogs of members of the jervine type of Veratrum alkaloids, such as cyclopamine. Also...
2017/0029432 (+)-MORPHINANS AS ANTAGONISTS OF TOLL-LIKE RECEPTOR 9 AND THERAPEUTIC USES THEREOF
The present invention provides (+)-morphinans comprising Toll-like receptor 9 (TLR9) antagonist activity, as well as methods for using the (+)-morphinans to...
2017/0029431 10',11'-MODIFIED SAXITOXINS USEFUL FOR THE TREATMENT OF PAIN
Provided herein are compounds, pharmaceutical compositions comprising the compounds, and methods of using the compounds and compositions in treating conditions...
2017/0029430 ANALOGUES OF 4H-PYRAZOLO[1,5-a] BENZIMIDAZOLE COMPOUND AS PARP INHIBITORS
Disclosed is a series of analogues of 4H-pyrazolo[1,5-.alpha.]benzimidazole compound as PARP inhibitors. In particular, disclosed in the invention is a...
2017/0029429 NOVEL CHIRAL N-ACYL-5,6,7,(8-SUBSTITUTED)-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-a]PYRAZINES AS SELECTIVE NK-3...
The present invention relates to novel compounds of Formula I and their use in therapeutic treatments. The invention further relates to a novel chiral...
2017/0029428 Solid Forms and Formulations of Imidazopyrazine Compound
In some embodiments, the invention relates to crystalline solid forms, including hydrates, polymorphs, and salt forms, of ...
2017/0029427 COMPOUNDS AND METHODS FOR ANTIVIRAL TREATMENT
Compounds and pharmaceutically acceptable salts and esters and compositions thereof, for treating viral infections are provided. The compounds and compositions...
2017/0029426 METHODS AND REAGENTS FOR RADIOLABELING
The present invention provides methods for radiolabeling compounds useful as Hsp90 inhibitors. The present invention also provides intermediates useful in such...
2017/0029425 NEW DIAZASPIROCYCLOALKANE AND AZASPIROCYCLOALKANE
Compounds having the general formula (I) ##STR00001## wherein R.sup.1, R.sup.2, Y and W are as described herein, compositions including the compounds and methods...
2017/0029424 IODONIUM ANALOGS AS INHIBITORS OF NADPH OXIDASES AND OTHER FLAVIN DEHYDROGENASES; FORMULATIONS THEREOF; AND...
Disclosed herein are novel iodonium analogs having anticancer and anti-inflammatory activity.
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